{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:40:16Z","timestamp":1794256816523,"version":"4.9.0"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This study aimed to present the treatment patterns and outcomes for adenoid cystic carcinoma (ACC) arising in the nasal cavity and paranasal sinus. Sixty-one sinonasal ACC patients were retrospectively reviewed: 31 (50.8%) underwent surgery followed by postoperative radiation therapy (S+PORT), and 30 (49.2%) received definitive radiation therapy (D(C)RT). T4 disease was significantly more frequent in the D(C)RT group (25.8% vs. 80.0%, p &lt; 0.001), where all T4b disease patients underwent D(C)RT. The 5-year local failure-free survival (LFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival were 61.8% versus 37.8% (p = 0.003), 64.8% versus 38.1% (p = 0.036), 52.6% versus 19.3% (p = 0.010), and 93.2% versus 73.4% (p = 0.001) in the S+PORT and D(C)RT groups, respectively. The absolute differences in 5-year rates of LFFS, DMFS, and PFS between the two groups were smaller in the T3\u20134 subgroup. The univariate analysis showed that T4b disease, neurologic symptoms, longest diameter of tumor, radiological evidence of nerve involvement, and undergoing D(C)RT were associated with worse clinical outcomes, but the significance disappeared in the multivariate analysis, except for in the case of radiological evidence of nerve involvement. In conclusion, most patients with extensive disease underwent upfront D(C)RT and generally exhibited inferior clinical outcomes when compared to those with less extensive disease and who underwent S+PORT.<\/jats:p>","DOI":"10.3390\/cancers16061235","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:37:22Z","timestamp":1711021042000},"page":"1235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Outcomes in Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinus: A Comparative Analysis of Treatment Modalities"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-3931","authenticated-orcid":false,"given":"Tae Hoon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangpyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju 63241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5643-5519","authenticated-orcid":false,"given":"Dongryul","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-997X","authenticated-orcid":false,"given":"Kyungmi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Sin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-7786","authenticated-orcid":false,"given":"Man Ki","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-8472","authenticated-orcid":false,"given":"Yong Chan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00020840-200404000-00013","article-title":"Adenoid cystic carcinoma of the head and neck: A review","volume":"12","author":"Bradley","year":"2004","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0002-9610(74)90265-7","article-title":"Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242 cases","volume":"128","author":"Spiro","year":"1974","journal-title":"Am. J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.oraloncology.2006.01.001","article-title":"Salivary gland adenoid cystic carcinoma: A review of chemotherapy and molecular therapies","volume":"42","author":"Dodd","year":"2006","journal-title":"Oral Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.oraloncology.2015.04.005","article-title":"Adenoid cystic carcinoma of the head and neck\u2014An update","volume":"51","author":"Rodrigo","year":"2015","journal-title":"Oral Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/hed.21830","article-title":"Incidence and survival in patients with sinonasal cancer: A historical analysis of population-based data","volume":"34","author":"Turner","year":"2012","journal-title":"Head. Neck"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1002\/cncr.30686","article-title":"A comprehensive comparative analysis of treatment modalities for sinonasal malignancies","volume":"123","author":"Robin","year":"2017","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0360-3016(87)90284-7","article-title":"Cervico-facial adenoid cystic carcinoma: Study of 102 cases. Influence of radiation therapy","volume":"13","author":"Miglianico","year":"1987","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ijrobp.2006.04.014","article-title":"Adenoid cystic carcinoma of the head and neck treated by surgery with or without postoperative radiation therapy: Prognostic features of recurrence","volume":"66","author":"Chen","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/cncr.33452","article-title":"Neoadjuvant chemotherapy for locoregionally advanced squamous cell carcinoma of the paranasal sinuses","volume":"127","author":"Abdelmeguid","year":"2021","journal-title":"Cancer"},{"key":"ref_10","first-page":"4092","article-title":"Systemic therapies for salivary gland adenoid cystic carcinoma","volume":"11","author":"Sahara","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hed.10380","article-title":"Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck","volume":"26","author":"Mendenhall","year":"2004","journal-title":"Head Neck"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1002\/cncr.23096","article-title":"Sinonasal adenoid cystic carcinoma: The M. D. Anderson Cancer Center experience","volume":"110","author":"Lupinetti","year":"2007","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ijrobp.2023.05.038","article-title":"Can Definitive Radiation Therapy Substitute Surgical Resection in Locally Advanced T3 or T4 Sinonasal Squamous Cell Carcinoma?","volume":"117","author":"Kim","year":"2023","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1001\/archotol.125.2.149","article-title":"Adenoid Cystic Carcinoma of the Head and Neck","volume":"125","author":"Fordice","year":"1999","journal-title":"Arch. Otolaryngol.