{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:05:19Z","timestamp":1792123519429,"version":"4.4.0"},"reference-count":144,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008342","name":"Western Sydney University","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100008342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Recent research has implicated the gut microbiota in the development of lymphoma. Dysbiosis of the gut microbial community can disrupt the production of gut microbial metabolites, thereby impacting host physiology and potentially contributing to lymphoma. Dysbiosis-driven release of gut microbial metabolites such as lipopolysaccharides can promote chronic inflammation, potentially elevating the risk of lymphoma. In contrast, gut microbial metabolites, such as short-chain fatty acids, have shown promise in preclinical studies by promoting regulatory T-cell function, suppressing inflammation, and potentially preventing lymphoma. Another metabolite, urolithin A, exhibited immunomodulatory and antiproliferative properties against lymphoma cell lines in vitro. While research on the role of gut microbial metabolites in lymphoma is limited, this article emphasizes the need to comprehend their significance, including therapeutic applications, molecular mechanisms of action, and interactions with standard chemotherapies. The article also suggests promising directions for future research in this emerging field of connection between lymphoma and gut microbiome.<\/jats:p>","DOI":"10.3390\/cancers16081464","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T07:09:28Z","timestamp":1712819368000},"page":"1464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Gut Connection: Exploring the Possibility of Implementing Gut Microbial Metabolites in Lymphoma Treatment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-0426","authenticated-orcid":false,"given":"Ahmad K.","family":"Al-Khazaleh","sequence":"first","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Chang","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald W.","family":"M\u00fcnch","sequence":"additional","affiliation":[{"name":"Pharmacology Unit, School of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-0197","authenticated-orcid":false,"given":"Deep Jyoti","family":"Bhuyan","sequence":"additional","affiliation":[{"name":"NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia"},{"name":"School of Science, Western Sydney University, Penrith, NSW 2751, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.pop.2016.07.012","article-title":"Lymphoma","volume":"43","author":"Mugnaini","year":"2016","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrclinonc.2015.61","article-title":"Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: Clinical update","volume":"12","author":"Takebe","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology meets immunology: The cancer-immunity cycle","volume":"39","author":"Chen","year":"2013","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/ajh.26301","article-title":"Efficacy and safety of CD19-directed CAR-T cell therapies in patients with relapsed\/refractory aggressive B-cell lymphomas: Observations from the JULIET, ZUMA-1, and TRANSCEND trials","volume":"96","author":"Westin","year":"2021","journal-title":"Am. J. Hematol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shen, G., Wu, J., Ye, B.-C., and Qi, N. (2021). Gut microbiota-derived metabolites in the development of diseases. Can. J. Infect. Dis. Med. Microbiol., 2021.","DOI":"10.1155\/2021\/6658674"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yoo, J.Y., Groer, M., Dutra, S.V.O., Sarkar, A., and McSkimming, D.I. (2020). Gut microbiota and immune system interactions. Microorganisms, 8.","DOI":"10.3390\/microorganisms8101587"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"106398","DOI":"10.1016\/j.intimp.2020.106398","article-title":"The suppressive effect of dabrafenib, a therapeutic agent for metastatic melanoma, in IgE-mediated allergic inflammation","volume":"83","author":"Choi","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2020.00025","article-title":"The role of short-chain fatty acids from gut microbiota in gut-brain communication","volume":"11","author":"Silva","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s13238-020-00694-x","article-title":"HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma","volume":"11","author":"Wang","year":"2020","journal-title":"Protein Cell"},{"key":"ref_12","unstructured":"Cure Cancer Australia (2023, June 07). Lymphoma 2022. Available online: https:\/\/www.curecancer.com.au\/cancer\/blood?gclid=CjwKCAjwitShBhA6EiwAq3RqAxkSFH_j88v6iU1QXyT5O2Bd7yaC39GQhXFNvPFpP_A_jEv-Ot5rhRoCklAQAvD_BwE."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0140-6736(03)12777-8","article-title":"Hodgkin\u2019s lymphoma","volume":"361","author":"Yung","year":"2003","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1172\/JCI61245","article-title":"Hodgkin lymphoma","volume":"122","author":"Engert","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_15","unstructured":"Abbas, A.K., Lichtman, A.H., and Pillai, S. (2014). Cellular and Molecular Immunology E-Book, Elsevier Health Sciences."