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HPV infection remains a prominent global health concern, with a spectrum of manifestations, from benign lesions to life-threatening cervical cancers. The CM and CVM, a unique collection of microorganisms inhabiting the cervix\/vagina, has emerged as a critical player in cervical health. Recent research has indicated that disruptions in the CM and CVM, characterized by a decrease in Lactobacillus and the overgrowth of other bacteria, might increase the risk of HPV persistence and the progression of cervical abnormalities. This alteration in the CM or CVM has been linked to a higher likelihood of HPV infection and cervical dysplasia. NGS technology has revolutionized the study of the cervical microbiome, providing insights into microbial diversity, dynamics, and taxonomic classifications. Bacterial 16S rRNA gene sequencing, has proven invaluable in characterizing the cervical microbiome, shedding light on its role in HPV infections and paving the way for more tailored strategies to combat cervical diseases. NGS-based studies offer personalized insights into an individual\u2019s cervical microbiome. This knowledge holds promise for the development of novel diagnostic tools, targeted therapies, and preventive interventions for cervix-related conditions, including cervical cancer.<\/jats:p>","DOI":"10.3390\/cancers16020399","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:41:28Z","timestamp":1705477288000},"page":"399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Human Papillomavirus Infections and the Role Played by Cervical and Cervico-Vaginal Microbiota\u2014Evidence from Next-Generation Sequencing Studies"],"prefix":"10.3390","volume":"16","author":[{"given":"Maria","family":"G\u0142owienka-Stodolak","sequence":"first","affiliation":[{"name":"Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Bagi\u0144ska-Drabiuk","sequence":"additional","affiliation":[{"name":"Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Szubert","sequence":"additional","affiliation":[{"name":"Division of Gynaecological Oncology, Department of Gynaecology, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-2237","authenticated-orcid":false,"given":"Ewa E.","family":"Hennig","sequence":"additional","affiliation":[{"name":"Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781Warsaw, Poland"},{"name":"Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, 02-781 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5390-9213","authenticated-orcid":false,"given":"Agnieszka","family":"Horala","sequence":"additional","affiliation":[{"name":"Division of Gynaecological Oncology, Department of Gynaecology, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalina","family":"D\u0105browska","sequence":"additional","affiliation":[{"name":"Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Micek","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 00-189 Warsaw, Poland"},{"name":"Warsaw Institute of Women\u2019s Health, 00-189 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-5983","authenticated-orcid":false,"given":"Micha\u0142","family":"Ciebiera","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 00-189 Warsaw, Poland"},{"name":"Warsaw Institute of Women\u2019s Health, 00-189 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Zeber-Lubecka","sequence":"additional","affiliation":[{"name":"Department of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781Warsaw, Poland"},{"name":"Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, 02-781 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Har\u0119\u017ca, D.A., Wilczy\u0144ski, J.R., and Paradowska, E. (2022). Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031818"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fonc.2019.00355","article-title":"Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology","volume":"9","author":"Gheit","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.16.1.1-17.2003","article-title":"Human Papillomavirus and Cervical Cancer","volume":"16","author":"Burd","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1604621","DOI":"10.3389\/ijph.2022.1604621","article-title":"Is It Time to Genotype Beyond HPV16 and HPV18 for Cervical Cancer Screening?","volume":"67","author":"Chua","year":"2022","journal-title":"Int. J. Public. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.14639\/0392-100X-suppl.1-43-2023-14","article-title":"Recurrent Laryngeal Papillomatosis: Multimodal Therapeutic Strategies. Literature Review and Multicentre Retrospective Study","volume":"43","author":"Bertino","year":"2023","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_6","unstructured":"Leslie, S.W., Sajjad, H., and Kumar, S. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1080\/01443615.2019.1634030","article-title":"Human Papillomavirus and Cervical Cancer","volume":"40","author":"Okunade","year":"2020","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","article-title":"Global Estimates of Incidence and Mortality of Cervical Cancer in 2020: A Baseline Analysis of the WHO Global Cervical Cancer Elimination Initiative","volume":"11","author":"Singh","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of Incidence and Mortality of Cervical Cancer in 2018: A Worldwide Analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_10","unstructured":"(2023, October 23). Cervical Cancer Statistics I World Cancer Research Fund International. Available online: https:\/\/www.wcrf.org\/cancer-trends\/cervical-cancer-statistics\/."