{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:21:54Z","timestamp":1785943314196,"version":"3.56.0"},"reference-count":33,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>While treatment of localized cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) is based on surgery, brachytherapy, which delivers a high dose of radiation to tumor tissue while sparing healthy tissue, is an alternative. Since the withdrawal of iridium wires from the market, brachytherapy has mainly been performed with high-dose-rate iridium-192 (HDR). This study evaluated the efficacy of HDR brachytherapy in terms of local control, survival, toxicity, and quality of life in patients with facial periorificial cutaneous SCC or BCC treated in our center between 2015 and 2021. Sixty-seven patients were treated for SCC (n = 49) or BCC (n = 18), on the nose (n = 29), lip (n = 28), eyelid (n = 7), or ear (n = 3). The majority had Tis or T1 tumors (73.1%). After a median follow-up of 28 months, 8 patients had a local recurrence. The local control rate at 3 years was 87.05% (95% CI 74.6\u201393.7). All patients developed grade 1\u20132 acute radio-mucositis or radiodermatitis and one experienced reversible grade 3 acute radio-mucositis. Of the 27 patients who completed the quality-of-life questionnaire, 77.8% recommended the treatment. This study confirms that HDR brachytherapy for facial cutaneous carcinomas provides good local control, good tolerance, and satisfactory functional outcome.<\/jats:p>","DOI":"10.3390\/cancers16152742","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T11:34:20Z","timestamp":1722512060000},"page":"2742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High-Dose-Rate Brachytherapy for Treatment of Facial Skin Cancers: Local Control, Toxicity, and Quality of Life in 67 Patients"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8575-4443","authenticated-orcid":false,"given":"Jeanne","family":"Monge-Cadet","sequence":"first","affiliation":[{"name":"Radiation Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Vairel","sequence":"additional","affiliation":[{"name":"Surgery Department, Institut Universitaire du Cancer, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Morisseau","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Data Science Unit, Oncopole Claudius Regaud and Institut Universitaire du Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Moyal","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ducassou","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Chira","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Pag\u00e8s","sequence":"additional","affiliation":[{"name":"Dermato-Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-6633","authenticated-orcid":false,"given":"Vincent","family":"Sibaud","sequence":"additional","affiliation":[{"name":"Dermato-Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brun","sequence":"additional","affiliation":[{"name":"Physics Department, Institut Universitaire du Cancer, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-6454","authenticated-orcid":false,"given":"Anouchka","family":"Modesto","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Oncopole Claudius Regaud and Institut Universitaire du Cancer de Toulouse, 1 Avenue Ir\u00e8ne Joliot-Curie, 31059 Toulouse, Cedex 9, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1365-2133.2012.10830.x","article-title":"A systematic review of worldwide incidence of nonmelanoma skin cancer","volume":"166","author":"Lomas","year":"2012","journal-title":"Br. 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