{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:20:22Z","timestamp":1790274022328,"version":"4.1.0"},"reference-count":57,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Stimulator of interferon genes protein (STING) activates the immune response in inflammatory cells. STING expression in cancer cells is less well characterized, but STING agonists are currently being evaluated as anticancer drugs. A tissue microarray containing 18,001 samples from 139 different tumor types was analyzed for STING by immunohistochemistry. STING-positive tumor cells were found in 130 (93.5%) of 139 tumor entities. The highest STING positivity rates occurred in squamous cell carcinomas (up to 96%); malignant mesothelioma (88.5%\u201395.7%); adenocarcinoma of the pancreas (94.9%), lung (90.3%), cervix (90.0%), colorectum (75.2%), and gallbladder (68.8%); and serous high-grade ovarian cancer (86.0%). High STING expression was linked to adverse phenotypes in breast cancer, clear cell renal cell carcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and papillary carcinoma of the thyroid (p &lt; 0.05). In pTa urothelial carcinomas, STING expression was associated with low-grade carcinoma (p = 0.0002). Across all tumors, STING expression paralleled PD-L1 positivity of tumor and inflammatory cells (p &lt; 0.0001 each) but was unrelated to the density of CD8+ lymphocytes. STING expression is variable across tumor types and may be related to aggressive tumor phenotype and PD-L1 positivity. The lack of relationship with tumor-infiltrating CD8+ lymphocytes argues against a significant IFN production by STING positive tumor cells.<\/jats:p>","DOI":"10.3390\/cancers16132425","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T08:17:29Z","timestamp":1719821849000},"page":"2425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Stimulator of Interferon Genes Protein (STING) Expression in Cancer Cells: A Tissue Microarray Study Evaluating More than 18,000 Tumors from 139 Different Tumor Entities"],"prefix":"10.3390","volume":"16","author":[{"given":"Anne","family":"Menz","sequence":"first","affiliation":[{"name":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Zerneke","sequence":"additional","affiliation":[{"name":"Institute of Pathology, 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Chen, J., Wang, D., Hu, G., Zhang, H., Luo, L., and Xiao, Z. (2023). Overcoming challenges in the delivery of STING agonists for cancer immunotherapy: A comprehensive review of strategies and future perspectives. Mater. Today Bio, 23.","DOI":"10.1016\/j.mtbio.2023.100839"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","article-title":"Targeting STAT3 in Cancer Immunotherapy","volume":"19","author":"Zou","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00005-017-0481-7","article-title":"STING Signaling in Cancer Cells: Important or Not?","volume":"66","author":"Sokolowska","year":"2018","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"283ra252","DOI":"10.1126\/scitranslmed.aaa4306","article-title":"STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade","volume":"7","author":"Fu","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"djw199","DOI":"10.1093\/jnci\/djw199","article-title":"Activation of STING-Dependent Innate Immune Signaling by S-Phase-Specific DNA Damage in Breast Cancer","volume":"109","author":"Parkes","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.ijrobp.2021.12.162","article-title":"Radiation Therapy Promotes Hepatocellular Carcinoma Immune Cloaking via PD-L1 Upregulation Induced by cGAS-STING Activation","volume":"112","author":"Du","year":"2022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7150\/ijbs.65019","article-title":"Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell lung cancer","volume":"18","author":"Yan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"eaaz2738","DOI":"10.1126\/sciimmunol.aaz2738","article-title":"NK cells mediate clearance of CD8(+) T cell-resistant tumors in response to STING agonists","volume":"5","author":"Nicolai","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.bbrc.2016.09.021","article-title":"STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation","volume":"478","author":"Takashima","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.immuni.2014.10.017","article-title":"STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors","volume":"41","author":"Woo","year":"2014","journal-title":"Immunity"},{"key":"ref_14","first-page":"1256","article-title":"Expression of STING and PD-L1 in colorectal cancer and their correlation with clinical prognosis","volume":"11","author":"Zhong","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39858","DOI":"10.1038\/srep39858","article-title":"Decreased expression of STING predicts poor prognosis in patients with gastric cancer","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_16","first-page":"1016","article-title":"Low expression of PTEN and high expression of STING in human tongue squamous cell carcinoma tissues are associated with poor prognosis","volume":"36","author":"Wang","year":"2020","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e005151","DOI":"10.1136\/jitc-2022-005151","article-title":"T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer","volume":"10","author":"Ni","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/cjp2.230","article-title":"STING pathway expression in low-grade serous carcinoma of the ovary: An unexpected therapeutic opportunity?","volume":"7","author":"Huvila","year":"2021","journal-title":"J. Pathol. Clin. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"498","DOI":"10.7150\/thno.37745","article-title":"Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells","volume":"10","author":"Miao","year":"2020","journal-title":"Theranostics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.21037\/jgo-22-957","article-title":"STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway","volume":"13","author":"Yao","year":"2022","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1111\/cas.14570","article-title":"Relapse-related molecular signature in early-stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor-infiltrating lymphocytes","volume":"111","author":"Yang","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Viculin, J., Degoricija, M., Vilovic, K., Gabela, I., Frankovic, L., Vrdoljak, E., and Korac-Prlic, J. (2023). Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer. Cancers, 15.","DOI":"10.3390\/cancers15133510"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00428-023-03549-y","article-title":"STING is a prognostic factor related to tumor necrosis, sarcomatoid dedifferentiation, and distant metastasis in clear cell renal cell carcinoma","volume":"483","author":"Marletta","year":"2023","journal-title":"Virchows Arch."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41523-023-00609-z","article-title":"cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer","volume":"10","author":"Chen","year":"2024","journal-title":"NPJ Breast Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1158\/2767-9764.CRC-23-0299","article-title":"Differential Regulation of the STING Pathway in Human Papillomavirus-Positive and -Negative Head and Neck Cancers","volume":"4","author":"Saulters","year":"2024","journal-title":"Cancer Res. