{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:47:16Z","timestamp":1789962436104,"version":"4.0.1"},"reference-count":96,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer-related fatigue (CRF) is a widespread symptom with high prevalence in cancer patients, seriously affecting their quality of life. In the context of precision care, constructing machine learning-based prediction models for early screening and assessment of CRF is beneficial to this situation. To further understand the predictors of CRF for model construction, we conducted a comprehensive search in PubMed, Web of Science, Embase, and Scopus databases, combining CRF with predictor-related terms. A total of 27 papers met the inclusion criteria. We evaluated the above studies into three subgroups following the predisposing, precipitating, and perpetuating (3P) factor model. (1) Predisposing factors\u2014baseline fatigue, demographic characteristics, clinical characteristics, psychosocial traits and physical symptoms. (2) Precipitating factors\u2014type and stage of chemotherapy, inflammatory factors, laboratory indicators and metabolic changes. (3) Perpetuating factors\u2014a low level of physical activity and poorer nutritional status. Future research should prioritize large-scale prospective studies with emerging technologies to identify accurate predictors of CRF. The assessment and management of CRF should also focus on the above factors, especially the controllable precipitating factors, to improve the quality of life of cancer survivors.<\/jats:p>","DOI":"10.3390\/cancers15245879","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:04:47Z","timestamp":1702893887000},"page":"5879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Multidimensional Predictors of Cancer-Related Fatigue Based on the Predisposing, Precipitating, and Perpetuating (3P) Model: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Yiming","family":"Wang","sequence":"first","affiliation":[{"name":"School of Nursing, Jilin University, No. 965 Xinjiang Street, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lv","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Nursing, Jilin University, No. 965 Xinjiang Street, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[{"name":"Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yanda Medical Research Institute, Hebei Yanda Hospital, Sanhe 065201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchun","family":"Tang","sequence":"additional","affiliation":[{"name":"Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Senior Department of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing 100071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Nie","sequence":"additional","affiliation":[{"name":"School of Nursing, Jilin University, No. 965 Xinjiang Street, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-9211","authenticated-orcid":false,"given":"Lisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing, Jilin University, No. 965 Xinjiang Street, Changchun 130021, China"},{"name":"Yanda Medical Research Institute, Hebei Yanda Hospital, Sanhe 065201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1200\/JCO.2001.19.14.3385","article-title":"Fatigue Coalition Cancer-Related Fatigue: Prevalence of Proposed Diagnostic Criteria in a United States Sample of Cancer Survivors","volume":"19","author":"Cella","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/jamasurg.2018.1645","article-title":"Effect of Exercise and Nutrition Prehabilitation on Functional Capacity in Esophagogastric Cancer Surgery: A Randomized Clinical Trial","volume":"153","author":"Minnella","year":"2018","journal-title":"JAMA Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cncr.28434","article-title":"Prevalence and Characteristics of Moderate to Severe Fatigue: A Multicenter Study in Cancer Patients and Survivors","volume":"120","author":"Wang","year":"2014","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpainsymman.2020.07.037","article-title":"Prevalence of Fatigue in Patients with Cancer: A Systematic Review and Meta-Analysis","volume":"61","author":"Tanash","year":"2021","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bbi.2006.11.004","article-title":"The Association between Fatigue and Inflammatory Marker Levels in Cancer Patients: A Quantitative Review","volume":"21","author":"Schubert","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X., and Chen, N. (2019). A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis. Cells, 8.","DOI":"10.3390\/cells8070738"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2015.10.038","article-title":"The Central Role of Hypothalamic Inflammation in the Acute Illness Response and Cachexia","volume":"54","author":"Burfeind","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/NCC.0000000000000406","article-title":"A Pilot Study of Proinflammatory Cytokines and Fatigue in Women with Breast Cancer During Chemotherapy","volume":"40","author":"Raudonis","year":"2017","journal-title":"Cancer Nurs."