{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:46:38Z","timestamp":1780458398064,"version":"3.54.1"},"reference-count":35,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction and objectives: To evaluate the oncological and functional outcomes of transperineal laser ablation (TPLA) as the focal therapy for localized prostate cancer (PCa) after a 12-month follow-up. Materials and methods: Patients with low- and intermediate-risk localized PCa were prospectively treated with focal TPLA between July 2021 and December 2022. The inclusion criteria were the following: clinical stage &lt; T2b; PSA &lt; 20 ng\/mL; International Society of Urological Pathology (ISUP) grade \u2264 2; MRI-fusion biopsy-confirmed lesion classified as PI-RADS v2.1 \u2265 3. Intra-, peri-, and post-operative data were collected. Variables including age, PSA, prostate volume (PVol), Charlson\u2019s Comorbidity Index (CCI), International Prostate Symptom Score (IPSS) with QoL score, International Index of Erectile Function (IIEF-5), International Consultation on Incontinence Questionnaire\u2014Short Form (ICIQ-SF), and Male Sexual Health Questionnaire\u2014Ejaculatory Dysfunction Short Form (MSHQ-EjD) were collected at baseline and at 3, 6 and 12 months after TPLA. Post-operative mpMRI was performed at 3 and 12 months. Finally, all patients underwent prostatic re-biopsy under fusion guidance at 12 months. The success of this technique was defined as no recurrence in the target treated lesion at the 12-month follow up. Results: Twenty-four patients underwent focal TPLA. Baseline features were age [median 67 years (IQR 12)], PSA [5.7 ng\/mL (3.9)], PVol [49 mL (27)], CCI [0 (0)], IPSS [11 (9)], IPSS-QoL [2 (2)], IIEF-5 [21 (6)], ICIQ-SF [0 (7)], MSHQ-EjD ejaculation domain [14 (4)] and bother score [0 (2)]. Median operative time was 34 min (IQR 12). Median visual analogue scale (VAS) 6 h after TPLA was 0 (IQR 1). The post-operative course was regular for all patients, who were discharged on the second post-operative day and underwent catheter removal on the seventh post-operative day. No patient had incontinence at catheter removal. A significant reduction in PSA (p = 0.01) and an improvement in IPSS (p = 0.009), IPSS-QoL (p = 0.02) and ICIQ-SF scores (p = 0.04) compared to baseline were observed at the 3-month follow-up. Erectile and ejaculatory functions did not show any significant variation during the follow-up. No intra- and peri-operative complications were recorded. Three Clavien\u2013Dindo post-operative complications were recorded (12%): grade 1 (two cases of urinary retention) and grade 2 (one case of urinary tract infection). At the 12-month follow-up, eight patients showed mpMRI images referable to suspicious recurrent disease (PIRADS v2.1 \u2265 3). After re-biopsy, 7\/24 patients\u2019 (29%) results were histologically confirmed as PCa, 3 of which were recurrences in the treated lesion (12.5%). The success rate was 87.5%. Conclusions: The focal TPLA oncological and functional results seemed to be encouraging. TPLA is a safe, painless, and effective technique with a good preservation of continence and sexual outcomes. Recurrence rate at 12 months was about 12.5%.<\/jats:p>","DOI":"10.3390\/cancers16152620","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T14:26:50Z","timestamp":1721744810000},"page":"2620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Transperineal Laser Ablation for Focal Therapy of Localized Prostate Cancer: 12-Month Follow-up Outcomes from a Single Prospective Cohort Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-3177","authenticated-orcid":false,"given":"Valerio","family":"Iacovelli","sequence":"first","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2416-9762","authenticated-orcid":false,"given":"Marco","family":"Carilli","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-4601","authenticated-orcid":false,"given":"Riccardo","family":"Bertolo","sequence":"additional","affiliation":[{"name":"Department of Urology, AOUI Verona, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9654-2327","authenticated-orcid":false,"given":"Valerio","family":"Forte","sequence":"additional","affiliation":[{"name":"Radiology Unit, San Carlo di Nancy Hospita, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5597-2742","authenticated-orcid":false,"given":"Matteo","family":"Vittori","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Filippi","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Di Giovanni","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-4966","authenticated-orcid":false,"given":"Chiara","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Petta","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maiorino","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Signoretti","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Antonucci","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9760-3702","authenticated-orcid":false,"given":"Alessio","family":"Guidotti","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Travaglia","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Caputo","sequence":"additional","affiliation":[{"name":"Radiology