{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:19:59Z","timestamp":1790882399749,"version":"4.1.0"},"reference-count":94,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Renal cancer is a common and serious malignant tumor of the urinary system. While surgery effectively treats early-stage renal cancer, advanced cases pose a significant challenge due to poor treatment outcomes and chemotherapy resistance. Therefore, there is an urgent need to develop alternative therapeutic strategies. Ferroptosis is a newly defined form of programmed cell death characterized by the accumulation of iron-dependent lipid peroxides, which plays a critical role in tumor progression and drug resistance. Recent studies have shown that ferroptosis is involved in the occurrence and development of renal cancer, and ferroptosis-related genes can induce cell apoptosis and can be used as potential biomarkers for early diagnosis of renal cancer and participate in drug resistance of renal cancer chemotherapy. With the continuous improvement of the mechanism of ferroptosis, drugs targeting ferroptosis for the treatment of renal cancer are emerging in an endless stream. Based on the theoretical basis of the occurrence of ferroptosis, this paper reviewed drug-induced ferroptosis in renal cancer cells from the aspects of herbal medicine, natural compounds, drug resistance mechanisms, and nanomaterials, and delves into the clinical application potential of ferroptosis-related drugs in the treatment of renal cancer.<\/jats:p>","DOI":"10.3390\/cancers16183131","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T02:30:23Z","timestamp":1726108223000},"page":"3131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ferroptosis in Renal Cancer Therapy: A Narrative Review of Drug Candidates"],"prefix":"10.3390","volume":"16","author":[{"given":"Lingyan","family":"Yu","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University, Hangzhou 310053, China"},{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital), Hangzhou Medical College, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyueyang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Biology, Grinnell College, Grinnell, IA 50112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Tong","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital), Hangzhou Medical College, Hangzhou 310014, China"},{"name":"Department of Laboratory Medicine, Affiliated Hangzhou First People\u2019s Hospital, School of Medicine, Westlake University, Hangzhou 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"ref_1","unstructured":"(2024, August 23). Cancer Today. Available online: http:\/\/gco.iarc.fr\/today\/home."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/ndt\/gfae036","article-title":"Global Epidemiology of Kidney Cancer","volume":"39","author":"Cirillo","year":"2024","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_3","unstructured":"(2023, August 28). Survival Rates for Kidney Cancer. Available online: https:\/\/www.cancer.org\/cancer\/types\/kidney-cancer\/detection-diagnosis-staging\/survival-rates.html."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Chen, V.J., Hernandez-Meza, G., Agrawal, P., Zhang, C.A., Xie, L., Gong, C.L., Hoerner, C.R., Srinivas, S., Oermann, E.K., and Fan, A.C. (2019). Time on Therapy for at Least Three Months Correlates with Overall Survival in Metastatic Renal Cell Carcinoma. Cancers, 11.","DOI":"10.3390\/cancers11071000"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.7150\/ijbs.85674","article-title":"Broadening Horizons: The Multifaceted Functions of Ferroptosis in Kidney Diseases","volume":"19","author":"Feng","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: Machinery and Regulation","volume":"17","author":"Chen","year":"2020","journal-title":"Autophagy"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1039\/D1FO00790D","article-title":"Juglone, a Novel Activator of Ferroptosis, Induces Cell Death in Endometrial Carcinoma Ishikawa Cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Food Funct."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1038\/onc.2017.11","article-title":"Iron Addiction: A Novel Therapeutic Target in Ovarian Cancer","volume":"36","author":"Basuli","year":"2017","journal-title":"Oncogene"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of Artesunate as a Specific Activator of Ferroptosis in Pancreatic Cancer Cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mc.22474","article-title":"Contribution of Reactive Oxygen Species to Ovarian Cancer Cell Growth Arrest and Killing by the Anti-Malarial Drug Artesunate: Impact of Artesunate on Ovarian Cancer","volume":"56","author":"Greenshields","year":"2017","journal-title":"Mol. Carcinog."