{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T08:08:47Z","timestamp":1767773327337,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Hungarian Diabetes Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>(1) Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cancer but how these two diseases associate is still debated. The goal of this study was the assessment of the overall incidence of cancer among patients with newly diagnosed T2DM in Hungary. (2) Methods: A nationwide, retrospective, longitudinal study was performed using a Hungarian database. After exclusion of cases of age &lt; 18 years, with gestational diabetes, with polycystic ovary syndrome, and with type 1 and prevalent type 2 diabetes mellitus, the incident T2DM (approx. 50,000 cases yearly) and for comparison, the diabetes-free Hungarian adult population (approx. 7,000,000 cases yearly) was included in the study. The primary endpoints were the overall and site-specific incidence and annual percentage change of the incidence of cancer in both populations. (3) Results: The overall incidence of cancer in patients amounted to 29.4\/1000 and 6.6\/1000 with or without T2DM, respectively, and the OR (95%CI) of cancer of the T2DM group was 4.32 (4.14\u20134.53), p &lt; 0.0001. The risk of having cancer was age dependent. The incidence of cancer was declining in the non-diabetic but was unchanged in the T2DM population. The average lag time of diagnosing cancer after the detection of T2DM was 3.86 months. (4) Conclusions: Incident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months.<\/jats:p>","DOI":"10.3390\/cancers16091745","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T04:01:52Z","timestamp":1714449712000},"page":"1745","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incident Cancer Risk in Patients with Incident Type 2 Diabetes Mellitus in Hungary (Part 1)"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-3313","authenticated-orcid":false,"given":"Zsolt","family":"Abonyi-T\u00f3th","sequence":"first","affiliation":[{"name":"RxTarget Ltd., 5000 Szolnok, Hungary"},{"name":"Department of Biostatistics, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0568-001X","authenticated-orcid":false,"given":"Gy\u00f6rgy","family":"Rokszin","sequence":"additional","affiliation":[{"name":"RxTarget Ltd., 5000 Szolnok, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibolya","family":"F\u00e1bi\u00e1n","sequence":"additional","affiliation":[{"name":"RxTarget Ltd., 5000 Szolnok, Hungary"},{"name":"Department of Biostatistics, University of Veterinary Medicine, 1078 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Kiss","sequence":"additional","affiliation":[{"name":"Second Department of Medicine and Nephrology-Diabetes Centre, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Jermendy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bajcsy-Zsilinszky Hospital, 1106 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Kempler","sequence":"additional","affiliation":[{"name":"Department of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Lengyel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Szeged, 6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-5733","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Second Department of Medicine and Nephrology-Diabetes Centre, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-5907","authenticated-orcid":false,"given":"Gerg\u0151 A.","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Second Department of Medicine and Nephrology-Diabetes Centre, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"S\u00fct\u0151","sequence":"additional","affiliation":[{"name":"Second Department of Medicine and Nephrology-Diabetes Centre, University of P\u00e9cs Medical School, 7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1573399812666151016101622","article-title":"Chronic Complications of Diabetes Mellitus: A Mini Review","volume":"13","author":"Lotfy","year":"2015","journal-title":"Curr. 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