{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:14:17Z","timestamp":1781115257560,"version":"3.54.1"},"reference-count":53,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Multiple myeloma (MM) is a hematological neoplasm of the early precursor of B-cells. The most characteristic symptoms observed during MM include hypocalcemia, anemia, bacterial infections, and renal damage. Nutritional disorders, especially malnutrition, are noted in about 35\u201371% of MM patients. Interleukin 1 beta (IL-1\u03b2) is a proinflammatory cytokine responsible for muscle atrophy and lipolysis during malnutrition and cachexia. This study aimed to evaluate the usefulness of the IL1B single-nucleotide polymorphism (SNP) (rs1143634) and plasma concentration of IL-1\u03b2 in the assessment of the risk of nutritional disorders and prognosis in patients with MM. Methods: In our study, 93 patients with the de novo MM were enrolled. The real-time PCR with specific TaqMan probes method was used in genotyping. The IL-1\u03b2 ELISA kit was used to determine IL-1\u03b2 concentration in plasma samples. Results: Patients with the CC genotype, compared to the carriers of the other variants of the IL1B, demonstrated significantly higher concentrations of IL-1\u03b2 in plasma (7.56 vs. 4.97 pg\/mL), a significantly higher risk of cachexia (OR = 5.11), and a significantly higher risk of death (HR = 2.03). Moreover, high IL-1\u03b2 plasma level was related to a significantly higher risk of cachexia (OR = 7.76); however, it was not significantly associated with progression-free survival (PFS) or overall survival (OS). Conclusions: Determination of the IL1B SNP (rs1143634) and plasma concentration of IL-1\u03b2 may be useful in the assessment of the risk of cachexia and prognosis in patients with MM.<\/jats:p>","DOI":"10.3390\/cancers16071263","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:28:06Z","timestamp":1711369686000},"page":"1263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["IL1B Polymorphism (rs1143634) and IL-1\u03b2 Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients"],"prefix":"10.3390","volume":"16","author":[{"given":"Marcin","family":"Mazurek","sequence":"first","affiliation":[{"name":"Department of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Szudy-Szczyrek","sequence":"additional","affiliation":[{"name":"Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Homa-Mlak","sequence":"additional","affiliation":[{"name":"Department of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Hus","sequence":"additional","affiliation":[{"name":"Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ma\u0142ecka-Massalska","sequence":"additional","affiliation":[{"name":"Department of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-8340","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Mlak","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Das, S., Juliana, N., Yazit, N.A.A., Azmani, S., and Abu, I.F. (2022). Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031649"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0140-6736(21)00135-5","article-title":"Multiple myeloma","volume":"397","author":"Pawlyn","year":"2021","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hon.2586","article-title":"Multiple myeloma: Every year a new standard?","volume":"37","author":"Rajkumar","year":"2019","journal-title":"Hematol. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1080\/10428194.2017.1365859","article-title":"Managing multiple myeloma in elderly patients","volume":"59","author":"Diamond","year":"2018","journal-title":"Leuk. Lymphoma"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Padala, S.A., Barsouk, A., Barsouk, A., Rawla, P., Vakiti, A., Kolhe, R., Kota, V., and Ajebo, G.H. (2021). Epidemiology, Staging, and Management of Multiple Myeloma. Med. Sci., 9.","DOI":"10.3390\/medsci9010003"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/ejh.12923","article-title":"Hypercalcemia remains an adverse prognostic factor for newly diagnosed multiple myeloma patients in the era of novel antimyeloma therapies","volume":"99","author":"Zagouri","year":"2017","journal-title":"Eur. J. Haematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1159\/000520312","article-title":"Multiple Myeloma: Molecular Pathogenesis and Disease Evolution","volume":"44","author":"Heider","year":"2021","journal-title":"Oncol. Res. Treat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.nut.2016.06.009","article-title":"Patient-Generated Subjective Global Assessment as a prognosis tool in patients with multiple myeloma","volume":"36","author":"Kim","year":"2017","journal-title":"Nutrition"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1245\/s10434-020-08819-6","article-title":"Orthopedic Surgical Treatment and Perioperative Complications in Multiple Myeloma Bone Disease: Analysis of a Series (2009\u20132018)","volume":"28","author":"Marco","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e13302","DOI":"10.1111\/tid.13302","article-title":"The nutrition risk index is associated with bacteremia within 30 days after autologous stem cell transplantation in patients with multiple myeloma","volume":"22","author":"Solano","year":"2020","journal-title":"Transpl. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bossi, P., Delrio, P., Mascheroni, A., and Zanetti, M. (2021). The Spectrum of Malnutrition\/Cachexia\/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13061980"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9341","DOI":"10.1007\/s00520-022-07358-y","article-title":"Nutrition support use and clinical outcomes in patients with multiple myeloma undergoing autologous stem cell transplant","volume":"30","author":"Kuypers","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Meza-Valderrama, D., Marco, E., D\u00e1valos-Yerovi, V., Muns, M.D., Tejero-S\u00e1nchez, M., Duarte, E., and S\u00e1nchez-Rodr\u00edguez, D. (2021). Sarcopenia, Malnutrition, and Cachexia: Adapting Definitions and Terminology of Nutritional Disorders in Older People with Cancer. Nutrients, 13.","DOI":"10.3390\/nu13030761"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.clnu.2023.05.013","article-title":"Disease-related malnutrition with inflammation and cachexia","volume":"42","author":"Muscaritoli","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4251\/wjgo.v7.i4.17","article-title":"Cancer cachexia, mechanism and treatment","volume":"7","author":"Aoyagi","year":"2015","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00016.2008","article-title":"Mechanisms of cancer cachexia","volume":"89","author":"Tisdale","year":"2009","journal-title":"Physiol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.clnu.2020.03.038","article-title":"Perioperative nutrition: Recommendations from the ESPEN expert group","volume":"39","author":"Lobo","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_19","first-page":"168","article-title":"Malnutrition and cancer, diagnosis and treatment","volume":"14","author":"Beirer","year":"2021","journal-title":"Memo-Mag. Eur. Med. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.critrevonc.2018.05.006","article-title":"Cancer cachexia: Diagnosis, assessment, and treatment","volume":"127","author":"Sadeghi","year":"2018","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.31557\/APJCP.2022.23.9.2937","article-title":"Serum Levels of Interleukin-1\u03b2 and Disease Progression in Multiple Myeloma Patients: A Case and Control Study","volume":"23","author":"Rasmi","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0889-8588(05)70115-5","article-title":"The role of interleukin-1 beta in the pathogenesis of multiple myeloma","volume":"13","author":"Lust","year":"1999","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Malla, J., Zahra, A., Venugopal, S., Selvamani, T.Y., Shoukrie, S.I., Selvaraj, R., Dhanoa, R.K., Hamouda, R.K., and Mostafa, J. (2022). What Role Do Inflammatory Cytokines Play in Cancer Cachexia?. Cureus, 14.","DOI":"10.7759\/cureus.26798"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.clinbiochem.2017.07.011","article-title":"Biomarkers of cancer cachexia","volume":"50","author":"Loumaye","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s10753-021-01429-8","article-title":"The Emerging Role of Interleukin 1\u03b2 (IL-1\u03b2) in Cancer Cachexia","volume":"44","author":"Laird","year":"2021","journal-title":"Inflammation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/iji.12212","article-title":"IL-1A rs1800587, IL-1B rs1143634 and IL-1R1 rs2234650 polymorphisms in Iranian patients with systemic sclerosis","volume":"42","author":"Abtahi","year":"2015","journal-title":"Int. J. Immunogenet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.clinbiochem.2014.04.009","article-title":"Interleukin-1\u03b2 genotype and circulating levels in cancer patients: Metastatic status and pain perception","volume":"47","author":"Oliveira","year":"2014","journal-title":"Clin. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s11033-022-08077-7","article-title":"Association between interleuleukin-1\u03b2 polymorphism (rs16944) and biomarkers levels in Iraqi patients with prostate cancer","volume":"50","author":"Abed","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3000605211060144","DOI":"10.1177\/03000605211060144","article-title":"Role of IL-1\u03b2 rs1143634 (+3954C>T) polymorphism in cancer risk: An updated meta-analysis and trial sequential analysis","volume":"49","author":"Jafrin","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e804","DOI":"10.1002\/mgg3.804","article-title":"The association between interleukin-1 polymorphisms and their protein expression in Chinese Han patients with breast cancer","volume":"7","author":"Wang","year":"2019","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhang, D., Zheng, H., Zhou, Y., Tang, X., Yu, B., and Li, J. (2007). Association of IL-1beta gene polymorphism with cachexia from locally advanced gastric cancer. BMC Cancer, 7.","DOI":"10.1186\/1471-2407-7-45"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Szudy-szczyrek, A., Mlak, R., Mazurek, M., Krajka, T., Chocholska, S., Ma\u0142ecka-massalska, T., and Hus, M. (2023). The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma. Cells, 12.","DOI":"10.3390\/cells12071029"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3126\/jngmc.v16i1.24231","article-title":"Burden of Anemia: A profile of a tertiary care hospital","volume":"16","author":"Joshi","year":"2019","journal-title":"J. Nepalgunj Med. Coll."