{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:01:30Z","timestamp":1782226890594,"version":"3.54.5"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FLL Research Grant 2020"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>A greater understanding of clinical trends in COVID-19 outcomes among patients with hematologic malignancies (HM) over the course of the pandemic, particularly the Omicron era, is needed. This ongoing, observational, and registry-based study with prospective data collection evaluated COVID-19 clinical severity and mortality in 1818 adult HM patients diagnosed with COVID-19 between 27 February 2020 and 1 October 2022, at 31 centers in the Madrid region of Spain. Of these, 1281 (70.5%) and 537 (29.5%) were reported in the pre-Omicron and Omicron periods, respectively. Overall, patients aged \u226570 years (odds ratio 2.16, 95% CI 1.64\u20132.87), with &gt;1 comorbidity (2.44, 1.85\u20133.21), or with an underlying HM of chronic lymphocytic leukemia (1.64, 1.19\u20132.27), had greater odds of severe\/critical COVID-19; odds were lower during the Omicron BA.1\/BA.2 (0.28, 0.2\u20130.37) or BA.4\/BA.5 (0.13, 0.08\u20130.19) periods and among patients vaccinated with one or two (0.51, 0.34\u20130.75) or three or four (0.22, 0.16\u20130.29) doses. The hospitalization rate (75.3% [963\/1279], 35.7% [191\/535]), rate of intensive care admission (30.0% [289\/963], 14.7% [28\/191]), and mortality rate overall (31.9% [409\/1281], 9.9% [53\/536]) and in hospitalized patients (41.3% [398\/963], 22.0% [42\/191]) decreased from the pre-Omicron to Omicron period. Age \u226570 years was the only factor associated with higher mortality risk in both the pre-Omicron (hazard ratio 2.57, 95% CI 2.03\u20133.25) and Omicron (3.19, 95% CI 1.59\u20136.42) periods. Receipt of prior stem cell transplantation, COVID-19 vaccination(s), and treatment with nirmatrelvir\/ritonavir or remdesivir were associated with greater survival rates. In conclusion, COVID-19 mortality in HM patients has decreased considerably in the Omicron period; however, mortality in hospitalized HM patients remains high. Specific studies should be undertaken to test new treatments and preventive interventions in HM patients.<\/jats:p>","DOI":"10.3390\/cancers16020379","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:56:59Z","timestamp":1705381019000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["COVID-19 Outcomes in Patients with Hematologic Malignancies in the Era of COVID-19 Vaccination and the Omicron Variant"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-0063","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Mart\u00ednez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12 Madrid, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"de la Cruz","sequence":"additional","affiliation":[{"name":"imas12 Research Institute, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2093-7119","authenticated-orcid":false,"given":"Rodrigo","family":"Gil-Manso","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12 Madrid, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Jim\u00e9nez","family":"Yuste","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario La Paz, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-9094","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Aspa-Cilleruelo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Pr\u00edncipe de Asturias, Universidad de Alcal\u00e1, 28805 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Escolano","family":"Escobar","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de Getafe, 28905 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-3002","authenticated-orcid":false,"given":"Javier","family":"L\u00f3pez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Ram\u00f3n Y Cajal, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Duarte","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Jacome","family":"Yerovi","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Severo Ochoa, 28914 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-757X","authenticated-orcid":false,"given":"Jos\u00e9-\u00c1ngel","family":"Hern\u00e1ndez-Rivas","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Herr\u00e1ez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keina","family":"Quiroz-Cervantes","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de M\u00f3stoles, 28935 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosal\u00eda","family":"Bustelos-Rodriguez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario del Sureste, 28500 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Benavente","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mart\u00ednez Barranco","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bastos Oteiro","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2423-822X","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Alegre","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-2037","authenticated-orcid":false,"given":"Jaime","family":"P\u00e9rez-Oteyza","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario del Tajo, 28300 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriel 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Bustamante","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario La Paz, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4945-9114","authenticated-orcid":false,"given":"Javier","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calbacho Robles","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12 Madrid, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-2544","authenticated-orcid":false,"given":"Julio","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Hospital Universitario 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