{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:39:23Z","timestamp":1790959163321,"version":"4.1.0"},"reference-count":182,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["P30-CA076292"],"award-info":[{"award-number":["P30-CA076292"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["PA10192"],"award-info":[{"award-number":["PA10192"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["P30-CA076292"],"award-info":[{"award-number":["P30-CA076292"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["PA10192"],"award-info":[{"award-number":["PA10192"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Cancers"],"abstract":"<jats:p>For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with fat loss, decreased appetite, lower tolerance and poorer response to treatment, poor quality of life, and reduced survival. Unfortunately, there are no effective therapeutic interventions to completely reverse cancer cachexia and no FDA-approved pharmacologic agents; hence, new approaches are urgently needed. In May of 2022, researchers and clinicians from Moffitt Cancer Center held an inaugural retreat on CAC that aimed to review the state of the science, identify knowledge gaps and research priorities, and foster transdisciplinary collaborative research projects. This review summarizes research priorities that emerged from the retreat, examples of ongoing collaborations, and opportunities to move science forward. The highest priorities identified include the need to (1) evaluate patient-reported outcome (PRO) measures obtained in clinical practice and assess their use in improving CAC-related outcomes; (2) identify biomarkers (imaging, molecular, and\/or behavioral) and novel analytic approaches to accurately predict the early onset of CAC and its progression; and (3) develop and test interventions (pharmacologic, nutritional, exercise-based, and through mathematical modeling) to prevent CAC progression and improve associated symptoms and outcomes.<\/jats:p>","DOI":"10.3390\/cancers16132364","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T11:19:02Z","timestamp":1719487142000},"page":"2364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Defining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration"],"prefix":"10.3390","volume":"16","author":[{"given":"Margaret","family":"Park","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"},{"name":"Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-2603","authenticated-orcid":false,"given":"Christopher","family":"Whelan","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabeen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Machine Learning, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha","family":"Boeringer","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Evolution, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"},{"name":"Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-9810","authenticated-orcid":false,"given":"Sylvia","family":"Crowder","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-3876","authenticated-orcid":false,"given":"Kenneth","family":"Gage","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gregg","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Utah, Salt Lake City, UT 84113, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-3711","authenticated-orcid":false,"given":"Heather","family":"Jim","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-291X","authenticated-orcid":false,"given":"Andrew","family":"Judge","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-1244","authenticated-orcid":false,"given":"Tina","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Nursing Research, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Behavior, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Qayyum","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, H. 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Econ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: An international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of Cancer Cachexia: ASCO Guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1200\/JCO.23.01280","article-title":"Cancer Cachexia: ASCO Guideline Rapid Recommendation Update","volume":"41","author":"Roeland","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1200\/JOP.2016.016832","article-title":"Cancer Cachexia: Beyond Weight Loss","volume":"12","author":"Bruggeman","year":"2016","journal-title":"J. Oncol. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103965","DOI":"10.1016\/j.critrevonc.2023.103965","article-title":"Overcoming barriers to timely recognition and treatment of cancer cachexia: Sharing Progress in Cancer Care Task Force Position Paper and Call to Action","volume":"185","author":"Arends","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/jcsm.12910","article-title":"Addressing unmet needs for people with cancer cachexia: Recommendations from a multistakeholder workshop","volume":"13","author":"Garcia","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/SPC.0000000000000301","article-title":"Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia","volume":"11","author":"Dunne","year":"2017","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_10","first-page":"61","article-title":"Patient-Reported Outcomes (PROs) and Patient-Reported Outcome Measures (PROMs)","volume":"6","author":"Weldring","year":"2013","journal-title":"Health Serv Insights"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcsm.12911","article-title":"Cancer cachexia: The elephant in the room?","volume":"13","author":"Roeland","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.clon.2020.07.020","article-title":"Supportive Care: An Indispensable Component of Modern Oncology","volume":"32","author":"Berman","year":"2020","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1002\/1878-0261.13278","article-title":"Palliative oncology and palliative