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting Ferroptosis as a Vulnerability in Cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","article-title":"Transferrin Receptor is a Specific Ferroptosis Marker","volume":"30","author":"Feng","year":"2020","journal-title":"Cell Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the Intersection of Lipid Metabolism and Cellular Signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","article-title":"Regulation of Ferroptosis by Lipid Metabolism","volume":"33","author":"Pope","year":"2023","journal-title":"Trends Cell Biol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Liu, Y., Wan, Y., Jiang, Y., Zhang, L., and Cheng, W. (2023). GPX4: The Hub of Lipid Oxidation, Ferroptosis, Disease and Treatment. Biochim. Biophys. Acta Rev. Cancer, 1878.","DOI":"10.1016\/j.bbcan.2023.188890"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a Glutathione-Independent Ferroptosis Suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-Mediated Ferroptosis Defence is a Targetable Vulnerability in Cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP Cyclohydrolase 1\/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e64806","DOI":"10.7554\/eLife.64806","article-title":"Anti-Ferroptotic Mechanism of IL4i1-Mediated Amino Acid Metabolism","volume":"10","author":"Zeitler","year":"2021","journal-title":"eLife"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of Ferroptotic Cancer Cell Death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41419-023-06144-w","article-title":"Emerging Significance and Therapeutic Targets of Ferroptosis: A Potential Avenue for Human Kidney Diseases","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","article-title":"BAP1 Links Metabolic Regulation of Ferroptosis to Tumour Suppression","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41419-018-1206-5","article-title":"BAP1 Regulates Different Mechanisms of Cell Death","volume":"9","author":"Affar","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a P53-Mediated Activity during Tumour Suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2122840119","DOI":"10.1073\/pnas.2122840119","article-title":"Hypersensitivity to Ferroptosis in Chromophobe RCC is Mediated by a Glutathione Metabolic Dependency and Cystine Import via Solute Carrier Family 7 Member 11","volume":"119","author":"Zhang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1111\/cas.13701","article-title":"Fumarate Hydratase Inactivation in Hereditary Leiomyomatosis and Renal Cell Cancer is Synthetic Lethal with Ferroptosis Induction","volume":"109","author":"Kerins","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.celrep.2019.07.107","article-title":"The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma","volume":"28","author":"Yang","year":"2019","journal-title":"Cell Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1038\/nrdp.2017.9","article-title":"Renal Cell Carcinoma","volume":"3","author":"Hsieh","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_30","first-page":"280","article-title":"Broadening Horizons: The Role of Ferroptosis in Cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-023-05719-x","article-title":"PDIA4 Confers Resistance to Ferroptosis via Induction of ATF4\/SLC7A11 in Renal Cell Carcinoma","volume":"14","author":"Kang","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1158\/0008-5472.CAN-22-4001","article-title":"DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma","volume":"83","author":"Chang","year":"2023","journal-title":"Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100916","DOI":"10.1016\/j.drup.2022.100916","article-title":"Overcoming Cancer Chemotherapy Resistance by the Induction of Ferroptosis","volume":"66","author":"Wang","year":"2023","journal-title":"Drug Resist. Updates"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/15384101.2022.2154543","article-title":"CircSCN8A Suppresses Malignant Progression and Induces Ferroptosis in Non-Small Cell Lung Cancer by Regulating miR-1290\/ACSL4 