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1188\/11.CJON.S1.66-76","article-title":"Renal complications in multiple myeloma and related disorders: Survivorship care plan of the International Myeloma Foundation Nurse Leadership Board","volume":"15","author":"Faiman","year":"2011","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14740\/jh536","article-title":"C-Reactive Protein Level: A Key Predictive Marker of Cachexia in Lymphoma and Myeloma Patients","volume":"8","author":"Mallard","year":"2019","journal-title":"J. Hematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/978-981-10-6020-5_11","article-title":"Metabolic Changes During Cancer Cachexia Pathogenesis","volume":"1026","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/21623945.2018.1551688","article-title":"Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression","volume":"8","author":"Wu","year":"2019","journal-title":"Adipocyte"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.26811","article-title":"Adipose tissue dysfunction in cancer cachexia","volume":"234","author":"Daas","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1182\/blood.V83.9.2587.2587","article-title":"Elevated levels of interleukin-1 beta (IL-1 beta) and IL-6 in serum and increased production of IL-1 beta mRNA in lymph nodes of patients with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome","volume":"83","author":"Gherardi","year":"1994","journal-title":"Blood"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/09537100903360007","article-title":"Thrombopoietic cytokines and platelet count in multiple myeloma","volume":"21","author":"Ozkurt","year":"2010","journal-title":"Platelets"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"B\u0119bnowska, D., Hrynkiewicz, R., Grywalska, E., Pasiarski, M., Sosnowska-Pasiarska, B., Smarz-Widelska, I., G\u00f3\u017ad\u017a, S., Roli\u0144ski, J., and Nied\u017awiedzka-Rystwej, P. (2021). Immunological Prognostic Factors in Multiple Myeloma. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073587"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.leukres.2006.06.012","article-title":"Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression","volume":"31","author":"Kline","year":"2007","journal-title":"Leuk. Res."},{"key":"ref_44","first-page":"72","article-title":"Tumor Necrosis Factor Alpha-308G\/A Polymorphism and the Risk of Multiple Myeloma: A Meta-Analysis of Pooled Data from Twelve Case-Control Studies","volume":"36","author":"Li","year":"2019","journal-title":"Turkish J. Haematol. Off. J. Turkish Soc. Haematol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e402","DOI":"10.1111\/ajco.12290","article-title":"Interleukin-6 gene-174 G\/C promoter polymorphism and its association with clinical profile of patients with multiple myeloma","volume":"13","author":"Chakraborty","year":"2017","journal-title":"Asia. Pac. J. Clin. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00277-011-1194-3","article-title":"Single nucleotide polymorphisms in the promoter region of the IL1B gene influence outcome in multiple myeloma patients treated with high-dose chemotherapy independently of relapse treatment with thalidomide and bortezomib","volume":"90","author":"Vangsted","year":"2011","journal-title":"Ann. Hematol."},{"key":"ref_47","first-page":"264","article-title":"Cytokine gene polymorphisms support diagnostic monitoring of Romanian multiple myeloma patients","volume":"4","author":"Banu","year":"2011","journal-title":"J. Med. Life"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2141.2012.09141.x","article-title":"A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma","volume":"158","author":"Vangsted","year":"2012","journal-title":"Br. J. Haematol."},{"key":"ref_49","first-page":"41","article-title":"Interleukin-1 genetic polymorphisms and their relationship to the cancer anorexia\/weight loss syndrome in metastatic gastric and gastroesophageal junction adenocarcinoma","volume":"5","author":"Jatoi","year":"2007","journal-title":"J. Support. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/ajcn\/82.5.1059","article-title":"Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1beta-511 single nucleotide polymorphism","volume":"82","author":"Broekhuizen","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/cncr.29154","article-title":"Racial\/ethnic disparities in inflammatory gene single-nucleotide polymorphisms as predictors of a high risk for symptom burden in patients with multiple myeloma 1 year after diagnosis","volume":"121","author":"Shi","year":"2015","journal-title":"Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/bmt.2008.351","article-title":"The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT","volume":"43","author":"Vangsted","year":"2009","journal-title":"Bone Marrow Transplant."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/7\/1263\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:46Z","timestamp":1760105866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/7\/1263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,24]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["cancers16071263"],"URL":"https:\/\/doi.org\/10.3390\/cancers16071263","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,24]]}}}