Unit, San Carlo di Nancy Hospita, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-5392","authenticated-orcid":false,"given":"Guglielmo","family":"Manenti","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention, Radiology Unit, Tor Vergata University of Rome, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Bove","sequence":"additional","affiliation":[{"name":"Urology Unit, San Carlo di Nancy Hospital, GVM Care and Research, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","article-title":"Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates","volume":"77","author":"Culp","year":"2020","journal-title":"Eur. Urol."},{"key":"ref_2","unstructured":"(2022). EAU Guidelines on Prostate Cancer 2022, EAU Guidelines Office. Available online: http:\/\/uroweb.org\/guidelines\/compilations-of-all-guidelines\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJMoa1606220","article-title":"ProtecT Study Group. 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer","volume":"375","author":"Hamdy","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/pon.3657","article-title":"A longitudinal study on the impact of active surveillance for prostate cancer on anxiety and distress levels","volume":"24","author":"Venderbos","year":"2015","journal-title":"Psychooncology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1007\/s00345-019-02636-7","article-title":"Focal laser ablation as clinical treatment of prostate cancer: Report from a Delphi consensus project","volume":"37","author":"Greenwood","year":"2019","journal-title":"World J. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1007\/s00270-017-1662-9","article-title":"Transperineal Laser Ablation for Percutaneous Treatment of Benign Prostatic Hyperplasia: A Feasibility Study","volume":"40","author":"Patelli","year":"2017","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41391-019-0196-4","article-title":"Transperineal laser ablation for percutaneous treatment of benign prostatic hyperplasia: A feasibility study. Results at 6 and 12 months from a retrospective multi-centric study","volume":"23","author":"Pacella","year":"2020","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1007\/s00345-021-03685-7","article-title":"Feasibility, safety, and efficacy of ultrasound-guided transperineal laser ablation for the treatment of benign prostatic hyperplasia: A single institutional experience","volume":"39","author":"Frego","year":"2021","journal-title":"World J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.euros.2022.02.012","article-title":"Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study","volume":"39","author":"Vis","year":"2022","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4081\/aiua.2022.4.406","article-title":"A single-operator experience using EchoLaser SoracteLiteTM for focal laser ablation of prostate cancer: One more arrow in the quiver for the conservative management of the disease","volume":"94","author":"Meneghetti","year":"2022","journal-title":"Arch. Ital. Urol. Androl."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/S0022-5347(17)36966-5","article-title":"The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association","volume":"148","author":"Barry","year":"1992","journal-title":"J. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction","volume":"11","author":"Rosen","year":"1999","journal-title":"Int. J. Impot. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/nau.20041","article-title":"ICIQ: A brief and robust measure for evaluating the symptoms and impact of urinary incontinence","volume":"23","author":"Avery","year":"2004","journal-title":"Neurourol. Urodyn."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.urology.2007.02.036","article-title":"Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction","volume":"69","author":"Rosen","year":"2007","journal-title":"Urology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.eururo.2024.02.001","article-title":"The Transatlantic Recommendations for Prostate Gland Evaluation with Magnetic Resonance Imaging after Focal Therapy (TARGET): A Systematic Review and International Consensus Recommendations","volume":"85","author":"Light","year":"2024","journal-title":"Eur. Urol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bju.16008","article-title":"Ejaculatory function following transperineal laser ablation vs TURP for benign prostatic obstruction: A randomized trial","volume":"132","author":"Bertolo","year":"2023","journal-title":"BJU Int."