{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:00:58Z","timestamp":1790402458549,"version":"4.1.0"},"reference-count":80,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access Publishing Fund of Philipps-Universit\u00e4t Marburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Despite its broad use in cranial and spinal surgery, navigation support and microscope-based augmented reality (AR) have not yet found their way into posterior fossa surgery in the sitting position. While this position offers surgical benefits, navigation accuracy and thereof the use of navigation itself seems limited. Intraoperative ultrasound (iUS) can be applied at any time during surgery, delivering real-time images that can be used for accuracy verification and navigation updates. Within this study, its applicability in the sitting position was assessed. Data from 15 patients with lesions within the posterior fossa who underwent magnetic resonance imaging (MRI)-based navigation-supported surgery in the sitting position were retrospectively analyzed using the standard reference array and new rigid image-based MRI-iUS co-registration. The navigation accuracy was evaluated based on the spatial overlap of the outlined lesions and the distance between the corresponding landmarks in both data sets, respectively. Image-based co-registration significantly improved (p &lt; 0.001) the spatial overlap of the outlined lesion (0.42 \u00b1 0.30 vs. 0.65 \u00b1 0.23) and significantly reduced (p &lt; 0.001) the distance between the corresponding landmarks (8.69 \u00b1 6.23 mm vs. 3.19 \u00b1 2.73 mm), allowing for the sufficient use of navigation and AR support. Navigated iUS can therefore serve as an easy-to-use tool to enable navigation support for posterior fossa surgery in the sitting position.<\/jats:p>","DOI":"10.3390\/cancers16111985","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T11:37:13Z","timestamp":1716464233000},"page":"1985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Enabling Navigation and Augmented Reality in the Sitting Position in Posterior Fossa Surgery Using Intraoperative Ultrasound"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1574-7572","authenticated-orcid":false,"given":"Miriam H. A.","family":"Bopp","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"},{"name":"Center for Mind, Brain and Behavior (CMBB), 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6545-0622","authenticated-orcid":false,"given":"Alexander","family":"Grote","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Gjorgjevski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6123-5589","authenticated-orcid":false,"given":"Mirza","family":"Pojskic","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-3443","authenticated-orcid":false,"given":"Benjamin","family":"Sa\u00df","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-9410","authenticated-orcid":false,"given":"Christopher","family":"Nimsky","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany"},{"name":"Center for Mind, Brain and Behavior (CMBB), 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/2019.8.FOCUS19621","article-title":"Reliable navigation registration in cranial and spine surgery based on intraoperative computed tomography","volume":"47","author":"Carl","year":"2019","journal-title":"Neurosurg. 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