{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T14:08:19Z","timestamp":1777298899402,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Universities of Spain","award":["FPU18\/00854"],"award-info":[{"award-number":["FPU18\/00854"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>(1) Background: The relationship between periodontitis and systemic pathologies continues to grow. Recently, the presence of periodontal pathogens has been linked to an increased risk of pancreatic cancer (PC) and its mortality. Thus, a systematic review is needed to identify whether an association between the two diseases can be established. The objective of this review is to elucidate the mechanisms responsible for this association. (2) Methods: A systematic review was carried out using three databases (PubMed, Embase and Scopus) with the following keywords \u201cPeriodontitis AND pancreatic cancer\u201d. A total of 653 articles were retrieved; before selection and screening, the inclusion and exclusion criteria were defined, resulting in a total of 13 articles being included in the review. (3) Results: The increase in low-grade systemic inflammation, pH changes, and the cytotoxicity of certain periodontopathogenic bacteria were found in the scientific literature reviewed as mechanisms linking periodontitis with the risk of PC. (4) Conclusions: Through this systematic review, we have seen how periodontitis can be related to PC and how it worsens its prognosis. Knowing the behavior of periodontopathogenic bacteria and the influence they have on our immune and inflammatory system may help to achieve an interdisciplinary approach to both pathologies.<\/jats:p>","DOI":"10.3390\/cancers16071257","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:28:06Z","timestamp":1711369686000},"page":"1257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Could Periodontitis Increase the Risk of Suffering from Pancreatic Cancer?\u2014A Systematic Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0185-6180","authenticated-orcid":false,"given":"Cecilia Fabiana","family":"M\u00e1rquez-Arrico","sequence":"first","affiliation":[{"name":"Stomatology Department, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-7735","authenticated-orcid":false,"given":"Francisco Javier","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Stomatology Department, University of Valencia, 46010 Valencia, Spain"},{"name":"Doctor Peset University Hospital, University of Valencia, 46017 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-1056","authenticated-orcid":false,"given":"Julia Elena","family":"Marquez-Arrico","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychobiology, University of Barcelona, 08035 Barcelona, Spain"},{"name":"Institut de Neuroci\u00e8ncies, University of Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-5063","authenticated-orcid":false,"given":"Javier","family":"Silvestre-Rangil","sequence":"additional","affiliation":[{"name":"Stomatology Department, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/jcpe.12064","article-title":"Periodontal Systemic Associations: Review of the Evidence","volume":"40","author":"Linden","year":"2013","journal-title":"J. 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