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.3390\/v7072802","article-title":"Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia","volume":"7","author":"Egawa","year":"2015","journal-title":"Viruses"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Moody, C. (2017). Mechanisms by Which HPV Induces a Replication Competent Environment in Differentiating Keratinocytes. Viruses, 9.","DOI":"10.3390\/v9090261"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Von Witzleben, A., Wang, C., Laban, S., Savelyeva, N., and Ottensmeier, C.H. (2020). HNSCC: Tumour Antigens and Their Targeting by Immunotherapy. Cells, 9.","DOI":"10.3390\/cells9092103"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/CEJ.0000000000000528","article-title":"A Roadmap for a Comprehensive Control of Cervical Cancer in Poland: Integration of Available Solutions into Current Practice in Primary and Secondary Prevention","volume":"29","author":"Nowakowski","year":"2020","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_15","first-page":"759","article-title":"Recommendations of the Polish Society of Gynaecologists and Obstetricians, Polish Paediatric Society, Polish Society of Family Medicine, Polish Society of Vaccinology, Polish Society of Oncological Gynaecology and Polish Society of Colposcopy and Pathophysiology of the Uterine Cervix on Prophylactic Vaccinations against Infections with Human Papillomaviruses in Poland","volume":"94","author":"Nowakowski","year":"2023","journal-title":"Ginekol. Pol."},{"key":"ref_16","first-page":"e31312","article-title":"Cervical Cancer: Early Detection and Prevention in Reproductive Age Group","volume":"14","author":"Basoya","year":"2022","journal-title":"Cureus"},{"key":"ref_17","first-page":"e30037","article-title":"Human Papillomavirus Prevention by Vaccination: A Review Article","volume":"14","author":"Charde","year":"2022","journal-title":"Cureus"},{"key":"ref_18","unstructured":"Mello, V., and Sundstrom, R.K. (2023). StatPearls, StatPearls Publishing."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5603\/OCP.2021.0027","article-title":"Precancerous Lesions of the Cervix\u2014Aetiology, Classification, Diagnosis, Prevention","volume":"17","author":"Kornovski","year":"2021","journal-title":"Oncol. Clin. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Shoupe, D. (2016). Handbook of Gynecology, Springer International Publishing.","DOI":"10.1007\/978-3-319-17798-4"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"963752","DOI":"10.3389\/frph.2022.963752","article-title":"The Female Reproductive Tract Microbiotas, Inflammation, and Gynecological Conditions","volume":"4","author":"Gholiof","year":"2022","journal-title":"Front. Reprod. Health"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kumar, L., Dwivedi, M., Jain, N., Shete, P., Solanki, S., Gupta, R., and Jain, A. (2023). The Female Reproductive Tract Microbiota: Friends and Foe. Life, 13.","DOI":"10.3390\/life13061313"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Plesniarski, A., Siddik, A.B., and Su, R.-C. (2021). The Microbiome as a Key Regulator of Female Genital Tract Barrier Function. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.790627"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Moosa, Y., Kwon, D., De Oliveira, T., and Wong, E.B. (2020). Determinants of Vaginal Microbiota Composition. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.00467"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.fertnstert.2018.06.036","article-title":"Cervicovaginal Microbiota, Women\u2019s Health, and Reproductive Outcomes","volume":"110","author":"Kroon","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Cascardi, E., Cazzato, G., Daniele, A., Silvestris, E., Cormio, G., Di Vagno, G., Malvasi, A., Loizzi, V., Scacco, S., and Pinto, V. (2022). Association between Cervical Microbiota and HPV: Could This Be the Key to Complete Cervical Cancer Eradication?. Biology, 11.","DOI":"10.3390\/biology11081114"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Molina, M.A., Melchers, W.J.G., N\u00fa\u00f1ez-Samudio, V., and Landires, I. (2023). The Emerging Role of Lactobacillus Acidophilus in the Cervicovaginal Microenvironment. Lancet Microbe, S2666524723003154.","DOI":"10.1016\/S2666-5247(23)00315-4"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zheng, N., Guo, R., Wang, J., Zhou, W., and Ling, Z. (2021). Contribution of Lactobacillus Iners to Vaginal Health and Diseases: A Systematic Review. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.792787"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fimmu.2018.00376","article-title":"Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense","volume":"9","author":"Valenti","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lin, Y.-P., Chen, W.-C., Cheng, C.-M., and Shen, C.