{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:45:50Z","timestamp":1775954750792,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004173","name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, and Programa de Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Ciudad de M\u00e9xico, M\u00e9xico","doi-asserted-by":"publisher","award":["UAM740101AR1"],"award-info":[{"award-number":["UAM740101AR1"]}],"id":[{"id":"10.13039\/501100004173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: The receptor activator of the nuclear factor-kB (RANK)\/RANK ligand (RANKL)\/osteoprotegerin (OPG) pathway is a determining pathway in the balance between bone formation and resorption, and disruptions in this complex can affect bone metabolism. Methods: This study analyzes the changes in RANKL, OPG, and 25(OH)D levels; the RANKL\/OPG ratio; and other bone turnover markers (BTMs) from diagnosis to complete remission in children with acute lymphoblastic leukemia (ALL). This is a prospective observational cohort study, carried out at the Instituto Mexicano del Seguro Social, Mexico City, including 33 patients (4\u201317 years) with newly diagnosed B-cell ALL. The patients were treated with the HP09 chemotherapy protocol. Children who had previously been treated with corticosteroids were excluded. A peripheral blood sample at diagnosis and remission was collected to determine the 25(OH)D and BTM concentrations. Results: Increased RANKL (p = 0.001) and osteocalcin (p &lt; 0.001) levels and RANKL\/OPG ratio (&lt;0.001) and a decreased OPG level (p = 0.005) were observed at remission, predominantly in the high-risk (HR) relapse and vitamin D deficiency groups. A negative association between RANKL and OPG (r = \u22120.454, p = 0.008) was observed. Conclusions: we suggest that the RANKL\/OPG ratio could serve as a bone remodeling marker in ALL patients.<\/jats:p>","DOI":"10.3390\/cancers16162811","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:54:08Z","timestamp":1723452848000},"page":"2811","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in RANKL, OPG, and 25(OH)D Levels in Children with Leukemia from Diagnosis to Remission"],"prefix":"10.3390","volume":"16","author":[{"given":"Salvador","family":"Atilano-Miguel","sequence":"first","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Ciudad de M\u00e9xico 14387, Mexico"},{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"},{"name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Unidad Iztapalapa, Ciudad de M\u00e9xico 9340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-7434","authenticated-orcid":false,"given":"Lourdes","family":"Barbosa-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Ortiz-Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Ciudad de M\u00e9xico 14387, Mexico"},{"name":"Departamento de Ciencias de la Salud, Divisi\u00f3n de Ciencias Biol\u00f3gicas y de la Salud, Universidad Aut\u00f3noma Metropolitana, Unidad Iztapalapa, Ciudad de M\u00e9xico 9340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Maldonado-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge A.","family":"Martin-Trejo","sequence":"additional","affiliation":[{"name":"Departamento Cl\u00ednico de Hematolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricela","family":"Rodr\u00edguez-Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Nutrici\u00f3n, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Balc\u00e1zar-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Endocrinolog\u00eda, Unidad M\u00e9dica de Alta Especialidad (UMAE), Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina A.","family":"Sol\u00eds-Labastida","sequence":"additional","affiliation":[{"name":"Departamento 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