{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T17:50:13Z","timestamp":1778953813013,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Oral potentially malignant disorders (OPMD) are lesions associated with an increased risk of transformation (MT) into cancer. Objective: A study was made of the salivary levels of adenosine deaminase (ADA), ferritin (FRR) and total proteins (TP) in healthy individuals and in patients with oral potentially malignant disorders (OPMD), assessing the potential role of saliva as a diagnostic tool. Methods: A total of 91 subjects participated in the study, divided into two groups\u201459 patients with OPMD (oral leukoplakia or oral lichen planus) and 32 healthy controls\u2014with measurements being made of salivary ADA, ferritin (FRR) and total proteins (TP). Results: There were no significant differences in salivary mean ADA between the OPMD group 0.85 \u00b1 2.18 UI\/I and the controls 0.71 \u00b1 1.72 UI\/I (p = 0.934), though the levels of both FRR mean OPMD, 12.66 \u00b1 10.50 (\u00b5g\/L), versus control, 7.19 \u00b1 4.44 (p = 0.001), and TP, 23.41 \u00b1 17, versus control, 14.15 \u00b1 15.19, were significantly higher in the OPMD group (p = 0.001). Patients with oral lichen planus showed significant differences in terms of FRR (p = 0.009) and TP (p = 0.003). The ferritin in LPO with a cut-off point of 8.5C showed a sensitivity and specificity of 54.3% and 82.3, respectively. The area under the curve (AUC) was 0.69 (95% confidence interval (95% CI): 0.58\u20130.82; p = 0.003). Conclusions: Ferritin and total proteins may constitute potential salivary biomarkers for oral lichen planus, though further studies are still needed in this field. In addition, saliva testing is a reliable and noninvasive diagnostic tool and appears to be a reliable strategy offering an interesting alternative for the screening of large populations.<\/jats:p>","DOI":"10.3390\/cancers15215256","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T07:24:04Z","timestamp":1698823444000},"page":"5256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preliminary Evaluation Salivary Biomarkers in Patients with Oral Potentially Malignant Disorders (OPMD): A Case\u2013Control Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3314-8613","authenticated-orcid":false,"given":"Pia","family":"L\u00f3pez-Jornet","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Odontology, Hospital Morales Meseguer, Cl\u00ednica Odontol\u00f3gica, Marqu\u00e9s del Los V\u00e9lez s\/n, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aitana","family":"Olmo-Monedero","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Odontology, Hospital Morales Meseguer, Cl\u00ednica Odontol\u00f3gica, Marqu\u00e9s del Los V\u00e9lez s\/n, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-4147","authenticated-orcid":false,"given":"Camila","family":"Peres-Rubio","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Pons-Fuster","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Humana y Psicobiolog\u00eda, Faculty of Medicine and Odontology, Biomedical Research Institute (IMIB-Arrixaca), University of Murcia Spain, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5323-5001","authenticated-orcid":false,"given":"Asta","family":"Tvarijonaviciute","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence Mare Nostrum, University of Murcia, Campus de Espinardo s\/n, Espinardo, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/odi.13704","article-title":"Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104550","DOI":"10.1016\/j.oraloncology.2019.104550","article-title":"Oral potentially malignant disorders: A comprehensive review on clinical aspects and management","volume":"102","author":"Warnakulasuriya","year":"2020","journal-title":"Oral Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Monteiro, L., Carey, B., Diniz-Freitas, M., Lombardi, N., Cook, R., Fricain, J.C., Brailo, V., Limeres, J., Varoni, E., and Fenelon, M. 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