Axis","volume":"22","author":"Liu","year":"2023","journal-title":"Cell Cycle"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"176007","DOI":"10.1016\/j.ejphar.2023.176007","article-title":"Evodiamine Impairs HIF1A Histone Lactylation to Inhibit Sema3A-Mediated Angiogenesis and PD-L1 by Inducing Ferroptosis in Prostate Cancer","volume":"957","author":"Yu","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.32604\/or.2023.046676","article-title":"Gastric Cancer Secreted miR-214-3p Inhibits the Anti-Angiogenesis Effect of Apatinib by Suppressing Ferroptosis in Vascular Endothelial Cells","volume":"32","author":"Wang","year":"2024","journal-title":"Oncol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00018-023-04907-4","article-title":"Ferroptosis and EMT: Key Targets for Combating Cancer Progression and Therapy Resistance","volume":"80","author":"Ren","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41420-024-01825-7","article-title":"Ferroptosis: Emerging Mechanisms, Biological Function, and Therapeutic Potential in Cancer and Inflammation","volume":"10","author":"Jin","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12935-019-0939-2","article-title":"Cell Death-Related Molecules and Biomarkers for Renal Cell Carcinoma Targeted Therapy","volume":"19","author":"Lai","year":"2019","journal-title":"Cancer Cell Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1038\/s41388-022-02460-1","article-title":"ISCA2 Inhibition Decreases HIF and Induces Ferroptosis in Clear Cell Renal Carcinoma","volume":"41","author":"Green","year":"2022","journal-title":"Oncogene"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154182","DOI":"10.1016\/j.phymed.2022.154182","article-title":"Icariside II Induces Ferroptosis in Renal Cell Carcinoma Cells by Regulating the miR-324-3p\/GPX4 Axis","volume":"102","author":"Yu","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.semcancer.2017.02.009","article-title":"From Ancient Herb to Modern Drug: Artemisia Annua and Artemisinin for Cancer Therapy","volume":"46","author":"Efferth","year":"2017","journal-title":"Semin. Cancer Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3892\/ol.2021.13042","article-title":"Ferroptosis is Involved in the Anti-Tumor Effect of Lycorine in Renal Cell Carcinoma Cells","volume":"22","author":"Du","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3846217","DOI":"10.1155\/2022\/3846217","article-title":"HO-1 Contributes to Luteolin-Triggered Ferroptosis in Clear Cell Renal Cell Carcinoma via Increasing the Labile Iron Pool and Promoting Lipid Peroxidation","volume":"2022","author":"Han","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"145992","DOI":"10.1016\/j.gene.2021.145992","article-title":"Everolimus Accelerates Erastin and RSL3-Induced Ferroptosis in Renal Cell Carcinoma","volume":"809","author":"Yangyun","year":"2022","journal-title":"Gene"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41419-023-05779-z","article-title":"Combination Treatment with FAAH Inhibitors\/URB597 and Ferroptosis Inducers Significantly Decreases the Growth and Metastasis of Renal Cell Carcinoma Cells via the PI3K-AKT Signaling Pathway","volume":"14","author":"Hao","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1166\/jbn.2022.3250","article-title":"Tumor Microenvironment-Responsive Nanodrug for Clear-Cell Renal Cell Carcinoma Therapy via Triggering Waterfall-like Cascade Ferroptosis","volume":"18","author":"Ni","year":"2022","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Huang, Z., Gan, S., Zhuang, X., Chen, Y., Lu, L., Wang, Y., Qi, X., Feng, Q., Huang, Q., and Du, B. (2022). Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy. Cells, 11.","DOI":"10.3390\/cells11162472"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/15548627.2023.2261758","article-title":"Artesunate Sensitizes Human Hepatocellular Carcinoma to Sorafenib via Exacerbating AFAP1L2-SRC-FUNDC1 Axis-Dependent Mitophagy","volume":"20","author":"Ma","year":"2024","journal-title":"Autophagy"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4062\/biomolther.2015.172","article-title":"Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells","volume":"24","author":"Lee","year":"2016","journal-title":"Biomol. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Markowitsch, S.D., Schupp, P., Lauckner, J., Vakhrusheva, O., Slade, K.S., Mager, R., Efferth, T., Haferkamp, A., and Juengel, E. (2020). Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis. Cancers, 12.","DOI":"10.3390\/cancers12113150"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","article-title":"The Tumor Suppressor Protein P53 and the Ferroptosis Network","volume":"133","author":"Kang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"154266","DOI":"10.1016\/j.phymed.2022.154266","article-title":"Lycorine and Organ Protection: Review of Its Potential Effects and Molecular Mechanisms","volume":"104","author":"Xiao","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Qi, J., Meng, M., Liu, J., Song, X., Chen, Y., Liu, Y., Li, X., Zhou, Z., Huang, X., and Wang, X. (2023). Lycorine Inhibits Pancreatic Cancer Cell Growth and Neovascularization by Inducing Notch1 Degradation and Downregulating Key Vasculogenic Genes. Biochem. Pharmacol., 217.","DOI":"10.1016\/j.bcp.2023.115833"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3892\/ijmm.2022.5201","article-title":"Lycorine Upregulates the Expression of RMB10, Promotes Apoptosis and Inhibits the Proliferation and Migration of Cervical Cancer Cells","volume":"50","author":"Li","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chen, Y.-H., Wu, J.-X., Yang, S.-F., and Hsiao, Y.-H. (2023). Synergistic Combination of Luteolin and Asiatic Acid on Cervical Cancer In Vitro and In Vivo. Cancers, 15.","DOI":"10.3390\/cancers15020548"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3892\/ijmm.2015.2439","article-title":"Amygdalin Inhibits the Growth of Renal Cell Carcinoma Cells in Vitro","volume":"37","author":"Juengel","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Rutz, J., Maxeiner, S., Juengel, E., Bernd, A., Kippenberger, S., Z\u00f6ller, N., Chun, F.K.-H., and Blaheta, R.A. (2019). Growth and Proliferation of Renal Cell Carcinoma Cells is Blocked by Low Curcumin Concentrations Combined with Visible Light Irradiation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061464"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2009.06.034","article-title":"Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening","volume":"138","author":"Gupta","year":"2009","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12943-019-1068-1","article-title":"Salinomycin Effectively Eliminates Cancer Stem-like Cells and Obviates Hepatic Metastasis in Uveal Melanoma","volume":"18","author":"Zhou","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Wang, Z., Zhang, H., and Cheng, Q. (2020). PDIA4: The Basic Characteristics, Functions and Its Potential Connection with Cancer. Biomed. Pharmacother., 122.","DOI":"10.1016\/j.biopha.2019.109688"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-Dependent Cancer Cell State Underlies the Clear-Cell Morphology and Confers Sensitivity to Ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa060655","article-title":"Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma","volume":"356","author":"Escudier","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e02523","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological Inhibition of Cystine-Glutamate Exchange Induces Endoplasmic Reticulum Stress and Ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"eLife"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/ijc.30571","article-title":"Contribution of Upregulated Dipeptidyl Peptidase 9 (DPP9) in Promoting Tumoregenicity, Metastasis and the Prediction of Poor Prognosis in Non-Small Cell Lung Cancer (NSCLC)","volume":"140","author":"Tang","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e14351","DOI":"10.15252\/emmm.202114351","article-title":"YAP\/TAZ and ATF4 Drive Resistance to Sorafenib in Hepatocellular Carcinoma by Preventing Ferroptosis","volume":"13","author":"Gao","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Park, J.S., Koo, K.C., Chung, D.Y., Kim, S.I., Kim, J., Oh, C.K., Kim, T.N., Kang, S.K., Park, J.W., and Yoon, Y.E. (2020). Visceral Adiposity as a Significant Predictor of Sunitinib-Induced Dose-Limiting Toxicities and Survival in Patients with Metastatic Clear Cell Renal Cell Carcinoma. Cancers, 12.","DOI":"10.3390\/cancers12123602"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.7150\/ijbs.79853","article-title":"AIM2 Promotes Renal Cell Carcinoma Progression and Sunitinib Resistance through FOXO3a-ACSL4 Axis-Regulated Ferroptosis","volume":"19","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-022-01004-z","article-title":"ACSL4, PUFA, and