{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:06:31Z","timestamp":1792033591125,"version":"4.4.0"},"reference-count":87,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence","award":["PI17\/02172"],"award-info":[{"award-number":["PI17\/02172"]}]},{"name":"Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence","award":["PI16\/01294"],"award-info":[{"award-number":["PI16\/01294"]}]},{"name":"Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence","award":["PIE15\/0081"],"award-info":[{"award-number":["PIE15\/0081"]}]},{"name":"European Union (FEDER)","award":["PI17\/02172"],"award-info":[{"award-number":["PI17\/02172"]}]},{"name":"European Union (FEDER)","award":["PI16\/01294"],"award-info":[{"award-number":["PI16\/01294"]}]},{"name":"European Union (FEDER)","award":["PIE15\/0081"],"award-info":[{"award-number":["PIE15\/0081"]}]},{"name":"AECC","award":["PI17\/02172"],"award-info":[{"award-number":["PI17\/02172"]}]},{"name":"AECC","award":["PI16\/01294"],"award-info":[{"award-number":["PI16\/01294"]}]},{"name":"AECC","award":["PIE15\/0081"],"award-info":[{"award-number":["PIE15\/0081"]}]},{"name":"Madrid Autonomous Community","award":["PI17\/02172"],"award-info":[{"award-number":["PI17\/02172"]}]},{"name":"Madrid Autonomous Community","award":["PI16\/01294"],"award-info":[{"award-number":["PI16\/01294"]}]},{"name":"Madrid Autonomous Community","award":["PIE15\/0081"],"award-info":[{"award-number":["PIE15\/0081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Myeloid neoplasms and acute leukemias include different entities that have been recently re-classified taking into account molecular and clinicopathological features. The myelodysplastic syndrome\/myeloproliferative neoplasm (MDS\/MPN) category comprises a heterogeneous group of hybrid neoplastic myeloid diseases characterized by the co-occurrence of clinical and pathological features of both myelodysplastic and myeloproliferative neoplasms. The most frequent entity in this category is chronic myelomonocytic leukemia (CMML) which is, after acute myeloid leukemia (AML), the main myeloid disorder prone to develop cutaneous manifestations. Skin lesions associated with myelodysplastic and myeloproliferative neoplasms include a broad clinical, histopathological and molecular spectrum of lesions, poorly understood and without a clear-cut classification in the current medical literature. The aim of this review is to describe and classify the main clinical, histopathological and molecular patterns of cutaneous lesions in the setting of MDS\/MPN in order to improve the diagnostic skills of the dermatologists, hematologists and pathologists who deal with these patients.<\/jats:p>","DOI":"10.3390\/cancers15245888","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:04:47Z","timestamp":1702893887000},"page":"5888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical, Histopathological and Molecular Spectrum of Cutaneous Lesions in Myelodysplastic Syndrome and Myeloproliferative Neoplasms (MDS\/MPN): An Integrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5066-5014","authenticated-orcid":false,"given":"Luc\u00eda","family":"Prieto-Torres","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital Cl\u00ednico Universitario Lozano Blesa, Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Requena","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro Maria","family":"Rodr\u00edguez-Pinilla","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma, 50019 Zaragoza, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic Neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/leu.2008.119","article-title":"The myelodysplastic\/myeloproliferative neoplasms: Myeloproliferative diseases with dysplastic features","volume":"22","author":"Orazi","year":"2008","journal-title":"Leukemia"},{"key":"ref_4","first-page":"27","article-title":"Leukemia cutis\u2014Epidemiology, clinical presentation, and differential diagnoses","volume":"10","author":"Wagner","year":"2012","journal-title":"J. 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