care","volume":"16","author":"Strang","year":"2022","journal-title":"Mol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13539-012-0099-x","article-title":"Nutrition impact symptoms in advanced cancer patients: Frequency and specific interventions, a case-control study","volume":"4","author":"Omlin","year":"2013","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_15","first-page":"3883","article-title":"Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) is a valid screening tool in chemotherapy outpatients","volume":"24","author":"Abbott","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/j.clnu.2018.06.974","article-title":"Assessing dietary intake in accordance with guidelines: Useful correlations with an ingesta-Verbal\/Visual Analogue Scale in medical oncology patients","volume":"38","author":"Flori","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Vagnildhaug, O.M., Brunelli, C., Hjermstad, M.J., Strasser, F., Baracos, V., Wilcock, A., Nabal, M., Kaasa, S., Laird, B., and Solheim, T.S. (2019). A prospective study examining cachexia predictors in patients with incurable cancer. BMC Palliat. Care, 18.","DOI":"10.1186\/s12904-019-0429-2"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.physbeh.2010.03.011","article-title":"Hypothalamic mechanisms in cachexia","volume":"100","author":"Grossberg","year":"2010","journal-title":"Physiol. Behav."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/01635581.2015.1073753","article-title":"An epidemiological survey of cachexia in advanced cancer patients and analysis on its diagnostic and treatment status","volume":"67","author":"Sun","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.21037\/jgo.2017.11.10","article-title":"Cachexia, and not obesity, prior to pancreatic cancer diagnosis worsens survival and is negated by chemotherapy","volume":"9","author":"Hendifar","year":"2018","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11605-008-0505-z","article-title":"Cachexia worsens prognosis in patients with resectable pancreatic cancer","volume":"12","author":"Bachmann","year":"2008","journal-title":"J. Gastrointest. Surg. Off. J. Soc. Surg. Aliment. Tract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.surg.2012.05.028","article-title":"Cachexia but not obesity worsens the postoperative outcome after pancreatoduodenectomy in pancreatic cancer","volume":"152","author":"Pausch","year":"2012","journal-title":"Surgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1017\/S0007114512001067","article-title":"Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: The relationship with diabetes and anaemia","volume":"109","author":"Yang","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/jcsm.12553","article-title":"Relationship between pancreatic cancer-associated diabetes and cachexia","volume":"11","author":"Liao","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1158\/1055-9965.EPI-19-0370","article-title":"Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer","volume":"28","author":"Babic","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-018-0235-7","article-title":"Altered exocrine function can drive adipose wasting in early pancreatic cancer","volume":"558","author":"Danai","year":"2018","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.clnu.2016.09.008","article-title":"Use of routinely available clinical, nutritional, and functional criteria to classify cachexia in advanced cancer patients","volume":"36","author":"Vigano","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Permuth, J.B., Dezsi, K.B., Vyas, S., Ali, K.N., Basinski, T.L., Utuama, O.A., Denbo, J.W., Klapman, J., Dam, A., and Carballido, E. (2021). The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer. Cancers, 13.","DOI":"10.3390\/cancers13040809"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/01635581.2013.755554","article-title":"Use of an abridged scored Patient-Generated Subjective Global Assessment (abPG-SGA) as a nutritional screening tool for cancer patients in an outpatient setting","volume":"65","author":"Gabrielson","year":"2013","journal-title":"Nutr. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jpainsymman.2010.04.020","article-title":"A multicenter study comparing two numerical versions of the Edmonton Symptom Assessment System in palliative care patients","volume":"41","author":"Watanabe","year":"2011","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0885-3924(98)00102-X","article-title":"A Canadian survey of cancer patients\u2019 experiences: Are their needs being met?","volume":"16","author":"Ashbury","year":"1998","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1017\/S1478951513000059","article-title":"What to do with screening for distress scores? Integrating descriptive data into clinical practice","volume":"12","author":"Blais","year":"2014","journal-title":"Palliat. Support. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1245\/ASO.2005.04.005","article-title":"Quality of life and functional long-term outcome after partial pancreatoduodenectomy: Pancreatogastrostomy versus pancreatojejunostomy","volume":"12","author":"Schmidt","year":"2005","journal-title":"Ann. Surg. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0959-8049(99)00047-7","article-title":"Development of a disease specific quality of life (QoL) questionnaire module to supplement the EORTC core cancer QoL questionnaire, the QLQ-C30 in patients with pancreatic cancer. EORTC Study Group on Quality of Life","volume":"35","author":"Fitzsimmons","year":"1999","journal-title":"Eur. J. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1572-0241.2005.40859.x","article-title":"Symptoms and quality of life in chronic pancreatitis assessed by structured interview and the EORTC QLQ-C30 and QLQ-PAN26","volume":"100","author":"Fitzsimmons","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Permuth, J.B., Park, M.A., Chen, D.T., Basinski, T.L., Powers, B.D., Gwede, C.K., Deszi, K.B., Gomez, M.F., Vyas, S., and Biachi de Castria, T. (2024). Leveraging Real World Data to Predict Cancer Cachexia Stage, Quality of Life, and Survival Ina Racially and Ethnically Diverse Multi-Institutional Cohort Oftreatment-Na\u00efve Patients with Pancreatic Ductal Adenocarcinoma, H. Lee Moffitt Cancer Center & Research Institute. Submitted, under review.","DOI":"10.3389\/fonc.2024.1362244"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1080\/01635581.2015.1004728","article-title":"Comparing two classifications of cancer cachexia and their association with survival in patients with unresected pancreatic cancer","volume":"67","author":"Hjermstad","year":"2015","journal-title":"Nutr. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1158\/1078-0432.CCR-23-0396","article-title":"Patient-Reported Outcomes as Interradiographic Predictors of Response in Non-Small Cell Lung Cancer","volume":"29","author":"Bhatt","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1200\/JOP.2015.010504","article-title":"Screening for Pancreatic Adenocarcinoma Using Signals From Web Search Logs: Feasibility Study and Results","volume":"12","author":"Paparrizos","year":"2016","journal-title":"J. Oncol. Pract."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"401.e1","DOI":"10.1016\/j.jtct.2022.05.015","article-title":"Change in Patients\u2019 Perceived Cognition Following Chimeric Antigen Receptor T-Cell Therapy for Lymphoma","volume":"28","author":"Barata","year":"2022","journal-title":"Transpl. Cell Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jval.2020.10.017","article-title":"Patient-Reported Outcomes as Independent Prognostic Factors for Survival in Oncology: Systematic Review and Meta-Analysis","volume":"24","author":"Efficace","year":"2021","journal-title":"Value Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e313","DOI":"10.1200\/JOP.19.00329","article-title":"Prognostic Significance of Patient-Reported Outcomes in Cancer","volume":"16","author":"Kerrigan","year":"2020","journal-title":"JCO Oncol. Pract."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e685","DOI":"10.1016\/S1470-2045(19)30656-4","article-title":"Prognostic value of patient-reported outcomes from international randomised clinical trials on cancer: A systematic review","volume":"20","author":"Mierzynska","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.radonc.2021.12.021","article-title":"Longitudinal patient-reported outcomes and survival among early-stage non-small cell lung cancer patients receiving stereotactic body radiotherapy","volume":"167","author":"Turner","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1001\/jamaoncol.2016.4911","article-title":"Evaluation of the Feasibility of Screening Patients for Early Signs of Lung Carcinoma in Web Search Logs","volume":"3","author":"White","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/jama.2018.18085","article-title":"Two-Year Survival Comparing Web-Based Symptom Monitoring vs Routine Surveillance Following Treatment for Lung Cancer","volume":"321","author":"Denis","year":"2019","journal-title":"JAMA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/annonc\/mdw211","article-title":"Relationship between efficacy outcomes and weight gain during treatment of advanced, non-squamous, non-small-cell lung cancer patients","volume":"27","author":"Patel","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/jcsm.13426","article-title":"The relationship between weight gain during chemotherapy and outcomes in patients with advanced non-small cell lung cancer","volume":"15","author":"Roeland","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"(2001). Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clin. Pharmacol. Ther., 69, 89\u201395.","DOI":"10.1067\/mcp.2001.113989"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.2147\/NDT.S114542","article-title":"Biomarkers for depression: Recent insights, current challenges and future prospects","volume":"13","author":"Strawbridge","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_51","first-page":"9","article-title":"Biomarkers-A General Review","volume":"76","author":"Aronson","year":"2017","journal-title":"Curr. Protoc. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sarhadi, V.K., and Armengol, G. (2022). Molecular Biomarkers in Cancer. Biomolecules, 12.","DOI":"10.3390\/biom12081021"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cao, Z., Zhao, K., Jose, I., Hoogenraad, N.J., and Osellame, L.D. (2021). Biomarkers for Cancer Cachexia: A Mini Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094501"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.clinbiochem.2017.07.011","article-title":"Biomarkers of cancer cachexia","volume":"50","author":"Loumaye","year":"2017","journal-title":"Clin. Biochem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jcsm.12360","article-title":"Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism","volume":"10","author":"Pin","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"O\u2019Connell, T.M., Golzarri-Arroyo, L., Pin, F., Barreto, R., Dickinson, S.L., Couch, M.E., and Bonetto, A. (2021). Metabolic Biomarkers for the Early Detection of Cancer Cachexia. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.720096"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Narasimhan, A., Zhong, X., Au, E.P., Ceppa, E.P., Nakeeb, A., House, M.G., Zyromski, N.J., Schmidt, C.M., Schloss, K.N.H., and Schloss, D.E.I. (2021). Profiling of Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways. Cancers, 13.","DOI":"10.20944\/preprints202103.0658.v1"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1002\/jcsm.12998","article-title":"Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: Role of Activin","volume":"13","author":"Zhong","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/jcsm.12188","article-title":"Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: A pilot study","volume":"8","author":"Ebhardt","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Miller, J., Alshehri, A., Ramage, M.I., Stephens, N.A., Mullen, A.B., Boyd, M., Ross, J.A., Wigmore, S.J., Watson, D.G., and Skipworth, R.J.E. (2019). Plasma Metabolomics Identifies Lipid and Amino Acid Markers of Weight Loss in Patients with Upper Gastrointestinal Cancer. Cancers, 11.","DOI":"10.3390\/cancers11101594"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jcsm.12270","article-title":"Multiplatform plasma fingerprinting in cancer cachexia: A pilot observational and translational study","volume":"9","author":"Cala","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13550-021-00834-2","article-title":"Imaging modalities for diagnosis and monitoring of cancer cachexia","volume":"11","author":"Han","year":"2021","journal-title":"EJNMMI Res."},{"key":"ref_63","first-page":"57","article-title":"Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art","volume":"42","author":"Engelke","year":"2023","journal-title":"J. Orthop. Transl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/j.gastro.2019.08.058","article-title":"Application of Artificial Intelligence to Gastroenterology and Hepatology","volume":"158","author":"Sandborn","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s10278-012-9488-0","article-title":"Body fat assessment method using CT images with separation mask algorithm","volume":"26","author":"Kim","year":"2013","journal-title":"J. Digit. Imaging"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1038\/s41598-017-08925-8","article-title":"Automated analysis of liver fat, muscle and adipose tissue distribution from CT suitable for large-scale studies","volume":"7","author":"Kullberg","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Parikh, A.M., Coletta, A.M., Yu, Z.H., Rauch, G.M., Cheung, J.P., Court, L.E., and Klopp, A.H. (2017). Development and validation of a rapid and robust method to determine visceral adipose tissue volume using computed tomography images. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183515"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1109\/TMI.2015.2479252","article-title":"Body Composition Assessment in Axial CT Images Using FEM-Based Automatic Segmentation of Skeletal Muscle","volume":"35","author":"Popuri","year":"2016","journal-title":"IEEE Trans. Med. Imaging"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.compmedimag.2019.04.007","article-title":"Muscle segmentation in axial computed tomography (CT) images at the lumbar (L3) and thoracic (T4) levels for body composition analysis","volume":"75","author":"Dabiri","year":"2019","journal-title":"Comput. Med. Imaging Graph."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s10278-017-9988-z","article-title":"Pixel-Level Deep Segmentation: Artificial Intelligence Quantifies Muscle on Computed Tomography for Body Morphometric Analysis","volume":"30","author":"Lee","year":"2017","journal-title":"J. Digit. Imaging"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/RLI.0000000000000647","article-title":"Fully Automated Segmentation of Connective Tissue Compartments for CT-Based Body Composition Analysis: A Deep Learning Approach","volume":"55","author":"Nowak","year":"2020","journal-title":"Investig. Radiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1007\/s00330-021-08313-x","article-title":"End-to-end automated body composition analyses with integrated quality control for opportunistic assessment of sarcopenia in CT","volume":"32","author":"Nowak","year":"2022","journal-title":"Eur. Radiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11548-021-02533-8","article-title":"Deep learning for abdominal adipose tissue segmentation with few labelled samples","volume":"17","author":"Wang","year":"2022","journal-title":"Int. J. Comput. Assist. Radiol. Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"i34","DOI":"10.1093\/bja\/aex393","article-title":"Fit for surgery? Perspectives on preoperative exercise testing and training","volume":"119","author":"Richardson","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuron.2017.01.033","article-title":"Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain","volume":"93","author":"Huang","year":"2017","journal-title":"Neuron"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.celrep.2019.07.038","article-title":"Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior","volume":"28","author":"Wong","year":"2019","journal-title":"Cell Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.tins.2018.07.005","article-title":"Epigenetic and Cellular Diversity in the Brain through Allele-Specific Effects","volume":"41","author":"Huang","year":"2018","journal-title":"Trends Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S1359-6446(03)02826-5","article-title":"Catabolic mediators as targets for cancer cachexia","volume":"8","author":"Argiles","year":"2003","journal-title":"Drug Discov. Today"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0002-8223(21)40940-5","article-title":"Tumor-host competition for nutrients in the cancer patient","volume":"71","author":"Munro","year":"1977","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bossi, P., Delrio, P., Mascheroni, A., and Zanetti, M. (2021). The Spectrum of Malnutrition\/Cachexia\/Sarcopenia in Oncology According to Different Cancer Types and Settings: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13061980"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Poulia, K.A., Sarantis, P., Antoniadou, D., Koustas, E., Papadimitropoulou, A., Papavassiliou, A.G., and Karamouzis, M.V. (2020). Pancreatic Cancer and Cachexia-Metabolic Mechanisms and Novel Insights. Nutrients, 12.","DOI":"10.3390\/nu12061543"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cytogfr.2021.11.002","article-title":"Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia","volume":"64","author":"Siddiqui","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_83","first-page":"214","article-title":"Computational modeling of cancer cachexia","volume":"11","author":"Hall","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.trecan.2022.01.004","article-title":"Emerging signaling mediators in the anorexia-cachexia syndrome of cancer","volume":"8","author":"Talbert","year":"2022","journal-title":"Trends Cancer"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Nishikawa, H., Goto, M., Fukunishi, S., Asai, A., Nishiguchi, S., and Higuchi, K. (2021). Cancer Cachexia: Its Mechanism and Clinical Significance. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168491"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e20190450","DOI":"10.1084\/jem.20190450","article-title":"Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia","volume":"218","author":"Rupert","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e47258","DOI":"10.15252\/embr.201847258","article-title":"Energy metabolism in cachexia","volume":"20","author":"Rohm","year":"2019","journal-title":"EMBO Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/s41416-023-02200-6","article-title":"Cancer cachexia and chronic inflammation: An unbreakable bond","volume":"128","author":"Madeddu","year":"2023","journal-title":"Br. J. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/bjh.15889","article-title":"Evaluation of the impact of cachexia on clinical outcomes in aggressive lymphoma","volume":"186","author":"Burkart","year":"2019","journal-title":"Br. J. Haematol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/jcsm.12115","article-title":"Prognostic impact of sarcopenia in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"7","author":"Go","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/jcsm.12837","article-title":"Cachexia index as a potential biomarker for cancer cachexia and a prognostic indicator in diffuse large B-cell lymphoma","volume":"12","author":"Go","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1080\/10428194.2020.1737686","article-title":"Prognostic impact of low muscle mass and low muscle density in patients with diffuse large B-cell lymphoma","volume":"61","author":"Rier","year":"2020","journal-title":"Leuk. Lymphoma"},{"key":"ref_94","first-page":"e12956","article-title":"Characteristics of muscle function and the effect of cachexia in patients with haematological malignancy","volume":"28","author":"Fukushima","year":"2019","journal-title":"Eur. J. Cancer Care"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-12-6","article-title":"Differences in routine laboratory parameters related to cachexia between patients with hematological diseases and patients with solid tumors or heart failure\u2014Is there only one cachexia?","volume":"12","author":"Letilovic","year":"2013","journal-title":"Nutr. J."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14740\/jh536","article-title":"C-Reactive Protein Level: A Key Predictive Marker of Cachexia in Lymphoma and Myeloma Patients","volume":"8","author":"Mallard","year":"2019","journal-title":"J. Hematol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1182\/bloodadvances.2018018051","article-title":"Development of a prognostically relevant cachexia index in primary myelofibrosis using serum albumin and cholesterol levels","volume":"2","author":"Tefferi","year":"2018","journal-title":"Blood Adv."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1002\/cam4.2180","article-title":"Racial and ethnic disparities in a state-wide registry of patients with pancreatic cancer and an exploratory investigation of cancer cachexia as a contributor to observed inequities","volume":"8","author":"Permuth","year":"2019","journal-title":"Cancer Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/jcsm.12466","article-title":"Clinical and biological characterization of skeletal muscle tissue biopsies of surgical cancer patients","volume":"10","author":"Bhullar","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_100","first-page":"79","article-title":"Loss of muscle mass in the end of life in patients with advanced cancer","volume":"23","author":"Wallengren","year":"2015","journal-title":"Support. Care Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.clnu.2011.12.008","article-title":"Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function","volume":"31","author":"Stephens","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s13539-010-0016-0","article-title":"Cancer-related fatigue: The impact of skeletal muscle mass and strength in patients with advanced cancer","volume":"1","author":"Kilgour","year":"2010","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1133s","DOI":"10.3945\/ajcn.2010.28608C","article-title":"Body composition in patients with non-small cell lung cancer: A contemporary view of cancer cachexia with the use of computed tomography image analysis","volume":"91","author":"Baracos","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1200\/OP.22.00674","article-title":"Race, Ethnicity, and Socioeconomic Factors as Determinants of Cachexia Incidence and Outcomes in a Retrospective Cohort of Patients With Gastrointestinal Tract Cancer","volume":"19","author":"Olaechea","year":"2023","journal-title":"JCO Oncol. Pract."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Johns, N., Hatakeyama, S., Stephens, N.A., Degen, M., Degen, S., Frieauff, W., Lambert, C., Ross, J.A., Roubenoff, R., and Glass, D.J. (2014). Clinical classification of cancer cachexia: Phenotypic correlates in human skeletal muscle. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0083618"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Della Peruta, C., Lozanoska-Ochser, B., Renzini, A., Moresi, V., Sanchez Riera, C., Bouch\u00e9, M., and Coletti, D. (2023). Sex Differences in Inflammation and Muscle Wasting in Aging and Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054651"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Welle, S., Tawil, R., and Thornton, C.A. (2008). Sex-related differences in gene expression in human skeletal muscle. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001385"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"pky043","DOI":"10.1093\/jncics\/pky043","article-title":"Skeletal Muscle Fibrosis in Pancreatic Cancer Patients with Respect to Survival","volume":"2","author":"Judge","year":"2018","journal-title":"JNCI Cancer Spectr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/jcsm.12984","article-title":"Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer","volume":"13","author":"Dolly","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/jcsm.12550","article-title":"Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle","volume":"11","author":"Nosacka","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1158\/0008-5472.CAN-19-1558","article-title":"MEF2c-dependent downregulation of Myocilin mediates cancer-induced muscle wasting and associates with cachexia in cancer patients","volume":"80","author":"Judge","year":"2020","journal-title":"Cancer Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s11914-020-00628-w","article-title":"Sex Differences in Cancer Cachexia","volume":"18","author":"Zhong","year":"2020","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-319-70178-3_9","article-title":"Sex Differences in Muscle Wasting","volume":"1043","author":"Anderson","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"C24","DOI":"10.1152\/ajpcell.00333.2021","article-title":"Skeletal muscle wasting: The estrogen side of sexual dimorphism","volume":"322","author":"McMillin","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_115","first-page":"100496","article-title":"Racial, Ethnic, and Socioeconomic Characteristics Independently Predict for Cachexia Risk and Associated Survival Outcomes in Stage IV NSCLC: A Brief Report","volume":"4","author":"Olaechea","year":"2023","journal-title":"JTO Clin. Res. Rep."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"600","DOI":"10.21037\/apm-22-1167","article-title":"Benefits and risks of off-label olanzapine use for symptom management in cancer patients-a case report","volume":"12","author":"Dev","year":"2023","journal-title":"Ann. Palliat. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1517\/14656560902960162","article-title":"Medroxyprogesterone acetate in the management of cancer cachexia","volume":"10","author":"Madeddu","year":"2009","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1517\/14712598.2011.627850","article-title":"A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer","volume":"11","author":"Bayliss","year":"2011","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/gut.2004.047563","article-title":"Thalidomide in the treatment of cancer cachexia: A randomised placebo controlled trial","volume":"54","author":"Gordon","year":"2005","journal-title":"Gut"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jcsm.12077","article-title":"MAP3K11\/GDF15 axis is a critical driver of cancer cachexia","volume":"7","author":"Lerner","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_121","unstructured":"(2024, May 17). Available online: https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05546476."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1172\/JCI138392","article-title":"Melanocortin-4 receptor antagonist TCMCB07 ameliorates cancer- and chronic kidney disease-associated cachexia","volume":"130","author":"Zhu","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13395-019-0193-2","article-title":"IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway","volume":"9","author":"Liu","year":"2019","journal-title":"Skelet. Muscle"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Li, L., Wazir, J., Huang, Z., Wang, Y., and Wang, H. (2023). A Comprehensive Review of Animal Models for Cancer Cachexia: Implications for Translational Research. Genes Dis., 101080.","DOI":"10.1016\/j.gendis.2023.101080"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/SPC.0000000000000233","article-title":"Animal models for cancer cachexia","volume":"10","author":"Costelli","year":"2016","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Bonetto, A., Rupert, J.E., Barreto, R., and Zimmers, T.A. (2016). The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia. J. Vis. Exp., e54893.","DOI":"10.3791\/54893"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.18632\/oncotarget.13593","article-title":"Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia","volume":"8","author":"Delitto","year":"2017","journal-title":"Oncotarget"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Deyhle, M.R., Callaway, C.S., Neyroud, D., D\u2019Lugos, A.C., Judge, S.M., and Judge, A.R. (2022). Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy. Cells, 11.","DOI":"10.3390\/cells11121893"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Judge, S.M., Wu, C.L., Beharry, A.W., Roberts, B.M., Ferreira, L.F., Kandarian, S.C., and Judge, A.R. (2014). Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-997"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1002\/jcsm.12346","article-title":"Tumour-derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour-bearing mice","volume":"9","author":"Kandarian","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jcsm.12666","article-title":"FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness","volume":"12","author":"Neyroud","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/jcsm.12232","article-title":"Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice","volume":"8","author":"Brown","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/ijc.29930","article-title":"Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and beta-2 agonist","volume":"138","author":"Toledo","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/jcsm.12354","article-title":"Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice","volume":"9","author":"Brown","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_135","first-page":"1451","article-title":"Animal models of the cancer anorexia-cachexia syndrome","volume":"19","author":"Walsh","year":"2011","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10974-019-09510-4","article-title":"Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content","volume":"40","author":"Neyroud","year":"2019","journal-title":"J. Muscle Res. Cell Motil."