{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:05:39Z","timestamp":1788001539238,"version":"build-2784847793"},"reference-count":68,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cutaneous malignant melanoma is one of the most common neoplasms among pregnancy-associated cancers (PACs). Risk factors include excessive exposure to ultraviolet radiation, the presence of benign and dysplastic nevi, and a patient or family history of melanoma. Self-examination and careful inspection of nevi are crucial, especially in the context of their progression over time. Physiological changes that occur during pregnancy, such as the darkening and enlargement of the nevi, delay the diagnosis of CMM. In the fetus, metastases are very rare, and if they do occur, they concern the placenta or fetal tissues. The choice of treatment is influenced by the cancer stage, symptoms, the time of termination of pregnancy, and the patient\u2019s decision. Essential procedures which are safe for the fetus are diagnostic biopsy, ultrasound, and the therapeutic excision of the lesion and the affected lymph nodes. Other imaging methods can be used with a safe radiation dose limit of 100 mGy. Immunotherapy and targeted treatments must be carefully considered, because of their possible adverse effects on the fetus. An interdisciplinary approach to the problem of melanoma during pregnancy is necessary, involving doctors of various specialties.<\/jats:p>","DOI":"10.3390\/cancers16122173","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T10:43:42Z","timestamp":1717757022000},"page":"2173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melanoma in Pregnancy\u2014Diagnosis, Treatment, and Consequences for Fetal Development and the Maintenance of Pregnancy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9532-6972","authenticated-orcid":false,"given":"Patrycja","family":"Pelczar","sequence":"first","affiliation":[{"name":"Student Scientific Society of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7021-4466","authenticated-orcid":false,"given":"Pola","family":"Kosteczko","sequence":"additional","affiliation":[{"name":"Student Scientific Society of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3763-0384","authenticated-orcid":false,"given":"Ewelina","family":"Wieczorek","sequence":"additional","affiliation":[{"name":"Student Scientific Society of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1055-8763","authenticated-orcid":false,"given":"Maciej","family":"Kwieci\u0144ski","sequence":"additional","affiliation":[{"name":"Student Scientific Society of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Koz\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Medical University of Lublin, 13 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-981X","authenticated-orcid":false,"given":"Paulina","family":"Gil-Kulik","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"ref_1","first-page":"e15087","article-title":"A Review of Epidemiology and Cancer Biology of Malignant Melanoma","volume":"13","author":"Davey","year":"2021","journal-title":"Cureus"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Saginala, K., Barsouk, A., Aluru, J.S., Rawla, P., and Barsouk, A. (2021). Epidemiology of Melanoma. Med. Sci., 9.","DOI":"10.3390\/medsci9040063"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"adv00136","DOI":"10.2340\/00015555-3491","article-title":"Melanoma Epidemiology and Sun Exposure","volume":"100","author":"Raimondi","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Strashilov, S., and Yordanov, A. (2021). Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126395"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Yuan, T.A., Lu, Y., Edwards, K., Jakowatz, J., Meyskens, F.L., and Liu-Smith, F. (2019). Race-, Age-, and Anatomic Site-Specific Gender Differences in Cutaneous Melanoma Suggest Differential Mechanisms of Early- and Late-Onset Melanoma. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16060908"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/bjd.15510","article-title":"The global burden of melanoma: Results from the Global Burden of Disease Study 2015","volume":"177","author":"Karimkhani","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1002\/cncr.29325","article-title":"Cancer during pregnancy and the postpartum period: A population-based study","volume":"121","author":"Andersson","year":"2015","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11912-020-0862-7","article-title":"Pregnancy and Cancer: The INCIP Project","volume":"22","author":"Maggen","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/jdv.12972","article-title":"Increased mortality for pregnancy-associated melanoma: Systematic review and