{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:36:45Z","timestamp":1793403405662,"version":"4.5.0"},"reference-count":138,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["FSWR-2023-0029"],"award-info":[{"award-number":["FSWR-2023-0029"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Approximately 30% of glioma patients are able to survive beyond one year postdiagnosis. And this short time is often overshadowed by glioma-associated epilepsy. This condition severely impairs the patient\u2019s quality of life and causes great suffering. The genetic, molecular and cellular mechanisms underlying tumour development and epileptogenesis remain incompletely understood, leading to numerous unanswered questions. The various types of gliomas, namely glioblastoma, astrocytoma and oligodendroglioma, demonstrate distinct seizure susceptibility and disease progression patterns. Patterns have been identified in the presence of IDH mutations and epilepsy, with tumour location in cortical regions, particularly the frontal lobe, showing a more frequent association with seizures. Altered expression of TP53, MGMT and VIM is frequently detected in tumour cells from individuals with epilepsy associated with glioma. However, understanding the pathogenesis of these modifications poses a challenge. Moreover, hypoxic effects induced by glioma and associated with the HIF-1a factor may have a significant impact on epileptogenesis, potentially resulting in epileptiform activity within neuronal networks. We additionally hypothesise about how the tumour may affect the functioning of neuronal ion channels and contribute to disruptions in the blood\u2013brain barrier resulting in spontaneous depolarisations.<\/jats:p>","DOI":"10.3390\/cancers15235539","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T10:41:51Z","timestamp":1700649711000},"page":"5539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Unexplained Causes of Glioma-Associated Epilepsies: A Review of Theories and an Area for Research"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-470X","authenticated-orcid":false,"given":"Mariia","family":"Saviuk","sequence":"first","affiliation":[{"name":"Institute of Neurosciences, National Research Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia"},{"name":"Cell Death Investigation and Therapy Laboratory, Anatomy and Embryology Unit, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Sleptsova","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, National Research Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0835-5143","authenticated-orcid":false,"given":"Tikhon","family":"Redkin","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, National Research Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4648-0738","authenticated-orcid":false,"given":"Victoria","family":"Turubanova","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences, National Research Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Ave., 603022 Nizhny Novgorod, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in Adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10859","DOI":"10.1038\/s41598-023-38049-1","article-title":"Tumor-Related Epilepsy and Post-Surgical Outcomes: Tertiary Hospital Experience in Vietnam","volume":"13","author":"Le","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1474-4422(23)00031-5","article-title":"The Complexities Underlying Epilepsy in People with Glioblastoma","volume":"22","author":"Sokolov","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ijrobp.2013.02.012","article-title":"Valproic Acid Use During Radiation Therapy for Glioblastoma Associated with Improved Survival","volume":"86","author":"Barker","year":"2013","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ryu, J.Y., Min, K.L., and Chang, M.J. (2019). Effect of Anti-Epileptic Drugs on the Survival of Patients with Glioblastoma Multiforme: A Retrospective, Single-Center Study. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225599"},{"key":"ref_6","first-page":"203","article-title":"Seizure Response to Temozolomide Chemotherapy in Patients with WHO Grade II Oligodendroglioma: A Single-Institution Descriptive Study","volume":"6","author":"Haggiagi","year":"2019","journal-title":"Neurooncol. