{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:32:23Z","timestamp":1784673143495,"version":"3.55.0"},"reference-count":83,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONAHCYT, Mexico","award":["CB-2016-285884"],"award-info":[{"award-number":["CB-2016-285884"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Colorectal cancer (CRC) is the third most common neoplasia in the world. Its mortality rate is high due to the lack of specific and effective treatments, metastasis, and resistance to chemotherapy, among other factors. The natural products in cancer are a primary source of bioactive molecules. In this research, we evaluated the antitumor activity of an acetogenin (ACG), laherradurin (LH), isolated from the Mexican medicinal plant Annona macroprophyllata Donn.Sm. in a CRC murine model. The CRC was induced by azoxymethane\u2013dextran sulfate sodium (AOM\/DSS) in Balb\/c mice and treated for 21 days with LH or cisplatin. This study shows for the first time the antitumor activity of LH in an AOM\/DSS CRC model. The acetogenin diminished the number and size of tumors compared with cisplatin; the histologic studies revealed a recovery of the colon tissue, and the blood toxicity data pointed to less damage in animals treated with LH. The TUNEL assay indicated cell death by apoptosis, and the in vitro studies exhibited that LH inhibited cell migration in HCT116 cells. Our study provides strong evidence of a possible anticancer agent for CRC.<\/jats:p>","DOI":"10.3390\/cancers16030573","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T05:14:32Z","timestamp":1706591672000},"page":"573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Laherradurin Inhibits Tumor Growth in an Azoxymethane\/Dextran Sulfate Sodium Colorectal Cancer Model In Vivo"],"prefix":"10.3390","volume":"16","author":[{"given":"Michael Joshue","family":"Rend\u00f3n-Barr\u00f3n","sequence":"first","affiliation":[{"name":"Unidad de Bioqu\u00edmica, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran, Av. Vasco de Quiroga 15, Col. Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de M\u00e9xico 14080, Mexico"},{"name":"Unidad Profesional Adolfo L\u00f3pez Mateos, Laboratorio de Gen\u00e9tica, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Zacatenco, Av. Wilfrido Massieu Esq Cda. Miguel Stampa S\/N, Alcald\u00eda Gustavo A. Madero, Ciudad de M\u00e9xico 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez-Arteaga","sequence":"additional","affiliation":[{"name":"Unidad de Bioqu\u00edmica, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran, Av. Vasco de Quiroga 15, Col. 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San Fernando 22, Belisario Dom\u00ednguez Secc 16, Tlalpan, Ciudad de M\u00e9xico 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Linares","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Biolog\u00eda de la Reproducci\u00f3n, Laboratorio de Endocrinolog\u00eda, Facultad de Estudios Superiores Zaragoza, Batalla 5 de Mayo S\/N, Ej\u00e9rcito de Oriente Zona Pe\u00f1on, Iztapalapa, Ciudad de M\u00e9xico 09230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-3466","authenticated-orcid":false,"given":"Alma Rosa","family":"Gonz\u00e1lez-Esquinca","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiolog\u00eda y Qu\u00edmica Vegetal, Instituto de Ciencias Biol\u00f3gicas, Universidad de Ciencias y Artes de Chiapas, Libramiento Norte Poniente 1150, Lajas Maciel, Tuxtla Guti\u00e9rrez 29039, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isela","family":"\u00c1lvarez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad Profesional Adolfo L\u00f3pez Mateos, Laboratorio de Gen\u00e9tica, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Zacatenco, Av. 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