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7725","DOI":"10.2147\/OTT.S222422","article-title":"The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma","volume":"12","author":"Wang","year":"2019","journal-title":"Onco Targets Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/jso.26804","article-title":"Loss of STING expression is prognostic in non-small cell lung cancer","volume":"125","author":"Lohinai","year":"2022","journal-title":"J. Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00262-022-03270-w","article-title":"Protein Expression of immune checkpoints STING and MHCII in small cell lung cancer","volume":"72","author":"Dora","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12739","DOI":"10.1038\/s41598-022-17122-1","article-title":"STING expression is an independent prognostic factor in patients with mycosis fungoides","volume":"12","author":"Sawada","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nm0798-844","article-title":"Tissue microarrays for high-throughput molecular profiling of tumor specimens","volume":"4","author":"Kononen","year":"1998","journal-title":"Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-4939-3204-7_3","article-title":"Tissue Microarrays","volume":"1381","author":"Dancau","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/CBM-220030","article-title":"PD-L1 expression and CD8 positive lymphocytes in human neoplasms: A tissue microarray study on 11,838 tumor samples","volume":"36","author":"Moller","year":"2023","journal-title":"Cancer Biomark."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-60761-806-5_12","article-title":"Immunohistochemical analysis of tissue microarrays","volume":"664","author":"Simon","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arr.2014.10.004","article-title":"DAMPs, ageing, and cancer: The \u2018DAMP Hypothesis\u2019","volume":"24","author":"Huang","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Baca, S.C., and Garraway, L.A. (2012). The genomic landscape of prostate cancer. Front. Endocrinol., 3.","DOI":"10.3389\/fendo.2012.00069"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/bju.15084","article-title":"The genetic landscapes of urological cancers and their clinical implications in the era of high-throughput genome analysis","volume":"126","author":"Light","year":"2020","journal-title":"BJU Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1038\/s41467-021-24812-3","article-title":"The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets","volume":"12","author":"Cuppen","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100238","DOI":"10.1016\/j.ctarc.2020.100238","article-title":"Title- Genomic landscape of squamous cell carcinoma- Different genetic pathways culminating in a common phenotype","volume":"25","author":"Krishnamurthy","year":"2020","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1158\/1078-0432.CCR-19-2861","article-title":"A New Pathway Emerges to Interpret Lung Cancer Genomic Alterations","volume":"25","author":"Blakely","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature14169","article-title":"Whole genomes redefine the mutational landscape of pancreatic cancer","volume":"518","author":"Waddell","year":"2015","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1158\/2159-8290.CD-19-0761","article-title":"The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer","volume":"10","author":"Kwon","year":"2020","journal-title":"Cancer Discov."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature25432","article-title":"Chromosomal instability drives metastasis through a cytosolic DNA response","volume":"553","author":"Bakhoum","year":"2018","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ccell.2020.11.006","article-title":"DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity","volume":"39","author":"Lu","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1610401","DOI":"10.3389\/pore.2022.1610401","article-title":"Expression of SASP, DNA Damage Response, and Cell Proliferation Factors in Early Gastric Neoplastic Lesions: Correlations and Clinical Significance","volume":"28","author":"Liang","year":"2022","journal-title":"Pathol. Oncol. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1158\/0008-5472.CAN-21-0785","article-title":"STINGing Viral Tumors: What We Know from Head and Neck Cancers","volume":"81","author":"Saulters","year":"2021","journal-title":"Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.micpath.2019.05.004","article-title":"cGAS-STING responses are dampened in high-risk HPV type 16 positive head and neck squamous cell carcinoma cells","volume":"132","author":"Shaikh","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1126\/science.aab3291","article-title":"DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway","volume":"350","author":"Lau","year":"2015","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kunac, N., Degoricija, M., Viculin, J., Omerovic, J., Terzic, J., Vilovic, K., and Korac-Prlic, J. (2022). Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer. Cancers, 15.","DOI":"10.3390\/cancers15010221"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1007\/s00262-022-03200-w","article-title":"Role of the cGAS-STING pathway in regulating the tumor-immune microenvironment in dMMR\/MSI colorectal cancer","volume":"71","author":"Kaneta","year":"2022","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10495-022-01763-8","article-title":"DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients","volume":"27","author":"Vasiyani","year":"2022","journal-title":"Apoptosis"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10495-021-01669-x","article-title":"The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells","volume":"26","author":"Vasiyani","year":"2021","journal-title":"Apoptosis"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41523-021-00283-z","article-title":"The clinical and molecular significance associated with STING signaling in breast cancer","volume":"7","author":"Parkes","year":"2021","journal-title":"NPJ Breast Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Cai, H., Yan, L., Liu, N., Xu, M., and Cai, H. (2020). IFI16 promotes cervical cancer progression by upregulating PD-L1 in immunomicroenvironment through STING-TBK1-NF-kB pathway. Biomed. Pharmacother., 123.","DOI":"10.1016\/j.biopha.2019.109790"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1038\/s41388-018-0581-9","article-title":"Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles","volume":"38","author":"Grabosch","year":"2019","journal-title":"Oncogene"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1158\/0008-5472.CAN-15-1885","article-title":"Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells","volume":"76","author":"Tang","year":"2016","journal-title":"Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.celrep.2015.12.029","article-title":"Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates with Tumorigenesis","volume":"14","author":"Xia","year":"2016","journal-title":"Cell Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nmeth.3995","article-title":"A proposal for validation of antibodies","volume":"13","author":"Uhlen","year":"2016","journal-title":"Nat. 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