},{"key":"ref_18","first-page":"20230042","article-title":"Transperineal laser ablation (TPLA) with ultrasound\/MRI fusion guidance in the treatment of localized radiotherapy-resistant prostate cancer","volume":"5","author":"Manenti","year":"2023","journal-title":"BJR Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000052577","article-title":"Secondary cancers in the prostate do not determine PSA biochemical failure in untreated men undergoing radical retropubic prostatectomy","volume":"39","author":"Stamey","year":"2001","journal-title":"Eur. Urol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/pros.23038","article-title":"Index lesion characterization by (11)C-Choline PET\/CT and Apparent Diffusion Coefficient parameters at 3 Tesla MRI in primary prostate carcinoma","volume":"76","author":"Quiceno","year":"2016","journal-title":"Prostate"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.eururo.2014.09.018","article-title":"Focal therapy: Patients, interventions, and outcomes\u2014A report from a consensus meeting","volume":"67","author":"Donaldson","year":"2015","journal-title":"Eur. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2217\/fon-2016-0229","article-title":"Focal therapy as primary treatment for localized prostate cancer: Definition, needs and future","volume":"13","author":"Ouzzane","year":"2017","journal-title":"Future Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.eururo.2018.01.001","article-title":"Focal Therapy in Primary Localised Prostate Cancer: The European Association of Urology Position in 2018","volume":"74","author":"Briers","year":"2018","journal-title":"Eur. Urol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.euros.2023.06.002","article-title":"Reliable Visualization of the Treatment Effect of Transperineal Focal Laser Ablation in Prostate Cancer Patients by Magnetic Resonance Imaging and Contrast-enhanced Ultrasound Imaging","volume":"54","author":"Freund","year":"2023","journal-title":"Eur. Urol. Open Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.eururo.2016.08.044","article-title":"New and Established Technology in Focal Ablation of the Prostate: A Systematic Review","volume":"71","author":"Valerio","year":"2017","journal-title":"Eur. Urol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.euo.2018.03.011","article-title":"Two-year Outcomes Following Focal Laser Ablation of Localized Prostate Cancer","volume":"1","author":"Chao","year":"2018","journal-title":"Eur. Urol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ajur.2023.07.001","article-title":"Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project","volume":"11","author":"Cocci","year":"2024","journal-title":"Asian J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Manenti, G., Perretta, T., Nezzo, M., Fraioli, F.R., Carreri, B., Gigliotti, P.E., Micillo, A., Malizia, A., Di Giovanni, D., and Ryan, C.P. (2024). Transperineal Laser Ablation (TPLA) Treatment of Focal Low-Intermediate Risk Prostate Cancer. Cancers, 16.","DOI":"10.20944\/preprints202402.1578.v1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41391-022-00563-0","article-title":"The role of preoperative prostatic shape in the recovery of urinary continence after robotic radical prostatectomy: A single cohort analysis","volume":"26","author":"Iacovelli","year":"2023","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.juro.2009.06.035","article-title":"Image guided photothermal focal therapy for localized prostate cancer: Phase I trial","volume":"182","author":"Lindner","year":"2009","journal-title":"J. Urol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.juro.2015.12.083","article-title":"Focal Laser Ablation of Prostate Cancer: Phase I Clinical Trial","volume":"196","author":"Natarajan","year":"2016","journal-title":"J. Urol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jvir.2018.09.016","article-title":"Focal Laser Ablation of Prostate Cancer: Results in 120 Patients with Low- to Intermediate-Risk Disease","volume":"30","author":"Walser","year":"2019","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.jvir.2024.04.023","article-title":"Transperineal Laser Ablation of the Prostate for Symptomatic Benign Prostatic Hyperplasia: Long-Term Follow-Up in 40 Patients","volume":"35","author":"Patelli","year":"2024","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s41747-021-00239-9","article-title":"3-T MRI and clinical validation of ultrasound-guided transperineal laser ablation of benign prostatic hyperplasia","volume":"5","author":"Manenti","year":"2021","journal-title":"Eur. Radiol. Exp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.eururo.2007.05.011","article-title":"Prospective validation of active surveillance in prostate cancer: The PRIAS study","volume":"52","author":"Roemeling","year":"2007","journal-title":"Eur. Urol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/15\/2620\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:21:45Z","timestamp":1760109705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/15\/2620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":35,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["cancers16152620"],"URL":"https:\/\/doi.org\/10.3390\/cancers16152620","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]}}}