{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:38:39Z","timestamp":1760150319437,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: There are several significant gaps in current studies of the relationship between anti-cancer medications and orthodontic care that call for more investigation. As a result, the main goals of this systematic review and meta-analysis were to summarise and assess the information that was available regarding the effect of radiotherapy and anti-cancer medications on the overall successful completion of an orthodontic treatment plan. Methods: A standardised data extraction form was devised in accordance with the PRISMA guidelines to conduct a systematic review and meta-analysis, with specific criteria implemented for selecting studies with low to moderate risk of bias. Results: Five studies involving different methodologies were selected at the conclusion of the search strategy. The statistical analysis revealed an estimated odds ratio (OR) of 0.31 and relative risk (RR) of 0.48, indicating a statistically significant association between the use of radiotherapy and anti-neoplastic drugs and a noticeable reduction in the successful completion of orthodontic treatment. The heterogeneity analysis showed significant heterogeneity among the studies. Conclusions: This review emphasises that, although orthodontic therapies can still be beneficial for children receiving chemotherapy, the effectiveness of the therapy may be diminished in older populations. The findings further highlight how crucial it is to take cancer therapies into account when planning and managing orthodontic treatment in order to optimise results and reduce problems.<\/jats:p>","DOI":"10.3390\/cancers15225387","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T08:35:52Z","timestamp":1699864552000},"page":"5387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Systematic Review and Meta-Analysis of the Impact of Cancer and Its Treatment Protocol on the Success of Orthodontic Treatment"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-1752","authenticated-orcid":false,"given":"Mohammad Khursheed","family":"Alam","sequence":"first","affiliation":[{"name":"Orthodontic Division, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia"},{"name":"Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai 600077, India"},{"name":"Department of Public Health, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-1797","authenticated-orcid":false,"given":"Mohammed","family":"Awawdeh","sequence":"additional","affiliation":[{"name":"Preventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Ministry of National Guard\u2014Health Affairs, Riyadh 11481, Saudi Arabia"},{"name":"Dental Services King Abdulaziz Medical City, Ministry of National Guard\u2014Health Affairs, Riyadh 11426, Saudi Arabia"},{"name":"Visiting Associate Professor, College of Medicine & Dentistry, Ulster University, Birmingham B4 6BN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-7773","authenticated-orcid":false,"given":"Sanjeev B.","family":"Khanagar","sequence":"additional","affiliation":[{"name":"Preventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia"},{"name":"King Abdullah International Medical Research Center, Ministry of National Guard\u2014Health Affairs, Riyadh 11481, Saudi Arabia"},{"name":"Dental Services King Abdulaziz Medical City, Ministry of National Guard\u2014Health Affairs, Riyadh 11426, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-9837","authenticated-orcid":false,"given":"Wael","family":"Aboelmaaty","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, Ministry of National Guard\u2014Health Affairs, Riyadh 11481, Saudi Arabia"},{"name":"Dental Services King Abdulaziz Medical City, Ministry of National Guard\u2014Health Affairs, Riyadh 11426, Saudi Arabia"},{"name":"Maxillofacial Surgery and Diagnostic Sciences Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 11426, Saudi Arabia"},{"name":"Oral Radiology and Diagnostic Sciences, Faculty of Dentistry, Mansoura University, Mansoura City 35516, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Abutayyem","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Center of Medical and Bio-Allied Health Sciences Research, College of Dentistry, Ajman University, Ajman 346, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-7959","authenticated-orcid":false,"given":"Haytham Jamil","family":"Alswairki","sequence":"additional","affiliation":[{"name":"School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Ali","family":"Alfawzan","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, College of Dentistry in Ar Rass, Qassim University, Ar Rass 52571, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-1297","authenticated-orcid":false,"given":"Mohammad Younis","family":"Hajeer","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus P.O. Box 16046, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref_1","unstructured":"Dalbah, L.N. (2023). The Role of the Orthodontist, IntechOpen."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Abe, M., Mitani, A., Yao, A., Zong, L., Hoshi, K., and Yanagimoto, S. (2020). Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents. Healthcare, 8.","DOI":"10.3390\/healthcare8030209"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Abe, M., Mitani, A., Yao, A., Zhang, C.-D., Hoshi, K., and Yanagimoto, S. (2021). Close Association between Awareness of Teeth-Alignment Disorder and Systemic Disorders in Late Adolescence. 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