},{"key":"ref_16","first-page":"k3204","article-title":"Non-Hodgkin lymphoma","volume":"362","author":"Ajithkumar","year":"2018","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/bjc.2015.94","article-title":"Lymphoma incidence, survival and prevalence 2004\u20132014: Sub-type analyses from the UK\u2019s Haematological Malignancy Research Network","volume":"112","author":"Smith","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0140-6736(12)60605-9","article-title":"Non-hodgkin lymphoma","volume":"380","author":"Shankland","year":"2012","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/bjc.2011.484","article-title":"11. Cancers attributable to infection in the UK in 2010","volume":"105","author":"Parkin","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jncimonographs\/lgu013","article-title":"Etiologic heterogeneity among non-Hodgkin lymphoma subtypes: The InterLymph non-Hodgkin lymphoma subtypes project","volume":"2014","author":"Morton","year":"2014","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/s41416-018-0029-6","article-title":"The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015","volume":"118","author":"Brown","year":"2018","journal-title":"Br. J. Cancer"},{"key":"ref_22","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., Thiele, J., and Vardiman, J.W. (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.chom.2014.02.011","article-title":"Human viral oncogenesis: A cancer hallmarks analysis","volume":"15","author":"Mesri","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1096-9071(199605)49:1<7::AID-JMV2>3.0.CO;2-A","article-title":"Transcriptional expression of Epstein-Barr virus genes and proto-oncogenes in north African nasopharyngeal carcinoma","volume":"49","author":"Djennaoui","year":"1996","journal-title":"J. Med. Virol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nrc2961","article-title":"Why do viruses cause cancer? Highlights of the first century of human tumour virology","volume":"10","author":"Moore","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1559325818813227","DOI":"10.1177\/1559325818813227","article-title":"Natural Products Mediated Targeting of Virally Infected Cancer","volume":"17","author":"Fatima","year":"2019","journal-title":"Dose Response"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1053\/j.seminoncol.2014.10.003","article-title":"Cancer \u201ccausation\u201d by infections--individual contributions and synergistic networks","volume":"41","year":"2014","journal-title":"Semin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Eladwy, R.A., Vu, H.T., Shah, R., Li, C.G., Chang, D., and Bhuyan, D.J. (2023). The Fight against the Carcinogenic Epstein-Barr Virus: Gut Microbiota, Natural Medicines, and Beyond. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021716"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Andrei, G., Trompet, E., and Snoeck, R. (2019). Novel therapeutics for Epstein\u2013Barr virus. Molecules, 24.","DOI":"10.3390\/molecules24050997"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/1097-0142(19930801)72:3+<962::AID-CNCR2820721303>3.0.CO;2-H","article-title":"The molecular biology of carcinogenesis","volume":"72","author":"Pitot","year":"1993","journal-title":"Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.3390\/v6104047","article-title":"Human viruses and cancer","volume":"6","year":"2014","journal-title":"Viruses"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1038\/sj.onc.1209612","article-title":"RB, the conductor that orchestrates life, death and differentiation","volume":"25","author":"Khidr","year":"2006","journal-title":"Oncogene"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/1348-0421.12155","article-title":"Regulation of Epstein\u2013Barr virus reactivation from latency","volume":"58","author":"Murata","year":"2014","journal-title":"Microbiol. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pagano, J.S., Whitehurst, C.B., and Andrei, G. (2018). Antiviral drugs for EBV. Cancers, 10.","DOI":"10.3390\/cancers10060197"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1080\/10428194.2018.1452211","article-title":"Omitting cardiophrenic lymph nodes in the treatment of patients with Hodgkin lymphoma via modified involved-site radiation therapy","volume":"59","author":"Pinnix","year":"2018","journal-title":"Leuk. Lymphoma"},{"key":"ref_36","unstructured":"National Cancer Institute (2002). Adult Hodgkin Lymphoma Treatment (PDQ\u00ae): Patient Version, PDQ Cancer Information Summaries."