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.semcdb.2015.09.002","article-title":"Experimental cancer cachexia: Evolving strategies for getting closer to the human scenario","volume":"54","author":"Penna","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Miyaguti, N., Chiocchetti, G.M.E., Salgado, C.M., Lopes-Aguiar, L., Viana, L.R., Blanchard, L., Santos, R.W.D., and Gomes-Marcondes, M.C.C. (2021). Walker-256 Tumour-Induced Cachexia Altered Liver Metabolomic Profile and Function in Weanling and Adult Rats. Metabolites, 11.","DOI":"10.3390\/metabo11120831"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1002\/jcb.29682","article-title":"Akt activation by insulin treatment attenuates cachexia in Walker-256 tumor-bearing rats","volume":"121","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/jcsm.12537","article-title":"MT-102 prevents tissue wasting and improves survival in a rat model of severe cancer cachexia","volume":"11","author":"Potsch","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0304-3835(94)90212-7","article-title":"Alanine metabolism in rats bearing the Yoshida AH-130 ascites hepatoma","volume":"87","author":"Argiles","year":"1994","journal-title":"Cancer Lett."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s13539-011-0044-4","article-title":"Ursodeoxycholic acid treatment in a rat model of cancer cachexia","volume":"3","author":"Tschirner","year":"2012","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1172\/JCI116897","article-title":"Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model","volume":"92","author":"Costelli","year":"1993","journal-title":"J. Clin. Investig."},{"key":"ref_144","first-page":"14.39.11","article-title":"Genetically Engineered Mouse Models of Pancreatic Cancer: The KPC Model (LSL-Kras(G12D\/+);LSL-Trp53(R172H\/+);Pdx-1-Cre), Its Variants, and Their Application in Immuno-oncology Drug Discovery","volume":"73","author":"Lee","year":"2016","journal-title":"Curr. Protoc. Pharmacol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice","volume":"7","author":"Hingorani","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Cortez, N.E., Pathak, S., Rodriguez Lanzi, C., Hong, B.V., Crone, R., Sule, R., Wang, F., Chen, S., Gomes, A.V., and Baar, K. (2023). A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202306.0482.v1"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1002\/jcsm.13093","article-title":"Lipopolysaccharide-induced hypothalamic inflammation in cancer cachexia-anorexia is amplified by tumour-derived prostaglandin E2","volume":"13","author":"Li","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Spadafora, V., Pryce, B.R., Oles, A., Talbert, E.E., Romeo, M., Vaena, S., Berto, S., Ostrowski, M.C., Wang, D.J., and Guttridge, D.C. (2024). Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12104-0"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"E743","DOI":"10.1073\/pnas.1714703115","article-title":"Fenofibrate prevents skeletal muscle loss in mice with lung cancer","volume":"115","author":"Goncalves","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06030","article-title":"LKB1 modulates lung cancer differentiation and metastasis","volume":"448","author":"Ji","year":"2007","journal-title":"Nature"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Langer, H.T., Ramsamooj, S., Dantas, E., Murthy, A., Ahmed, M., Hwang, S.K., Grover, R., Pozovskiy, R., Liang, R.J., and Queiroz, A.L. (2023). Restoring adiponectin via rosiglitazone ameliorates tissue wasting in mice with lung cancer. bioRxiv.","DOI":"10.1101\/2023.07.31.551241"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.celrep.2019.07.016","article-title":"Modeling Human Cancer-induced Cachexia","volume":"28","author":"Talbert","year":"2019","journal-title":"Cell Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41392-024-01740-4","article-title":"Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma","volume":"9","author":"Capece","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"van de Worp, W., Schols, A., Theys, J., van Helvoort, A., and Langen, R.C.J. (2020). Nutritional Interventions in Cancer Cachexia: Evidence and Perspectives From Experimental Models. Front. Nutr., 7.","DOI":"10.3389\/fnut.2020.601329"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.appet.2015.04.049","article-title":"Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial","volume":"91","author":"Mattens","year":"2015","journal-title":"Appetite"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.nut.2013.05.004","article-title":"Influence of a nutritional intervention on dietary intake and quality of life in cancer patients: A randomized controlled trial","volume":"29","author":"Uster","year":"2013","journal-title":"Nutrition"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.oooo.2013.01.015","article-title":"Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia","volume":"116","author":"Yeh","year":"2013","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_158","first-page":"1090","article-title":"A randomized clinical trial with two doses of a omega 3 fatty acids oral and arginine enhanced formula in clinical and biochemical parameters of head and neck cancer ambulatory patients","volume":"17","author":"Izaola","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.smhs.2020.11.004","article-title":"Exercise as a therapy for cancer-induced muscle wasting","volume":"2","author":"Halle","year":"2020","journal-title":"Sports Med. Health Sci."