{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:21:11Z","timestamp":1760145671069,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Breast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa. A retrospective study was conducted. We included 191 Mexican women with BCa without SAH and with SAH treated with nsBBs, sBBs, and diuretics. BMD was evaluated using a bone density scan (DEX scan). A greater average BMD (p &lt; 0.05) was observed in patients with prior treatment with both nsBBs and sBBs (0.54 \u00b1 0.94 and \u22120.44 \u00b1 1.22, respectively) compared to patients treated with diuretics or without SAH (\u22121.73 \u00b1 0.83 and \u22121.22 \u00b1 0.98, respectively). Regarding the diagnosis of osteoporosis\/osteopenia, no cases were observed in patients treated with nsBBs, whereas 5.6% of the patients treated with sBBs presented osteopenia. A total of 23.1% and 10.6% patients managed with diuretics or without treatment presented with osteoporosis and 61.5% and 48% patients managed with loop diuretics and without treatment presented with osteopenia, respectively (p &lt; 0.05). Treatment with nsBBs is a promising option for the prevention and management of osteoporosis\/osteopenia in Mexican patients with BCa; however, further prospective studies are needed.<\/jats:p>","DOI":"10.3390\/cancers16162891","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T10:03:12Z","timestamp":1724148192000},"page":"2891","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Selective and Nonselective Beta Blockers on Bone Mineral Density in Mexican Patients with Breast Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-5257","authenticated-orcid":false,"given":"C\u00e9sar Miguel","family":"Mej\u00eda-Barradas","sequence":"first","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Amador-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Radiolog\u00eda e Imagen, Centro M\u00e9dico ABC, Mexico City 01120, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleazar","family":"Lara-Padilla","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-3440","authenticated-orcid":false,"given":"Noem\u00ed","family":"C\u00e1rdenas-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurociencias, Instituto Nacional de Pediatria, Mexico City 04530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-4613","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Ignacio-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Traslacional, Escuela Militar de Graduados en Sanidad, Universidad Del Ej\u00e9rcito y Fuerza A\u00e9rea, Mexico City 11200, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-4327","authenticated-orcid":false,"given":"Valent\u00edn","family":"Mart\u00ednez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Unidad de Ingenier\u00eda de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Iba\u00f1ez-Cervantes","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"},{"name":"Divisi\u00f3n de Investigaci\u00f3n, Hospital Ju\u00e1rez de M\u00e9xico, Mexico City 07760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando de Jes\u00fas","family":"Picado-Garcia","sequence":"additional","affiliation":[{"name":"Ciudad de la Salud para la Mujer-Cl\u00ednica Materna Huixquilucan, Huixquilucan de Degollado 52760, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brayan","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Bandala","sequence":"additional","affiliation":[{"name":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"ref_1","unstructured":"Mayrovitz, H.N. 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