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/cncr.31790","article-title":"The Role of Neuro-immune Interactions in Cancer-related Fatigue: Biobehavioral Risk Factors and Mechanisms","volume":"125","author":"Bower","year":"2019","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/1099800414534313","article-title":"Cytokine Gene Associations with Self-Report Ratings of Morning and Evening Fatigue in Oncology Patients and Their Family Caregivers","volume":"17","author":"Dhruva","year":"2015","journal-title":"Biol. Res. Nurs."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tian, T., Qin, W., Liu, B., Wang, D., Wang, J., Jiang, T., and Yu, C. (2013). Catechol-O-Methyltransferase Val158Met Polymorphism Modulates Gray Matter Volume and Functional Connectivity of the Default Mode Network. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078697"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s00520-012-1688-0","article-title":"A Literature Synthesis of Symptom Prevalence and Severity in Persons Receiving Active Cancer Treatment","volume":"21","author":"Reilly","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s11136-019-02255-0","article-title":"Patient-Reported Outcomes as Predictors of Survival in Patients with Bowel Cancer: A Systematic Review","volume":"28","author":"Rutherford","year":"2019","journal-title":"Qual. Life Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3322\/caac.21268","article-title":"Screening, Evaluation, and Management of Cancer-Related Fatigue: Ready for Implementation to Practice?","volume":"65","author":"Berger","year":"2015","journal-title":"CA A Cancer J. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.6004\/jnccn.2015.0122","article-title":"Cancer-Related Fatigue, Version 2.2015","volume":"13","author":"Berger","year":"2015","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00520-010-0848-3","article-title":"Cancer-Related Fatigue: Clinical Practice versus Practice Guidelines","volume":"19","author":"Hilarius","year":"2011","journal-title":"Support. Care Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tolotti, A., Bonetti, L., Pedrazzani, C., Bianchi, M., Moser, L., Pagnucci, N., Sari, D., and Valcarenghi, D. (2021). Nursing Management of Fatigue in Cancer Patients and Suggestions for Clinical Practice: A Mixed Methods Study. BMC Nurs., 20.","DOI":"10.1186\/s12912-021-00699-9"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1188\/08.CJON.S2.37-47","article-title":"Cancer-Related Fatigue: Role of Oncology Nurses in Translating National Comprehensive Cancer Network Assessment Guidelines into Practice","volume":"12","author":"Piper","year":"2008","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E191","DOI":"10.1188\/11.ONF.E191-E203","article-title":"Patients\u2019 Experiences with Cancer-Related Fatigue: A Review and Synthesis of Qualitative Research","volume":"38","author":"Scott","year":"2011","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41580-021-00407-0","article-title":"A Guide to Machine Learning for Biologists","volume":"23","author":"Greener","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13875","DOI":"10.1007\/s00432-023-05197-w","article-title":"Characteristics and Predictors Associated with Cancer-Related Fatigue among Solid and Liquid Tumors","volume":"149","author":"Satheeshkumar","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00520-022-07570-w","article-title":"Development and External Validation of a Machine Learning-Based Prediction Model for the Cancer-Related Fatigue Diagnostic Screening in Adult Cancer Patients: A Cross-Sectional Study in China","volume":"31","author":"Du","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/jamia\/ocac002","article-title":"Trends in the Conduct and Reporting of Clinical Prediction Model Development and Validation: A Systematic Review","volume":"29","author":"Yang","year":"2022","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/jamia\/ocw042","article-title":"Opportunities