{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:27:33Z","timestamp":1792168053608,"version":"4.4.0"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council of The Republic of China","award":["NSTC 112-2221-E-194-036"],"award-info":[{"award-number":["NSTC 112-2221-E-194-036"]}]},{"name":"National Science and Technology Council of The Republic of China","award":["CYCH-CCU-2023-02"],"award-info":[{"award-number":["CYCH-CCU-2023-02"]}]},{"name":"National Science and Technology Council of The Republic of China","award":["KAFGH_D_112030"],"award-info":[{"award-number":["KAFGH_D_112030"]}]},{"name":"Ditmanson Medical Foundation Chia-Yi Christian Hospital, and the National Chung Cheng University Joint Research Program","award":["NSTC 112-2221-E-194-036"],"award-info":[{"award-number":["NSTC 112-2221-E-194-036"]}]},{"name":"Ditmanson Medical Foundation Chia-Yi Christian Hospital, and the National Chung Cheng University Joint Research Program","award":["CYCH-CCU-2023-02"],"award-info":[{"award-number":["CYCH-CCU-2023-02"]}]},{"name":"Ditmanson Medical Foundation Chia-Yi Christian Hospital, and the National Chung Cheng University Joint Research Program","award":["KAFGH_D_112030"],"award-info":[{"award-number":["KAFGH_D_112030"]}]},{"DOI":"10.13039\/501100015045","name":"Kaohsiung Armed Forces General Hospital","doi-asserted-by":"publisher","award":["NSTC 112-2221-E-194-036"],"award-info":[{"award-number":["NSTC 112-2221-E-194-036"]}],"id":[{"id":"10.13039\/501100015045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015045","name":"Kaohsiung Armed Forces General Hospital","doi-asserted-by":"publisher","award":["CYCH-CCU-2023-02"],"award-info":[{"award-number":["CYCH-CCU-2023-02"]}],"id":[{"id":"10.13039\/501100015045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015045","name":"Kaohsiung Armed Forces General Hospital","doi-asserted-by":"publisher","award":["KAFGH_D_112030"],"award-info":[{"award-number":["KAFGH_D_112030"]}],"id":[{"id":"10.13039\/501100015045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This study pioneers the application of artificial intelligence (AI) and hyperspectral imaging (HSI) in the diagnosis of skin cancer lesions, particularly focusing on Mycosis fungoides (MF) and its differentiation from psoriasis (PsO) and atopic dermatitis (AD). By utilizing a comprehensive dataset of 1659 skin images, including cases of MF, PsO, AD, and normal skin, a novel multi-frame AI algorithm was used for computer-aided diagnosis. The automatic segmentation and classification of skin lesions were further explored using advanced techniques, such as U-Net Attention models and XGBoost algorithms, transforming images from the color space to the spectral domain. The potential of AI and HSI in dermatological diagnostics was underscored, offering a noninvasive, efficient, and accurate alternative to traditional methods. The findings are particularly crucial for early-stage invasive lesion detection in MF, showcasing the model\u2019s robust performance in segmenting and classifying lesions and its superior predictive accuracy validated through k-fold cross-validation. The model attained its optimal performance with a k-fold cross-validation value of 7, achieving a sensitivity of 90.72%, a specificity of 96.76%, an F1-score of 90.08%, and an ROC-AUC of 0.9351. This study marks a substantial advancement in dermatological diagnostics, thereby contributing significantly to the early and precise identification of skin malignancies and inflammatory conditions.<\/jats:p>","DOI":"10.3390\/cancers16010217","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T10:36:59Z","timestamp":1704191819000},"page":"217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Identification of Skin Lesions by Snapshot Hyperspectral Imaging"],"prefix":"10.3390","volume":"16","author":[{"given":"Hung-Yi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chia Yi City 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Thai","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi City 62102, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Dalin Tzu Chi General Hospital, No. 2, Min-Sheng Rd., Dalin Town, Chia Yi City 62247, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penchun","family":"Saenprasarn","sequence":"additional","affiliation":[{"name":"School of Nursing, Shinawatra University, 99 Moo 10, Bangtoey, Samkhok, Pathum Thani 12160, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Hung","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, 