{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:46:51Z","timestamp":1760143611432,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"5 \u00d7 1000 anno di riferimento 201","award":["099142 CUP J99J21006120001"],"award-info":[{"award-number":["099142 CUP J99J21006120001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Every year in Italy, about 60,000 new cases of nodular thyroid pathology are diagnosed, of which almost 30% are cytologically indeterminate (TIR3A\/3B). The risk of malignancy reported in the literature on thyroid nodules ranges from 5% to 15% for TIR3A and from 15% to 30% for TIR3B. It is suspected that these percentages are higher in practice. We performed univariate and multivariate analyses of clinical risk factors. The medical records of 291 patients who underwent surgery for cytologically indeterminate nodular thyroid disease were retrospectively reviewed. Clinical parameters and preoperative serum markers were then compared between the benign nodular thyroid disease and thyroid cancer groups. For each patient, clinical characteristics, comorbidities, neck ultrasonographic features, and histological reports were statistically analyzed using Chi-squared and Fisher\u2019s exact tests. A total of 134 malignant neoplasms were found (46%), divided into 55 cases (35%) in the TIR3A group and 79 cases (59%) in the TIR3B group. Statistical analysis was not significant in both populations for both sex and age (TIR3A p-value = 0.5097 and p-value = 0.1430, TIR3B p-value = 0.5191 p-value = 0.3384), while it was statistically significant in patients with TIR3A nodules associated with thyroiditis (p-value = 0.0009). In addition, the patients with TIR3A and 3B nodules were stratified by ultrasound risk for the prediction of malignancy and it was significant (p = 0.0004 and p &lt; 0.0001). In light of these results, it emerges that surgical treatment of nodular thyroid pathology with indeterminate cytology TIR3A should always be considered, and surgery for TIR3B is mandatory.<\/jats:p>","DOI":"10.3390\/cancers16050875","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T06:07:39Z","timestamp":1708668459000},"page":"875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uni- and Multivariate Analyses of Cancer Risk in Cytologically Indeterminate Thyroid Nodules: A Single-Center Experience"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4781-8013","authenticated-orcid":false,"given":"Enrico","family":"Battistella","sequence":"first","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Veneto Institute of Oncology, IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marica","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Veneto Institute of Oncology, IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Pomba","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Veneto Institute of Oncology, IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Toniato","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Padua, Via Giustiniani 2, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Giacomini","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Veneto Institute of Oncology, IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1839-2586","authenticated-orcid":false,"given":"Giovanna","family":"Magni","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Veneto Institute of Oncology, IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Toniato","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Department of Surgery, Veneto Institute of Oncology, IOV-IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(23)00020-X","article-title":"Thyroid cancer","volume":"401","author":"Chen","year":"2023","journal-title":"Lancet"},{"key":"ref_2","unstructured":"Spiezia, S., and Pace, D. (2020). Il Collo Endocrino e Patologie Correlate, Manuale di Ecografia Diagnostica, Volume 1, Tiroide e Paratiroide, E.L.I. Medica."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1089\/thy.2022.0346","article-title":"History of Thyroid Ultrasound","volume":"33","author":"Levine","year":"2023","journal-title":"Thyroid"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1113977","DOI":"10.3389\/fendo.2023.1113977","article-title":"Thyroid nodules: Global, economic, and personal burdens","volume":"14","author":"Uppal","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1089\/thy.2022.0672","article-title":"Malignancy Risk of Thyroid Nodules That Are Not Classifiable by the American Thyroid Association Ultrasound Risk Stratification System: A Systematic Review and Meta-Analysis","volume":"33","author":"Kwon","year":"2023","journal-title":"Thyroid"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s13304-023-01522-7","article-title":"Management of surgical diseases of thyroid gland indications of the United Italian Society of Endocrine Surgery (SIUEC)","volume":"75","author":"Polistena","year":"2023","journal-title":"Updat. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s40618-018-0884-2","article-title":"Italian consensus on diagnosis and treatment of differentiated thyroid cancer: Joint statements of six Italian societies","volume":"41","author":"Pacini","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s40618-014-0062-0","article-title":"Italian consensus for the classification and reporting of thyroid cytology","volume":"37","author":"Nardi","year":"2014","journal-title":"J. Endocrinol. Investig."