and Challenges in Developing Risk Prediction Models with Electronic Health Records Data: A Systematic Review","volume":"24","author":"Goldstein","year":"2017","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Sleight, A.G., Crowder, S.L., Skarbinski, J., Coen, P., Parker, N.H., Hoogland, A.I., Gonzalez, B.D., Playdon, M.C., Cole, S., and Ose, J. (2022). A New Approach to Understanding Cancer-Related Fatigue: Leveraging the 3P Model to Facilitate Risk Prediction and Clinical Care. Cancers, 14.","DOI":"10.3390\/cancers14081982"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2017.01.007","article-title":"A Systematic Review of the Association between Fatigue and Genetic Polymorphisms","volume":"62","author":"Wang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1007\/s00520-019-4660-4","article-title":"Predictors of Fatigue in Cancer Patients: A Longitudinal Study","volume":"27","author":"Susanne","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/01635581.2015.1040520","article-title":"Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy","volume":"67","author":"Schulzke","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/S0885-3924(03)00218-5","article-title":"Multidimensional Independent Predictors of Cancer-Related Fatigue","volume":"26","author":"Hwang","year":"2003","journal-title":"J. Pain Symptom Manag."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical Evaluation of the Newcastle-Ottawa Scale for the Assessment of the Quality of Nonrandomized Studies in Meta-Analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"ref_32","unstructured":"Peters, M., Godfrey, C., McInerney, P., Soares, C.B., Khalil, H., and Parker, D. (2015). The Joanna Briggs Institute Reviewers Manual 2015, Joanna Briggs Institute."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s Tool for Assessing Risk of Bias in Randomised Trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41398-020-00990-4","article-title":"Brain-Derived Neurotrophic Factor Polymorphism Val66Met Protects against Cancer-Related Fatigue","volume":"10","author":"Feng","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4103\/IJPC.IJPC_223_19","article-title":"To Assess the Prevalence and Predictors of Cancer-Related Fatigue and Its Impact on Quality of Life in Advanced Cancer Patients Receiving Palliative Care in a Tertiary Care Hospital: A Cross-Sectional Descriptive Study","volume":"26","author":"Garg","year":"2020","journal-title":"Indian. J. Palliat. Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1093\/annonc\/mdw252","article-title":"Fatigue in People with Localized Colorectal Cancer Who Do and Do Not Receive Chemotherapy: A Longitudinal Prospective Study","volume":"27","author":"Vardy","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/NCC.0000000000000381","article-title":"Exploratory Investigation of Early Biomarkers for Chronic Fatigue in Prostate Cancer Patients Following Radiation Therapy","volume":"40","author":"Feng","year":"2017","journal-title":"Cancer Nurs."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41398-018-0161-3","article-title":"mGluR5 Mediates Post-Radiotherapy Fatigue Development in Cancer Patients","volume":"8","author":"Feng","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000494620","article-title":"Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer","volume":"96","author":"Feng","year":"2019","journal-title":"Oncology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110127","DOI":"10.1016\/j.jpsychores.2020.110127","article-title":"Cancer-Related Fatigue and Functional Impairment\u2013Towards an Understanding of Cognitive and Behavioural Factors","volume":"134","author":"Hughes","year":"2020","journal-title":"J. Psychosom. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s00520-010-0986-7","article-title":"Factors Predicting Clinically Significant Fatigue in Women Following Treatment for Primary Breast Cancer","volume":"19","author":"Gerber","year":"2011","journal-title":"Support. Care Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00520-022-07526-0","article-title":"Serum Metabolomics Reveals the Effects of Accompanying Treatment on Fatigue in Patients with Multiple Myeloma","volume":"31","author":"Zhang","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Kleckner, A.S., Culakova, E., Kleckner, I.R., Belcher, E.K., Demark-Wahnefried, W., Parker, E.A., Padula, G.D.A., Ontko, M., Janelsins, M.C., and