{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:15:19Z","timestamp":1790651719230,"version":"4.1.0"},"reference-count":58,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["SFB815"],"award-info":[{"award-number":["SFB815"]}]},{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["IllL6-519\/03\/03.u001-(0006)"],"award-info":[{"award-number":["IllL6-519\/03\/03.u001-(0006)"]}]},{"name":"Mildred Scheel Career Center","award":["SFB815"],"award-info":[{"award-number":["SFB815"]}]},{"name":"Mildred Scheel Career Center","award":["IllL6-519\/03\/03.u001-(0006)"],"award-info":[{"award-number":["IllL6-519\/03\/03.u001-(0006)"]}]},{"name":"LOEWE Main Research Focus DynaMem","award":["SFB815"],"award-info":[{"award-number":["SFB815"]}]},{"name":"LOEWE Main Research Focus DynaMem","award":["IllL6-519\/03\/03.u001-(0006)"],"award-info":[{"award-number":["IllL6-519\/03\/03.u001-(0006)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Multiple myeloma (MM) is a malignant plasma cell disorder in which the MYC oncogene is frequently dysregulated. Due to its central role, MYC has been proposed as a drug target; however, the development of a clinically applicable molecule modulating MYC activity remains an unmet challenge. Consequently, an alternative is the development of therapeutic options targeting proteins located downstream of MYC. Therefore, we aimed to identify undescribed MYC-target proteins in MM cells using Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC) and mass spectrometry. We revealed a cluster of proteins associated with the regulation of translation initiation. Herein, the RNA-binding proteins Heterogeneous Nuclear Ribonucleoprotein C (hnRNPC) and La Ribonucleoprotein 1 (LARP1) were predominantly downregulated upon MYC depletion. CRISPR-mediated knockout of either hnRNPC or LARP1 in conjunction with redundant LARP family proteins resulted in a proliferative disadvantage for MM cells. Moreover, high expression levels of these proteins correlate with high MYC expression and with poor survival and disease progression in MM patients. In conclusion, our study provides valuable insights into MYC\u2019s role in translation initiation by identifying hnRNPC and LARP1 as proliferation drivers of MM cells and as both predictive factors for survival and disease progression in MM patients.<\/jats:p>","DOI":"10.3390\/cancers15235508","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:12:13Z","timestamp":1700568733000},"page":"5508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival"],"prefix":"10.3390","volume":"15","author":[{"given":"Marcel","family":"Seibert","sequence":"first","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-1279","authenticated-orcid":false,"given":"Sebastian E.","family":"Koschade","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"},{"name":"University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Stolp","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"H\u00e4upl","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Wempe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-5516","authenticated-orcid":false,"given":"Hubert","family":"Serve","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"},{"name":"University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-1489","authenticated-orcid":false,"given":"Nina","family":"Kurrle","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-6685","authenticated-orcid":false,"given":"Frank","family":"Schn\u00fctgen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"von Metzler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hematology\/Oncology, University Hospital, Goethe University Frankfurt, 60590 Frankfurt, Germany"},{"name":"Frankfurt Cancer Institute, Goethe-University Frankfurt, 60596 Frankfurt, Germany"},{"name":"University Cancer Center Frankfurt (UCT), University Hospital Frankfurt, Goethe University, 60590 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1056\/NEJMra041875","article-title":"Multiple myeloma","volume":"351","author":"Kyle","year":"2004","journal-title":"N. 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