{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:02:36Z","timestamp":1789624956231,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This study investigates the impact of bisphosphonate therapy on the stomatognathic system in 80 patients with cancer of the breast and prostate with bone metastases. Bisphosphonates are integral for managing skeletal complications in these malignancies but are associated with bisphosphonate-related osteonecrosis of the jaw (BRONJ), affecting 0.8\u201318.5% of patients. BRONJ manifests with pain, neuropathy, tissue swelling, mucosal ulceration, tooth mobility, and abscesses, yet its pathogenesis remains elusive, complicating risk prediction. The research employed comprehensive dental and radiological evaluations. Dental status was assessed using DMFT and OHI-S indices, Eichner\u2019s classification, and clinical periodontal measurements like the pocket depth (PD), clinical attachment loss (CAL), and modified Sulcus Bleeding Index (mSBI). A radiological analysis included panoramic X-rays for radiomorphometric measurements and TMJ lateral radiographs. Results indicated a significant decline in oral hygiene in patients with cancer after bisphosphonate therapy, marked by increased DMFT and OHI-S scores. Periodontal health also showed deterioration, with increased PD and CAL readings. The incidence of BRONJ symptoms was noted, although exact figures are not quantified in this abstract. The study also revealed changes in radiomorphometric parameters, suggesting bisphosphonates\u2019 impact on bone density and structure. No substantial alterations were observed in TMJ function, indicating a need for extended observation to understand bisphosphonates\u2019 long-term effects on the stomatognathic system. These findings highlight the importance of continuous dental monitoring and prophylaxis in patients undergoing bisphosphonate therapy. Implementing meticulous oral care protocols is essential for mitigating BRONJ risk and managing the complex oral health challenges in patients with cancer.<\/jats:p>","DOI":"10.3390\/cancers16061124","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T11:05:10Z","timestamp":1710155110000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Bisphosphonate Therapy on Oral Health in Patients with Breast and Prostate Cancer and Bone Metastases: A Comprehensive Study"],"prefix":"10.3390","volume":"16","author":[{"given":"Jacek","family":"Calik","sequence":"first","affiliation":[{"name":"Department of Clinical Oncology, Wroclaw Medical University, 50-556 Wroc\u0142aw, Poland"},{"name":"Old Town Clinic, 50-136 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Calik","sequence":"additional","affiliation":[{"name":"Old Town Clinic, 50-136 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-3952","authenticated-orcid":false,"given":"Natalia","family":"Sauer","sequence":"additional","affiliation":[{"name":"Old Town Clinic, 50-136 Wroc\u0142aw, Poland"},{"name":"Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogucki","family":"Zdzis\u0142aw","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Wroclaw Medical University, 50-425 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Giedziun","sequence":"additional","affiliation":[{"name":"Faculty of Information and Communication Technology, Wroc\u0142aw University of Science and Technology Centre for Scientific and Technical Knowledge and Information, 50-370 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Mackiewicz","sequence":"additional","affiliation":[{"name":"Department of Medical and Experimental Oncology, Institute of Oncology, Poznan University of Medical Sciences, 60-512 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Murawski","sequence":"additional","affiliation":[{"name":"1st Department of Gynecology and Obstetrics, Wroclaw Medical University, 50-599 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-1385","authenticated-orcid":false,"given":"Piotr","family":"Dzi\u0119giel","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroc\u0142aw, Poland"},{"name":"Department of Physiotherapy, University School of Physical Education, 51-612 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref_1","first-page":"ed16","article-title":"The difficulties in cancer treatment","volume":"6","author":"Chakraborty","year":"2012","journal-title":"Ecancermedicalscience"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Di Fede, O., Yarom, N., Bagan, J., Otto, S., and Fedele, S. 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