meta-analysis","volume":"29","author":"Byrom","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.jaad.2015.11.014","article-title":"Risk factors and outcomes of cutaneous melanoma in women less than 50 years of age","volume":"74","author":"Tellez","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/cncr.20925","article-title":"Malignant melanoma in pregnancy. A population-based evaluation","volume":"103","author":"Cress","year":"2005","journal-title":"Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jaad.2014.09.018","article-title":"Mortality in women with pregnancy-associated malignant melanoma","volume":"71","author":"Johansson","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jamcollsurg.2017.02.011","article-title":"Is Pregnancy-Associated Melanoma Associated with Adverse Outcomes?","volume":"225","author":"Jones","year":"2017","journal-title":"J. Am. Coll. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejca.2022.02.016","article-title":"Melanoma in pregnancy: Diagnosis and management in early-stage and advanced disease","volume":"166","author":"Carter","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4103\/2249-4863.148099","article-title":"Pregnancy and skin","volume":"3","author":"Vora","year":"2014","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/ajo.12279","article-title":"Incidence and outcomes of pregnancy-associated melanoma in New South Wales 1994\u20132008","volume":"55","author":"Roberts","year":"2015","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.ajpath.2010.12.044","article-title":"Pregnancy promotes melanoma metastasis through enhanced lymphangiogenesis","volume":"178","author":"Khosrotehrani","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/modpathol.3800410","article-title":"Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes","volume":"18","author":"Dadras","year":"2005","journal-title":"Mod. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/ijgc-2020-001776","article-title":"Management of pregnancy in women with cancer","volume":"31","author":"Wolters","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"E6566","DOI":"10.1073\/pnas.1701129114","article-title":"Embryo implantation evolved from an ancestral inflammatory attachment reaction","volume":"114","author":"Griffith","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Costanzo, V., Bardelli, A., Siena, S., and Abrignani, S. (2018). Exploring the links between cancer and placenta development. Open Biol., 8.","DOI":"10.1098\/rsob.180081"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/1753495X17695001","article-title":"Melanoma in pregnancy","volume":"10","author":"Still","year":"2017","journal-title":"Obstet. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"15953","DOI":"10.18632\/oncotarget.3643","article-title":"Pregnancy associated plasma protein\u2014A links pregnancy and melanoma progression by promoting cellular migration and invasion","volume":"6","author":"Prithviraj","year":"2015","journal-title":"Oncotarget"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijwd.2017.11.006","article-title":"Pregnancy and Melanoma: Recommendations for Clinical Scenarios","volume":"4","author":"Liebman","year":"2018","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.31128\/AJGP-04-19-48952","article-title":"Management of pigmented skin lesions during pregnancy","volume":"48","author":"Friedman","year":"2019","journal-title":"Aust. J. Gen. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1001\/archdermatol.2009.115","article-title":"Using dermoscopic criteria and patient-related factors for the management of pigmented melanocytic nevi","volume":"145","author":"Zalaudek","year":"2009","journal-title":"Arch. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"727319","DOI":"10.3389\/fmed.2021.727319","article-title":"Dermatoscopic Features of Naevi during Pregnancy\u2014A Mini Review","volume":"8","author":"Cosgarea","year":"2021","journal-title":"Front. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/14737140.2018.1489246","article-title":"The eighth edition American Joint Committee on Cancer (AJCC) melanoma staging system: Implications for melanoma treatment and care","volume":"18","author":"Keung","year":"2018","journal-title":"Expert. Rev. Anticancer Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1590\/abd1806-4841.20132359","article-title":"Melanoma developed during pregnancy\u2014A case report","volume":"89","author":"Mestnik","year":"2014","journal-title":"Bras. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e2023059","DOI":"10.5826\/dpc.1301a59","article-title":"Diving Into the Blue: A Case of Melanoma Arising in a Giant Congenital Blue Nevus during Pregnancy","volume":"13","author":"Curti","year":"2023","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijwd.2016.12.004","article-title":"Prognosis for women diagnosed with melanoma during, before, or after pregnancy: Weighing the evidence","volume":"3","author":"Todd","year":"2017","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_32","first-page":"186","article-title":"Malignant melanoma arising in an in vitro fertilisation pregnancy: A case report","volume":"14","author":"Pabuccu","year":"2013","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"vi160","DOI":"10.1093\/annonc\/mdt199","article-title":"Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Peccatori","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.det.2019.03.002","article-title":"Cutaneous Surgery in Patients Who Are Pregnant or Breastfeeding","volume":"37","author":"Li","year":"2019","journal-title":"Dermatol. Clin."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"MMT48","DOI":"10.2217\/mmt-2020-0007","article-title":"Melanoma in pregnancy: Certainties unborn","volume":"7","author":"Zelin","year":"2020","journal-title":"Melanoma Manag."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s43055-020-00276-1","article-title":"PET\/CT in restaging, prognosis, and recurrence in patients with malignant melanoma","volume":"51","author":"Mashaly","year":"2020","journal-title":"Egypt. J. Radiol. Nucl. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ygyno.2020.03.015","article-title":"Gynecologic cancer in pregnancy","volume":"157","author":"Korenaga","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jare.2016.01.004","article-title":"A mini review on pregnant mothers with cancer: A paradoxical coexistence","volume":"7","author":"Mitrou","year":"2016","journal-title":"J. Adv. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1001\/jama.2016.12126","article-title":"Association between MRI Exposure during Pregnancy and Fetal and Childhood Outcomes","volume":"316","author":"Ray","year":"2016","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"rju103","DOI":"10.1093\/jscr\/rju103","article-title":"Videoscopic inguinal lymphadenectomy in malignant melanoma: Safe in pregnancy?","volume":"2014","author":"Davis","year":"2014","journal-title":"J. Surg. Case Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2340\/00015555-0227","article-title":"Spectrophotometric analysis of melanocytic naevi during pregnancy","volume":"87","author":"Wyon","year":"2007","journal-title":"Acta Derm. Venereol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bpobgyn.2015.10.005","article-title":"Difficulties with diagnosis of malignancies in pregnancy","volume":"33","author":"Vandecaveye","year":"2016","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(23)00821-8","article-title":"Cutaneous melanoma","volume":"402","author":"Long","year":"2023","journal-title":"Lancet"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.ejca.2009.10.032","article-title":"Diagnosis and treatment of melanoma: European consensus-based interdisciplinary guideline","volume":"46","author":"Garbe","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1007\/s00261-022-03796-8","article-title":"Melanoma in pregnancy","volume":"48","author":"Kluger","year":"2023","journal-title":"Abdom. Radiol."},{"key":"ref_46","first-page":"e1275","article-title":"Lidocaine-Induced Systemic Toxicity: A Case Report and Review of Literature","volume":"9","author":"Hasan","year":"2017","journal-title":"Cureus"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"401.e1","DOI":"10.1016\/j.jaad.2013.09.010","article-title":"Safety of dermatologic medications in pregnancy and lactation: Part, I. Pregnancy","volume":"70","author":"Murase","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.det.2022.07.017","article-title":"Melanoma classification and management in the era of molecular medicine","volume":"41","author":"Rashid","year":"2023","journal-title":"Dermatol. Clin."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"710","DOI":"10.4103\/ija.IJA_463_18","article-title":"Anaesthesia for non-obstetric surgery in obstetric patients","volume":"62","author":"Ravindra","year":"2018","journal-title":"Indian J. Anaesth."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-3-030-41596-9_14","article-title":"Aspects of Anesthesia for Breast Surgery during Pregnancy","volume":"1252","author":"Eskandari","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"i72","DOI":"10.1093\/bja\/aer343","article-title":"Anaesthetic considerations for non-obstetric surgery during pregnancy","volume":"107","author":"Reitman","year":"2011","journal-title":"Br. J. Anaesth."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1007\/s00261-023-03861-w","article-title":"Effects of ionizing radiation exposure during pregnancy","volume":"48","author":"Mainprize","year":"2023","journal-title":"Abdom. Radiol."