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Cancer","award":["ARCPGA2022120005732_6344"],"award-info":[{"award-number":["ARCPGA2022120005732_6344"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["PRE05\/DSL"],"award-info":[{"award-number":["PRE05\/DSL"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["PRE07\/DSL"],"award-info":[{"award-number":["PRE07\/DSL"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["PRE11\/NA"],"award-info":[{"award-number":["PRE11\/NA"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["b2008-029\/LL-LC"],"award-info":[{"award-number":["b2008-029\/LL-LC"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["INCa-DGOS-4654"],"award-info":[{"award-number":["INCa-DGOS-4654"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["01P0751\u201301P0752\u201301P0753\u201301P0754\u201301P0755"],"award-info":[{"award-number":["01P0751\u201301P0752\u201301P0753\u201301P0754\u201301P0755"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["2002\u201303, EP 2004-03 RB 2016\u201322"],"award-info":[{"award-number":["2002\u201303, EP 2004-03 RB 2016\u201322"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["2001009761"],"award-info":[{"award-number":["2001009761"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["2005011201"],"award-info":[{"award-number":["2005011201"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["PRE04\/NA"],"award-info":[{"award-number":["PRE04\/NA"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["PRE07\/NA"],"award-info":[{"award-number":["PRE07\/NA"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["PRE2015 LNCC\/NA"],"award-info":[{"award-number":["PRE2015 LNCC\/NA"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["AAP12-COH-110"],"award-info":[{"award-number":["AAP12-COH-110"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["CEST NC2013-015"],"award-info":[{"award-number":["CEST NC2013-015"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["INCa-9578"],"award-info":[{"award-number":["INCa-9578"]}]},{"name":"Fondation ARC pour la recherche sur le cancer","award":["ARCPGA2022120005732_6344"],"award-info":[{"award-number":["ARCPGA2022120005732_6344"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The Ataxia\u2013Telangiectasia Mutated (ATM) gene is implicated in DNA double-strand break repair. Controversies in clinical radiosensitivity remain known for monoallelic carriers of the ATM pathogenic variant (PV). An evaluation of the single-nucleotide polymorphism (SNP) rs1801516 (G-A) showed different results regarding late subcutaneous fibrosis after breast radiation therapy (RT). The main objective of this study was to evaluate acute and late toxicities in carriers of a rare ATM PV or predicted PV and in carriers of minor allele A of rs1801516 facing breast RT. Fifty women with localized breast cancer treated with adjuvant RT between 2000 and 2014 at Institut Curie were selected. Acute and late toxicities in carriers of a rare PV or predicted PV (n= 9), in noncarriers (n = 41) and in carriers of SNP rs1801516 (G-A) (n = 8), were examined. The median age at diagnosis was 53 years old and 82% of patients had an invasive ductal carcinoma and 84% were at clinical stage I\u2013IIB. With a median follow-up of 13 years, no significant difference between carriers and noncarriers was found for acute toxicities (p &gt; 0.05). The same results were observed for late toxicities without an effect from the rs1801516 genotype on toxicities. No significant difference in acute or late toxicities was observed between rare ATM variant carriers and noncarriers after breast RT for localized breast cancer.<\/jats:p>","DOI":"10.3390\/cancers16071417","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T08:27:52Z","timestamp":1712305672000},"page":"1417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety of the Breast Cancer Adjuvant Radiotherapy in Ataxia\u2013Telangiectasia Mutated Variant Carriers"],"prefix":"10.3390","volume":"16","author":[{"given":"Rayan","family":"Bensenane","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Beddok","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut Godinot, 51454 Reims, France"},{"name":"CRESTIC EA 3804, University Reims Champagne-Ardenne, 51454 Reims, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7404-4549","authenticated-orcid":false,"given":"Fabienne","family":"Lesueur","sequence":"additional","affiliation":[{"name":"Inserm U900, Institut Curie, PSL Research University, Mines ParisTech, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Fourquet","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Warcoin","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institut Curie, 75248 Paris, France"},{"name":"Inserm U830, Institut Curie, Paris-Cit\u00e9 University, 75248 Paris, France"},{"name":"Paris Sciences & Lettres Research University, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Le Mentec","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institut Curie, 75248 Paris, France"},{"name":"Inserm U830, Institut Curie, Paris-Cit\u00e9 University, 75248 Paris, France"},{"name":"Paris Sciences & Lettres Research University, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Cavaciuti","sequence":"additional","affiliation":[{"name":"Inserm U900, Institut Curie, PSL Research University, Mines ParisTech, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0595-7676","authenticated-orcid":false,"given":"Doroth\u00e9e","family":"Le Gal","sequence":"additional","affiliation":[{"name":"Inserm U900, Institut Curie, PSL Research University, Mines ParisTech, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Eon-Marchais","sequence":"additional","affiliation":[{"name":"Inserm U900, Institut Curie, PSL Research University, Mines ParisTech, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Andrieu","sequence":"additional","affiliation":[{"name":"Inserm U900, Institut Curie, PSL Research University, Mines ParisTech, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-8309","authenticated-orcid":false,"given":"Dominique","family":"Stoppa-Lyonnet","sequence":"additional","affiliation":[{"name":"Department of Genetics, Institut Curie, 75248 Paris, France"},{"name":"Inserm U830, Institut Curie, Paris-Cit\u00e9 University, 75248 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-7509","authenticated-orcid":false,"given":"Youlia","family":"Kirova","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75248 Paris, France"},{"name":"University Versailles, 02100 St. Quentin, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer Statistics for the Year 2020: An Overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. 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