{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:13:27Z","timestamp":1774124007021,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Oropharyngeal cancer is a global health concern due to its multifaceted nature. Recent molecular studies have linked p16 overexpression, associated with the human papillomavirus, to oropharyngeal cancer and its prognostic implications. Materials and Methods: This retrospective study in Western Romania examined 60 patients, categorizing them based on p16 biomarker status: 28 were p16 positive, and 32 were p16 negative. Statistical tests, including Fisher\u2019s exact and chi2, were used for analysis. Results: Patients with p16-positive oropharyngeal cancer exhibited a better prognosis (3-year survival, p = 0.0477; midtreatment, p = 0.0349) and reported lower alcohol (p = 0.0046) and tobacco (p &lt; 0.0001) use. Conclusions: The study highlights the importance of p16 testing in oropharyngeal carcinoma diagnosis. It suggests modifying treatment approaches based on p16 status and underscores the differing prognoses associated with p16-positive and p16-negative cases.<\/jats:p>","DOI":"10.3390\/cancers16050945","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T11:31:21Z","timestamp":1708947081000},"page":"945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Retrospective Analysis from Western Romania Comparing the Treatment and Survivability of p16-Positive versus p16-Negative Oropharyngeal Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Alexandru","family":"Chioreanu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-4608","authenticated-orcid":false,"given":"Nicolae","family":"Balica","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timi\u0219oara, Romania"},{"name":"OftalmoSensory-Tumor Research Center-ORL (EYE-ENT), \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Mot","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radmila","family":"Bugari","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology, \u201cVasile Goldis\u201d Western University of Arad, 310045 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca","family":"Morar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-179X","authenticated-orcid":false,"given":"Flavia","family":"Baderca","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology\/Histology, Angiogenesis Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Service of Pathology, Emergency City Hospital, 300254 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Medicine, \u201cVasile Goldis\u201d University of Medicine and Pharmacy, 310414 Arad, Romania"},{"name":"Department of Microbiology, Emergency County Hospital, 310037 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casiana","family":"Boru","sequence":"additional","affiliation":[{"name":"Department of Medicine, \u201cVasile Goldis\u201d University of Medicine and Pharmacy, 310414 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Residential Training and Post-University Courses, \u201cVasile Goldis\u201d Western University, 310414 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"Dema","sequence":"additional","affiliation":[{"name":"Discipline of Radiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1046-7272","authenticated-orcid":false,"given":"Dan","family":"Vulcanescu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Department of Microbiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Horhat","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.47162\/RJME.63.1.16","article-title":"Laryngeal malignancies\u2014Epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016\u2013July 2020)","volume":"63","author":"Sitaru","year":"2022","journal-title":"Rom. 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