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.radonc.2021.12.019","article-title":"Re-Irradiation for Recurrent High Grade Glioma (HGG) Patients: Results of a Single Arm Prospective Phase 2 Study","volume":"167","author":"Navarria","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_8","unstructured":"WHO Classification of Tumours Editorial Board (2021). Central Nervous System Tumours: WHO Classification of Tumours, International Agency for Research on Cancer. [5th ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jocn.2015.11.030","article-title":"An Analysis of 170 Glioma Patients and Systematic Review to Investigate the Association between IDH-1 Mutations and Preoperative Glioma-Related Epilepsy","volume":"31","author":"Yang","year":"2016","journal-title":"J. Clin. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"106430","DOI":"10.1016\/j.eplepsyres.2020.106430","article-title":"Correlation of Preoperative Seizures with a Wide Range of Tumor Molecular Markers in Gliomas: An Analysis of 442 Glioma Patients from China","volume":"166","author":"Shen","year":"2020","journal-title":"Epilepsy Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.seizure.2018.01.011","article-title":"IDH1 Mutation Is Associated with a Higher Preoperative Seizure Incidence in Low-Grade Glioma: A Systematic Review and Meta-Analysis","volume":"55","author":"Li","year":"2018","journal-title":"Seizure"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2217\/cns.15.29","article-title":"Seizures in Oligodendroglial Tumors","volume":"4","author":"Kerkhof","year":"2015","journal-title":"CNS Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.seizure.2019.05.018","article-title":"Potential Influence of IDH1 Mutation and MGMT Gene Promoter Methylation on Glioma-Related Preoperative Seizures and Postoperative Seizure Control","volume":"69","author":"Feyissa","year":"2019","journal-title":"Seizure"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/cns.14109","article-title":"Altering Patterns of Sensorimotor Network in Patients with Different Pathological Diagnoses and Glioma-related Epilepsy under the Latest Glioma Classification of the Central Nervous System","volume":"29","author":"Fang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/neuonc\/noac197","article-title":"IDH1\/2 Wildtype Gliomas Grade 2 and 3 with Molecular Glioblastoma-like Profile Have a Distinct Course of Epilepsy Compared to IDH1\/2 Wildtype Glioblastomas","volume":"25","author":"Tesileanu","year":"2023","journal-title":"Neuro. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-018-1913-0","article-title":"CIMPACT-NOW Update 3: Recommended Diagnostic Criteria for \u201cDiffuse Astrocytic Glioma, IDH-Wildtype, with Molecular Features of Glioblastoma, WHO Grade IV\u201d","volume":"136","author":"Brat","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.seizure.2015.12.013","article-title":"Clinicopathological Factors Predictive of Postoperative Seizures in Patients with Gliomas","volume":"35","author":"Yang","year":"2016","journal-title":"Seizure"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/jnen\/nlaa137","article-title":"Somatic Focal Copy Number Gains of Noncoding Regions of Receptor Tyrosine Kinase Genes in Treatment-Resistant Epilepsy","volume":"80","author":"Vasudevaraja","year":"2021","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"681","DOI":"10.21037\/tp-23-196","article-title":"Identification of Epidermal Growth Factor Receptor as an Immune-Related Biomarker in Epilepsy Using Multi-Transcriptome Data","volume":"12","author":"Luo","year":"2023","journal-title":"Transl. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1111\/febs.14603","article-title":"Impaired Neural Stem Cell Expansion and Hypersensitivity to Epileptic Seizures in Mice Lacking the EGFR in the Brain","volume":"285","author":"Robson","year":"2018","journal-title":"FEBS J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1109\/TBME.2018.2871415","article-title":"Epilepsy-on-a-Chip System for Antiepileptic Drug Discovery","volume":"66","author":"Liu","year":"2019","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00401-018-1905-0","article-title":"Distribution of EGFR Amplification, Combined Chromosome 7 Gain and Chromosome 10 Loss, and TERT Promoter Mutation in Brain Tumors and Their Potential for the Reclassification of IDHwt Astrocytoma to Glioblastoma","volume":"136","author":"Stichel","year":"2018","journal-title":"Acta Neuropathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.jmoldx.2011.06.003","article-title":"Detailed Characterization of Alterations of Chromosomes 7, 9, and 10 in Glioblastomas as Assessed by Single-Nucleotide Polymorphism Arrays","volume":"13","author":"Crespo","year":"2011","journal-title":"J. Mol. Diagn."