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Helsinki","award":["2012\u20132020"],"award-info":[{"award-number":["2012\u20132020"]}]},{"name":"University of Helsinki","award":["2012\u20132017"],"award-info":[{"award-number":["2012\u20132017"]}]},{"name":"University of Helsinki","award":["2016\u20132023"],"award-info":[{"award-number":["2016\u20132023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The primary tumor location (PTL) is associated with the phenotype, metastatic sites, mutations, and outcomes of metastatic colorectal cancer (mCRC) patients, but this has mostly been studied according to sidedness (right vs. left sided). We studied right colon vs. left colon vs. rectal PTL in a real-life study population (n = 1080). Health-related quality of life (HRQoL) was assessed multi-cross-sectionally with QLQ-C30, QLQ-CR29, EQ-5D, and 15D. A chi-square, Kaplan\u2013Meier, and Cox regression were used to compare the groups. The PTL was in the right colon in 310 patients (29%), the left colon in 396 patients (37%), and the rectum in 375 patients (35%). The PTL was associated with distinct differences in metastatic sites during the disease trajectory. The resectability, conversion, and resection rates were lowest in the right colon, followed by the rectum, and were highest in the left colon. Overall survival was shortest for right colon compared with left colon or rectal PTL (median 21 vs. 35 vs. 36 months), with the same trends after metastasectomy or systemic therapy only. PTL also remained statistically significant in a multivariable model. The distribution of symptoms varied according to PTL, especially between the right colon (with general symptoms of metastases) and rectal PTL (with sexual- and bowel-related symptoms). mCRC, according to PTL, behaves differently regarding metastatic sites, resectability of the metastases, outcomes of treatment, and HRQoL.<\/jats:p>","DOI":"10.3390\/cancers16051052","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T05:31:19Z","timestamp":1709616679000},"page":"1052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study)"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-5580","authenticated-orcid":false,"given":"Sonja","family":"Aho","sequence":"first","affiliation":[{"name":"Department of Oncology, Tays Cancer Centre, Tampere University Hospital, El\u00e4m\u00e4naukio 2, 33520 Tampere, Finland"},{"name":"Faculty of Medicine and Health Technology, Tampere University, Arvo Ylp\u00f6n katu 23, 33520 Tampere, Finland"},{"name":"TUNI Palliative Care Research Group, Faculty of Medicine and Health Technology, Tampere University, Arvo Ylp\u00f6n katu 23, 33520 Tampere, Finland"},{"name":"Palliative Care Centre, Tampere University Hospital, El\u00e4m\u00e4naukio 2, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-6332","authenticated-orcid":false,"given":"Emerik","family":"Osterlund","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden"},{"name":"Department of Transplantation and Liver Surgery, Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Ristim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Pathology, HUSLAB, HUS Diagnostic Center, Helsinki University Hospital, Haartmaninkatu 3, 00290 Helsinki, Finland"},{"name":"Applied Tumor Genomics Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Department of Pathology, FIMLAB, Tampere University Hospital, El\u00e4m\u00e4naukio 2, 33520 Tampere, Finland"},{"name":"Department of Pathology, University of Tampere, Arvo Ylp\u00f6n katu 23, 33520 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jari","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Pathology, Turku University Hospital, Kiinanmyllynkatu 4-8, 20520 Turku, Finland"},{"name":"Institute of Biomedicine, University of Turku, Kiinanmyllynkatu 10, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus J.","family":"M\u00e4kinen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland"},{"name":"Translational Medicine Research Unit, Department of Pathology, University of Oulu, Pentti Kaiteran katu 1, 90570 Oulu, Finland"},{"name":"Medical Research Center Oulu, Pentti Kaiteran katu 1, 90570 Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-4094","authenticated-orcid":false,"given":"Teijo","family":"Kuopio","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Nova, Hoitajantie 3, 40620 Jyv\u00e4skyl\u00e4, Finland"},{"name":"Department of Biological and Environmental Science, University of Jyv\u00e4skyl\u00e4, Seminaarinkatu 15, 40014 Jyv\u00e4skyl\u00e4n yliopisto, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soili","family":"Kyt\u00f6l\u00e4","sequence":"additional","affiliation":[{"name":"Department of Genetics, HUSLAB, HUS Diagnostic Center, Helsinki University Hospital, Haartmaninkatu 3, 00290 Helsinki, Finland"},{"name":"Department of Genetics, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"\u00c5lgars","sequence":"additional","affiliation":[{"name":"Department of Oncology, Turku University Hospital and University of Turku, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raija","family":"Ristam\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Oncology, Turku University Hospital and University of Turku, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eetu","family":"Heerv\u00e4","sequence":"additional","affiliation":[{"name":"Department of Oncology, Turku University Hospital and University of Turku, H\u00e4meentie 11, 20520 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-496X","authenticated-orcid":false,"given":"Raija","family":"Kallio","sequence":"additional","affiliation":[{"name":"Department of Oncology, Oulu University Hospital, Kajaanintie 50, 90220 Oulu, Finland"},{"name":"Department of Oncology, University of Oulu, Pentti Kaiteran katu 1, 90570 Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Halonen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Helsinki University Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland"},{"name":"Department of Oncology, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena-Maija","family":"Soveri","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland"},{"name":"Home 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