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/ajh.25871","article-title":"ABVD vs BEACOPP escalated in advanced-stage Hodgkin\u2019s lymphoma: Results from a multicenter European study","volume":"95","author":"Mondello","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1000067","article-title":"Reduced treatment intensity in patients with early-stage Hodgkin\u2019s lymphoma","volume":"363","author":"Engert","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"114714","DOI":"10.1016\/j.taap.2019.114714","article-title":"Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation","volume":"381","author":"Wang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrcardio.2015.65","article-title":"Cardiotoxicity of anticancer treatments","volume":"12","author":"Ewer","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","article-title":"2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines: The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC)","volume":"37","author":"Zamorano","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/2040620712443076","article-title":"Safety and efficacy of brentuximab vedotin in patients with Hodgkin lymphoma or systemic anaplastic large cell lymphoma","volume":"3","author":"Vaklavas","year":"2012","journal-title":"Ther. Adv. Hematol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ctrv.2016.11.007","article-title":"Resistance to PD1\/PDL1 checkpoint inhibition","volume":"52","author":"Long","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/PPO.0000000000000453","article-title":"Radiotherapy for Non-Hodgkin Lymphomas","volume":"26","author":"Imber","year":"2020","journal-title":"Cancer J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.clml.2014.09.001","article-title":"Pegylated liposomal doxorubicin replacing conventional doxorubicin in standard R-CHOP chemotherapy for elderly patients with diffuse large B-cell lymphoma: An open label, single arm, phase II trial","volume":"15","author":"Oki","year":"2015","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00002820-199712000-00007","article-title":"Side effects of CHOP in the treatment of non-Hodgkin\u2019s lymphoma","volume":"20","author":"Sitzia","year":"1997","journal-title":"Cancer Nurs."},{"key":"ref_47","unstructured":"Ansell, S.M., and Armitage, J. (2005). Mayo Clinic Proceedings, Elsevier."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/10428194.2022.2136956","article-title":"Pembrolizumab for patients with non-Hodgkin lymphoma: Phase 1b KEYNOTE-013 study","volume":"64","author":"Kuruvilla","year":"2023","journal-title":"Leuk. Lymphoma"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Guevara-Ram\u00edrez, P., Cadena-Ullauri, S., Paz-Cruz, E., Tamayo-Trujillo, R., Ruiz-Pozo, V.A., and Zambrano, A.K. (2023). Role of the gut microbiota in hematologic cancer. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1185787"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1105293","DOI":"10.3389\/fimmu.2023.1105293","article-title":"The gut microbiota correlate with the disease characteristics and immune status of patients with untreated diffuse large B-cell lymphoma","volume":"14","author":"Lin","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Upadhyay Banskota, S., Skupa, S.A., El-Gamal, D., and D\u2019Angelo, C.R. (2023). Defining the Role of the Gut Microbiome in the Pathogenesis and Treatment of Lymphoid Malignancies. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032309"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1158\/1541-7786.MCR-23-0080","article-title":"The Role of the Gut Microbiome in Hematological Cancers","volume":"22","author":"Hussein","year":"2024","journal-title":"Mol. Cancer Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/hematolrep16010007","article-title":"The Gut Microbiome Correlated to Chemotherapy Efficacy in Diffuse Large B-Cell Lymphoma Patients","volume":"16","author":"Xu","year":"2024","journal-title":"Hematol. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3892\/ol.2024.14340","article-title":"Characteristics and prognostic value of gut microbiota in follicular lymphoma","volume":"27","author":"Xu","year":"2024","journal-title":"Oncol. Lett."},{"key":"ref_56","first-page":"e19047","article-title":"The Role of Microbiota in the Development of Cancer Tumour Cells and Lymphoma of B and T Cells","volume":"13","author":"Mamgain","year":"2021","journal-title":"Cureus"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Yuan, L., Wang, W., Zhang, W., Zhang, Y., Wei, C., Li, J., and Zhou, D. (2021). Gut Microbiota in Untreated Diffuse Large B Cell Lymphoma Patients. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.646361"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1034\/j.1399-0004.1999.550501.x","article-title":"Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene","volume":"55","author":"Meyn","year":"1999","journal-title":"Clin. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/(SICI)1096-911X(199906)32:6<479::AID-MPO25>3.0.CO;2-H","article-title":"Treatment of lymphoid malignancies in patients with ataxia-telangiectasia","volume":"32","author":"MW","year":"1999","journal-title":"Med. Pediatr. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1182\/blood.V87.2.423.bloodjournal872423","article-title":"Leukemia and lymphoma in ataxia telangiectasia","volume":"87","author":"Taylor","year":"1996","journal-title":"Blood"},{"key":"ref_61","first-page":"8","article-title":"Cancer susceptibility in ataxia-telangiectasia","volume":"6","author":"Peterson","year":"1992","journal-title":"Leukemia"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-4608(90)90003-S","article-title":"Cancer in ataxia-telangiectasia patients","volume":"46","author":"Hecht","year":"1990","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_63","first-page":"89","article-title":"Mortality and cancer incidence in 263 patients with ataxia-telangiectasia","volume":"77","author":"Morrell","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Cheema, A.K., Maier, I., Dowdy, T., Wang, Y., Singh, R., Ruegger, P.M., Borneman, J., Fornace, A.J., and Schiestl, R.H. (2016). Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151190"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1158\/0008-5472.CAN-13-0022","article-title":"Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity","volume":"73","author":"Yamamoto","year":"2013","journal-title":"Cancer Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.3390\/ijerph110909038","article-title":"Lymphoma caused by intestinal microbiota","volume":"11","author":"Yamamoto","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2038865","DOI":"10.1080\/19490976.2022.2038865","article-title":"The role of key gut microbial metabolites in the development and treatment of cancer","volume":"14","author":"Jaye","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1007\/s12325-019-00995-6","article-title":"Inosine Pranobex: A Key Player in the Game Against a Wide Range of Viral Infections and Non-Infectious Diseases","volume":"36","author":"Sliva","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrmicro1273","article-title":"Bacteriocins: Developing innate immunity for food","volume":"3","author":"Cotter","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/apt.13302","article-title":"Chemotherapy-driven dysbiosis in the intestinal microbiome","volume":"42","author":"Montassier","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1126\/science.aar6918","article-title":"The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies","volume":"359","author":"Zitvogel","year":"2018","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.trsl.2016.07.021","article-title":"Microbiota as a mediator of cancer progression and therapy","volume":"179","author":"Pope","year":"2017","journal-title":"Transl. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2013-304833","article-title":"A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis","volume":"63","author":"Machiels","year":"2014","journal-title":"Gut"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Petrelli, F., Ghidini, M., Ghidini, A., Perego, G., Cabiddu, M., Khakoo, S., Oggionni, E., Abeni, C., Hahne, J.C., and Tomasello, G. (2019). Use of antibiotics and risk of cancer: A systematic review and meta-analysis of observational studies. Cancers, 11.","DOI":"10.3390\/cancers11081174"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ebiom.2016.04.038","article-title":"Genomic profiling of adult and pediatric B-cell acute lymphoblastic leukemia","volume":"8","author":"Liu","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nrgastro.2015.47","article-title":"Towards a more comprehensive concept for prebiotics","volume":"12","author":"Bindels","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev-nutr-072610-145146","article-title":"Interaction between obesity and the gut microbiota: Relevance in nutrition","volume":"31","author":"Delzenne","year":"2011","journal-title":"Annu. Rev. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Uccello, M., Malaguarnera, G., Basile, F., D\u2019agata, V., Malaguarnera, M., Bertino, G., Vacante, M., Drago, F., and Biondi, A. (2012). Potential role of probiotics on colorectal cancer prevention. BMC Surg., 12.","DOI":"10.1186\/1471-2482-12-S1-S35"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.aau5812","article-title":"The gut microbiota at the intersection of diet and human health","volume":"362","author":"Gentile","year":"2018","journal-title":"Science"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"8776","DOI":"10.1021\/jf2053959","article-title":"Up-regulating the human intestinal microbiome using whole plant foods, polyphenols, and\/or fiber","volume":"60","author":"Tuohy","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Rattanathammethee, T., Tuitemwong, P., Thiennimitr, P., Sarichai, P., Pombejra, S.N., Piriyakhuntorn, P., Hantrakool, S., Chai-Adisaksopha, C., Rattarittamrong, E., and Tantiworawit, A. (2020). Gut microbiota profiles of treatment-na\u00efve adult acute myeloid leukemia patients with neutropenic fever during intensive chemotherapy. PLoS ONE, 15.","DOI":"10.1101\/2020.07.09.194910"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/nbu.12334","article-title":"Probiotics for human use","volume":"43","author":"Sanders","year":"2018","journal-title":"Nutr. Bull."