Mustian, K.M. (2021). Nutritional Status Predicts Fatty Acid Uptake from Fish and Soybean Oil Supplements for Treatment of Cancer-Related Fatigue: Results from a Phase II Nationwide Study. Nutrients, 14.","DOI":"10.3390\/nu14010184"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1007\/s00520-021-06054-7","article-title":"Multidimensional Fatigue in Patients with Nasopharyngeal Carcinoma Receiving Concurrent Chemoradiotherapy: Incidence, Severity, and Risk Factors","volume":"29","author":"Chen","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/PSY.0000000000000816","article-title":"Association Among Glucocorticoid Receptor Sensitivity, Fatigue, and Inflammation in Patients with Head and Neck Cancer","volume":"82","author":"Xiao","year":"2020","journal-title":"Psychosom. Med."},{"key":"ref_46","first-page":"1013","article-title":"Prevalence and Predictors of Fatigue in Haemo-Oncological Patients","volume":"44","author":"Zordan","year":"2014","journal-title":"Cancer Inform."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2217\/fon.14.15","article-title":"Cancer-Related Fatigue and Chemotherapy-Associated Adverse Effects: Correlation with TNF-\u03b1, IL-1 and 17-Hydroxycorticosteroids","volume":"10","author":"Zhang","year":"2014","journal-title":"Future Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbi.2013.07.177","article-title":"C-Reactive Protein Predicts Fatigue Independently of Depression in Breast Cancer Patients Prior to Chemotherapy","volume":"34","author":"Pertl","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1200\/JCO.2011.34.6148","article-title":"Cancer-Related Fatigue in Women with Breast Cancer: Outcomes of a 5-Year Prospective Cohort Study","volume":"30","author":"Goldstein","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/NNR.0b013e3181903d7b","article-title":"Testing a Theoretical Model of Perceived Self-Efficacy for Cancer-Related Fatigue Self-Management and Optimal Physical Functional Status","volume":"58","author":"Hoffman","year":"2009","journal-title":"Nurs. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1188\/09.ONF.194-202","article-title":"Fatigue and Physical Activity in Older Patients with Cancer: A Six-Month Follow-Up Study","volume":"36","author":"Groll","year":"2009","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1188\/09.ONF.209-216","article-title":"The Relationships Among Physiologic Variables, Quality of Life, and Fatigue in Patients with Multiple Myeloma","volume":"36","author":"Booker","year":"2009","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/01.NCC.0000305704.84164.54","article-title":"Predictors of Cancer-Related Fatigue in Women with Breast Cancer Before, during, and after Adjuvant Therapy","volume":"31","author":"Kang","year":"2008","journal-title":"Cancer Nurs."},{"key":"ref_54","first-page":"4647","article-title":"Prevalence, Changes in and Correlates of Fatigue in the First Year after Diagnosis of Testicular Cancer","volume":"25","author":"Fleer","year":"2005","journal-title":"Anticancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1200\/JCO.2005.07.024","article-title":"Use of a Case Definition Approach to Identify Cancer-Related Fatigue in Women Undergoing Adjuvant Therapy for Breast Cancer","volume":"23","author":"Andrykowski","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1188\/04.ONF.269-278","article-title":"Factors Related to Persistent Fatigue Following Completion of Breast Cancer Treatment","volume":"31","author":"Fillion","year":"2004","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1099800403259500","article-title":"Levels of Fatigue Compared to Levels of Cytokines and Hemoglobin during Pelvic Radiotherapy: A Pilot Study","volume":"5","author":"Ahlberg","year":"2004","journal-title":"Biol. Res. Nurs."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/cncr.10245","article-title":"Fatigue in Cancer Patients Compared with Fatigue in the General United States Population","volume":"94","author":"Cella","year":"2002","journal-title":"Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1188\/08.ONF.815-821","article-title":"Strength, Physical Activity, and Age Predict Fatigue in Older Breast Cancer Survivors","volume":"35","author":"Bennett","year":"2008","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1007\/s00520-021-06218-5","article-title":"Prevalence and Correlates of Cancer-Related Fatigue in Breast Cancer Survivors","volume":"29","author":"Ramos","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11764-020-00953-0","article-title":"Body Composition and Its Association with Fatigue in the First 2 Years after Colorectal Cancer Diagnosis","volume":"15","author":"Bours","year":"2021","journal-title":"J. Cancer Surviv."