{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:33:18Z","timestamp":1777804398433,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"P01","doi-asserted-by":"publisher","award":["AG034906"],"award-info":[{"award-number":["AG034906"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"P01","doi-asserted-by":"publisher","award":["21820"],"award-info":[{"award-number":["21820"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AIRC IG 2018","award":["AG034906"],"award-info":[{"award-number":["AG034906"]}]},{"name":"AIRC IG 2018","award":["21820"],"award-info":[{"award-number":["21820"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Fasting mimicking diets (FMDs) are effective in the treatment of many solid tumors in mouse models, but their effect on hematologic malignancies is poorly understood, particularly in combination with standard therapies. Here we show that cycles of a 3-day FMD given to high-fat-diet-fed mice once a week increased the efficacy of vincristine to improve survival from BCR-ABL B acute lymphoblastic leukemia (ALL). In mice fed a standard diet, FMD cycles in combination with vincristine promoted cancer-free survival. RNA seq and protein assays revealed a vincristine-dependent decrease in the expression of multiple autophagy markers, which was exacerbated by the fasting\/FMD conditions. The autophagy inhibitor chloroquine could substitute for fasting\/FMD to promote cancer-free survival in combination with vincristine. In vitro, targeted inhibition of autophagy genes ULK1 and ATG9a strongly potentiated vincristine\u2019s toxicity. Moreover, anti-CD8 antibodies reversed the effects of vincristine plus fasting\/FMD in promoting leukemia-free survival in mice, indicating a central role of the immune system in this response. Thus, the inhibition of autophagy and enhancement of immune responses appear to be mediators of the fasting\/FMD-dependent cancer-free survival in ALL mice.<\/jats:p>","DOI":"10.3390\/cancers15245870","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:04:47Z","timestamp":1702893887000},"page":"5870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival"],"prefix":"10.3390","volume":"15","author":[{"given":"Roberta","family":"Buono","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA"},{"name":"Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Tucci","sequence":"additional","affiliation":[{"name":"Center for Endocrinology, Diabetes & Metabolism, Children\u2019s Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaello","family":"Cutri","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Novella","family":"Guidi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serghei","family":"Mangul","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of California Los Angeles, 580 Portola Plaza, Los Angeles, CA 90095, USA"},{"name":"Institute for Quantitative and Computational Biosciences, Boyer Hall, 611 Charles Young Drive, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Raucci","sequence":"additional","affiliation":[{"name":"IFOM AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-9564","authenticated-orcid":false,"given":"Matteo","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Institute for Quantitative and Computational Biosciences, Boyer Hall, 611 Charles Young Drive, University of California Los Angeles, Los Angeles, CA 90095, USA"},{"name":"Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, 801 Hilgard Avenue, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Mittelman","sequence":"additional","affiliation":[{"name":"Center for Endocrinology, Diabetes & Metabolism, Children\u2019s Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA"},{"name":"Division of Pediatric Endocrinology, UCLA Mattel Children\u2019s Hospital, 10833 Le Conte Avenue, MDCC 22-315, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valter D.","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Longevity Institute, School of Gerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA"},{"name":"IFOM AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy"},{"name":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0140-6736(19)33018-1","article-title":"Acute lymphoblastic leukaemia","volume":"395","author":"Malard","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.mayocp.2016.09.010","article-title":"Adult Acute Lymphoblastic Leukemia","volume":"91","author":"Paul","year":"2016","journal-title":"Mayo Clin. 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