-J. (2021). Vaginal PH Value for Clinical Diagnosis and Treatment of Common Vaginitis. Diagnostics, 11.","DOI":"10.3390\/diagnostics11111996"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Molina, M.A., Andralojc, K.M., Huynen, M.A., Leenders, W.P.J., and Melchers, W.J.G. (2022). In-Depth Insights into Cervicovaginal Microbial Communities and HrHPV Infections Using High-Resolution Microbiome Profiling. NPJ Biofilms Microbiomes, 8.","DOI":"10.1038\/s41522-022-00336-6"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal Microbiome of Reproductive-Age Women","volume":"108","author":"Ravel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"France, M.T., Ma, B., Gajer, P., Brown, S., Humphrys, M.S., Holm, J.B., Waetjen, L.E., Brotman, R.M., and Ravel, J. (2020). VALENCIA: A Nearest Centroid Classification Method for Vaginal Microbial Communities Based on Composition. Microbiome, 8.","DOI":"10.1186\/s40168-020-00934-6"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Mitra, A., MacIntyre, D.A., Marchesi, J.R., Lee, Y.S., Bennett, P.R., and Kyrgiou, M. (2016). The Vaginal Microbiota, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia: What Do We Know and Where Are We Going Next?. Microbiome, 4.","DOI":"10.1186\/s40168-016-0203-0"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Stoian, I.L., Botezatu, A., Fudulu, A., Ilea, C.G., and Socolov, D.G. (2023). Exploring Microbiota Diversity in Cervical Lesion Progression and HPV Infection through 16S RRNA Gene Metagenomic Sequencing. J. Clin. Med., 12.","DOI":"10.3390\/jcm12154979"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1002\/jmv.27837","article-title":"Microbiota and HPV: The Role of Viral Infection on Vaginal Microbiota","volume":"94","author":"Santella","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ntuli, L., Mtshali, A., Mzobe, G., Liebenberg, L.J., and Ngcapu, S. (2022). Role of Immunity and Vaginal Microbiome in Clearance and Persistence of Human Papillomavirus Infection. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.927131"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000511477","article-title":"Microbiome and Cervical Cancer","volume":"88","author":"Castanheira","year":"2021","journal-title":"Pathobiology"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhou, Z.-W., Long, H.-Z., Cheng, Y., Luo, H.-Y., Wen, D.-D., and Gao, L.-C. (2021). From Microbiome to Inflammation: The Key Drivers of Cervical Cancer. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.767931"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Choi, S., Ismail, A., Pappas-Gogos, G., and Boussios, S. (2023). HPV and Cervical Cancer: A Review of Epidemiology and Screening Uptake in the UK. Pathogens, 12.","DOI":"10.3390\/pathogens12020298"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Andralojc, K.M., Molina, M.A., Qiu, M., Spruijtenburg, B., Rasing, M., Pater, B., Huynen, M.A., Dutilh, B.E., Ederveen, T.H.A., and Elmelik, D. (2021). Novel High-Resolution Targeted Sequencing of the Cervicovaginal Microbiome. BMC Biol., 19.","DOI":"10.1186\/s12915-021-01204-z"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1016\/j.csbj.2023.09.011","article-title":"Longitudinal Analysis on the Ecological Dynamics of the Cervicovaginal Microbiome in HrHPV Infection","volume":"21","author":"Molina","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Alizadehmohajer, N., Shojaeifar, S., Nedaeinia, R., Esparvarinha, M., Mohammadi, F., Ferns, G.A., Ghayour-Mobarhan, M., Manian, M., and Balouchi, A. (2020). Association between the Microbiota and Women\u2019s Cancers\u2014Cause or Consequences?. Biomed. Pharmacother., 127.","DOI":"10.1016\/j.biopha.2020.110203"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1136\/ijgc-2019-000801","article-title":"Changes in the Cervical Microbiota of Cervical Cancer Patients after Primary Radio-Chemotherapy","volume":"30","author":"Tsakmaklis","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1258\/0956462971918850","article-title":"Sex, Thrush and Bacterial Vaginosis","volume":"8","author":"Hay","year":"1997","journal-title":"Int. J. STD AIDS"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e00487-20","DOI":"10.1128\/IAI.00487-20","article-title":"The Complex Link between the Female Genital Microbiota, Genital Infections, and Inflammation","volume":"89","author":"Dabee","year":"2021","journal-title":"Infect. Immun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ajog.2018.12.011","article-title":"Vaginal Dysbiosis and the Risk of Human Papillomavirus and Cervical Cancer: Systematic Review and Meta-Analysis","volume":"221","author":"Brusselaers","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"319460","DOI":"10.1155\/2011\/319460","article-title":"Bacterial Vaginosis and the Natural History of Human Papillomavirus","volume":"2011","author":"King","year":"2011","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Holdcroft, A.M., Ireland, D.J., and Payne, M.S. (2023). The Vaginal Microbiome in Health and Disease\u2014What Role Do Common Intimate Hygiene Practices Play?. Microorganisms, 11.","DOI":"10.3390\/microorganisms11020298"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1005537","DOI":"10.3389\/fonc.2022.1005537","article-title":"Increased Diversity of a Cervical Microbiome Associates with Cervical Cancer","volume":"12","author":"Kulecka","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1002\/cam4.3027","article-title":"Comparison of Vaginal Microbiota in Gynecologic Cancer Patients Pre- and Post-radiation Therapy and Healthy Women","volume":"9","author":"Tsementzi","year":"2020","journal-title":"Cancer Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","article-title":"Microbiota in Health and Diseases","volume":"7","author":"Hou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"902695","DOI":"10.3389\/fonc.2022.902695","article-title":"Gut Microbes