\u2013Head. Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.oraloncology.2009.07.001","article-title":"Perineural invasion in adenoid cystic carcinoma of the salivary glands: A valid prognostic indicator?","volume":"45","author":"Barrett","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3171\/2015.1.JNS142462","article-title":"Adenoid cystic carcinoma of the skull base: Results with an aggressive multidisciplinary approach","volume":"124","author":"Ramakrishna","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1748-717X-7-44","article-title":"Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas","volume":"7","author":"Kosaki","year":"2012","journal-title":"Radiat. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.radonc.2019.08.019","article-title":"Lower doses to hippocampi and other brain structures for skull-base meningiomas with intensity modulated proton therapy compared to photon therapy","volume":"142","author":"Florijn","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.oraloncology.2016.11.016","article-title":"Definitive proton beam therapy for adenoid cystic carcinoma of the nasopharynx involving the base of skull","volume":"65","author":"Gentile","year":"2017","journal-title":"Oral Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"572493","DOI":"10.3389\/fonc.2020.572493","article-title":"Particle Beam Radiation Therapy for Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses","volume":"10","author":"Hu","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.canrad.2017.11.015","article-title":"Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and\/or Tomotherapy","volume":"22","author":"Dautruche","year":"2018","journal-title":"Cancer Radiother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1158\/1541-7786.MCR-04-0032","article-title":"Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining","volume":"3","author":"Boeckman","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E1472","DOI":"10.1002\/hed.24262","article-title":"Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature","volume":"38","author":"Bhattasali","year":"2016","journal-title":"Head Neck"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3904\/kjim.2019.104","article-title":"Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma","volume":"36","author":"Ha","year":"2021","journal-title":"Korean J. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1007\/s00405-021-06654-3","article-title":"Concurrent chemoradiotherapy for locally advanced unresectable adenoid cystic carcinoma of head and neck: Experience from a single institute","volume":"278","author":"Swain","year":"2021","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105945","DOI":"10.1016\/j.oraloncology.2022.105945","article-title":"Current opinions on diagnosis and treatment of adenoid cystic carcinoma","volume":"130","author":"Fang","year":"2022","journal-title":"Oral Oncol."},{"key":"ref_27","first-page":"3045","article-title":"Clinical Outcomes and Prognostic Factors of Adenoid Cystic Carcinoma of the Head and Neck","volume":"37","author":"Jang","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"60639","DOI":"10.18632\/oncotarget.10259","article-title":"Clinical significance of post-surgical residual tumor burden and radiation therapy in treating patients with lacrimal adenoid cystic carcinoma","volume":"7","author":"Noh","year":"2016","journal-title":"Oncotarget"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13005-020-00226-2","article-title":"Management of adenoid cystic carcinoma of the head and neck: A single-institute study with over 25-year follow-up","volume":"16","author":"Ishida","year":"2020","journal-title":"Head Face Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e28098","DOI":"10.1097\/MD.0000000000028098","article-title":"Adenoid cystic carcinoma of the sublingual gland developing lung metastasis 20 years after primary treatment: A case report and literature review","volume":"100","author":"Ohta","year":"2021","journal-title":"Medicine"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/6\/1235\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:29Z","timestamp":1760105849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/6\/1235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["cancers16061235"],"URL":"https:\/\/doi.org\/10.3390\/cancers16061235","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]}}}