{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:35:07Z","timestamp":1767846907500,"version":"3.49.0"},"reference-count":221,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The story of acute promyelocytic leukemia (APL) discovery, physiopathology, and treatment is a unique journey, transforming the most aggressive form of leukemia to the most curable. It followed an empirical route fueled by clinical breakthroughs driving major advances in biochemistry and cell biology, including the discovery of PML nuclear bodies (PML NBs) and their central role in APL physiopathology. Beyond APL, PML NBs have emerged as key players in a wide variety of biological functions, including tumor-suppression and SUMO-initiated protein degradation, underscoring their broad importance. The APL story is an example of how clinical observations led to the incremental development of the first targeted leukemia therapy. The understanding of APL pathogenesis and the basis for cure now opens new insights in the treatment of other diseases, especially other acute myeloid leukemias.<\/jats:p>","DOI":"10.3390\/cancers16071351","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:28:00Z","timestamp":1711891680000},"page":"1351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["History of Developing Acute Promyelocytic Leukemia Treatment and Role of Promyelocytic Leukemia Bodies"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-8155","authenticated-orcid":false,"given":"Pierre","family":"Bercier","sequence":"first","affiliation":[{"name":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, CNRS, INSERM, Universit\u00e9 PSL, 75231 Paris, France"},{"name":"GenCellDis, Inserm U944, CNRS UMR7212, Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1113-4472","authenticated-orcid":false,"given":"Hugues","family":"de Th\u00e9","sequence":"additional","affiliation":[{"name":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, CNRS, INSERM, Universit\u00e9 PSL, 75231 Paris, France"},{"name":"GenCellDis, Inserm U944, CNRS UMR7212, Universit\u00e9 Paris Cit\u00e9, 75010 Paris, France"},{"name":"Hematology Laboratory, H\u00f4pital St Louis, AP\/HP, 75010 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.leukres.2011.09.028","article-title":"The Discovery and Early Understanding of Leukemia","volume":"36","author":"Kampen","year":"2012","journal-title":"Leuk. 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