},{"key":"ref_53","unstructured":"(2024, May 02). American College of Radiology ACR-SPR Practice Parameterfor Imaging Pregnant or Potentially Pregnant Patients with Ionizing Radiation, Revised 2023 (Resolution 31). Available online: https:\/\/www.acr.org."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"S522","DOI":"10.1088\/1361-6498\/ac1c95","article-title":"Radiation exposures in pregnancy, health effects and risks to the embryo\/foetus\u2014Information to inform the medical management of the pregnant patient","volume":"41","author":"Applegate","year":"2021","journal-title":"J. Radiol. Prot."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.canrad.2021.09.001","article-title":"Radiotherapy and pregnancy","volume":"26","author":"Michalet","year":"2022","journal-title":"Cancer Radiother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1148\/rg.220005","article-title":"Imaging Cancer in Pregnancy","volume":"42","author":"Jha","year":"2022","journal-title":"Radiographics"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Nomeda, R.V., Varyte, G., Zakarevi\u010dien\u0117, J., Kontrimavi\u010di\u016bt\u0117, E., Rama\u0161auskait\u0117, D., and Rutkauskait\u0117-Valan\u010dien\u0117, D. (2019). Use of Magnetic Resonance Imaging in Evaluating Fetal Brain and Abdomen Malformations during Pregnancy. Medicina, 55.","DOI":"10.3390\/medicina55020055"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00117-023-01207-7","article-title":"Safety of Magnetic Resonance Imaging in Pregnancy","volume":"63","author":"Pejman","year":"2023","journal-title":"Radiologie"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/eji.201948382","article-title":"Immune checkpoint molecules in pregnancy: Focus on regulatory T cells","volume":"50","author":"Zhang","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/CMR.0000000000000586","article-title":"Pregnancy with successful foetal and maternal outcome in a melanoma patient treated with nivolumab in the first trimester: Case report and review of the literature","volume":"29","author":"Xu","year":"2019","journal-title":"Melanoma Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/CMR.0000000000000657","article-title":"Conception and viable twin pregnancy in a patient with metastatic melanoma while treated with CTLA-4 and PD-1 checkpoint inhibition","volume":"30","author":"Bucheit","year":"2020","journal-title":"Melanoma Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"100248","DOI":"10.1016\/j.esmoop.2021.100248","article-title":"Fertility preservation and management of pregnancy in melanoma patients requiring systemic therapy","volume":"6","author":"Hassel","year":"2021","journal-title":"ESMO Open"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e00142","DOI":"10.1016\/j.crwh.2019.e00142","article-title":"Treatment of metastatic malignant melanoma during pregnancy with a BRAF kinase inhibitor: A case report","volume":"24","author":"Pagan","year":"2019","journal-title":"Case Rep. Women\u2019s Health"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/ajd.12568","article-title":"Melanoma and pregnancy","volume":"58","author":"Morton","year":"2017","journal-title":"Australas. J. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/ijc.30914","article-title":"The risk of preterm birth and growth restriction in pregnancy after cancer","volume":"141","author":"Hartnett","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/jwh.2018.6962","article-title":"Pregnancy-Associated Cancer: A U.S. Population-Based Study","volume":"28","author":"Cottreau","year":"2002","journal-title":"J. Women\u2019s Health"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"100005","DOI":"10.1016\/j.ejcskn.2023.100005","article-title":"CLAUDIUS Study: Risk of materno-fetal transmission of melanoma cells in pregnant women with high grade melanoma\u2014A retrospective multicenter study and literature review","volume":"1","author":"Wiedemann","year":"2023","journal-title":"EJC Ski. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1200\/JCO.2003.12.149","article-title":"Metastatic melanoma in pregnancy: Risk of transplacental metastases in the infant","volume":"21","author":"Alexander","year":"2003","journal-title":"J. Clin. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/12\/2173\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:55:33Z","timestamp":1760108133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/12\/2173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,7]]},"references-count":68,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["cancers16122173"],"URL":"https:\/\/doi.org\/10.3390\/cancers16122173","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,7]]}}}