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Angiogenesis is one of the main signals supporting the survival and development of cells and tissues not only under physiological conditions. Therefore, it is necessary that we understand pathological hyperactivation in all uterine diseases, from endometriosis through ovarian endometrioid adenocarcinoma to malignant transformed cells of the uterine epithelium and body. This work presents the gene expression results of selected angiogenesis targets (VEGF-A, TGF-\u03b21, ANG1\/2, and HIF-1\u03b1), cell migration, and cell\u2013cell interaction determined in vitro. Our results suggest that angiogenesis varies in the tested pathological conditions (ectopic endometriosis\u201412Z; ovarian endometrioid adenocarcinoma\u2014A2780; tumors\u2014SK-UT-1 and RL-95-2) compared to physiological angiogenesis (HME1). The differential expression of angiogenic factors may contribute (or is a contributing factor) to the observed differences to acknowledge an inherent variability in angiogenesis among cell lines. Determining the genomic phenomena responsible for processes associated with inadequate angiogenesis in the pelvic region could help us to develop individual treatment strategies and explain resistance to treatment.<\/jats:p>","DOI":"10.3390\/cancers16162772","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T08:07:59Z","timestamp":1722931679000},"page":"2772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Pivotal Role of the Key Angiogenic Factors in the Development of Endometrioid Pathologies of the Uterus and Ovary"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0363-2403","authenticated-orcid":false,"given":"Gabriela","family":"Sabolov\u00e1","sequence":"first","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, P. J. \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, SK-04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"\u0160pakov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, P. J. \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, SK-04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-5425","authenticated-orcid":false,"given":"Peter","family":"Artimovi\u010d","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, P. J. \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, SK-04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bohu\u0161","sequence":"additional","affiliation":[{"name":"Department of Pathology, P. J. \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, SK-04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Rabajdov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, P. J. \u0160af\u00e1rik University in Ko\u0161ice, Trieda SNP 1, SK-04011 Ko\u0161ice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-4710","authenticated-orcid":false,"given":"M\u00e1ria","family":"Marekov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Biochemistry, P. 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