},{"key":"ref_160","first-page":"Cd010804","article-title":"Exercise for cancer cachexia in adults","volume":"3","author":"Grande","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"McWilliams, S., Carter, W., Cooper-Mullin, C., DeMoranville, K., Frawley, A., Pierce, B., and Skrip, M. (2021). How birds during migration maintain (oxidative) balance. Front. Ecol. Evol., 9.","DOI":"10.3389\/fevo.2021.742642"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s003600000135","article-title":"Hibernation induces oxidative stress and activation of NK-kappaB in ground squirrel intestine","volume":"170","author":"Carey","year":"2000","journal-title":"J. Comp. Physiol. B"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"458","DOI":"10.2307\/1939549","article-title":"Polyunsaturate content and diet selection by ground squirrels (Spermophilus lateralis)","volume":"75","author":"Frank","year":"1994","journal-title":"Ecology"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Patnaik, P., and Sahoo, D.D. (2021). Variations in oxidative stress and antioxidant defense level during different phases of hibernation in common Asian toad, Duttaphrynus melanostictus. Biol. Open, 10.","DOI":"10.1242\/bio.058567"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Ensminger, D.C., Salvador-Pascual, A., Arango, B.G., Allen, K.N., and V\u00e1zquez-Medina, J.P. (2021). Fasting ameliorates oxidative stress: A review of physiological strategies across life history events in wild vertebrates. Comp. Biochem. Physiol. A Mol. Integr. Physiol., 256.","DOI":"10.1016\/j.cbpa.2021.110929"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1016\/j.celrep.2019.10.102","article-title":"Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity","volume":"29","author":"Ferris","year":"2019","journal-title":"Cell Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"28088","DOI":"10.1021\/acsomega.0c03691","article-title":"Night Migratory Songbirds Exhibit Metabolic Ability to Support High Aerobic Capacity during Migration","volume":"5","author":"Gupta","year":"2020","journal-title":"ACS Omega"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Swanson, D.L., Zhang, Y., and Jimenez, A.G. (2022). Skeletal muscle and metabolic flexibility in response to changing energy demands in wild birds. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.961392"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/s41467-020-16129-4","article-title":"Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds","volume":"11","author":"Castiglione","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cbpa.2019.04.004","article-title":"Twenty years of the \u2018Preparation for Oxidative Stress\u2019 (POS) theory: Ecophysiological advantages and molecular strategies","volume":"234","author":"Moreira","year":"2019","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0305-0491(98)10053-6","article-title":"Antioxidant defenses and metabolic depression. The hypothesis of preparation for oxidative stress in land snails","volume":"120","author":"Storey","year":"1998","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jofo.12135","article-title":"Oxidative balance in birds: An atoms-to-organisms-to-ecology primer for ornithologists","volume":"87","author":"Skrip","year":"2016","journal-title":"J. Field Ornithol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1242\/jeb.02299","article-title":"Performance-enhancing role of dietary fatty acids in a long-distance migrant shorebird: The semipalmated sandpiper","volume":"209","author":"Maillet","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1676\/13-014.1","article-title":"The importance of antioxidants for avian fruit selection during autumn migration","volume":"125","author":"Alan","year":"2013","journal-title":"Wilson J. Ornithol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.nutr.25.050304.092514","article-title":"Annual lipid cycles in hibernators: Integration of physiology and behavior","volume":"25","author":"Dark","year":"2005","journal-title":"Annu. Rev. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Cooper-Mullin, C., Carter, W.A., Amato, R.S., Podlesak, D., and McWilliams, S.R. (2021). Dietary vitamin E reaches the mitochondria in the flight muscle of zebra finches but only if they exercise. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0253264"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1200\/JCO.2024.42.17_suppl.LBA12007","article-title":"Results from a randomised, open-label trial of a multimodal intervention (exercise, nutrition and anti-inflammatory medication) plus standard care versus standard care alone to attenuate cachexia in patients with advanced cancer undergoing chemotherapy","volume":"42","author":"Solheim","year":"2024","journal-title":"JCO"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4103\/apjon.apjon-219","article-title":"The Psychosocial Components of Multimodal Interventions Offered to People with Cancer Cachexia: A Scoping Review","volume":"8","author":"Hopkinson","year":"2021","journal-title":"Asia Pac. J. Oncol. Nurs."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/SPC.0000000000000168","article-title":"Patient-reported outcomes in cancer cachexia clinical trials","volume":"9","author":"Wheelwright","year":"2015","journal-title":"Curr. Opin. Support. Palliat. Care"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1111\/1759-7714.14529","article-title":"Predicting the efficacy of first-line immunotherapy by combining cancer cachexia and tumor burden in advanced non-small cell lung cancer","volume":"13","author":"Miyawaki","year":"2022","journal-title":"Thorac. Cancer"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Ikeda, S., Naito, T., Miura, S., Ito, K., Furuya, N., Misumi, T., Ogura, T., and Kato, T. (2022). Pharmacotherapy for Advanced Non-Small Cell Lung Cancer with Performance Status 2 without Druggable Gene Alterations: Could Immune Checkpoint Inhibitors Be a Game Changer?. 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