{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:59:30Z","timestamp":1785164370734,"version":"3.55.0"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007707","name":"Istituto Nazionale per l\u2019Assicurazione Contro gli Infortuni sul Lavoro","doi-asserted-by":"publisher","award":["PB-0162"],"award-info":[{"award-number":["PB-0162"]}],"id":[{"id":"10.13039\/501100007707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Although rare, sinonasal cancers (SNCs) have a high occupational attributable fraction. Methods: We applied gender-based approaches to descriptive analyses, incidence, and patterns of exposures using the Italian National Sinonasal Cancer Registry (ReNaTuNS: Registro Nazionale Tumori Naso-Sinusali). Results: The study included 2851 SNC patients. SNC was diagnosed more often in men (73%) than in women (27%). The most frequent morphology in men was intestinal-type adenocarcinoma (33%), whereas in women, it was squamous cell carcinoma (49%). Nasal cavities were predominant in both genders (50%), ethmoidal sinus in men (24%), and maxillary in women (24%). Incidence rates were 0.76 (per 100,000 person-years) in men and 0.24 in women and increased by age, more evidently in men, peaking over 75 years in both. Occupational exposures to wood and leather dusts were the most frequent (41% for men, 33% for women). Few exposures were extra-occupational or domestic. Unlikely exposure was relevant in women (57%). Conclusions: The surveillance of SNC cases through a registry that allows for the identification of and compensation for this occupational disease is important in Italy, where numerous workers are exposed to carcinogens for SNC, without even being aware. Considering the rarity of the disease, particularly among women, the ReNaTuNS can provide a method to analyze gender differences.<\/jats:p>","DOI":"10.3390\/cancers16112053","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T06:58:07Z","timestamp":1716965887000},"page":"2053","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gender Differences in Sinonasal Cancer Incidence: Data from the Italian Registry"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-600X","authenticated-orcid":false,"given":"Alessandra","family":"Binazzi","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology, Hygiene, National Institute for Insurance against Accidents at Work (INAIL), 00100 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"di Marzio","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology, Hygiene, National Institute for Insurance against Accidents at Work (INAIL), 00100 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-3684","authenticated-orcid":false,"given":"Carolina","family":"Mensi","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Lombardy, Epidemiology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20100 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-3843","authenticated-orcid":false,"given":"Dario","family":"Consonni","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Lombardy, Epidemiology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20100 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Miligi","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Prevention and Clinical Network (ISPRO) Foundation, 50139 Firenze, Italy"},{"name":"Sinonasal Cancer Registry of Tuscany, Occupational and Environmental Epidemiology Unit, (ISPRO), 50139 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-7035","authenticated-orcid":false,"given":"Sara","family":"Piro","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Tuscany, Occupational and Environmental Epidemiology Unit, (ISPRO), 50139 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7247-4174","authenticated-orcid":false,"given":"Jana","family":"Zajacov\u00e0","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Piedmont, Occupational Health and Safety Department, CN1 Local Health Authority, 12037 Saluzzo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Sorasio","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Piedmont, Occupational Health and Safety Department, CN1 Local Health Authority, 12037 Saluzzo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Galli","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Emilia Romagna, Occupational Safety and Prevention Unit, Public Health Department, Bologna Local Health Authority, 40121 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Camagni","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Emilia Romagna, Occupational Safety and Prevention Unit, Public Health Department, Bologna Local Health Authority, 40121 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Calisti","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Marche, Unit of Workplace Prevention and Safety and of Occupational Epidemiology (SPreSAL Epi Occ), Department of Prevention, Macerata Health Authority, 62012 Civitanova Marche, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Massacesi","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Marche, Unit of Workplace Prevention and Safety and of Occupational Epidemiology (SPreSAL Epi Occ), Department of Prevention, Macerata Health Authority, 62012 Civitanova Marche, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-9799","authenticated-orcid":false,"given":"Ilaria","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Lazio, Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, 00147 Roma, Italy"},{"name":"Laboratory of Industrial Hygiene, Department of Prevention, CRRA ASL Lazio, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Balestri","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Lazio, Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1, 00147 Roma, Italy"},{"name":"Laboratory of Industrial Hygiene, Department of Prevention, CRRA ASL Lazio, 01100 Viterbo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Murano","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Autonomous Province of Bolzano, Alto Adige Health Authority, Occupational Medicine Unit, 39100 Bolzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-3398","authenticated-orcid":false,"given":"Ugo","family":"Fedeli","sequence":"additional","affiliation":[{"name":"Azienda Zero, Epidemiological Department, Veneto Region, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Comiati","sequence":"additional","affiliation":[{"name":"Azienda Zero, Epidemiological Department, Veneto Region, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Eccher","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Autonomous Province of Trento, Hygiene and Occupational Medicine, Provincial Unit of Health, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lattanzio","sequence":"additional","affiliation":[{"name":"Sinonasal Cancer Registry of Autonomous Province of Trento, Hygiene and Occupational Medicine, Provincial Unit of Health, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9068-2137","authenticated-orcid":false,"given":"Alessandro","family":"Marinaccio","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Epidemiology, Hygiene, National Institute for Insurance against Accidents at Work (INAIL), 00100 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ReNaTuNS Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"ref_1","unstructured":"International Agency for Research on Cancer (IARC) (2023). 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