{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:55:47Z","timestamp":1789232147679,"version":"build-2803163510"},"reference-count":62,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Joint Programme on Rare Diseases","award":["825575"],"award-info":[{"award-number":["825575"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Large datasets in paediatric oncology are inherently rare. Therefore, it is paramount to fully exploit all available data, which are distributed over several resources, including biomaterials, images, clinical trials, and registries. With privacy-preserving record linkage (PPRL), personalised or pseudonymised datasets can be merged, without disclosing the patients\u2019 identities. Although PPRL is implemented in various settings, use case descriptions are currently fragmented and incomplete. The present paper provides a comprehensive overview of current and future use cases for PPRL in paediatric oncology. We analysed the literature, projects, and trial protocols, identified use cases along a hypothetical patient journey, and discussed use cases with paediatric oncology experts. To structure PPRL use cases, we defined six key dimensions: distributed personalised records, pseudonymisation, distributed pseudonymised records, record linkage, linked data, and data analysis. Selected use cases were described (a) per dimension and (b) on a multi-dimensional level. While focusing on paediatric oncology, most aspects are also applicable to other (particularly rare) diseases. We conclude that PPRL is a key concept in paediatric oncology. Therefore, PPRL strategies should already be considered when starting research projects, to avoid distributed data silos, to maximise the knowledge derived from collected data, and, ultimately, to improve outcomes for children with cancer.<\/jats:p>","DOI":"10.3390\/cancers16152696","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T16:37:17Z","timestamp":1722271037000},"page":"2696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use Cases Requiring Privacy-Preserving Record Linkage in Paediatric Oncology"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1822-9033","authenticated-orcid":false,"given":"Dieter","family":"Hayn","sequence":"first","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6066-9708","authenticated-orcid":false,"given":"Karl","family":"Kreiner","sequence":"additional","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Sandner","sequence":"additional","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-6873","authenticated-orcid":false,"given":"Martin","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"},{"name":"Institute of Neural Engineering, Graz University of Technology, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Jammerbund","sequence":"additional","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Falgenhauer","sequence":"additional","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"D\u00fcster","sequence":"additional","affiliation":[{"name":"St. Anna Kinderkrebsforschungs GmbH, 1090 Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-423X","authenticated-orcid":false,"given":"Priyanka","family":"Devi-Marulkar","sequence":"additional","affiliation":[{"name":"Institut Curie, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-5879","authenticated-orcid":false,"given":"Gudrun","family":"Schleiermacher","sequence":"additional","affiliation":[{"name":"Institut Curie, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Ladenstein","sequence":"additional","affiliation":[{"name":"St. Anna Kinderkrebsforschungs GmbH, 1090 Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-4255","authenticated-orcid":false,"given":"Guenter","family":"Schreier","sequence":"additional","affiliation":[{"name":"Center for Health and Bioresources, AIT Austrian Institute of Technology, 8020 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020). International Agency for Research on Cancer Cancer Today, World Health Organization."},{"key":"ref_2","unstructured":"Office for Civil Rights (2012). Guidance Regarding Methods for De-identification of Protected Health Information in Accordance with the Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule."},{"key":"#cr-split#-ref_3.1","doi-asserted-by":"crossref","unstructured":"The European Parliament and of the Council (2016). Regulation","DOI":"10.59403\/1v8s9t8"},{"key":"#cr-split#-ref_3.2","unstructured":"(eu) 2016\/679 of the European Parliament and of the Council of 27 April 2016 on the Protection of Natural Persons with Regard to the Processing of Personal Data and on the Free Movement of Such Data, and Repealing Directive 95\/46\/EC (General Data Protection Regulation), The European Parliament and of the Council."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"160018","DOI":"10.1038\/sdata.2016.18","article-title":"The FAIR Guiding Principles for scientific data management and stewardship","volume":"3","author":"Wilkinson","year":"2016","journal-title":"Sci. Data"},{"key":"ref_5","unstructured":"SIOP Europe, CCI Europe, and PANCARE (2022). A Europe for Children & Adolescents with Cancer: Don\u2019t Leave Them Behind\u2014Position Paper of the European Paediatric Cancer Community, SIOP Europe."