in Gynecologic Cancers: Causes or Biomarkers and Therapeutic Potential","volume":"12","author":"Han","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1097\/IGC.0000000000000999","article-title":"Systematic Review: The Impact of Cancer Treatment on the Gut and Vaginal Microbiome in Women With a Gynecological Malignancy","volume":"27","author":"Muls","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13568-019-0763-z","article-title":"Altered Diversity and Composition of the Gut Microbiome in Patients with Cervical Cancer","volume":"9","author":"Wang","year":"2019","journal-title":"AMB Expr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ygyno.2019.09.002","article-title":"Gut Microbial Diversity and Genus-Level Differences Identified in Cervical Cancer Patients versus Healthy Controls","volume":"155","author":"Sims","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The Immune Response to Prevotella Bacteria in Chronic Inflammatory Disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Sims, T.T., El Alam, M.B., Karpinets, T.V., Dorta-Estremera, S., Hegde, V.L., Nookala, S., Yoshida-Court, K., Wu, X., Biegert, G.W.G., and Delgado Medrano, A.Y. (2021). Gut Microbiome Diversity Is an Independent Predictor of Survival in Cervical Cancer Patients Receiving Chemoradiation. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-01741-x"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kang, G.-U., Jung, D.-R., Lee, Y.H., Jeon, S.Y., Han, H.S., Chong, G.O., and Shin, J.-H. (2020). Dynamics of Fecal Microbiota with and without Invasive Cervical Cancer and Its Application in Early Diagnosis. Cancers, 12.","DOI":"10.3390\/cancers12123800"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clnu.2022.10.024","article-title":"Butyrate\u2019s Role in Human Health and the Current Progress towards Its Clinical Application to Treat Gastrointestinal Disease","volume":"42","author":"Hodgkinson","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Chang, L., Qiu, L., Lei, N., Zhou, J., Guo, R., Gao, F., Dong, S., Chen, M., Wu, F., and Qin, B. (2023). Characterization of Fecal Microbiota in Cervical Cancer Patients Associated with Tumor Stage and Prognosis. Front. Cell. Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1145950"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1355S","DOI":"10.3945\/jn.109.119776","article-title":"Equol: History, Chemistry, and Formation","volume":"140","author":"Setchell","year":"2010","journal-title":"J. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-2971-8","article-title":"The Gut Microbiota Is Associated with Immune Cell Dynamics in Humans","volume":"588","author":"Schluter","year":"2020","journal-title":"Nature"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"17055","DOI":"10.1038\/sigtrans.2017.55","article-title":"The Role of TLRs in Cervical Cancer with HPV Infection: A Review","volume":"2","author":"Yang","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern Recognition Receptors in Health and Diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1126\/science.1183021","article-title":"Regulation of Adaptive Immunity by the Innate Immune System","volume":"327","author":"Iwasaki","year":"2010","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like Receptors in Innate Immunity","volume":"17","author":"Takeda","year":"2004","journal-title":"Int. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.mgene.2018.07.003","article-title":"Absence of Association between TLR4 Thr399Ile Polymorphism and Cervical Cancer Susceptibility","volume":"17","author":"Pandey","year":"2018","journal-title":"Meta Gene"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ygyno.2009.05.032","article-title":"Impact of Toll-like Receptors [TLR] 2 (\u2212196 to \u2212174 Del) and TLR 4 (Asp299Gly, Thr399Ile) in Cervical Cancer Susceptibility in North Indian Women","volume":"114","author":"Pandey","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12253-015-0009-6","article-title":"Evaluation of Toll-Like Receptors 2\/3\/4\/9 Gene Polymorphisms in Cervical Cancer Evolution","volume":"22","author":"Zidi","year":"2016","journal-title":"Pathol. Oncol. Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"de Moura, E.L., dos Santos, I.F., de Freitas, P.P., da Silva, D.M., dos Santos, A.C.M., Lira Neto, A.B., e Silva, A.C.P., Barbosa, N.R., Nascimento, C.A., and Balliano, T.L. (2022). Polymorphisms in Toll-like Receptors Genes Changes the Host\u2019s Immune Response and Is Associated with Cervical Cancer. Immunobiology, 227.","DOI":"10.1016\/j.imbio.2022.152187"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1753425910392934","article-title":"Expression of Integrins and Toll-like Receptors in Cervical Cancer: Effect of Infectious Agents","volume":"18","author":"Werner","year":"2012","journal-title":"Innate Immun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00232-014-9675-7","article-title":"Expression and Functional Analysis of Toll-like Receptor 4 in Human Cervical Carcinoma","volume":"247","author":"Wang","year":"2014","journal-title":"J. Membr. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0166-3542(99)00033-9","article-title":"Enhancement of the Innate and Cellular Immune Response in Patients with Genital Warts Treated with Topical Imiquimod Cream 5%","volume":"43","author":"Arany","year":"1999","journal-title":"Antivir. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e29238","DOI":"10.1002\/jmv.29238","article-title":"Recent Advances in Treating Female Genital Human Papillomavirus Related Neoplasms with Topical Imiquimod","volume":"95","author":"Borella","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Li, Z.J., Sohn, K.-C., Choi, D.-K., Shi, G., Hong, D., Lee, H.-E., Whang, K.U., Lee, Y.H., Im, M., and Lee, Y. (2013). Roles of TLR7 in Activation of NF-\u039aB Signaling of Keratinocytes by Imiquimod. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0077159"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.tjog.2012.09.006","article-title":"Topical Imiquimod Treatment for Human Papillomavirus Infection in Patients with and without Cervical\/Vaginal Intraepithelial Neoplasia","volume":"51","author":"Lin","year":"2012","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1097\/AOG.0000000000004384","article-title":"Topical Imiquimod for the Treatment of High-Grade Squamous Intraepithelial Lesions of the Cervix: A Randomized Controlled Trial","volume":"137","author":"Fonseca","year":"2021","journal-title":"Obstet. Gynecol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/AOG.0b013e31825bc6e8","article-title":"Treatment of Cervical Intraepithelial Neoplasia With Topical Imiquimod: A Randomized Controlled Trial","volume":"120","author":"Grimm","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ygyno.2020.09.031","article-title":"Imiquimod for Vaginal Intraepithelial Neoplasia 2\u20133: A Systematic Review and Meta-Analysis","volume":"160","author":"Inayama","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/AOG.0000000000005256","article-title":"Imiquimod for Cervical and Vaginal Intraepithelial Neoplasia: A Systematic Review and Meta-Analysis","volume":"142","author":"Inayama","year":"2023","journal-title":"Obstet. Gynecol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.currproblcancer.2018.01.016","article-title":"Chemotherapy and Targeted Therapy in the Management of Cervical Cancer","volume":"42","author":"Kumar","year":"2018","journal-title":"Curr. Probl. Cancer"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13073-016-0300-5","article-title":"Alterations in Fecal Microbiota Composition by Probiotic Supplementation in Healthy Adults: A Systematic Review of Randomized Controlled Trials","volume":"8","author":"Kristensen","year":"2016","journal-title":"Genome Med."},{"key":"ref_84","first-page":"S2666524723002574","article-title":"Genital Tract Microbiota Composition Profiles and Use of Prebiotics and Probiotics in Gynaecological Cancer Prevention: Review of the Current Evidence, the European Society of Gynaecological Oncology Prevention Committee Statement","volume":"2023","author":"Mitra","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Latif, A., Shehzad, A., Niazi, S., Zahid, A., Ashraf, W., Iqbal, M.W., Rehman, A., Riaz, T., Aadil, R.M., and Khan, I.M. (2023). Probiotics: Mechanism of Action, Health Benefits and Their Application in Food Industries. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1216674"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Mazziotta, C., Tognon, M., Martini, F., Torreggiani, E., and Rotondo, J.C. (2023). Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells, 12.","DOI":"10.3390\/cells12010184"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/07315724.2015.1032443","article-title":"The Consumption of Synbiotic Bread Containing Lactobacillus Sporogenes and Inulin Affects Nitric Oxide and Malondialdehyde in Patients with Type 2 Diabetes Mellitus: Randomized, Double-Blind, Placebo-Controlled Trial","volume":"35","author":"Bahmani","year":"2016","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000342079","article-title":"Probiotic Mechanisms of Action","volume":"61","author":"Gil","year":"2012","journal-title":"Ann. Nutr. Metab."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1007\/s12325-020-01594-6","article-title":"Therapeutic Efficacy of a Coriolus Versicolor-Based Vaginal Gel in Women with Cervical Uterine High-Risk HPV Infection: A Retrospective Observational Study","volume":"38","author":"Criscuolo","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Lavitola, G., Della Corte, L., De Rosa, N., Nappi, C., and Bifulco, G. (2020). Effects on Vaginal Microbiota Restoration and Cervical Epithelialization in Positive HPV Patients Undergoing Vaginal Treatment with Carboxy-Methyl-Beta-Glucan. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/5476389"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/LGT.0000000000000596","article-title":"Efficacy of a Coriolus Versicolor\u2013Based Vaginal Gel in Women With Human Papillomavirus\u2013Dependent Cervical Lesions: The PALOMA Study","volume":"25","author":"Serrano","year":"2021","journal-title":"J. Low. Genit. Tract. Dis."},{"key":"ref_92","first-page":"113","article-title":"Effect of the Treatment with \u03b2-Glucan in Women with Cervical Cytologic Report of Atypical Squamous Cells of Undetermined Significance (ASCUS) and Low-Grade Squamous Intraepithelial Lesions (L-SIL)","volume":"67","author":"Laccetta","year":"2015","journal-title":"Minerva Ginecol."