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/cncr.28737","article-title":"Comparison of Younger and Older Breast Cancer Survivors and Age-Matched Controls on Specific and Overall QoL Domains","volume":"120","author":"Champion","year":"2014","journal-title":"Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/s11764-020-00950-3","article-title":"Quality of Life and Mental Health in Breast Cancer Survivors Compared with Non-Cancer Controls: A Study of Patient-Reported Outcomes in the United Kingdom","volume":"15","author":"Carreira","year":"2021","journal-title":"J. Cancer Surviv."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1200\/jco.2007.25.18_suppl.9048","article-title":"A Case Control Study on Risk Factors of Lymphedema after Axillary Lymph Node Dissection for Breast Cancer in Hong Kong","volume":"25","author":"Mak","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"6889","DOI":"10.1007\/s00520-022-07125-z","article-title":"Symptom Clusters in Outpatients with Cancer Using Different Dimensions of the Symptom Experience","volume":"30","author":"Harris","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jncimonographs\/lgh023","article-title":"Symptom Clusters: The New Frontier in Symptom Management Research","volume":"2004","author":"Miaskowski","year":"2004","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jpainsymman.2009.12.023","article-title":"The Association of Depression and Pain with Health-Related Quality of Life, Disability, and Health Care Use in Cancer Patients","volume":"40","author":"Kroenke","year":"2010","journal-title":"J. Pain Symptom Manag."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1136\/bmjspcare-2018-001533","article-title":"Depression and Survival Outcomes after Emergency Department Cancer Pain Visits","volume":"9","author":"Reyes","year":"2019","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbr.2014.04.042","article-title":"Pain and Depression Comorbidity: A Preclinical Perspective","volume":"276","author":"Li","year":"2015","journal-title":"Behav. Brain Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clbc.2020.07.011","article-title":"Cancer-Related Fatigue in Breast Cancer Survivors: A Review","volume":"21","year":"2021","journal-title":"Clin. Breast Cancer"},{"key":"ref_71","first-page":"845","article-title":"Sleep Disturbance and Cancer-Related Fatigue Symptom Cluster in Breast Cancer Patients Undergoing Chemotherapy","volume":"28","author":"Fox","year":"2020","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/pon.3303","article-title":"Relationship between Cancer-Related Fatigue and Personality in Patients with Breast Cancer after Chemotherapy","volume":"22","author":"Wang","year":"2013","journal-title":"Psychooncology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00277-018-3420-8","article-title":"Fatigue at Baseline Is Associated with Geriatric Impairments and Represents an Adverse Prognostic Factor in Older Patients with a Hematological Malignancy","volume":"97","author":"Hofer","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1152\/japplphysiol.00746.2021","article-title":"Skeletal Muscle Mitochondrial Dysfunction and Muscle and Whole Body Functional Deficits in Cancer Patients with Weight Loss","volume":"132","author":"Kunz","year":"2022","journal-title":"J. Appl. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"dju057","DOI":"10.1093\/jnci\/dju057","article-title":"Effect of Cytotoxic Chemotherapy on Markers of Molecular Age in Patients with Breast Cancer","volume":"106","author":"Sanoff","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-Related Fatigue--Mechanisms, Risk Factors, and Treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.bbi.2012.06.011","article-title":"Inflammation and Cancer-Related Fatigue: Mechanisms, Contributing Factors, and Treatment Implications","volume":"30","author":"Bower","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s11764-021-01115-6","article-title":"Physiological and Psychosocial Correlates of Cancer-Related Fatigue","volume":"16","author":"Brownstein","year":"2022","journal-title":"J. Cancer Surviv."