{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T21:53:44Z","timestamp":1774043624489,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Magnetic resonance imaging (MRI) can be used for the preoperative local staging of endometrial cancer (EC). The presence of \u2265pT1b disease (i.e., tumor invasion in \u226550% of the myometrium, into the cervical stroma or spread outside the uterus) has important prognostic value and implications for the decision to perform lymphadenectomy. The purpose of this study was to assess the performance of MRI for the detection of \u2265pT1b disease and to evaluate whether tumor size measured via MRI was predictive for \u2265pT1b disease, independent of imaging signs of deep invasion. MRI T-staging and tumor diameter and volume were correlated with histopathology of the hysterectomy specimen in 126 patients. MRI had a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 70.0%, 83.3%, 79.2%, 75.3% and 77.0%, respectively, for the detection of \u2265pT1b disease. A tumor diameter of \u226540 mm and volume of \u226520 mL measured via MRI were predictive for \u2265pT1b disease at rates of 78.3% and 87.1%, respectively. An EC size of at least 5 mm upon MRI was predictive for \u2265pT1b disease in more than 50% of cases. Our results support the use of MRI in the preoperative staging of EC and suggest including size criteria in EC staging guidelines.<\/jats:p>","DOI":"10.3390\/cancers16061142","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:08:43Z","timestamp":1710335323000},"page":"1142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Performance of MRI for Detection of \u2265pT1b Disease in Local Staging of Endometrial Cancer"],"prefix":"10.3390","volume":"16","author":[{"given":"Leonie","family":"Van Vynckt","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Tummers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8897-9430","authenticated-orcid":false,"given":"Hannelore","family":"Denys","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-5542","authenticated-orcid":false,"given":"Menekse","family":"G\u00f6ker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigi","family":"Hendrickx","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eline","family":"Naert","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rawand","family":"Salihi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-9790","authenticated-orcid":false,"given":"Koen","family":"Van de Vijver","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-582X","authenticated-orcid":false,"given":"Gabri\u00eblle H.","family":"van Ramshorst","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-106X","authenticated-orcid":false,"given":"Donatienne","family":"Van Weehaeghe","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-0811","authenticated-orcid":false,"given":"Katrien","family":"Vandecasteele","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert M.","family":"Villeirs","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-7877","authenticated-orcid":false,"given":"Pieter J. L.","family":"De Visschere","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Ghent University Hospital, Corneel Heymanslaan 10, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"ref_1","first-page":"468","article-title":"Diagnosis and Management of Endometrial Cancer","volume":"93","author":"Braun","year":"2016","journal-title":"Am. Fam. Physician"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ejrad.2014.11.010","article-title":"MRI for local staging of endometrial carcinoma: Is endovenous contrast medium administration still needed?","volume":"84","author":"Bonatti","year":"2015","journal-title":"Eur. J. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/S0140-6736(22)00323-3","article-title":"Endometrial cancer","volume":"399","author":"Crosbie","year":"2022","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(05)67063-8","article-title":"Endometrial cancer","volume":"366","author":"Amant","year":"2005","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.soncn.2019.02.002","article-title":"Endometrial Cancer: An Overview of Pathophysiology, Management, and Care","volume":"35","author":"Passarello","year":"2019","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s00330-006-0555-0","article-title":"Staging of carcinoma of the uterine cervix and endometrium","volume":"17","author":"Koyama","year":"2007","journal-title":"Eur. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/j.sult.2019.04.001","article-title":"Imaging and Staging of Endometrial Cancer","volume":"40","author":"Faria","year":"2019","journal-title":"Semin. Ultrasound CT MR"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/ijgo.12618","article-title":"Role of imaging in the routine management of endometrial cancer","volume":"143","author":"Lin","year":"2018","journal-title":"Int. J. Gynaecol. Obs."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejogrb.2017.04.015","article-title":"BGCS uterine cancer guidelines: Recommendations for practice","volume":"213","author":"Sundar","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ijgo.14923","article-title":"FIGO staging of endometrial cancer: 2023","volume":"162","author":"Berek","year":"2023","journal-title":"Int. J. Gynaecol. Obstet. Off. Organ. Int. Fed. Gynaecol. Obstet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/RCT.0000000000000280","article-title":"The Combination of Diffusion- and T2-Weighted Imaging in Predicting Deep Myometrial Invasion of Endometrial Cancer: A Systematic Review and Meta-Analysis","volume":"39","author":"Deng","year":"2015","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s00330-018-5515-y","article-title":"Endometrial Cancer MRI staging: Updated Guidelines of the European Society of Urogenital Radiology","volume":"29","author":"Nougaret","year":"2019","journal-title":"Eur. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"20201347","DOI":"10.1259\/bjr.20201347","article-title":"MRI of the endometrium\u2014from normal appearances to rare pathology","volume":"94","author":"Pintican","year":"2021","journal-title":"Br. J. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium","volume":"105","author":"Pecorelli","year":"2009","journal-title":"Int. J. Gynaecol. Obstet. Off. Organ. Int. Fed. Gynaecol. Obstet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8233","DOI":"10.3390\/curroncol30090597","article-title":"Diagnostic Performance of Preoperative Imaging in Endometrial Cancer","volume":"30","author":"Hashimoto","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.acra.2019.09.018","article-title":"The Diagnostic Value of MRI for Preoperative Staging in Patients with Endometrial Cancer: A Meta-Analysis","volume":"27","author":"Bi","year":"2020","journal-title":"Acad. Radiol."},{"key":"ref_17","first-page":"11","article-title":"MRI of endometrium cancer\u2014how we do it","volume":"16","author":"Meissnitzer","year":"2016","journal-title":"Cancer Imaging Off. Publ. Int. Cancer Imaging Soc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11912-016-0506-0","article-title":"What Is the Best Preoperative Imaging for Endometrial Cancer?","volume":"18","author":"Haldorsen","year":"2016","journal-title":"Curr. Oncol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00330-009-1309-6","article-title":"Staging of endometrial cancer with MRI: Guidelines of the European Society of Urogenital Imaging","volume":"19","author":"Kinkel","year":"2009","journal-title":"Eur. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/IGC.0000000000000367","article-title":"Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas","volume":"25","author":"Husby","year":"2015","journal-title":"Int. J. Gynecol. Cancer Off. J. Int. Gynecol. Cancer Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/IGC.0b013e31828c85c6","article-title":"Tumor size: A better independent predictor of distant failure and death than depth of myometrial invasion in International Federation of Gynecology and Obstetrics stage I endometrioid endometrial cancer","volume":"23","author":"Chattopadhyay","year":"2013","journal-title":"Int. J. Gynecol. Cancer Off. J. Int. Gynecol. Cancer Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1245\/s10434-015-4583-3","article-title":"Tumor Size, an Additional Prognostic Factor to Include in Low-Risk Endometrial Cancer: Results of a French Multicenter Study","volume":"23","author":"Canlorbe","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2478\/raon-2020-0064","article-title":"Tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer","volume":"55","author":"Coronado","year":"2021","journal-title":"Radiol. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ijgo.14954","article-title":"Role of tumor volume in endometrial cancer: An imaging analysis and prognosis significance","volume":"163","author":"Alvarez","year":"2023","journal-title":"Int. J. Gynaecol. Obs."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Burg, L.C., Kruitwagen, R., de Jong, A., Bulten, J., Bonestroo, T.J.J., Kraayenbrink, A.A., Boll, D., Lambrechts, S., Smedts, H.P.M., and Bouman, A. (2022). Sentinel Lymph Node Mapping in Presumed Low- and Intermediate-Risk Endometrial Cancer Management (SLIM): A Multicenter, Prospective Cohort Study in The Netherlands. Cancers, 15.","DOI":"10.3390\/cancers15010271"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.3802\/jgo.2017.28.e86","article-title":"Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with endometrial cancer: A systematic review and meta-analysis","volume":"28","author":"Alcazar","year":"2017","journal-title":"J. Gynecol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int. J. Gynecol. Cancer Off. J. Int. Gynecol. Cancer Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ygyno.2014.05.018","article-title":"Endometrial cancer: A review and current management strategies: Part I","volume":"134","author":"Group","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13244-021-01152-w","article-title":"MRI in female pelvis: An ESUR\/ESR survey","volume":"13","author":"Nougaret","year":"2022","journal-title":"Insights Into Imaging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13244-023-01491-w","article-title":"Dissemination of endometrial cancer MRI staging guidelines among young radiologists: An ESUR Junior Network survey","volume":"14","author":"Stanzione","year":"2023","journal-title":"Insights Into Imaging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1148\/radiol.2019190088","article-title":"2018 FIGO Staging System for Uterine Cervical Cancer: Enter Cross-sectional Imaging","volume":"292","author":"Lee","year":"2019","journal-title":"Radiology"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bogani, G., Chiappa, V., Lopez, S., Salvatore, C., Interlenghi, M., D\u2019Oria, O., Giannini, A., Leone Roberti Maggiore, U., Chiarello, G., and Palladino, S. (2022). Radiomics and Molecular Classification in Endometrial Cancer (The ROME Study): A Step Forward to a Simplified Precision Medicine. Healthcare, 10.","DOI":"10.3390\/healthcare10122464"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"887546","DOI":"10.3389\/fonc.2022.887546","article-title":"Multimodal MRI-Based Radiomics-Clinical Model for Preoperatively Differentiating Concurrent Endometrial Carcinoma From Atypical Endometrial Hyperplasia","volume":"12","author":"Zhang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Moreira, A.S.L., Ribeiro, V., Aringhieri, G., Fanni, S.C., Tumminello, L., Faggioni, L., Cioni, D., and Neri, E. (2023). Endometrial Cancer Staging: Is There Value in ADC?. J. Pers. Med., 13.","DOI":"10.3390\/jpm13050728"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/6\/1142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:13:07Z","timestamp":1760105587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/6\/1142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["cancers16061142"],"URL":"https:\/\/doi.org\/10.3390\/cancers16061142","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]}}}