{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:40:07Z","timestamp":1785883207663,"version":"3.56.0"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Karl Landsteiner University of Health Sciences, Krems, Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Pleural mesothelioma (PM), linked to asbestos-induced inflammation, carries a poor prognosis. Therapy ranges from therapy limitation to aggressive multimodality treatment. Given the uncertainty about treatment benefits for patients, this study aimed to assess the role of Ki67 as a prognostic and predictive parameter in PM. Ki67 was measured in the specimens of 70 PM patients (17 female, 53 male) from two centers and correlated to overall survival (OS) and therapy outcome. The median OS was 16.1 months. The level of Ki67 expression was divided into low (\u226415%) and high (&gt;15%). A low value of Ki67 expression was associated with a longer OS (Ki67 \u2264 15%: 31.2 (95% CI 6.5\u201355.8) months vs. Ki67 &gt; 15%: 11.1 (95% CI 7.7\u201314.6) months, p = 0.012). The 5-year survival represents 22% in the low Ki67 expression group, in contrast to 5% in the high Ki67 expression group. We found a significant interaction term of Ki67 with multimodality treatment (p = 0.031) translating to an OS of 48.1 months in the low expression Ki67 group compared to 24.3 months in the high Ki67 expression group when receiving surgery within multimodality therapy. Therefore, Ki67 stands out as a validated prognostic and, most importantly, novel predictive biomarker for treatment benefits, particularly regarding surgery within multimodality therapy.<\/jats:p>","DOI":"10.3390\/cancers16101817","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T03:21:04Z","timestamp":1715311264000},"page":"1817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ki67 Tumor Expression Predicts Treatment Benefit Achieved by Macroscopic Radical Lung-Preserving Surgery in Pleural Mesothelioma\u2014A Retrospective Multicenter Analysis"],"prefix":"10.3390","volume":"16","author":[{"given":"Sarah","family":"Hintermair","sequence":"first","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Department of General and Thoracic Surgery, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Iser","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Varga","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Biesinger","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Department of General and Thoracic Surgery, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Bohanes","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Department of General and Thoracic Surgery, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5402-9031","authenticated-orcid":false,"given":"Muhammet","family":"Sayan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykut","family":"Kanko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2644-4609","authenticated-orcid":false,"given":"Nalan","family":"Akyurek","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"\u00d6\u011f\u00fct","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Gazi University, Besevler, Ankara 06500, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Stubenberger","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Department of General and Thoracic Surgery, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6563-5643","authenticated-orcid":false,"given":"Bahil","family":"Ghanim","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Department of General and Thoracic Surgery, University Hospital Krems, Karl Landsteiner University of Health Sciences, Mitterweg 10, 3500 Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1186\/s13014-015-0575-5","article-title":"Long-term results in malignant pleural mesothelioma 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