},{"key":"ref_9","unstructured":"(2024, February 19). Linee Guida AIOM, Tumori Della Tiroide. Available online: https:\/\/www.aiom.it\/linee-guida-aiom-2021-tumori-della-tiroide\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1158\/1055-9965.EPI-21-1440","article-title":"Epidemiology of Thyroid Cancer","volume":"31","author":"Kitahara","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/jamaoto.2014.1","article-title":"Current Thyroid Cancer Trends in the United States","volume":"140","author":"Davies","year":"2014","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF03346587","article-title":"American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive Summary of recommendations","volume":"33","author":"Gharib","year":"2010","journal-title":"J. Endocrinol. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s13193-022-01515-9","article-title":"Hashimoto\u2019s Thyroiditis and Papillary Cancer Thyroid Coexistence Exerts a Protective Effect: A Single Centre Experience","volume":"13","author":"Battistella","year":"2022","journal-title":"Indian J. Surg. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/CCO.0000000000000150","article-title":"Association of Hashimoto\u2019s thyroiditis and thyroid cancer","volume":"27","author":"Noureldine","year":"2015","journal-title":"Curr. Opin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"622","DOI":"10.4158\/EP161208.GL","article-title":"American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules\u20142016 Update Appendix","volume":"22","author":"Gharib","year":"2016","journal-title":"Endocr. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/EJE-18-0083","article-title":"Differences between ATA, AACE\/ACE\/AME and ACR TI-RADS ultrasound classifications performance in identifying cytological high-risk thyroid nodules","volume":"178","author":"Pantano","year":"2018","journal-title":"Eur. J. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12020-020-02295-4","article-title":"Comparison of different systems of ultrasound (US) risk stratification for malignancy in elderly patients with thyroid nodules. Real world experience","volume":"69","author":"Sforza","year":"2020","journal-title":"Endocrine"},{"key":"ref_18","unstructured":"Spiezia, S., and Pace, D. (2020). Il Collo Endocrino e Patologie Correlate, Manuale di Ecografia Diagnostica e Interventistica, Volume 2, Linfonodi, Ghiandole Salivari, FNAC, Alcolizzazione e Termoablazione, E.L.I. Medica."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jacr.2017.01.046","article-title":"ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee","volume":"14","author":"Tessler","year":"2017","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/cncr.30360","article-title":"2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: What is new and what has changed?","volume":"123","author":"Haugen","year":"2016","journal-title":"Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3348\/kjr.2016.17.3.370","article-title":"Ultrasonography Diagnosis and Imaging-Based Management of Thyroid Nodules: Revised Korean Society of Thyroid Radiology Consensus Statement and Recommendations","volume":"17","author":"Shin","year":"2016","journal-title":"Korean J. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e230067","DOI":"10.1530\/ETJ-23-0067","article-title":"2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management","volume":"12","author":"Durante","year":"2023","journal-title":"Eur. Thyroid. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e231481","DOI":"10.1148\/radiol.231481","article-title":"International Expert Consensus on US Lexicon for Thyroid Nodules","volume":"309","author":"Durante","year":"2023","journal-title":"Radiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1007\/s40618-021-01571-y","article-title":"Combination of ultrasound and molecular testing in malignancy risk estimate of Bethesda category IV thyroid nodules: Results from a single-institution prospective study","volume":"44","author":"Marina","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12020-018-1825-8","article-title":"Italian consensus for the classification and reporting of thyroid cytology: The risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis","volume":"63","author":"Trimboli","year":"2018","journal-title":"Endocrine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.21037\/gs.2019.01.03","article-title":"Surgical management of cytologically indeterminate thyroid nodules","volume":"8","author":"Almquist","year":"2019","journal-title":"Gland. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.surg.2010.01.020","article-title":"Indeterminate thyroid nodules: A challenge for the surgical strategy","volume":"148","author":"Asari","year":"2010","journal-title":"Surgery"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s13304-021-01096-2","article-title":"Thyroid nodules with indeterminate cytology: Association between nodule size, histopathological characteristics and clinical outcome in differentiated thyroid carcinomas\u2014A multicenter retrospective cohort study on 761 patients","volume":"73","author":"Cozzani","year":"2021","journal-title":"Updat. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.2018.0898","article-title":"The Diagnosis and Management of Thyroid Nodules","volume":"319","author":"Durante","year":"2018","journal-title":"JAMA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s13304-011-0060-0","article-title":"Features of papillary thyroid carcinoma in patients older than 75 years","volume":"63","author":"Toniato","year":"2011","journal-title":"Updat. Surg."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/5\/875\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:03:08Z","timestamp":1760104988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/5\/875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,22]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["cancers16050875"],"URL":"https:\/\/doi.org\/10.3390\/cancers16050875","relation":{},"ISSN":["2072-6694"],"issn-type":[{"type":"electronic","value":"2072-6694"}],"subject":[],"published":{"date-parts":[[2024,2,22]]}}}