2, Zhongzheng 1st.Rd., Lingya District, Kaohsiung City 80284, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-2062","authenticated-orcid":false,"given":"Hsiang-Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Chung Cheng University, 168, University Rd., Min Hsiung, Chia Yi City 62102, Taiwan"},{"name":"Director of Technology Development, Hitspectra Intelligent Technology Co., Ltd., Kaohsiung City 80661, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-3-319-99716-2_11","article-title":"Primary cutaneous T-Cell lymphomas: Mycosis fungoides and Sezary syndrome","volume":"176","author":"Querfeld","year":"2019","journal-title":"T-Cell NK-Cell Lymphomas Biol. Nov. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jaad.2021.04.080","article-title":"Primary cutaneous T-cell lymphomas other than mycosis fungoides and S\u00e9zary syndrome. Part I: Clinical and histologic features and diagnosis","volume":"85","author":"Stoll","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-D\u00edaz, N., Piris, M.\u00c1., Ortiz-Romero, P.L., and Vaqu\u00e9, J.P. (2021). Mycosis fungoides and s\u00e9zary syndrome: An integrative review of the pathophysiology, molecular drivers, and targeted therapy. Cancers, 13.","DOI":"10.3390\/cancers13081931"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dobos, G., Lazaridou, I., and de Masson, A. (2023). Mycosis Fungoides and S\u00e9zary Syndrome: Microenvironment and Cancer Progression. Cancers, 15.","DOI":"10.3390\/cancers15030746"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s11082-014-0017-x","article-title":"Identified early stage mycosis fungoides from psoriasis and atopic dermatitis using non-invasive color contrast enhancement by LEDs lighting","volume":"47","author":"Hsiao","year":"2015","journal-title":"Opt. Quantum Electron."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/j.1365-2133.2008.08504.x","article-title":"Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides","volume":"158","author":"Fujimura","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2133.2006.07526.x","article-title":"Mycosis fungoides: A dermatological masquerader","volume":"156","author":"Nashan","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.12788\/j.sder.2018.002","article-title":"Mycosis fungoides-clinical and histopathologic features, differential diagnosis, and treatment","volume":"37","author":"Cerroni","year":"2018","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/cup.13477","article-title":"Mycosis fungoides with spongiosis: A potential diagnostic pitfall","volume":"46","author":"Shamim","year":"2019","journal-title":"J. Cutan. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/cup.13615","article-title":"Plaque stage folliculotropic mycosis fungoides: Histopathologic features and prognostic factors in a series of 40 patients","volume":"47","author":"Jansen","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40257-022-00732-w","article-title":"Real-Life barriers to diagnosis of early mycosis fungoides: An international expert panel discussion","volume":"24","author":"Hodak","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/bjd.18481","article-title":"Revisiting the initial diagnosis and blood staging of mycosis fungoides and S\u00e9zary syndrome with the KIR3DL2 marker","volume":"182","author":"Roelens","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/cyto.b.21878","article-title":"Flow cytometric evaluation of peripheral blood for suspected S\u00e9zary syndrome or mycosis fungoides: International guidelines for assay characteristics","volume":"100","author":"Horna","year":"2021","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/cyto.b.21933","article-title":"Determination of immunophenotypic aberrancies provides better assessment of peripheral blood involvement by mycosis fungoides\/S\u00e9zary syndrome than quantification of CD26\u2212 or CD7\u2212 CD4+ T-cells","volume":"100","author":"Lyapichev","year":"2021","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/cncr.34579","article-title":"Staging lymph nodes and blood at diagnosis in mycosis fungoides identifies patients at increased risk of progression to advanced stage: A retrospective cohort study","volume":"129","author":"Allen","year":"2023","journal-title":"Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/cyto.b.21870","article-title":"S\u00e9zary syndrome and mycosis fungoides flow cytometric evaluation: The clinicians\u2019 perspective","volume":"100","author":"Guitart","year":"2021","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/bjd.21053","article-title":"Flow cytometry for the assessment of blood tumour burden in cutaneous T-cell lymphoma: Towards a standardized approach","volume":"187","author":"Vermeer","year":"2022","journal-title":"Br. J. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/cyto.b.21963","article-title":"International guidelines for the flow cytometric evaluation of peripheral blood for suspected S\u00e9zary syndrome or mycosis fungoides: Assay development\/optimization, validation, and ongoing quality monitors","volume":"100","author":"Illingworth","year":"2021","journal-title":"Cytom. Part B Clin. Cytom."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/bjd.19303","article-title":"Should we be imaging lymph nodes at initial diagnosis of early-stage mycosis fungoides? Results from the PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) international study","volume":"184","author":"Hodak","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/bjd.19796","article-title":"Image-guided lymph node core-needle biopsy predicts survival in mycosis fungoides and S\u00e9zary syndrome","volume":"185","author":"Calvani","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_21","first-page":"1307","article-title":"Mycosis fungoides and S\u00e9zary syndrome","volume":"19","author":"Jonak","year":"2021","journal-title":"JDDG J. Der Dtsch. Dermatol. Ges."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s12149-023-01830-3","article-title":"The role of 18F-FDG PET\/CT in primary cutaneous lymphoma: An educational review","volume":"37","author":"McDonald","year":"2023","journal-title":"Ann. Nucl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3390\/cancers6041821","article-title":"Positron emission tomography (PET) in oncology","volume":"6","author":"Gallamini","year":"2014","journal-title":"Cancers"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Salem, A.E., Shah, H.R., Covington, M.F., Koppula, B.R., Fine, G.C., Wiggins, R.H., Hoffman, J.M., and Morton, K.A. (2022). PET-CT in Clinical Adult Oncology: I. Hematologic Malignancies. Cancers, 14.","DOI":"10.3390\/cancers14235941"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hsiao, Y.-P., Chiu, C.-W., Lu, C.-W., Nguyen, H.T., Tseng, Y.S., Hsieh, S.-C., and Wang, H.-C. (2021). Identification of skin lesions by using single-step multiframe detector. J. Clin. Med., 10.","DOI":"10.3390\/jcm10010144"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"102693","DOI":"10.1016\/j.media.2022.102693","article-title":"Ssd-kd: A self-supervised diverse knowledge distillation method for lightweight skin lesion classification using dermoscopic images","volume":"84","author":"Wang","year":"2023","journal-title":"Med. Image Anal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.procs.2015.03.090","article-title":"Segmentation and classification of skin lesions for disease diagnosis","volume":"45","author":"Sumithra","year":"2015","journal-title":"Procedia Comput. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"107922","DOI":"10.1016\/j.measurement.2020.107922","article-title":"Skin disease detection and segmentation using dynamic graph cut algorithm and classification through Naive Bayes classifier","volume":"163","author":"Balaji","year":"2020","journal-title":"Measurement"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102327","DOI":"10.1016\/j.media.2021.102327","article-title":"FAT-Net: Feature adaptive transformers for automated skin lesion segmentation","volume":"76","author":"Wu","year":"2022","journal-title":"Med. Image Anal."},{"key":"ref_30","first-page":"3149","article-title":"Lightgbm: A highly efficient gradient boosting decision tree","volume":"30","author":"Ke","year":"2017","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/ijd.14153","article-title":"Characteristics and management of Asian skin","volume":"58","author":"Chan","year":"2019","journal-title":"Int. J. Dermatol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/1\/217\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:38:29Z","timestamp":1760103509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/1\/217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["cancers16010217"],"URL":"https:\/\/doi.org\/10.3390\/cancers16010217","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]}}}