},{"key":"ref_6","unstructured":"SIOP Europe, CCI Europe, and PANCARE (2020). International Childhood Cancer Awareness Day (ICCD2020): Artificial Intelligence and Big Data: Towards the Next Frontier in Paediatric Cancer Research & Innovation in Europe, SIOP Europe."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S1470-2045(22)00287-X","article-title":"The impact of the EU General Data Protection Regulation on childhood cancer research in Europe","volume":"23","author":"Vassal","year":"2022","journal-title":"Lancet Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5626\/JCSE.2011.5.3.223","article-title":"Secure Blocking + Secure Matching = Secure Record Linkage","volume":"5","author":"Karakasidis","year":"2011","journal-title":"J. Comput. Sci. Eng."},{"key":"ref_9","unstructured":"Etienne, B., Cheatham, M., and Grzebala, P. (2016, January 17\u201319). An Analysis of Blocking Methods for Private Record Linkage. Proceedings of the AAAI Fall Symposia Symposium Series, Arlington, VA, USA."},{"key":"ref_10","first-page":"644","article-title":"A one way public key cryptosystem for the linkage of nominal files in epidemiological studies","volume":"8","author":"Dusserre","year":"1995","journal-title":"Medinfo"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1386-5056(98)00019-7","article-title":"How to ensure data security of an epidemiological follow-up: Quality assessment of an anonymous record linkage procedure","volume":"49","author":"Quantin","year":"1998","journal-title":"Int. J. Med. Inform."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"McClean, S., Millard, P., El-Darzi, E., and Nugent, C. (2009). Privacy-Preserving Fuzzy Matching Using a Public Reference Table. Intelligent Patient Management, Springer Berlin Heidelberg.","DOI":"10.1007\/978-3-642-00179-6"},{"key":"ref_13","unstructured":"Vatsalan, D. (2014). Scalable and Approximate Privacy-Preserving Record Linkage, Australian National University."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Scannapieco, M., Figotin, I., Bertino, E., and Elmagarmid, A.K. (2007, January 11\u201314). Privacy preserving schema and data matching. Proceedings of the ACM SIGMOD Conference, Beijing, China.","DOI":"10.1145\/1247480.1247553"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Yakout, M., Atallah, M.J., and Elmagarmid, A. (April, January 29). Efficient Private Record Linkage. Proceedings of the 2009 IEEE 25th International Conference on Data Engineering, Shanghai, China.","DOI":"10.1109\/ICDE.2009.221"},{"key":"ref_16","unstructured":"Bonomi, L., Xiong, L., Chen, R., and Fung, B.C.M. (November, January 29). Frequent grams based embedding for privacy preserving record linkage. Proceedings of the 21st ACM International Conference on Information and Knowledge Management, Maui, HI, USA."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"He, X., Machanavajjhala, A., Flynn, C., and Srivastava, D. (November, January 30). Composing Differential Privacy and Secure Computation: A Case Study on Scaling Private Record Linkage. Proceedings of the 2017 ACM SIGSAC Conference on Computer and Communications Security, Dallas, TX, USA.","DOI":"10.1145\/3133956.3134030"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Inan, A., Kantarcioglu, M., Bertino, E., and Scannapieco, M. (2008, January 7\u201312). A Hybrid Approach to Private Record Linkage. Proceedings of the 2008 IEEE 24th International Conference on Data Engineering, Cancun, Mexico.","DOI":"10.1109\/ICDE.2008.4497458"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kuzu, M., Kantarcioglu, M., Inan, A., Bertino, E., Durham, E., and Malin, B. (2013, January 18\u201322). Efficient Privacy-Aware Record Integration. Proceedings of the 16th International Conference on Extending Database Technology, Genoa, Italy.","DOI":"10.1145\/2452376.2452398"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/bioinformatics\/btaa764","article-title":"Mainzelliste SecureEpiLinker (MainSEL): Privacy-preserving record linkage using secure multi-party computation","volume":"38","author":"Stammler","year":"2022","journal-title":"Bioinformatics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1186\/s12967-022-03671-6","article-title":"Record linkage based patient intersection cardinality for rare disease studies using Mainzelliste and secure multi-party computation","volume":"20","author":"Kussel","year":"2022","journal-title":"J. Transl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"n1270","DOI":"10.1136\/bmj.n1270","article-title":"Virtual and in-person cardiac rehabilitation","volume":"373","author":"Dalal","year":"2021","journal-title":"BMJ"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.is.2012.11.005","article-title":"A taxonomy of privacy-preserving record linkage techniques","volume":"38","author":"Vatsalan","year":"2013","journal-title":"Inf. Syst."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.1109\/TIFS.2021.3114026","article-title":"Modern Privacy-Preserving Record Linkage Techniques: An Overview","volume":"16","author":"Vatsalan","year":"2021","journal-title":"IEEE Trans. Inf. Forensics Secur."