{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:18:46Z","timestamp":1785799126173,"version":"3.56.0"},"reference-count":32,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Despite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospective case\u2013control study was performed to identify clinical\u2013dermoscopic and histopathological variables linked to local and distant metastases in melanomas \u22640.8 mm. Data from 1 January 2000 to 22 June 2022 were analyzed from two Italian skin cancer referral centers. Sixteen patients with \u22640.8 mm melanomas developing metastases were studied compared to controls without metastases over 5 years. Statistical analysis involved Pearson\u2019s chi-squared test or Fisher\u2019s exact test. Of the 1396 cases, 1.1% progressed. The median diagnosis age was 49 (range 28\u201383), with 56.3% men and 43.7% women. The torso was the primary tumor site (43.7%). Clinically, lesions were pigmented (&gt;10 mm diameter: 73.3%, \u22653 colors: 80%). Dermoscopically, the common features were white patches (73.3%), atypical vascular patterns (66.5%), blue-gray areas (60%) and absent pigment networks (60%). Histopathologically, all cases had adverse features like regression (87.4%), dermal mitoses (50%), a vertical growth phase (62.5%) and ulceration (12.5%). These findings were statistically significant compared to controls (p &lt; 0.05). In \u22640.8 mm melanomas, specific clinical\u2013dermoscopic traits might indicate higher metastatic potential when paired with adverse histopathological features.<\/jats:p>","DOI":"10.3390\/cancers16071394","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T07:18:28Z","timestamp":1711955908000},"page":"1394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Dermoscopy as a Tool for Identifying Potentially Metastatic Thin Melanoma: A Clinical\u2013Dermoscopic and Histopathological Case\u2013Control Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6531-7998","authenticated-orcid":false,"given":"Vincenzo","family":"De Giorgi","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"},{"name":"Cancer Research \u201cAttilia Pofferi\u201d Foundation, 51100 Pistoia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-1458","authenticated-orcid":false,"given":"Flavia","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cecchi","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-4172","authenticated-orcid":false,"given":"Federico","family":"Venturi","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1060-3211","authenticated-orcid":false,"given":"Biancamaria","family":"Zuccaro","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Perillo","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Cosso","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Careggi University Hospital, 50134 Florence, Italy"},{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Maio","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-8275","authenticated-orcid":false,"given":"Sara","family":"Simi","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Antonini","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"},{"name":"Section of Pathology, Department of Diagnostic and Public Health, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-8718","authenticated-orcid":false,"given":"Serena","family":"Pillozzi","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Careggi University Hospital, 50134 Florence, Italy"},{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Antonuzzo","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Careggi University Hospital, 50134 Florence, Italy"},{"name":"Department of Experimental and Clinical Medicine, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-5923","authenticated-orcid":false,"given":"Daniela","family":"Massi","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Health Sciences, University of Florence, 50121 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Doni","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Careggi University Hospital, 50134 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.5858\/2009-0479-RA.1","article-title":"Thin melanoma","volume":"135","author":"Elder","year":"2011","journal-title":"Arch. 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