{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:05:14Z","timestamp":1760144714324,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agence R\u00e9gionale de la Sant\u00e9 de Guyane"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>French Guiana is a French territory in South America. The exposome of persons living there is quite different from that in mainland France and the ethnic make-up of the population is also quite different. Poverty is also widespread with difficulties in accessing care magnified by the low medical-professional density. In this singular context, we aimed to measure the incidence of pediatric cancers and to compare it with other continents. We used French Guiana\u2019s certified cancer registry to study this between 2003 and 2017. Incidences were standardized using the world population with three strata: 0\u20134 years, 5\u20139 years, and 10\u201314 years. There were 164 solid tumors or hematologic malignancies diagnosed in children under the age of 15 (92 in boys and 72 in girls). Over the study period, the standardized incidence rate was 14.1 per 100,000 among children aged under 15 years. There was no significant trend during the study period. The three most common causes of cancer were leukemias\u2014mostly lymphoblastic\u2014CNS tumors, and sarcoma. The standardized incidence of pediatric cancers in French Guiana was similar to those in Western Europe and North America. As others have discovered, we found that males tended to be more likely to develop cancer, notably leukemia, CNS tumors, sarcoma, and retinoblastoma. As elsewhere, the predominant cancer types changed with age. Our initial assumption was that given the singular context of French Guiana, there may have been differences in pediatric cancer incidences. Here we showed that overall, contrary to our assumption and to trends in tropical countries, the incidence of pediatric cancers was in a range between Western Europe and North America with some apparent but non-significant differences in the main types of cancers observed in global statistics. Quality cancer registry data in this tropical region confirm the suspicion that lower incidences in tropical low- and middle-income countries are likely to result from incomplete diagnosis and data collection.<\/jats:p>","DOI":"10.3390\/cancers16101829","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:33:03Z","timestamp":1715589183000},"page":"1829","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Pediatric Cancers in French Guiana: How Does It Compare to Global Estimates?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-3204","authenticated-orcid":false,"given":"Mathieu","family":"Nacher","sequence":"first","affiliation":[{"name":"Centre d\u2019Investigation Clinique (INSERM 1424), Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiannan","family":"Wang","sequence":"additional","affiliation":[{"name":"Registre des Cancers de Guyane, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Osei","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Faivre","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcisse","family":"Elenga","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"},{"name":"Service de P\u00e9diatrie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-4981","authenticated-orcid":false,"given":"Antoine","family":"Adenis","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique (INSERM 1424), Institut Sant\u00e9 des Populations en Amazonie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"Universit\u00e9 de Guyane, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6202-5762","authenticated-orcid":false,"given":"Nathalie","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Service de Neurologie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-2627","authenticated-orcid":false,"given":"Kinan","family":"Drak Alsibai","sequence":"additional","affiliation":[{"name":"Registre des Cancers de Guyane, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"Service d\u2019Anatomo-Pathologie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"},{"name":"Centre de Ressources Biologiques Amazonie, Centre Hospitalier de Cayenne, 97300 Cayenne, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International Incidence of Childhood Cancer, 2001\u20132010: A Population-Based Registry Study","volume":"18","author":"Colombet","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ctrv.2010.02.003","article-title":"Epidemiology of Childhood Cancer","volume":"36","author":"Kaatsch","year":"2010","journal-title":"Cancer Treat. 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