{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:08Z","timestamp":1790630528676,"version":"4.1.0"},"reference-count":106,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Retroperitoneal soft tissue sarcoma (RPS) is a rare and heterogenous disease for which surgery is the cornerstone of treatment. However, the local recurrence rate is much higher than in soft tissue sarcoma of the extremities since wide resection is usually unfeasible in RPS due to its large size, indistinct tumour borders, anatomical constraints and the thinness of the overlying peritoneum. Local recurrence is the leading cause of death for low-grade RPS, whereas high-grade tumours are prone to distant metastases. In recent decades, the role of emerging therapeutic strategies, such as more extended surgery and (neo)adjuvant treatments to improve oncological outcome in primary localised RPS, has been extensively investigated. In this review, the recent data on the evolving multidisciplinary management of primary localised RPS are comprehensively discussed. The heterogeneity of RPS, with their different histological subtypes and biological behaviour, renders a standard therapeutic \u2018one-size-fits-all\u2019 approach inappropriate, and treatment should be modified according to histological type and malignancy grade. There is sufficient evidence that frontline extended surgery with compartmental resection including all ipsilateral retroperitoneal fat and liberal en bloc resection of adjacent organs and structures, even if they are not macroscopically involved, increases local tumour control in low-grade sarcoma and liposarcoma, but not in leiomyosarcoma for which complete macroscopic resection seems sufficient. Additionally, preoperative radiotherapy is not indicated for all RPSs, but seems to be beneficial in well-differentiated liposarcoma and grade I\/II dedifferentiated liposarcoma, and probably in solitary fibrous tumour. Whether neoadjuvant chemotherapy is of benefit in high-grade RPS remains unclear from retrospective data and is subject of the ongoing randomised STRASS 2 trial, from which the results are eagerly awaited. Personalised, histology-tailored multimodality treatment is promising and will likely further evolve as our understanding of the molecular and genetic characteristics within RPS improves.<\/jats:p>","DOI":"10.3390\/cancers15225469","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T07:33:18Z","timestamp":1700292798000},"page":"5469","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-3727","authenticated-orcid":false,"given":"Eelco","family":"de Bree","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7182-2664","authenticated-orcid":false,"given":"Dimosthenis","family":"Michelakis","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Heretis","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-5003","authenticated-orcid":false,"given":"Nikolaos","family":"Kontopodis","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Spanakis","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Lagoudaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3896-8426","authenticated-orcid":false,"given":"Maria","family":"Tolia","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5376-9580","authenticated-orcid":false,"given":"Michail","family":"Zografakis-Sfakianakis","sequence":"additional","affiliation":[{"name":"Department of Nursing, School of Health Sciences, Hellenic Mediterranean University, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Mavroudis","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Medical School of Crete University Hospital, 71110 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jss.2007.02.026","article-title":"Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry","volume":"141","author":"Gutierrez","year":"2007","journal-title":"J. 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