},{"key":"ref_93","first-page":"425","article-title":"Efficacy of Carboxymethyl Beta-Glucan in Cervical Intraepithelial Neoplasia: A Retrospective, Case-Control Study","volume":"69","author":"Stentella","year":"2017","journal-title":"Minerva Obs. Gynecol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Gil-Antu\u00f1ano, S.P., Serrano Cogollor, L., L\u00f3pez D\u00edaz, A.C., Gonz\u00e1lez Rodr\u00edguez, S.P., Dexeus Carter, D., Centeno Mediavilla, C., Coronado Mart\u00edn, P., de la Fuente Valero, J., L\u00f3pez Fern\u00e1ndez, J.A., and Vanrell Barbat, C. (2022). Efficacy of a Coriolusversicolor-Based Vaginal Gel in Human Papillomavirus-Positive Women Older Than 40 Years: A Sub-Analysis of PALOMA Study. J. Pers. Med., 12.","DOI":"10.3390\/jpm12101559"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13027-022-00465-9","article-title":"Lactobacillus Crispatus M247 Oral Administration: Is It Really an Effective Strategy in the Management of Papillomavirus-Infected Women?","volume":"17","author":"Dellino","year":"2022","journal-title":"Infect. Agents Cancer"},{"key":"ref_96","first-page":"621","article-title":"Oral Administration of Lactobacillus Crispatus M247 to Papillomavirus-Infected Women: Results of a Preliminary, Uncontrolled, Open Trial","volume":"73","author":"Criscuolo","year":"2021","journal-title":"Minerva Obs. Gynecol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"881902","DOI":"10.3389\/fonc.2022.881902","article-title":"AHCC\u00ae Supplementation to Support Immune Function to Clear Persistent Human Papillomavirus Infections","volume":"12","author":"Smith","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0895-4356(91)90039-C","article-title":"The Effect of Beta-Carotene on the Regression and Progression of Cervical Dysplasia: A Clinical Experiment","volume":"44","author":"Knipschild","year":"1991","journal-title":"J. Clin. Epidemiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13167-015-0048-9","article-title":"Double-Blind Randomized Placebo-Controlled Multicenter Clinical Trial (Phase IIa) on Diindolylmethane\u2019s Efficacy and Safety in the Treatment of CIN: Implications for Cervical Cancer Prevention","volume":"6","author":"Ashrafian","year":"2015","journal-title":"EPMA J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00008469-200310000-00007","article-title":"Protective Effects of Green Tea Extracts (Polyphenon E and EGCG) on Human Cervical Lesions","volume":"12","author":"Ahn","year":"2003","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/gyno.2000.5847","article-title":"Placebo-Controlled Trial of Indole-3-Carbinol in the Treatment of CIN","volume":"78","author":"Bell","year":"2000","journal-title":"Gynecol. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.31557\/APJCP.2022.23.4.1285","article-title":"Efficacy of Oral Zinc Sulfate Supplementation on Clearance of Cervical Human Papillomavirus (HPV); A Randomized Controlled Clinical Trial","volume":"23","author":"Ayatollahi","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"601","DOI":"10.4155\/bio-2017-0012","article-title":"A Metabolite Profiling Method for Diagnosis of Precancerous Cervical Lesions and HPV Persistence","volume":"9","author":"Walker","year":"2017","journal-title":"Bioanalysis"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"17718","DOI":"10.1038\/s41598-021-96038-8","article-title":"Metabolic Rewiring Is Associated with HPV-Specific Profiles in Cervical Cancer Cell Lines","volume":"11","author":"Pappa","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fonc.2018.00099","article-title":"Molecular Signatures of High-Grade Cervical Lesions","volume":"8","author":"Porcari","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Audirac-Chalifour, A., Torres-Poveda, K., Bahena-Rom\u00e1n, M., T\u00e9llez-Sosa, J., Mart\u00ednez-Barnetche, J., Cortina-Ceballos, B., L\u00f3pez-Estrada, G., Delgado-Romero, K., Burguete-Garc\u00eda, A.I., and Cant\u00fa, D. (2016). Cervical Microbiome and Cytokine Profile at Various Stages of Cervical Cancer: A Pilot Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153274"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Fang, B., Li, Q., Wan, Z., OuYang, Z., and Zhang, Q. (2022). Exploring the Association Between Cervical Microbiota and HR-HPV Infection Based on 16S RRNA Gene and Metagenomic Sequencing. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.922554"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1038\/s41598-020-80176-6","article-title":"Changes to the Cervicovaginal Microbiota and Cervical Cytokine Profile Following Surgery for Cervical Intraepithelial Neoplasia","volume":"11","author":"Kawahara","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e00064-22","DOI":"10.1128\/msystems.00064-22","article-title":"Cervicovaginal DNA Virome Alterations Are Associated with Genital Inflammation and Microbiota Composition","volume":"7","author":"Kaelin","year":"2022","journal-title":"mSystems"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1002\/cam4.4801","article-title":"Changes in the Cervicovaginal Microbiota Composition of HPV16-infected Patients after Clinical Treatment","volume":"11","author":"Li","year":"2022","journal-title":"Cancer Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"674.e1","DOI":"10.1016\/j.cmi.2015.02.026","article-title":"The Association of Uterine Cervical Microbiota with an Increased Risk for Cervical Intraepithelial Neoplasia in Korea","volume":"21","author":"Oh","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1158\/1940-6207.CAPR-15-0350","article-title":"Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses","volume":"9","author":"Piyathilake","year":"2016","journal-title":"Cancer Prev. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1158\/1940-6207.CAPR-18-0233","article-title":"Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women","volume":"12","author":"Ritu","year":"2019","journal-title":"Cancer Prev. Res."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Satam, H., Joshi, K., Mangrolia, U., Waghoo, S., Zaidi, G., Rawool, S., Thakare, R.P., Banday, S., Mishra, A.K., and Das, G. (2023). Next-Generation Sequencing Technology: Current Trends and Advancements. Biology, 12.","DOI":"10.3390\/biology12070997"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Wiik, J., Sengpiel, V., Kyrgiou, M., Nilsson, S., Mitra, A., Tanbo, T., Monceyron Jonassen, C., M\u00f8ller Tann\u00e6s, T., and Sj\u00f8borg, K. (2019). Cervical Microbiota in Women with Cervical Intra-Epithelial Neoplasia, Prior to and after Local Excisional Treatment, a Norwegian Cohort Study. BMC Women\u2019s Health, 19.","DOI":"10.1186\/s12905-019-0727-0"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ygyno.2021.08.016","article-title":"The Feature of Cervical Microbiota Associated with the Progression of Cervical Cancer among Reproductive Females","volume":"163","author":"Wu","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"489","DOI":"10.33073\/pjm-2021-046","article-title":"Characteristics of the Cervicovaginal Microenvironment in Childbearing-Age Women with Different Degrees of Cervical Lesions and HR-HPV Positivity","volume":"70","author":"Zhai","year":"2021","journal-title":"Pol. J. Microbiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/cam4.1471","article-title":"The Direct and Indirect Association of Cervical Microbiota with the Risk of Cervical Intraepithelial Neoplasia","volume":"7","author":"Zhang","year":"2018","journal-title":"Cancer Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1038\/s41598-018-23389-0","article-title":"Cervical Microbiome Is Altered in Cervical Intraepithelial Neoplasia after Loop Electrosurgical Excision Procedure in China","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"699793","DOI":"10.3389\/fgene.2021.699793","article-title":"The Application of High-Throughput Technologies for the Study of Microbiome and Cancer","volume":"12","author":"Wei","year":"2021","journal-title":"Front. Genet."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.tibtech.2019.12.021","article-title":"Enabling Technologies for Personalized and Precision Medicine","volume":"38","author":"Ho","year":"2020","journal-title":"Trends Biotechnol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Winand, R., Bogaerts, B., Hoffman, S., Lefevre, L., Delvoye, M., Van Braekel, J., Fu, Q., Roosens, N.H., De Keersmaecker, S.C., and Vanneste, K. (2019). Targeting the 16S RRNA Gene for Bacterial Identification in Complex Mixed Samples: Comparative Evaluation of Second (Illumina) and Third (Oxford Nanopore Technologies) Generation Sequencing Technologies. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010298"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1128\/CMR.17.4.840-862.2004","article-title":"Impact of 16S RRNA Gene Sequence Analysis for Identification of Bacteria on Clinical Microbiology and Infectious Diseases","volume":"17","author":"Clarridge","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Smith, B.C., McAndrew, T., Chen, Z., Harari, A., Barris, D.M., Viswanathan, S., Rodriguez, A.C., Castle, P., Herrero, R., and Schiffman, M. (2012). The Cervical Microbiome over 7 Years and a Comparison of Methodologies for Its Characterization. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040425"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1038\/s41598-017-09842-6","article-title":"Characterization of Cervico-Vaginal Microbiota in Women Developing Persistent High-Risk Human Papillomavirus Infection","volume":"7","author":"Sani","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"17364","DOI":"10.1038\/s41598-017-17351-9","article-title":"Analysis of the Cervical Microbiome and Potential Biomarkers from Postpartum HIV-Positive Women Displaying Cervical Intraepithelial Lesions","volume":"7","author":"Curty","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.31342","article-title":"Cervicovaginal Microbiota Composition Correlates with the Acquisition of High-Risk Human Papillomavirus Types","volume":"143","author":"Huang","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"15479","DOI":"10.1038\/s41598-018-33750-y","article-title":"Association of Cervical Microbial Community with Persistence, Clearance and Negativity of Human Papillomavirus in Korean Women: A Longitudinal Study","volume":"8","author":"Arokiyaraj","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"153473541989306","DOI":"10.1177\/1534735419893063","article-title":"Cervical Microbiome and Response to a Human Papillomavirus Therapeutic Vaccine for Treating High-Grade Cervical Squamous Intraepithelial Lesion","volume":"18","author":"Ravilla","year":"2019","journal-title":"Integr. Cancer Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pvr.2019.04.006","article-title":"The Cervical Microbiota in Reproductive-Age South African Women with and without Human Papillomavirus Infection","volume":"7","author":"Onywera","year":"2019","journal-title":"Papillomavirus Res."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Usyk, M., Zolnik, C.P., Castle, P.E., Porras, C., Herrero, R., Gradissimo, A., Gonzalez, P., Safaeian, M., Schiffman, M., and Burk, R.D. (2020). Cervicovaginal Microbiome and Natural History of HPV in a Longitudinal Study. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008376"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Li, T., Zhang, D., Zong, X., Bai, H., Bi, H., and Liu, Z. (2021). Distinction between Vaginal and Cervical Microbiota in High-Risk Human Papilloma Virus-Infected Women in China. BMC Microbiol., 21.","DOI":"10.1186\/s12866-021-02152-y"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Sasivimolrattana, T., Chantratita, W., Sensorn, I., Chaiwongkot, A., Oranratanaphan, S., Bhattarakosol, P., and Bhattarakosol, P. (2022). Cervical Microbiome in Women Infected with HPV16 and High-Risk HPVs. Int. J. Environ. Res. Public. Health, 19.","DOI":"10.3390\/ijerph192214716"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"955150","DOI":"10.3389\/fonc.2022.955150","article-title":"Vaginal Microbiota and HPV Clearance: A Longitudinal Study","volume":"12","author":"Shi","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Liu, C.-J., Xiao, W.-Y., Fang, J.-F., Dong, Y.-H., Ye, K.-F., He, M.-P., Wang, Y.-S., Li, X., Zhao, Z.-M., and Yuan, T. (2022). Genital Microbiota of Women From Six Ethnic Groups With and Without Human Papillomavirus Infection in Shangri-La, China. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.935068"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Hu, J., Wu, Y., Quan, L., Yang, W., Lang, J., Tian, G., and Meng, B. (2022). Research of Cervical Microbiota Alterations with Human Papillomavirus Infection Status and Women Age in Sanmenxia Area of China. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1004664"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Guo, C., Dai, W., Zhou, Q., Gui, L., Cai, H., Wu, D., Hou, J., Li, C., Li, S., and Du, H. (2022). Cervicovaginal Microbiota Significantly Changed for HPV-Positive Women with High-Grade Squamous Intraepithelial Lesion. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.973875"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Vikramdeo, K.S., Anand, S., Pierce, J.Y., Singh, A.P., Singh, S., and Dasgupta, S. (2022). Distribution of Microbiota in Cervical Preneoplasia of Racially Disparate Populations. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-10112-6"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Wang, H., Jiang, Y., Liang, Y., Wei, L., Zhang, W., and Li, L. (2022). Observation of the Cervical Microbiome in the Progression of Cervical Intraepithelial Neoplasia. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-09452-0"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e00151-22","DOI":"10.1128\/spectrum.00151-22","article-title":"Association of Cervical Dysbacteriosis, HPV Oncogene Expression, and Cervical Lesion Progression","volume":"10","author":"Liu","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"ref_141","first-page":"e00357-23","article-title":"The Cervical Microbiota of Hispanics Living in Puerto Rico Is Nonoptimal Regardless of HPV Status","volume":"8","author":"Romaguera","year":"2023","journal-title":"mSystems"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Teka, B., Yoshida-Court, K., Firdawoke, E., Chanyalew, Z., Gizaw, M., Addissie, A., Mihret, A., Colbert, L.E., Napravnik, T.C., and El Alam, M.B. (2023). Cervicovaginal Microbiota Profiles in Precancerous Lesions and Cervical Cancer among Ethiopian Women. Microorganisms, 11.","DOI":"10.3390\/microorganisms11040833"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Rokos, T., Holubekova, V., Kolkova, Z., Hornakova, A., Pribulova, T., Kozubik, E., Biringer, K., and Kudela, E. (2022). Is the Physiological Composition of the Vaginal Microbiome Altered in High-Risk HPV Infection of the Uterine Cervix?. Viruses, 14.","DOI":"10.3390\/v14102130"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"16865","DOI":"10.1038\/srep16865","article-title":"Cervical Intraepithelial Neoplasia Disease Progression Is Associated with Increased Vaginal Microbiome Diversity","volume":"5","author":"Mitra","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"104617","DOI":"10.1016\/j.micpath.2020.104617","article-title":"Cervicovaginal Microbiota Dysbiosis Correlates with HPV Persistent Infection","volume":"152","author":"Qingqing","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Chorna, N., Romaguera, J., and Godoy-Vitorino, F. (2020). Cervicovaginal Microbiome and Urine Metabolome Paired Analysis Reveals Niche Partitioning of the Microbiota in Patients with Human Papilloma Virus Infections. Metabolites, 10.","DOI":"10.3390\/metabo10010036"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41467-020-15856-y","article-title":"The Vaginal Microbiota Associates with the Regression of Untreated Cervical Intraepithelial Neoplasia 2 Lesions","volume":"11","author":"Mitra","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12985-020-01420-z","article-title":"Temporal Changes in the Vaginal Microbiota in Self-Samples and Its Association with Persistent HPV16 Infection and CIN2+","volume":"17","author":"Berggrund","year":"2020","journal-title":"Virol. J."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.21037\/atm-20-5832","article-title":"Association of High-Risk Human Papillomavirus Infection Duration and Cervical Lesions with Vaginal Microbiota Composition","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. 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