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ctrv.2014.01.004","article-title":"Management of Fatigue in Patients with Cancer\u2014A Practical Overview","volume":"40","author":"Koornstra","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.clcc.2016.04.010","article-title":"A Practical Approach to Fatigue Management in Colorectal Cancer","volume":"16","author":"Aapro","year":"2017","journal-title":"Clin. Colorectal Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.breast.2021.02.008","article-title":"Tired of Feeling Tired\u2013The Role of Circulating Inflammatory Biomarkers and Long-Term Cancer Related Fatigue in Breast Cancer Survivors","volume":"56","author":"Maurer","year":"2021","journal-title":"Breast"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Yennu, S., Urbauer, D.L., and Bruera, E. (2012). Factors Associated with the Severity and Improvement of Fatigue in Patients with Advanced Cancer Presenting to an Outpatient Palliative Care Clinic. BMC Palliat. Care, 11.","DOI":"10.1186\/1472-684X-11-16"},{"key":"ref_83","first-page":"1319","article-title":"Clinical Factors Associated with Cancer-Related Fatigue in Patients Being Treated for Leukemia and Non-Hodgkin\u2019s Lymphoma","volume":"20","author":"Wang","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jpainsymman.2015.12.054","article-title":"Association of Cancer-Related Fatigue with Other Symptoms and Impact on Quality of Life of Palliative Care Patients in a Tertiary Cancer Institute: A Prospective Observational Study (S751)","volume":"51","author":"Ghoshal","year":"2016","journal-title":"J. Pain Symptom Manag."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbi.2015.10.005","article-title":"Cancer-Related Fatigue Shows a Stable Association with Diurnal Cortisol Dysregulation in Breast Cancer Patients","volume":"52","author":"Schmidt","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-3999(03)00561-0","article-title":"Alterations in Morning Cortisol Associated with PTSD in Women with Breast Cancer","volume":"56","author":"Luecken","year":"2004","journal-title":"J. Psychosom. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/1534735410392581","article-title":"Altered Circadian Rhythms and Cancer-Related Fatigue Outcomes","volume":"10","author":"Payne","year":"2011","journal-title":"Integr. Cancer Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3322\/caac.21670","article-title":"Metabolomics in Cancer Research and Emerging Applications in Clinical Oncology","volume":"71","author":"Schmidt","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_89","first-page":"E3749","article-title":"Metabolic Features of Chronic Fatigue Syndrome","volume":"113","author":"Naviaux","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00296-016-3426-2","article-title":"Metabolomics Study of Fatigue in Patients with Rheumatoid Arthritis Na\u00efve to Biological Treatment","volume":"36","author":"Surowiec","year":"2016","journal-title":"Rheumatol. Int."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Twomey, R., Martin, T., Temesi, J., Culos-Reed, S.N., and Millet, G.Y. (2018). Tailored Exercise Interventions to Reduce Fatigue in Cancer Survivors: Study Protocol of a Randomized Controlled Trial. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4668-z"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/01635581.2019.1669674","article-title":"Cancer-Related Fatigue, Laboratory Markers as Indicators for Nutritional Status among Patients with Colorectal Cancer","volume":"72","author":"Sharour","year":"2020","journal-title":"Nutr. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1017\/S000711451800363X","article-title":"Nutrition Therapy for the Management of Cancer-Related Fatigue and Quality of Life: A Systematic Review and Meta-Analysis","volume":"122","author":"Baguley","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"103707","DOI":"10.1016\/j.ijnurstu.2020.103707","article-title":"Prevalence and Risk Factors of Cancer-Related Fatigue: A Systematic Review and Meta-Analysis","volume":"111","author":"Ma","year":"2020","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1176\/appi.ajp.160.2.221","article-title":"Chronic Fatigue Syndrome: A Review","volume":"160","author":"Afari","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0022-3999(02)00300-8","article-title":"Fatigue after Breast Cancer and in Chronic Fatigue Syndrome: Similarities and Differences","volume":"52","author":"Servaes","year":"2002","journal-title":"J. Psychosom. 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