{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:04:45Z","timestamp":1790366685031,"version":"4.1.0"},"reference-count":160,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Endometriosis is a gynecological condition where endometrium-like tissue grows outside the uterus, posing challenges in understanding and treatment. This article delves into the deep cellular and molecular processes underlying endometriosis, with a focus on the crucial roles played by cyclins and cytoskeletal proteins in its pathogenesis, particularly in the context of Epithelial\u2013Mesenchymal Transition (EMT). The investigation begins by examining the activities of cyclins, elucidating their diverse biological roles such as cell cycle control, proliferation, evasion of apoptosis, and angiogenesis among ectopic endometrial cells. A comprehensive analysis of cytoskeletal proteins follows, emphasizing their fundamental biological roles and their specific significance to endometriotic cell features. This review sheds light on the interconnected pathways through which cyclins and cytoskeletal proteins converge, contributing to the genesis and progression of endometriosis. Understanding these molecular complexities not only provides insight into the underlying causes of the disease but also holds promise for the development of specific therapeutic approaches, ushering in a new era in the management of this devastating disorder.<\/jats:p>","DOI":"10.3390\/cancers16040836","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:50:07Z","timestamp":1708429807000},"page":"836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Cyclins and Cytoskeletal Proteins in Endometriosis: Insights into Pathophysiology"],"prefix":"10.3390","volume":"16","author":[{"given":"Marcin","family":"Szyma\u0144ski","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2098-2799","authenticated-orcid":false,"given":"Klaudia","family":"Bonowicz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland"},{"name":"Faculty of Medicine, Collegium Medicum, Mazovian Academy in P\u0142ock, 08-110 P\u0142ock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7099-8115","authenticated-orcid":false,"given":"Paulina","family":"Antosik","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3777-598X","authenticated-orcid":false,"given":"Dominika","family":"Jerka","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5734-116X","authenticated-orcid":false,"given":"Mariola","family":"G\u0142owacka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Collegium Medicum, Mazovian Academy in P\u0142ock, 08-110 P\u0142ock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Soroka","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Collegium Medicum, Mazovian Academy in P\u0142ock, 08-110 P\u0142ock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-2158","authenticated-orcid":false,"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-263X","authenticated-orcid":false,"given":"Konrad","family":"Kleszczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5445-8821","authenticated-orcid":false,"given":"Maciej","family":"Gagat","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-092 Bydgoszcz, Poland"},{"name":"Faculty of Medicine, Collegium Medicum, Mazovian Academy in P\u0142ock, 08-110 P\u0142ock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1020827","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-Associated Infertility: From Pathophysiology to Tailored Treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front. 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