{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T22:58:09Z","timestamp":1774652289728,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Abbott"},{"name":"Amarin"},{"name":"Amgen"},{"name":"Athera"},{"name":"Biotronik"},{"name":"Boston Scientific"},{"name":"Dalcor"},{"name":"Daiichi Sankyo"},{"name":"Edwards Lifesciences"},{"name":"GE Healthcare Johnson and Johnson"},{"name":"Lilly"},{"name":"Medtronic"},{"name":"Merck-Schering-Plough"},{"name":"Novartis"},{"name":"Novo Nordisk"},{"name":"Pfizer"},{"name":"Roche"},{"name":"Sanofi Aventis"},{"name":"the Netherlands Heart Foundation"},{"name":"CardioVascular Research the Netherlands (CVON)"},{"name":"the Netherlands Heart Institute"},{"name":"European Community Framework KP7 Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Thoracic radiotherapy is one of the corner stones of HL treatment, but it is associated with increased risk of cardiovascular events. As HL is often diagnosed at a young age, long-term follow-up including screening for coronary artery disease (CAD) is recommended. Objectives: This study aims to evaluate the presence of coronary artery calcium score (CACS) in relation to cardiovascular events in HL patients treated with thoracic radiotherapy compared to a non-cancer control group. Methods: Consecutive HL patients who underwent evaluation for asymptomatic CAD with coronary computed tomography angiography &gt; 10 years after thoracic irradiation were included. The study population consisted of 97 HL patients matched to 97 non-cancer patients on gender, age, cardiovascular risk factors, and statin use. Results: Mean age during CT scan in the HL population was 45.5 \u00b1 9.9 and in the non-cancer population 45.5 \u00b1 10.3 years. CACS was elevated (defined as &gt;0) in 49 (50.5%) HL patients and 30 (30.9%) control patients. HL survivors had an odds ratio of 2.28 [95% CI: 1.22\u20134.28] for having a CACS &gt; 0 compared to the matched population (p = 0.006). Prevalence of CACS &gt; 90th percentile differed significantly: 17.1% in HL survivors vs. 4.6% in the matched population (p = 0.009). Non-obstructive coronary artery stenosis was more prevalent in the HL population than in the control population (45.7% vs. 28.4%, respectively, p = 0.01). During follow-up of 8.5 [5.3; 9.9] years, nine HL patients experienced an event including two patients with a CACS of zero. No events occurred in the control population. Conclusion: In a matched study population, HL survivors have a higher prevalence of a CACS &gt; 0 and an increased risk of cardiovascular events after thoracic irradiation compared to a matched non-cancer control group.<\/jats:p>","DOI":"10.3390\/cancers15245831","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T12:00:37Z","timestamp":1702468837000},"page":"5831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relation between Coronary Artery Calcium Score and Cardiovascular Events in Hodgkin Lymphoma Survivors: A Cross-Sectional Matched Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8620","authenticated-orcid":false,"given":"Elissa A. S.","family":"Polomski","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6892-5227","authenticated-orcid":false,"given":"Julius C.","family":"Heemelaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel A.","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3257-3634","authenticated-orcid":false,"given":"Augustinus D. G.","family":"Krol","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marloes","family":"Louwerens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4705-4837","authenticated-orcid":false,"given":"J. Lauran","family":"St\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R. M.","family":"van Dijkman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin J.","family":"Schalij","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"},{"name":"Netherlands Heart Institute, 3511 EP Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1831-6698","authenticated-orcid":false,"given":"M. Louisa","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"ref_1","unstructured":"Nederlandse Kanker Registratie (NKR) (2022, August 19). Intergraal Kankercentrum Nederland (IKNL). Available online: www.iknl.nl."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Aleman, B.M.P., van den Belt-Dusebout, A.W., de Bruin, M.L., van\u2019t Veer, M.B., Baaijens, M.H.A., de Boer, J.P., Hart, A.A.M., Klokman, W.J., Kuenen, M.A., and Ouwens, G.M. (2006). Late cardiotoxicity after treatment for Hodgkin\u2019s lymphoma. Int. J. Radiat. Oncol. Biol. 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