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Christen, P., Ranbaduge, T., and Schnell, R. (2020). Linking Sensitive Data, Springer.","DOI":"10.1007\/978-3-030-59706-1"},{"key":"ref_26","unstructured":"European Union Agency for Cybersecurity (2021). Data Pseudonymisation: Advanced Techniques & Use Cases\u2014Technical Analysis of Cybersecurity Measures in Data Protection and Privacy, European Union Agency for Cybersecurity."},{"key":"ref_27","unstructured":"European Union Agency for Cybersecurity (2022). Deploying Pseudonymisation Techniques\u2014The case of the Health Sector, European Union Agency for Cybersecurity."},{"key":"ref_28","unstructured":"European Union Agency for Cybersecurity (2019). Pseudonymisation Techniques and Best Practices\u2014Recommendations on Shaping Technology According to Data Protection and Privacy Provisions, European Union Agency for Cybersecurity."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1470-2045(13)70548-5","article-title":"Childhood cancer survival in Europe 1999\u20132007: Results of EUROCARE-5\u2014A population-based study","volume":"15","author":"Gatta","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_30","first-page":"211","article-title":"Patient identity management for secondary use of biomedical research data in a distributed computing environment","volume":"198","author":"Nitzlnader","year":"2014","journal-title":"Stud. Health Technol. Inform."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ly, S., Runacres, F., and Poon, P. (2021). Journey mapping as a novel approach to healthcare: A qualitative mixed methods study in palliative care. BMC Health Serv. Res., 21.","DOI":"10.1186\/s12913-021-06934-y"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1089\/bio.2020.0144","article-title":"BBMRI-ERIC Negotiator: Implementing Efficient Access to Biobanks","volume":"19","author":"Reihs","year":"2021","journal-title":"Biopreserv. Biobank."},{"key":"ref_33","first-page":"717","article-title":"The RD-Connect Genome-Phenome Analysis Platform: Accelerating diagnosis, research, and gene discovery for rare diseases","volume":"43","author":"Laurie","year":"2022","journal-title":"Hum. Mutat."},{"key":"ref_34","first-page":"287","article-title":"IT Infrastructure for Merging Data from Different Clinical Trials and Across Independent Research Networks","volume":"228","author":"Hayn","year":"2016","journal-title":"Stud. Health Technol. Inform."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejca.2015.10.007","article-title":"Transition guidelines: An important step in the future care for childhood cancer survivors. A comprehensive definition as groundwork","volume":"54","author":"Mulder","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.ejca.2015.04.002","article-title":"Survivorship after childhood cancer: PanCare: A European Network to promote optimal long-term care","volume":"51","author":"Hjorth","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e020980","DOI":"10.1136\/bmjopen-2017-020980","article-title":"Cohort profile: Prescriptions dispensed in the community linked to the national cancer registry in England","volume":"8","author":"Henson","year":"2018","journal-title":"BMJ Open"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1200\/CCI.20.00074","article-title":"Tailoring Therapy for Children With Neuroblastoma on the Basis of Risk Group Classification: Past, Present, and Future","volume":"4","author":"Liang","year":"2020","journal-title":"JCO Clin. Cancer Inform."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ladenstein, R., P\u00f6tschger, U., Valteau-Couanet, D., Luksch, R., Castel, V., Ash, S., Laureys, G., Brock, P., Michon, J.M., and Owens, C. (2020). Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1). Cancers, 12.","DOI":"10.3390\/cancers12020309"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11060-017-2372-5","article-title":"The international diffuse intrinsic pontine glioma registry: An infrastructure to accelerate collaborative research for an orphan disease","volume":"132","author":"Baugh","year":"2017","journal-title":"J. Neurooncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/humrep\/dead026","article-title":"Paternity through use of assisted reproduction technology in male adult and childhood cancer survivors: A nationwide register study","volume":"38","author":"Kitlinski","year":"2023","journal-title":"Hum. Reprod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.canep.2015.02.008","article-title":"Conditional survival estimates for childhood cancer in Australia, 2002\u20132011: A population-based study","volume":"39","author":"Youlden","year":"2015","journal-title":"Cancer Epidemiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1080\/02841860903188635","article-title":"Are survival rates for Tyrol published in the Eurocare studies biased?","volume":"48","author":"Oberaigner","year":"2009","journal-title":"Acta Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Botta, L., Gatta, G., Didon\u00e8, F., Lopez Cortes, A., Pritchard-Jones, K., and Group, B.P.W. (2022). International benchmarking of childhood cancer survival by stage at diagnosis: The BENCHISTA project protocol. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0276997"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/jmg-2022-108800","article-title":"Germline mismatch repair (MMR) gene analyses from English NHS regional molecular genomics laboratories 1996\u20132020: Development of a national resource of patient-level genomics laboratory records","volume":"60","author":"Loong","year":"2023","journal-title":"J. Med. Genet."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Walker, J.L., Grint, D.J., Strongman, H., Eggo, R.M., Peppa, M., Minassian, C., Mansfield, K.E., Rentsch, C.T., Douglas, I.J., and Mathur, R. (2021). UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: A point prevalence study using electronic health records. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-10427-2"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/jamadermatol.2019.3353","article-title":"Age-Specific Incidence of Melanoma in the United States","volume":"156","author":"Paulson","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sayeed, S., Barnes, I., and Ali, R. (2017). Childhood cancer incidence by ethnic group in England, 2001\u20132007: A descriptive epidemiological study. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3551-7"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1055\/s-0029-1245235","article-title":"Cancer incidence rate after diagnostic X-ray exposure in 1976\u20132003 among patients of a university children\u2019s hospital","volume":"182","author":"Hammer","year":"2010","journal-title":"Rofo"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S1470-2045(18)30479-0","article-title":"Maternal use of hormonal contraception and risk of childhood leukaemia: A nationwide, population-based cohort study","volume":"19","author":"Hargreave","year":"2018","journal-title":"Lancet Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/jamia\/ocab269","article-title":"Enhancing PCORnet Clinical Research Network data completeness by integrating multistate insurance claims with electronic health records in a cloud environment aligned with CMS security and privacy requirements","volume":"29","author":"Waitman","year":"2022","journal-title":"J. Am. Med. Inform. Assoc"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1093\/neuonc\/noad012","article-title":"Computed tomography scan radiation and brain cancer incidence","volume":"25","author":"Smoll","year":"2023","journal-title":"Neuro Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12937-018-0317-2","article-title":"The influence of prenatal exposure to trans-fatty acids for development of childhood haematopoietic neoplasms (EnTrance): A natural societal experiment and a case-control study","volume":"17","author":"Specht","year":"2018","journal-title":"Nutr. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1177\/1010539511413459","article-title":"Trends in hospital admissions for sunburn in Western Australia, 1988 to 2008","volume":"25","author":"Duke","year":"2013","journal-title":"Asia Pac. J. Public Health"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hylin, H., Thrane, H., Pedersen, K., Kristiansen, I.S., and Burger, E.A. (2019). The healthcare costs of treating human papillomavirus-related cancers in Norway. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5596-2"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejso.2018.02.015","article-title":"Evidence-based data and rare cancers: The need for a new methodological approach in research and investigation","volume":"45","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mushtaq, N., Qureshi, B.M., Javed, G., Sheikh, N.A., Bakhshi, S.K., Laghari, A.A., Enam, S.A., Anwar, S.S.M., Hilal, K., and Kabir, A. (2024). Capacity building for pediatric neuro-oncology in Pakistan- a project by my child matters program of Foundation S. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1325167"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.ejca.2015.02.017","article-title":"EUROCOURSE recipe for cancer surveillance by visible population-based cancer RegisTrees in Europe: From roots to fruits","volume":"51","author":"Coebergh","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejca.2018.07.006","article-title":"The \u2018Survivorship Passport\u2019 for childhood cancer survivors","volume":"102","author":"Haupt","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"ref_60","first-page":"161","article-title":"Factors Influencing Implementation of the Survivorship Passport: The IT Perspective","volume":"293","author":"Chronaki","year":"2022","journal-title":"Stud. Health Technol. Inform."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s41747-020-00150-9","article-title":"PRIMAGE project: Predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers","volume":"4","author":"Ladenstein","year":"2020","journal-title":"Eur. Radiol. Exp."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/15\/2696\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:25:59Z","timestamp":1760109959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/15\/2696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":62,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["cancers16152696"],"URL":"https:\/\/doi.org\/10.3390\/cancers16152696","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]}}}