{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:14:11Z","timestamp":1791659651214,"version":"4.3.4"},"reference-count":59,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Conventional ultrasonography (US), including greyscale imaging and colour Doppler US (CDUS), is pivotal for diagnosing scrotal pathologies, but it has limited specificity. Historically, solid focal testicular abnormalities often led to radical orchidectomy. This retrospective study evaluated the utilisation of contrast-enhanced ultrasound (CEUS) and strain elastography (SE) in investigating intratesticular focal abnormalities. A total of 124 cases were analysed. This study underscored the superior diagnostic capabilities of CEUS in detecting vascular enhancement in all malignant cases, even those with undetectable vascularity by CDUS. It also highlighted the potential of CEUS in identifying distinctive vascular patterns in benign vascular tumours. Definitive confirmation of benignity could be obtained when the absence of enhancement was demonstrated on CEUS. While SE alone offered no distinctive advantage in differentiating between benign and malignant pathologies, we demonstrated that incorporating a combination of CEUS and SE into the evaluation of focal testicular abnormalities could improve diagnostic performance metrics over conventional CDUS. Our findings underscore the role of advanced ultrasound techniques in enhancing the evaluation of focal testicular abnormalities in clinical practice and could aid a shift towards testis-sparing management strategies.<\/jats:p>","DOI":"10.3390\/cancers16132309","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:16:18Z","timestamp":1719206178000},"page":"2309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multiparametric Ultrasound for Focal Testicular Pathology: A Ten-Year Retrospective Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-6723","authenticated-orcid":false,"given":"Dean Y.","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology, King\u2019s College Hospital, London SE5 9RS, UK"},{"name":"Department of Imaging Sciences, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed","family":"Alsadiq","sequence":"additional","affiliation":[{"name":"Department of Imaging, The Royal London Hospital, London E1 1FR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gibran T.","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, King\u2019s College Hospital, London SE5 9RS, UK"},{"name":"Department of Imaging Sciences, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-9604","authenticated-orcid":false,"given":"Annamaria","family":"Deganello","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, King\u2019s College Hospital, London SE5 9RS, UK"},{"name":"Department of Imaging Sciences, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Sellars","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, King\u2019s College Hospital, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-4077","authenticated-orcid":false,"given":"Paul S.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, King\u2019s College Hospital, London SE5 9RS, UK"},{"name":"Department of Imaging Sciences, School of Biomedical Engineering and Imaging Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110000","DOI":"10.1016\/j.ejrad.2021.110000","article-title":"Ultrasonography of the scrotum: Revisiting a classic technique","volume":"145","author":"Tsili","year":"2021","journal-title":"Eur. 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