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programme","award":["Open Access Publication Funding"],"award-info":[{"award-number":["Open Access Publication Funding"]}]},{"DOI":"10.13039\/501100001652","name":"Deutsche Forschungsgemeinschaft and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","award":["ETI 2021-1-Tech-05-Haug"],"award-info":[{"award-number":["ETI 2021-1-Tech-05-Haug"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Deutsche Forschungsgemeinschaft and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","award":["GSC 80"],"award-info":[{"award-number":["GSC 80"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Deutsche Forschungsgemeinschaft and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","award":["DS\/eh 11\/14"],"award-info":[{"award-number":["DS\/eh 11\/14"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Deutsche Forschungsgemeinschaft and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","award":["Myo-Des"],"award-info":[{"award-number":["Myo-Des"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001652","name":"Deutsche Forschungsgemeinschaft and Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","doi-asserted-by":"publisher","award":["Open Access Publication Funding"],"award-info":[{"award-number":["Open Access Publication Funding"]}],"id":[{"id":"10.13039\/501100001652","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Patients with aggressive cancer, e.g., gastrointestinal cancer, are prone (\u226550% chance) to developing cancer cachexia (CC). Little is known about the effects of CC on the biomechanical function of muscle. A promising prevention strategy was found in the form of a multi-modal therapy combining mild resistance exercise (e.g., whole-body electro-myostimulation, WB-EMS) and a protein-rich diet. In a previous study of ours, this was effective in counteracting the loss of muscle mass, yet a systematic and comprehensive assessment of active and passive single muscle fibre functions was so far absent. This pilot study investigated the biomechanical function of single muscle fibres (rectus abdominis) from the biopsies of conventionally treated (pre-)cachectic cancer ((pre-)CC) patients (m = 9), those receiving the multi-modal therapy comprising WB-EMS training and protein-rich nutrition (m = 3), and a control group (m = 5). Our findings not only align with previous findings showing the absolute force loss in CC that is accelerated by atrophy but also speak in favour of a different, potentially energy- and Ca2+-homeostasis-related effect that compromises muscle contraction (F ~0.9 mN vs. F ~0.6 mN in control patients). However, myofibrillar Ca2+ sensitivity and the quality of contraction were unaltered (pCa50: 5.6\u20135.8). Single fibres from the (pre-)CC patients receiving WB-EMS training and protein supplementation were significantly more compliant (p &lt; 0.001 at \u2265130% of resting length L0). Those fibres displayed a similar softness to the ones from the control patients (axial compliance ~15 m\/N at \u2265130% L0), while single fibres from the patients with (developing) cachexia were significantly stiffer (axial compliance ~7 m\/N, p &lt; 0.001 at \u2265130% L0). Adjuvant multi-modal therapy (WB-EMS training and nutritional support) contributes to maintaining the axial compliance of single fibres and potentially improves the quality of life for patients at risk of developing CC.<\/jats:p>","DOI":"10.3390\/cancers16081608","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T09:53:52Z","timestamp":1713779632000},"page":"1608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Adjuvant Exercise and Nutrition Therapy on Muscle Fibre Biomechanics in Gastrointestinal Cancer Patients"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-2593","authenticated-orcid":false,"given":"Michael","family":"Haug","sequence":"first","affiliation":[{"name":"Institute of Medical Biotechnology (MBT), Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 3, 91052 Erlangen, Germany"},{"name":"Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 6, 91052 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaela","family":"Schwappacher","sequence":"additional","affiliation":[{"name":"Hector-Centre for Nutrition, Exercise and Sports, Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"},{"name":"Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Pollmann","sequence":"additional","affiliation":[{"name":"Institute of Medical Biotechnology (MBT), Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 3, 91052 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-8031","authenticated-orcid":false,"given":"Paul","family":"Ritter","sequence":"additional","affiliation":[{"name":"Institute of Medical Biotechnology (MBT), Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 3, 91052 Erlangen, Germany"},{"name":"Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 6, 91052 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4805-0333","authenticated-orcid":false,"given":"Mena","family":"Michael","sequence":"additional","affiliation":[{"name":"Institute of Medical Biotechnology (MBT), Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 3, 91052 Erlangen, Germany"},{"name":"Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Joachim","family":"Hermann","sequence":"additional","affiliation":[{"name":"Hector-Centre for Nutrition, Exercise and Sports, Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"},{"name":"Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gr\u00fctzmann","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Krankenhausstr. 12, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1716-3547","authenticated-orcid":false,"given":"Anke","family":"Mittelst\u00e4dt","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Krankenhausstr. 12, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus Friedrich","family":"Neurath","sequence":"additional","affiliation":[{"name":"Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3432-7488","authenticated-orcid":false,"given":"Yurdag\u00fcl","family":"Zopf","sequence":"additional","affiliation":[{"name":"Hector-Centre for Nutrition, Exercise and Sports, Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"},{"name":"Medical Department 1, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-2049","authenticated-orcid":false,"given":"Oliver","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Institute of Medical Biotechnology (MBT), Department of Chemical and Biological Engineering, Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 3, 91052 Erlangen, Germany"},{"name":"Erlangen Graduate School in Advanced Optical Technologies (SAOT), Friedrich-Alexander-University Erlangen-N\u00fcrnberg, Paul-Gordan-Str. 6, 91052 Erlangen, Germany"},{"name":"School of Biomedical Sciences, University of New South Wales, Wallace Wurth Building, 18 High St, Sydney, NSW 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: Understanding the molecular basis","volume":"14","author":"Busquets","year":"2014","journal-title":"Nat. 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