{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:03:36Z","timestamp":1788476616045,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"DOR 2023 (University of Padova)"},{"name":"BIRD 2021 (University of Padova)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Sinonasal intestinal-type adenocarcinoma (ITAC) is a very rare, closely occupational-related tumor with strong histological similarities to colorectal cancer (CRC). In the latter, tumor budding (TB) is widely recognized as a negative prognostic parameter. The aim of this study was to evaluate the prognostic role of TB in ITAC and to correlate it with other established or emerging biomarkers of the disease, such as p53 and deficient DNA mismatch repair (MMR) system status\/microsatellite instability (MSI). We retrospectively analyzed 32 consecutive specimens of patients with ITAC diagnosis treated in two institutions in Northern Italy. We reviewed surgical specimens for TB evaluation (low-intermediate\/high); p53 expression and MMR proteins were evaluated via immunohistochemistry. Results were retrospectively stratified using clinical data and patients\u2019 outcomes. According to bud counts, patients were stratified into two groups: intermediate\/high budding (&gt;4 TB) and low budding (\u22644 TB). Patients with high TB (&gt;4) have an increased risk of recurrence and death compared to those with low TB, with a median survival of 13 and 54 months, respectively. On multivariate analysis, considering TB, therapy, and stage as covariates, TB emerged as an independent prognostic factor net of the stage of disease or type of therapy received. No impact of p53 status as a biomarker of prognosis was observed and no alterations regarding MMR proteins were identified. The results of the present work provide further significant evidence on the prognostic role of TB in ITAC and underline the need for larger multicenter studies to implement the use of TB in clinical practice.<\/jats:p>","DOI":"10.3390\/cancers16101895","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T06:44:31Z","timestamp":1715841871000},"page":"1895","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tumor Budding, p53, and DNA Mismatch Repair Markers in Sinonasal Intestinal-Type Adenocarcinoma: A Retrospective Study Supports the Adverse Prognostic Impact of Tumor Budding"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-1568","authenticated-orcid":false,"given":"Sebastiano","family":"Puccio","sequence":"first","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neuroscience, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d University of Padova, via Giustiniani, 2, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Azzarello","sequence":"additional","affiliation":[{"name":"Department of Oncology, Local Health Unit 3 Serenissima, Via don Giacobbe Sartor 4, 30035 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-3724","authenticated-orcid":false,"given":"Valeria","family":"Maffeis","sequence":"additional","affiliation":[{"name":"Anatomia Patologica, Azienda Ospedaliera Universitaria Integrata Verona (AOVR), Ospedale Borgo Trento, Piazzale Aristide Stefani, 1, 37126 Verona, Italy"},{"name":"Department of Pathology, Local Health Unit 2 Marca Trevigiana, Piazzale dell\u2019Ospedale 1, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Laurino","sequence":"additional","affiliation":[{"name":"Department of Pathology, Local Health Unit 3 Serenissima, Via Paccagnella 11, 30174 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mairani","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neuroscience, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d University of Padova, via Giustiniani, 2, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-1075","authenticated-orcid":false,"given":"Federica","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Milano-Bicocca, 20126 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Tessari","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neuroscience, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d University of Padova, via Giustiniani, 2, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-7469","authenticated-orcid":false,"given":"Diego","family":"Cazzador","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neuroscience, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d University of Padova, via Giustiniani, 2, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zanoletti","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neuroscience, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d University of Padova, via Giustiniani, 2, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doriano","family":"Politi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Local Health Unit 3 Serenissima, Via Paccagnella, 11, 30174 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Emanuelli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Local Health Unit 2 Marca Trevigiana, Piazzale dell\u2019Ospedale 1, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-5077","authenticated-orcid":false,"given":"Giacomo","family":"Spinato","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neuroscience, \u201cAzienda Ospedale Universit\u00e0 di Padova\u201d University of Padova, via Giustiniani, 2, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-9364","authenticated-orcid":false,"given":"Simonetta","family":"Ausoni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova, Via Ugo Bassi 58b, 35121 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11912-021-01154-3","article-title":"Molecular Biomarkers in Sinonasal Cancers: New Frontiers in Diagnosis and Treatment","volume":"24","author":"Gravante","year":"2022","journal-title":"Curr. 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