{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:36:05Z","timestamp":1790739365914,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GRACE","award":["1189729"],"award-info":[{"award-number":["1189729"]}]},{"name":"GRACE","award":["216235"],"award-info":[{"award-number":["216235"]}]},{"name":"General Charities of the City of Coventry","award":["1189729"],"award-info":[{"award-number":["1189729"]}]},{"name":"General Charities of the City of Coventry","award":["216235"],"award-info":[{"award-number":["216235"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Protein Tyrosine Phosphatase Receptor Type D (PTPRD) is involved in the regulation of cell growth, differentiation, and oncogenic transformation, as well as in brain development. PTPRD also mediates the effects of asprosin, which is a glucogenic hormone\/adipokine derived following the cleavage of the C-terminal of fibrillin 1. Since the asprosin circulating levels are elevated in certain cancers, research is now focused on the potential role of this adipokine and its receptors in cancer. As such, in this study, we investigated the expression of PTPRD in endometrial cancer (EC) and the placenta, as well as in glioblastoma (GBM). Methods: An array of in silico tools, in vitro models, tissue microarrays (TMAs), and liquid biopsies were employed to determine the gene and protein expression of PTPRD in healthy tissues\/organs and in patients with EC and GBM. Results: PTPRD exhibits high expression in the occipital lobe, parietal lobe, globus pallidus, ventral thalamus, and white matter, whereas in the human placenta, it is primarily localised around the tertiary villi. PTPRD is significantly upregulated at the mRNA and protein levels in patients with EC and GBM compared to healthy controls. In patients with EC, PTPRD is significantly downregulated with obesity, whilst it is also expressed in the peripheral leukocytes. The EC TMAs revealed abundant PTPRD expression in both low- and high-grade tumours. Asprosin treatment upregulated the expression of PTPRD only in syncytialised placental cells. Conclusions: Our data indicate that PTPRD may have potential as a biomarker for malignancies such as EC and GBM, further implicating asprosin as a potential metabolic regulator in these cancers. Future studies are needed to explore the potential molecular mechanisms\/signalling pathways that link PTPRD and asprosin in cancer.<\/jats:p>","DOI":"10.3390\/cancers16030582","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T05:14:32Z","timestamp":1706591672000},"page":"582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma"],"prefix":"10.3390","volume":"16","author":[{"given":"Sophie","family":"Orton","sequence":"first","affiliation":[{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-1397","authenticated-orcid":false,"given":"Rebecca","family":"Karkia","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Mustafov","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"},{"name":"School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9JA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5935-8950","authenticated-orcid":false,"given":"Seley","family":"Gharanei","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK"},{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Braoudaki","sequence":"additional","affiliation":[{"name":"School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9JA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Filipe","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Panfilov","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeh","family":"Saravi","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Khan","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-3439","authenticated-orcid":false,"given":"Ioannis","family":"Kyrou","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK"},{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK"},{"name":"Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK"},{"name":"Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry CV1 5FB, UK"},{"name":"College of Health, Psychology and Social Care, University of Derby, Derby DE22 1GB, UK"},{"name":"Laboratory of Dietetics and Quality of Life, School of Food and Nutritional Sciences, Agricultural University of Athens, 11855 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Karteris","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanta","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK"},{"name":"Academic Department of Gynaecological Oncology, Royal Surrey NHS Foundation Trust Hospital, Guildford GU2 7XX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal S.","family":"Randeva","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK"},{"name":"Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK"},{"name":"Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry CV1 5FB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cell.2016.02.063","article-title":"Asprosin, a Fasting-Induced Glucogenic Protein Hormone","volume":"165","author":"Romere","year":"2016","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"106979","DOI":"10.1016\/j.ymgme.2022.106979","article-title":"Fibrillin-1 and asprosin, novel players in 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