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/gut.52.7.988","article-title":"Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC)","volume":"52","author":"Barrett","year":"2003","journal-title":"Gut."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"R\u00edos-Covi\u00e1n, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., De Los Reyes-Gavil\u00e1n, C.G., and Salazar, N. (2016). Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00185"},{"key":"ref_86","first-page":"97417","article-title":"Pathogenic microbes, the microbiome, and Alzheimer\u2019s disease (AD)","volume":"6","author":"Hill","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1600240","DOI":"10.1002\/mnfr.201600240","article-title":"Probiotics, gut microbiota, and their influence on host health and disease","volume":"61","author":"Delgado","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3748\/wjg.v13.i6.912","article-title":"Use of probiotics for prevention of radiation-induced diarrhea","volume":"13","author":"Delia","year":"2007","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1572-0241.2006.00465.x","article-title":"Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease","volume":"101","author":"McFarland","year":"2006","journal-title":"Off. J. Am. Coll. Gastroenterol.|ACG"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6603990","article-title":"Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: A randomised study","volume":"97","author":"Ruotsalainen","year":"2007","journal-title":"Br. J. Cancer"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","article-title":"The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics","volume":"18","author":"Salminen","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"\u017b\u00f3\u0142kiewicz, J., Marzec, A., Ruszczy\u0144ski, M., and Feleszko, W. (2020). Postbiotics\u2014A step beyond pre-and probiotics. Nutrients, 12.","DOI":"10.3390\/nu12082189"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Plaza-D\u00edaz, J., Ruiz-Ojeda, F.J., Vilchez-Padial, L.M., and Gil, A. (2017). Evidence of the anti-inflammatory effects of probiotics and synbiotics in intestinal chronic diseases. Nutrients, 9.","DOI":"10.3390\/nu9060555"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1365-2672.2006.02963.x","article-title":"Probiotics and their fermented food products are beneficial for health","volume":"100","author":"Parvez","year":"2006","journal-title":"J. Appl. Microbiol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tifs.2020.12.004","article-title":"Postbiotics: Metabolites and mechanisms involved in microbiota-host interactions","volume":"108","author":"Peluzio","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_96","unstructured":"Inamura, K. (2021). Seminars in Cancer Biology, Elsevier."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/apt.14689","article-title":"Short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders","volume":"48","author":"Gill","year":"2018","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Astakhova, L., Ngara, M., Babich, O., Prosekov, A., Asyakina, L., Dyshlyuk, L., Midtvedt, T., Zhou, X., Ernberg, I., and Matskova, L. (2016). Short Chain Fatty Acids (SCFA) Reprogram Gene Expression in Human Malignant Epithelial and Lymphoid Cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154102"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.4049\/jimmunol.1500640","article-title":"The neurorepellent Slit2 inhibits postadhesion stabilization of monocytes tethered to vascular endothelial cells","volume":"195","author":"Mukovozov","year":"2015","journal-title":"J. Immunol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.4149\/av_2017_01_32","article-title":"The effect of Isoprinosine treatment on persistent infection of Balb\/c mice infected with murine gammaherpesvirus 68","volume":"61","author":"Briestenska","year":"2017","journal-title":"Acta Virol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fphar.2015.00272","article-title":"Bacteriocins as potential anticancer agents","volume":"6","author":"Kaur","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"10393","DOI":"10.1007\/s00253-018-9420-8","article-title":"Bacteriocins: Perspective for the development of novel anticancer drugs","volume":"102","author":"Baindara","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"131","DOI":"10.14789\/jmj.2021.67.JMJ20-R17","article-title":"The Potential as New Treatment Agent of Urolithin-A Metabolized from Ellagic Acid by Gut Microbiota in Cancer","volume":"67","author":"Okumura","year":"2021","journal-title":"Juntendo Med. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"17273","DOI":"10.1002\/jcb.28989","article-title":"Urolithin B suppresses tumor growth in hepatocellular carcinoma through inducing the inactivation of Wnt\/\u03b2-catenin signaling","volume":"120","author":"Lv","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"15242","DOI":"10.18632\/oncotarget.14839","article-title":"Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ijbiomac.2019.08.032","article-title":"Effect of oat and soybean rich in distinct non-starch polysaccharides on fermentation, appetite regulation and fat accumulation in rat","volume":"140","author":"Tian","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/gut.28.10.1221","article-title":"Short chain fatty acids in human large intestine, portal, hepatic and venous blood","volume":"28","author":"Cummings","year":"1987","journal-title":"Gut"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1194\/jlr.R067629","article-title":"Short-and medium-chain fatty acids in energy metabolism: The cellular perspective","volume":"57","author":"Wojtczak","year":"2016","journal-title":"J. Lipid Res."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zaky, A., Glastras, S.J., Wong, M.Y., Pollock, C.A., and Saad, S. (2021). The role of the gut microbiome in diabetes and obesity-related kidney disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22179641"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1152\/physiol.00004.2020","article-title":"Gut microbial metabolites and blood pressure regulation: Focus on SCFAs and TMAO","volume":"35","author":"Poll","year":"2020","journal-title":"Physiology"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.abc3421","article-title":"Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy","volume":"369","author":"Mager","year":"2020","journal-title":"Science"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"986","DOI":"10.6004\/jnccn.2018.0066","article-title":"Cancer in people living with HIV, version 1.2018, NCCN clinical practice guidelines in oncology","volume":"16","author":"Reid","year":"2018","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1021\/acs.bioconjchem.8b00404","article-title":"Encapsulation and Systemic Delivery of 5-Fluorouracil Conjugated with Silkworm Pupa Derived Protein Nanoparticles for Experimental Lymphoma Cancer","volume":"29","author":"Reneeta","year":"2018","journal-title":"Bioconjugate Chem."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Chen, Z., Yu, H., Chen, X., Chen, W., Song, W., and Li, Z. (2023). Mutual regulation between glycosylation and transforming growth factor-\u03b2 isoforms signaling pathway. Int. J. Biol. Macromol., 236.","DOI":"10.1016\/j.ijbiomac.2023.123818"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.4161\/cbt.6.7.4318","article-title":"Short-chain fatty acid modulation of apoptosis in the Kato III human gastric carcinoma cell line","volume":"6","author":"Matthews","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000335672","article-title":"Short-Chain Fatty Acids Induce Apoptosis in Colon Cancer Cells Associated with Changes to Intracellular Redox State and Glucose Metabolism","volume":"58","author":"Matthews","year":"2012","journal-title":"Chemotherapy"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.21873\/anticanres.13647","article-title":"Antiproliferative Effects of Short-chain Fatty Acids on Human Colorectal Cancer Cells via Gene Expression Inhibition","volume":"39","author":"Ohara","year":"2019","journal-title":"Anticancer. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5005\/jp-journals-10018-1251","article-title":"Intake of Bifidobacterium longum and Fructo-oligosaccharides prevents Colorectal Carcinogenesis","volume":"8","author":"Ohara","year":"2018","journal-title":"Euroasian J. Hepato-Gastroenterol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Matthews, G.M. (2007). Short-Chain Fatty Acid Modulation of Apoptosis in Gastric and Colon Cancer Cells. [Ph.D. Thesis, The University of Adelaide].","DOI":"10.4161\/cbt.6.7.4318"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3892\/or.2011.1585","article-title":"Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells","volume":"27","author":"Shin","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"31342","DOI":"10.18632\/oncotarget.25809","article-title":"A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells","volume":"9","author":"Kobayashi","year":"2018","journal-title":"Oncotarget"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1182\/blood-2006-01-024703","article-title":"A phase 1\/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus\u2013associated lymphoid malignancies","volume":"109","author":"Perrine","year":"2007","journal-title":"Blood"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0168-6445(93)90057-G","article-title":"Genetics of bacteriocins produced by lactic acid bacteria","volume":"12","author":"Klaenhammer","year":"1993","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1073\/pnas.1218418110","article-title":"Occam\u2019s razor and probiotics activity on Listeria monocytogenes","volume":"110","author":"Million","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1473-3099(13)70179-8","article-title":"Related actions of probiotics and antibiotics on gut microbiota and weight modification","volume":"13","author":"Angelakis","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1038\/nutd.2014.6","article-title":"Comparative genomics analysis of Lactobacillus species associated with weight gain or weight