{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:58:05Z","timestamp":1766401085043,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>A radical hysterectomy is the standard method of surgical treatment for patients with early-stage cancer of the uterine cervix. It was first introduced more than 100 years ago. Since then, various and many different radical procedures, which diverge in terms of radicality, have been described. Inconsistencies are clearly seen in practical anatomy, which were defined as surgically created artifacts. Moreover, the disparity of the procedure is most notable regarding the terminology of pelvic connective tissues and spaces. Despite these controversies, the procedure is widely performed and implemented in the majority of guidelines for the surgical treatment of cancer of the uterine cervix. However, a different and unique concept of surgical treatment of cervical cancer has been reported. It is based on ontogenetic anatomy and maps any tissue in the mature organism according to its embryologic development. The clinical implementation of this theory in the context of early cervical cancer is total mesometrial resection. The present article aims to describe and compare the anatomical and surgical basics of a radical hysterectomy (type C1\/C2) and total mesometrial resection. Discrepancies regarding the terminology, resection lines, and surgical planes of both procedures are highlighted in detail. The surgical anatomy of the pelvic autonomic nerves and its surgical dissection is also delineated. This is the first article that compares the discrepancy of classic anatomy and ontogenic anatomy regarding surgical treatment of cancer of the uterine cervix. Clinical data, oncological outcome, and neoadjuvant and adjuvant treatment regarding both procedures are not the topic of the present article.<\/jats:p>","DOI":"10.3390\/cancers15215295","type":"journal-article","created":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T07:35:06Z","timestamp":1699169706000},"page":"5295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Radical Hysterectomy or Total Mesometrial Resection\u2014Two Anatomical Concepts for Surgical Treatment of Cancer of the Uterine Cervix"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-3095","authenticated-orcid":false,"given":"Stoyan","family":"Kostov","sequence":"first","affiliation":[{"name":"Department of Gynecology, Hospital \u201cSaint Anna\u201d, Medical University\u2014\u201cProf. Dr. Paraskev Stoyanov\u201d, 9002 Varna, Bulgaria"},{"name":"Research Institute, Medical University Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4118-9642","authenticated-orcid":false,"given":"Pavel","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Moscow City Oncology Hospital No. 62, Istra, 27, Str. 1-30, Moscow Region 143515, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Rezende","sequence":"additional","affiliation":[{"name":"Department of Gynecologic oncology, Londrina Cancer Hospital, Londrina 86015-520, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Maternity Hospital, 06800 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-5722","authenticated-orcid":false,"given":"Ilker","family":"Sel\u00e7uk","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Maternity Hospital, 06800 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Muallem, M.Z., J\u00f6ns, T., Seidel, N., Sehouli, J., Diab, Y., and Querleu, D. 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