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00432-021-03536-3","article-title":"Human TERT Promoter Mutations as a Prognostic Biomarker in Glioma","volume":"147","author":"Powter","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12672-023-00760-w","article-title":"TERT Mutations-Associated Alterations in Clinical Characteristics, Immune Environment and Therapy Response in Glioblastomas","volume":"14","author":"Tang","year":"2023","journal-title":"Discover. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2016.12.013","article-title":"Epileptic Features and Survival in Glioblastomas Presenting with Seizures","volume":"130","author":"Toledo","year":"2017","journal-title":"Epilepsy Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"106641","DOI":"10.1016\/j.eplepsyres.2021.106641","article-title":"A Novel Nomogram for Predicting the Risk of Epilepsy Occurrence after Operative in Gliomas Patients without Preoperative Epilepsy History","volume":"174","author":"Pan","year":"2021","journal-title":"Epilepsy Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1038\/cddis.2010.55","article-title":"Loss of P53 Results in Protracted Electrographic Seizures and Development of an Aggravated Epileptic Phenotype Following Status Epilepticus","volume":"1","author":"Engel","year":"2010","journal-title":"Cell Death Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/jnen\/nlw052","article-title":"MGMT-Methylated Alleles Are Distributed Heterogeneously Within Glioma Samples Irrespective of IDH Status and Chromosome 10q Deletion","volume":"75","author":"Fontana","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.4103\/1673-5374.235073","article-title":"Spatiotemporal MicroRNA Profile in Peripheral Nerve Regeneration: MiR-138 Targets Vimentin and Inhibits Schwann Cell Migration and Proliferation","volume":"13","author":"Sullivan","year":"2018","journal-title":"Neural. Regen. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Liu, Y., Zhao, S., Chen, Y., Ma, W., Lu, S., He, L., Chen, J., Chen, X., Zhang, X., and Shi, Y. (2023). Vimentin Promotes Glioma Progression and Maintains Glioma Cell Resistance to Oxidative Phosphorylation Inhibition. Cell. Oncol.","DOI":"10.1007\/s13402-023-00844-3"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"He, C., Sheng, L., Pan, D., Jiang, S., Ding, L., Ma, X., Liu, Y., and Jia, D. (2021). Single-Cell Transcriptomic Analysis Revealed a Critical Role of SPP1\/CD44-Mediated Crosstalk Between Macrophages and Cancer Cells in Glioma. Front. Cell. Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.779319"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1093\/neuonc\/noac111","article-title":"HIP1R and Vimentin Immunohistochemistry Predict 1p\/19q Status in IDH-Mutant Glioma","volume":"24","author":"Felix","year":"2022","journal-title":"Neuro. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10014-021-00411-4","article-title":"Revisiting Vimentin: A Negative Surrogate Marker of Molecularly Defined Oligodendroglioma in Adult Type Diffuse Glioma","volume":"38","author":"Kim","year":"2021","journal-title":"Brain Tumor Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3349","DOI":"10.1007\/s11064-023-03950-8","article-title":"EGR1-Driven METTL3 Activation Curtails VIM-Mediated Neuron Injury in Epilepsy","volume":"48","author":"Dong","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1097\/PAS.0b013e31804a7ebb","article-title":"Angiocentric Glioma","volume":"31","author":"Preusser","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.4161\/cbt.7.9.6954","article-title":"PTEN Signaling Pathways in Glioblastoma","volume":"7","author":"Koul","year":"2008","journal-title":"Cancer Biol. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41419-021-03657-0","article-title":"Mutation-Specific Non-Canonical Pathway of PTEN as a Distinct Therapeutic Target for Glioblastoma","volume":"12","author":"Choi","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1523\/JNEUROSCI.3144-14.2015","article-title":"Hyperactivity of Newborn Pten Knock-out Neurons Results from Increased Excitatory Synaptic Drive","volume":"35","author":"Williams","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng832","article-title":"Mutations in LGI1 Cause Autosomal-Dominant Partial Epilepsy with Auditory Features","volume":"30","author":"Kalachikov","year":"2002","journal-title":"Nat. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e17984","DOI":"10.1016\/j.heliyon.2023.e17984","article-title":"Imbalance of Glutamatergic and GABAergic Neurotransmission in Audiogenic Seizure-Susceptible Leucine-Rich Glioma-Inactivated 1 (Lgi1)-Mutant Rats","volume":"9","author":"Kinboshi","year":"2023","journal-title":"Heliyon"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kinboshi, M., Ikeda, A., and Ohno, Y. (2020). Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.626658"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00428-003-0874-3","article-title":"Expression of the LGI1 Gene Product in Astrocytic Gliomas: Downregulation with Malignant Progression","volume":"443","author":"Besleaga","year":"2003","journal-title":"Virchows. Archiv."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wang, E., Zhang, C., Polavaram, N., Liu, F., Wu, G., Schroeder, M.A., Lau, J.S., Mukhopadhyay, D., Jiang, S.-W., and O\u2019Neill, B.P. (2014). The Role of Factor Inhibiting HIF (FIH-1) in Inhibiting HIF-1 Transcriptional Activity in Glioblastoma Multiforme. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086102"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1367-5931(99)80067-2","article-title":"The Development and Therapeutic Potential of Protein Kinase Inhibitors","volume":"3","author":"Cohen","year":"1999","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1124\/mol.54.5.815","article-title":"Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells","volume":"54","author":"Hosoi","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e2023017","DOI":"10.53388\/2023623017","article-title":"Novel Insights into MTOR Signalling Pathways: A Paradigm for Targeted Tumor Therapy","volume":"6","author":"Riis","year":"2023","journal-title":"Cancer Adv."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hashemi, M., Etemad, S., Rezaei, S., Ziaolhagh, S., Rajabi, R., Rahmanian, P., Abdi, S., Koohpar, Z.K., Rafiei, R., and Raei, B. (2023). Progress in Targeting PTEN\/PI3K\/Akt Axis in Glioblastoma Therapy: Revisiting Molecular Interactions. Biomed. Pharmacother., 158.","DOI":"10.1016\/j.biopha.2022.114204"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.phrs.2016.03.039","article-title":"MTOR Pathway Inhibition as a New Therapeutic Strategy in Epilepsy and Epileptogenesis","volume":"107","author":"Citraro","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jns.2013.05.029","article-title":"Role of the MTOR Signaling Pathway in Epilepsy","volume":"332","author":"Meng","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s40120-023-00476-7","article-title":"Effect of MTOR Inhibitors in Epilepsy Treatment in Children with Tuberous Sclerosis Complex Under 2 Years of Age","volume":"12","author":"Kotulska","year":"2023","journal-title":"Neurol. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jpeds.2013.12.053","article-title":"Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex","volume":"164","author":"Cardamone","year":"2014","journal-title":"J. Pediatr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"182ra53","DOI":"10.1126\/scitranslmed.3005271","article-title":"Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder","volume":"5","author":"Parker","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1055\/a-2104-1614","article-title":"Observation of a Possible Successful Treatment of DEPDC5-Related Epilepsy with MTOR Inhibitor","volume":"54","author":"Hadzsiev","year":"2023","journal-title":"Neuropediatrics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/0883073818813238","article-title":"MTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report","volume":"34","author":"Xu","year":"2019","journal-title":"J. Child. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10072-016-2706-7","article-title":"Activation of the MTOR Signaling Pathway in Peritumoral Tissues Can Cause Glioma-Associated Seizures","volume":"38","author":"Yuan","year":"2017","journal-title":"Neurol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/neuonc\/noac003","article-title":"IDH-Mutated Gliomas Promote Epileptogenesis through D-2-hydroxyglutarate-dependent MTOR Hyperactivation","volume":"24","author":"Mortazavi","year":"2022","journal-title":"Neuro. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1152\/jappl.2000.88.4.1474","article-title":"HIF-1: Mediator of Physiological and Pathophysiological Responses to Hypoxia","volume":"88","author":"Semenza","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3892\/or.2016.5309","article-title":"Advances in the Targeting of HIF-1\u03b1 and Future Therapeutic Strategies for Glioblastoma Multiforme","volume":"37","author":"Wang","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.clinph.2021.01.033","article-title":"SPECT Imaging of Cerebral Blood Flow Changes Induced by Acute Trigeminal Nerve Stimulation in Drug-Resistant Epilepsy: A Pilot Study","volume":"132","author":"Mercante","year":"2021","journal-title":"Clin. Neurophysiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0920-1211(96)00049-6","article-title":"Hypoxia-Induced Hyperexcitability in Vivo and in Vitro in the Immature Hippocampus","volume":"26","author":"Jensen","year":"1996","journal-title":"Epilepsy Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1523\/JNEUROSCI.21-20-08154.2001","article-title":"Decreased Glutamate Receptor 2 Expression and Enhanced Epileptogenesis in Immature Rat Hippocampus after Perinatal Hypoxia-Induced Seizures","volume":"21","author":"Sanchez","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0091-3057(02)00998-X","article-title":"The Epileptogenic Effect of Seizures Induced by Hypoxia","volume":"74","author":"Rubaj","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/cns.13942","article-title":"Relationship between Chronic Hypoxia and Seizure Susceptibility","volume":"28","author":"Xu","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1111\/j.1528-1167.2012.03591.x","article-title":"Investigation of Hypoxia-Inducible Factor-1\u03b1 in Hippocampal Sclerosis: A Postmortem Study","volume":"53","author":"Feast","year":"2012","journal-title":"Epilepsia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s12017-012-8203-0","article-title":"Hypoxia Markers Are Expressed in Interneurons Exposed to Recurrent Seizures","volume":"15","author":"Gualtieri","year":"2013","journal-title":"Neuromolecular. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/WNR.0000000000001345","article-title":"Involvement of Hypoxia-Inducible Factor-1 Alpha in the Upregulation of P-Glycoprotein in Refractory Epilepsy","volume":"30","author":"Wang","year":"2019","journal-title":"NeuroReport"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Berendsen, S., Spliet, W.G.M., Geurts, M., Van Hecke, W., Seute, T., Snijders, T.J., Bours, V., Bell, E.H., Chakravarti, A., and Robe, P.A. (2019). Epilepsy Associates with Decreased HIF-1\u03b1\/STAT5b Signaling in Glioblastoma. Cancers, 11.","DOI":"10.3390\/cancers11010041"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Chen, T.-S., Lai, M.-C., Huang, H.-Y.I., Wu, S.-N., and Huang, C.-W. (2022). Immunity, Ion Channels and Epilepsy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126446"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2011\/590249","article-title":"Ion Channels in Glioblastoma","volume":"2011","author":"Molenaar","year":"2011","journal-title":"ISRN Neurol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5607\/en.2019.28.1.30","article-title":"Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient","volume":"28","author":"Woo","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1158\/1535-7163.MCT-19-0929","article-title":"Ion Channels and Their Role in the Pathophysiology of Gliomas","volume":"19","author":"Takayasu","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"10166","DOI":"10.1073\/pnas.1810134115","article-title":"Potentiating KCC2 Activity Is Sufficient to Limit the Onset and Severity of Seizures","volume":"115","author":"Moore","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Griffin, M., Khan, R., Basu, S., and Smith, S. (2020). Ion Channels as Therapeutic Targets in High Grade Gliomas. Cancers, 12.","DOI":"10.3390\/cancers12103068"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/neuonc\/nox175","article-title":"Is the Blood\u2013Brain Barrier Really Disrupted in All Glioblastomas? A Critical Assessment of Existing Clinical Data","volume":"20","author":"Sarkaria","year":"2018","journal-title":"Neuro. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1038\/ncomms5196","article-title":"Disruption of Astrocyte\u2013Vascular Coupling and the Blood\u2013Brain Barrier by Invading Glioma Cells","volume":"5","author":"Watkins","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.bbamem.2006.02.018","article-title":"Three Distinct Roles of Aquaporin-4 in Brain Function Revealed by Knockout Mice","volume":"1758","author":"Verkman","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1007\/s11033-022-07656-y","article-title":"The Role of Aquaporin 4 in Brain Tumors: Implications for Pathophysiology, Diagnosis and Therapy","volume":"49","author":"Behnam","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.2147\/CMAR.S288720","article-title":"Remodelling and Treatment of the Blood-Brain Barrier in Glioma","volume":"13","author":"Wang","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awl318","article-title":"Blood-Brain Barrier Leakage May Lead to Progression of Temporal Lobe Epilepsy","volume":"130","author":"Redeker","year":"2007","journal-title":"Brain"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/brain\/awl317","article-title":"TGF-\u03b2 Receptor-Mediated Albumin Uptake into Astrocytes Is Involved in Neocortical Epileptogenesis","volume":"130","author":"Ivens","year":"2007","journal-title":"Brain"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/glia.22311","article-title":"Blood-brain Barrier Dysfunction, TGF\u03b2 Signaling, and Astrocyte Dysfunction in Epilepsy","volume":"60","author":"Heinemann","year":"2012","journal-title":"Glia"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fneur.2019.00382","article-title":"The Blood-Brain Barrier Breakdown During Acute Phase of the Pilocarpine Model of Epilepsy Is Dynamic and Time-Dependent","volume":"10","author":"Mendes","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn.2018.13","article-title":"Fibrinogen in Neurological Diseases: Mechanisms, Imaging and Therapeutics","volume":"19","author":"Petersen","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"15638","DOI":"10.1523\/JNEUROSCI.3355-10.2010","article-title":"Spontaneous Network Events Driven by Depolarizing GABA Action in Neonatal Hippocampal Slices Are Not Attributable to Deficient Mitochondrial Energy Metabolism","volume":"30","author":"Ruusuvuori","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0166-2236(92)90191-A","article-title":"Modulation of PH by Neuronal Activity","volume":"15","author":"Chesler","year":"1992","journal-title":"Trends Neurosci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.semcdb.2014.10.003","article-title":"Blood\u2013Brain Barrier Dysfunction, Seizures and Epilepsy","volume":"38","author":"Aronica","year":"2015","journal-title":"Semin. Cell. Dev. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nm.2453","article-title":"Glutamate Release by Primary Brain Tumors Induces Epileptic Activity","volume":"17","author":"Buckingham","year":"2011","journal-title":"Nat. Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Corsi, L., Mescola, A., and Alessandrini, A. (2019). Glutamate Receptors and Glioblastoma Multiforme: An Old \u201cRoute\u201d for New Perspectives. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071796"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11060-009-9990-5","article-title":"In Vivo Assessment of High-Grade Glioma Biochemistry Using Microdialysis: A Study of Energy-Related Molecules, Growth Factors and Cytokines","volume":"97","author":"Marcus","year":"2010","journal-title":"J. Neurooncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1212\/WNL.0b013e318266fa89","article-title":"Glutamate Is Associated with a Higher Risk of Seizures in Patients with Gliomas","volume":"79","author":"Yuen","year":"2012","journal-title":"Neurology"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nm0901-1010","article-title":"Glutamate Release Promotes Growth of Malignant Gliomas","volume":"7","author":"Takano","year":"2001","journal-title":"Nat. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"key":"ref_95","first-page":"S14","article-title":"The Role of Glutamate in Epilepsy and Other CNS Disorders","volume":"44","author":"Meldrum","year":"1994","journal-title":"Neurology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/neu.2016.47","article-title":"Inflammatory Aspects of Epileptogenesis: Contribution of Molecular Inflammatory Mechanisms","volume":"29","author":"Alyu","year":"2017","journal-title":"Acta Neuropsychiatr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8692","DOI":"10.1523\/JNEUROSCI.23-25-08692.2003","article-title":"Interleukin-1\u03b2 Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases","volume":"23","author":"Viviani","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1528-1167.2011.03242.x","article-title":"Therapeutic Potential of New Antiinflammatory Drugs","volume":"52","author":"Vezzani","year":"2011","journal-title":"Epilepsia"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3171\/jns.1992.77.2.0209","article-title":"Changes in Gamma-Aminobutyric Acid and Somatostatin in Epileptic Cortex Associated with Low-Grade Gliomas","volume":"77","author":"Haglund","year":"1992","journal-title":"J. Neurosurg."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/glia.22730","article-title":"GABAergic Disinhibition and Impaired KCC2 Cotransporter Activity Underlie Tumor-Associated Epilepsy","volume":"63","author":"Campbell","year":"2015","journal-title":"Glia"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/onc.2016.245","article-title":"Endogenous GABAA Receptor Activity Suppresses Glioma Growth","volume":"36","author":"Blanchart","year":"2017","journal-title":"Oncogene"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Smits, A., Jin, Z., Elsir, T., Pedder, H., Nist\u00e9r, M., Alafuzoff, I., Dimberg, A., Edqvist, P.-H., Pont\u00e9n, F., and Aronica, E. (2012). GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037041"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1474-4422(07)70103-5","article-title":"Epilepsy in Patients with Brain Tumours: Epidemiology, Mechanisms, and Management","volume":"6","author":"Wilms","year":"2007","journal-title":"Lancet Neurol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.mehy.2012.07.037","article-title":"Gliomas and Seizures","volume":"79","author":"Prakash","year":"2012","journal-title":"Med. Hypotheses"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"100586","DOI":"10.1016\/j.ebr.2023.100586","article-title":"Glioma Features and Seizure Control during Long-Term Follow-Up","volume":"21","author":"Ollila","year":"2023","journal-title":"Epilepsy Behav. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Liang, S., Zhang, J., Zhang, S., and Fu, X. (2016). Epilepsy in Adults with Supratentorial Glioblastoma: Incidence and Influence Factors and Prophylaxis in 184 Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158206"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/epi.17658","article-title":"Time-dependent Risk Factors for Epileptic Seizures in Glioblastoma Patients: A Retrospective Analysis of 520 Cases","volume":"64","author":"Stritzelberger","year":"2023","journal-title":"Epilepsia"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clineuro.2017.11.015","article-title":"Quantifying the Prognostic Significance in Glioblastoma of Seizure History at Initial Presentation: A Systematic Review and Meta-Analysis","volume":"164","author":"Lu","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00701-017-3434-3","article-title":"Long-Term Control and Predictors of Seizures in Intracranial Meningioma Surgery: A Population-Based Study","volume":"160","author":"Xue","year":"2018","journal-title":"Acta Neurochir."},{"key":"ref_110","first-page":"209","article-title":"Seizure Burden Pre- and Postresection of Low-Grade Gliomas as a Predictor of Tumor Progression in Low-Grade Gliomas","volume":"6","author":"Park","year":"2019","journal-title":"Neurooncol. Pract."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.clineuro.2015.10.002","article-title":"Prognostic Implications of Epilepsy in Glioblastomas","volume":"139","author":"Toledo","year":"2015","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"E722","DOI":"10.1093\/neuros\/nyz079","article-title":"Association Between Tumor Compartment Volumes, the Incidence of Pretreatment Seizures, and Statin-Mediated Protective Effects in Glioblastoma","volume":"85","author":"Henker","year":"2019","journal-title":"Neurosurgery"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/neuonc\/nou130","article-title":"Localizing Seizure-Susceptible Brain Regions Associated with Low-Grade Gliomas Using Voxel-Based Lesion-Symptom Mapping","volume":"17","author":"Wang","year":"2015","journal-title":"Neuro. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3171\/JNS\/2008\/108\/2\/0227","article-title":"Seizure Characteristics and Control Following Resection in 332 Patients with Low-Grade Gliomas","volume":"108","author":"Chang","year":"2008","journal-title":"J. Neurosurg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fonc.2020.00235","article-title":"Predicting the Type of Tumor-Related Epilepsy in Patients with Low-Grade Gliomas: A Radiomics Study","volume":"10","author":"Wang","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","article-title":"Electrical and Synaptic Integration of Glioma into Neural Circuits","volume":"573","author":"Venkatesh","year":"2019","journal-title":"Nature"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10143-018-1014-5","article-title":"Correlation between Glioma Location and Preoperative Seizures: A Systematic Review and Meta-Analysis","volume":"42","author":"Zhang","year":"2019","journal-title":"Neurosurg. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1093\/brain\/awab119","article-title":"Activation of the Basal Ganglia and Indirect Pathway Neurons during Frontal Lobe Seizures","volume":"144","author":"Brodovskaya","year":"2021","journal-title":"Brain"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1684\/epd.2015.0788","article-title":"Relationship between Tumour Location and Preoperative Seizure Incidence in Patients with Gliomas: A Systematic Review and Meta-analysis","volume":"17","author":"Su","year":"2015","journal-title":"Epileptic Disord."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"10259","DOI":"10.18632\/aging.103212","article-title":"Structural Plasticity of the Bilateral Hippocampus in Glioma Patients","volume":"12","author":"Yuan","year":"2020","journal-title":"Aging"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.seizure.2021.03.002","article-title":"Multi-Omics in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: Clues into the Underlying Mechanisms Leading to Disease","volume":"90","author":"Bruxel","year":"2021","journal-title":"Seizure"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2009.5.FOCUS0998","article-title":"Chronic Epilepsy Associated with Temporal Tumors: Long-Term Surgical Outcome","volume":"27","author":"Ruban","year":"2009","journal-title":"Neurosurg. Focus"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.3171\/2012.1.JNS112120","article-title":"Intractable Epilepsy in Paralimbic World Health Organization Grade II Gliomas: Should the Hippocampus Be Resected When Not Invaded by the Tumor?","volume":"116","author":"Ghareeb","year":"2012","journal-title":"J. Neurosurg."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11060-022-03948-2","article-title":"Postoperative Epilepsy and Survival in Glioma Patients: A Nationwide Population-Based Cohort Study from 2009 to 2018","volume":"157","author":"Marku","year":"2022","journal-title":"J. Neurooncol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jnr.23689","article-title":"Contribution of Amygdala Pathology to Comorbid Emotional Disturbances in Temporal Lobe Epilepsy","volume":"94","author":"McDermott","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.wneu.2021.09.097","article-title":"Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma","volume":"157","author":"Carnevale","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s10014-017-0294-8","article-title":"Long-Term Epilepsy-Associated Tumor in the Amygdala of a 16-Year-Old Boy: Report of a Rare Case Having Intranuclear Filaments","volume":"34","author":"Cha","year":"2017","journal-title":"Brain Tumor Pathol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/epi.12448","article-title":"Resection Strategies in Tumoral Epilepsy: Is a Lesionectomy Enough?","volume":"54","author":"Tandon","year":"2013","journal-title":"Epilepsia"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Andrews, J.P., Wozny, T.A., Yue, J.K., and Wang, D.D. (2022). Improved Psychotic Symptoms Following Resection of Amygdalar Low-Grade Glioma: Illustrative Case. J. Neurosurg. Case Lessons, 4.","DOI":"10.3171\/CASE22362"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-018-0055-y","article-title":"Brain Metastases","volume":"5","author":"Achrol","year":"2019","journal-title":"Nat. Rev. Dis. 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