protection","volume":"4","author":"Drissi","year":"2014","journal-title":"Nutr. Diabetes"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41385-018-0053-0","article-title":"Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them","volume":"12","author":"Sorbara","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.micpath.2017.08.037","article-title":"The apoptotic impact of nisin as a potent bacteriocin on the colon cancer cells","volume":"111","author":"Ahmadi","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Kamarajan, P., Hayami, T., Matte, B., Liu, Y., Danciu, T., Ramamoorthy, A., Worden, F., Kapila, S., and Kapila, Y. (2015). Nisin ZP, a bacteriocin and food preservative, inhibits head and neck cancer tumorigenesis and prolongs survival. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131008"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.micpath.2018.07.006","article-title":"Nisin, a potent bacteriocin and anti-bacterial peptide, attenuates expression of metastatic genes in colorectal cancer cell lines","volume":"123","author":"Norouzi","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biopha.2011.03.006","article-title":"Induction of apoptosis of azurin synthesized from P. aeruginosa MTCC 2453 against Dalton\u2019s lymphoma ascites model","volume":"65","author":"Ramachandran","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/cam4.35","article-title":"Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC 1","volume":"1","author":"Joo","year":"2012","journal-title":"Cancer Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ijantimicag.2005.02.005","article-title":"An antibacterial and antiviral peptide produced by Enterococcus mundtii ST4V isolated from soya beans","volume":"25","author":"Todorov","year":"2005","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-3542(02)00099-2","article-title":"Enterocin CRL35 inhibits late stages of HSV-1 and HSV-2 replication in vitro","volume":"58","author":"Wachsman","year":"2003","journal-title":"Antivir. Res."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"F\u00e9rir, G., Petrova, M.I., Andrei, G., Huskens, D., Hoorelbeke, B., Snoeck, R., Vanderleyden, J., Balzarini, J., Bartoschek, S., and Br\u00f6nstrup, M. (2013). The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064010"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12602-012-9123-x","article-title":"Safety, formulation and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1","volume":"5","author":"Torres","year":"2013","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Srinivasan, S., Torres, A.G., and de Pouplana, L.R. (2021). Inosine in Biology and Disease. Genes, 12.","DOI":"10.3390\/genes12040600"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1515\/acph-2015-0015","article-title":"Immunomodulatory effects of inosine pranobex on cytokine production by human lymphocytes","volume":"65","author":"Lasek","year":"2015","journal-title":"Acta Pharm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0192-0561(83)90041-3","article-title":"An in vitro study on the effects of isoprinosine on immune responses in cancer patients","volume":"5","author":"Tsang","year":"1983","journal-title":"Int. J. Immunopharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.intimp.2016.11.023","article-title":"Inosine Acedoben Dimepranol promotes an early and sustained increase in the natural killer cell component of circulating lymphocytes: A clinical trial supporting anti-viral indications","volume":"42","author":"Ahmed","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_141","first-page":"155","article-title":"Immunorestorative properties of isoprinosine in the treatment of patients at high risk of developing ARC or AIDS","volume":"24","author":"Bekesi","year":"1987","journal-title":"J. Clin. Lab. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0192-0561(85)90027-X","article-title":"In vitro restoration of immune responses in aging humans by isoprinosine","volume":"7","author":"Tsang","year":"1985","journal-title":"Int. J. Immunopharmacol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1500901","DOI":"10.1002\/mnfr.201500901","article-title":"Urolithins, the rescue of \u201cold\u201d metabolites to understand a \u201cnew\u201d concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status","volume":"61","author":"Selma","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_144","first-page":"92","article-title":"Research progress on the anticarcinogenic actions and mechanisms of ellagic acid","volume":"11","author":"Zhang","year":"2014","journal-title":"Cancer Biol. Med."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/8\/1464\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:26:16Z","timestamp":1760106376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/8\/1464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":144,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["cancers16081464"],"URL":"https:\/\/doi.org\/10.3390\/cancers16081464","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]}}}