{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:55:24Z","timestamp":1784847324964,"version":"3.55.0"},"reference-count":23,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Objectives: To assess the efficacy of thoracoscopy and the outcome for children with thoracic neurogenic tumors. Methods: We performed a retrospective review of 15 European centers between 2000 and 2020 with patients who underwent thoracoscopy for a neurogenic mediastinal tumor. We assessed preoperative data, complications, and outcomes. Results were expressed with the median and range values. Results: We identified 119 patients with a median age of 4 years old (3 months\u201317 years). The diameter was 5.7 cm (1.1\u201315). INRG stage was L1 n = 46, L2 n = 56, MS n = 5, M n = 12. Of 69 patients with image-defined risk factors (IDRF), 29 had only (T9\u2013T12) locations. Twenty-three out of 34 patients with preoperative chemotherapy had an 18 mm (7\u201324) decrease in diameter. Seven out of 31 patients lost their IDRF after chemotherapy. Fourteen had a conversion to thoracotomy. The length of the hospital stay was 4 days (0\u201346). The main complications included chylothorax (n = 7) and pneumothorax (n = 5). Long-term complications included Horner\u2019s syndrome (n = 5), back pain, and scoliosis (n = 5). Pathology was 53 neuroblastomas, 36 ganglioneuromas, and 30 ganglioneuroblastomas. Fourteen had a postoperative residue. With a median follow-up of 21 months (4\u2013195), 9 patients had a recurrence, and 5 died of disease. Relapses were associated with tumor biology, histology, and the need for chemotherapy (p = 0.034, &lt;0.001, and 0.015, respectively). Residues were associated with preoperative IDRF (excluding T9\u2013T12 only) and the need for preoperative chemotherapy (p = 0.04 and 0.020). Conclusion: Our results show that thoracoscopy is safe, with good outcomes for thoracic neurogenic tumors in selected cases. Surgical outcomes are related to the IDRFs, whereas oncologic outcomes are related to tumor histology and biology.<\/jats:p>","DOI":"10.3390\/cancers15225467","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T07:33:18Z","timestamp":1700292798000},"page":"5467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Thoracoscopy for Pediatric Thoracic Neurogenic Tumors\u2014A European Multi-Center Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Jean Fran\u00e7ois","family":"Lecompte","sequence":"first","affiliation":[{"name":"Fondation Lenval, University Nice C\u00f4te d\u2019Azur, 06200 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sarnacki","sequence":"additional","affiliation":[{"name":"Necker Enfants Malade Hospital, Universit\u00e9 Paris-Cit\u00e9, GHU Centre Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Irtan","sequence":"additional","affiliation":[{"name":"Trousseau Hospital, Universit\u00e9 Paris-Sorbonne, GHU-Paris Sorbonne Assistance Publique-H\u00f4pitaux de Paris (AP-HP), 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Piolat","sequence":"additional","affiliation":[{"name":"Grenoble-Alpes University Hospital, 38700 La Tronche, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Scalabre","sequence":"additional","affiliation":[{"name":"Saint-Etienne University Hospital, 42270 Saint-Priest-en-Jarez, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Talon","sequence":"additional","affiliation":[{"name":"Hopital Hautepierre, CHRU Strasbourg, 67200 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8467-5253","authenticated-orcid":false,"given":"Julien","family":"Rod","sequence":"additional","affiliation":[{"name":"CHU C\u00f4te de N\u00e2cre, 14033 Caen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta","family":"Panait","sequence":"additional","affiliation":[{"name":"La Timone Hospital, Aix-Marseille University, Assistance Publique-H\u00f4pitaux de Marseille (AP-HM), 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Rodesch","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire des Enfants Reine Fabiola, 1020 Bruxelles, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7615-2911","authenticated-orcid":false,"given":"Ana Lourdes","family":"Luis Huertas","sequence":"additional","affiliation":[{"name":"Hospital Universitario Infantil Ni\u00f1o Jes\u00fas, 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Abbo","sequence":"additional","affiliation":[{"name":"H\u00f4pital des Enfants, CHU de Toulouse, 31300 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Demarche","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional Citadelle, 4000 Liege, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Habonimana","sequence":"additional","affiliation":[{"name":"Rennes University Hospital, 35033 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-9946","authenticated-orcid":false,"given":"Quentin","family":"Ballouhey","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la m\u00e8re et de l\u2019enfant, Centre Hospitalier Universitaire de Limoges, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valteau-Couanet","sequence":"additional","affiliation":[{"name":"Gustave Roussy, Paris-Saclay University, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-3745","authenticated-orcid":false,"given":"Florent","family":"Gu\u00e9rin","sequence":"additional","affiliation":[{"name":"Bic\u00eatre Hospital, Paris-Saclay University, GHU Paris Saclay Assistance Publique H\u00f4pitaux de Paris (AP-HP), 94270 Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2008-1072390","article-title":"The Characteristics of Mediastinal Neuroblastoma","volume":"10","author":"Suita","year":"2000","journal-title":"Eur. 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