Ferroptosis: New Arsenal in Anti-Tumor Immunity","volume":"7","author":"Gan","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","article-title":"Ferroptotic Damage Promotes Pancreatic Tumorigenesis through a TMEM173\/STING-Dependent DNA Sensor Pathway","volume":"11","author":"Dai","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/cmdc.202100120","article-title":"Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase","volume":"16","author":"Jaiswal","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1080\/15384047.2015.1078028","article-title":"Antitumor Effect of Pyrrolo-1,5-Benzoxazepine-15 and Its Synergistic Effect with Oxaliplatin and 5-FU in Colorectal Cancer Cells","volume":"17","author":"Fiore","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"ref_73","first-page":"441","article-title":"Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors","volume":"6","author":"Straub","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1605897","DOI":"10.1002\/adma.201605897","article-title":"Dynamic Nanoparticle Assemblies for Biomedical Applications","volume":"29","author":"Li","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1002\/anie.201903417","article-title":"A Biomimetic Coordination Nanoplatform for Controlled Encapsulation and Delivery of Drug-Gene Combinations","volume":"58","author":"Liu","year":"2019","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1908865","DOI":"10.1002\/adfm.201908865","article-title":"Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification","volume":"30","author":"Liu","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1039\/C9BM00641A","article-title":"A Cascade-Reaction Enabled Synergistic Cancer Starvation\/ROS-Mediated\/Chemo-Therapy with an Enzyme Modified Fe-Based MOF","volume":"7","author":"Liu","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7150\/thno.67375","article-title":"Repurposing Ferumoxytol: Diagnostic and Therapeutic Applications of an FDA-Approved Nanoparticle","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"15812","DOI":"10.1021\/jacs.1c07471","article-title":"Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy","volume":"143","author":"Liang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"154668","DOI":"10.1016\/j.phymed.2023.154668","article-title":"Tiliroside Targets TBK1 to Induce Ferroptosis and Sensitize Hepatocellular Carcinoma to Sorafenib","volume":"111","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13046-022-02567-z","article-title":"Targeting Fatty Acid Synthase Modulates Sensitivity of Hepatocellular Carcinoma to Sorafenib via Ferroptosis","volume":"42","author":"Li","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4103\/1673-5374.245480","article-title":"Deferoxamine Promotes Recovery of Traumatic Spinal Cord Injury by Inhibiting Ferroptosis","volume":"14","author":"Yao","year":"2019","journal-title":"Neural Regen. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e13158","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1\u03b1\/SLC7A11 Pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e0246","DOI":"10.1097\/HC9.0000000000000246","article-title":"Sorafenib Induces Ferroptosis by Promoting TRIM54-Mediated FSP1 Ubiquitination and Degradation in Hepatocellular Carcinoma","volume":"7","author":"Liu","year":"2023","journal-title":"Hepatol. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.neo.2021.11.002","article-title":"ABCC5 Facilitates the Acquired Resistance of Sorafenib through the Inhibition of SLC7A11-Induced Ferroptosis in Hepatocellular Carcinoma","volume":"23","author":"Huang","year":"2021","journal-title":"Neoplasia"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41401-022-00981-9","article-title":"Sorafenib Triggers Ferroptosis via Inhibition of HBXIP\/SCD Axis in Hepatocellular Carcinoma","volume":"44","author":"Zhang","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1002\/1878-0261.13305","article-title":"Loss of GABARAPL1 Confers Ferroptosis Resistance to Cancer Stem-like Cells in Hepatocellular Carcinoma","volume":"16","author":"Du","year":"2022","journal-title":"Mol. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Sun, J., Zhou, C., Zhao, Y., Zhang, X., Chen, W., Zhou, Q., Hu, B., Gao, D., Raatz, L., and Wang, Z. (2021). Quiescin Sulfhydryl Oxidase 1 Promotes Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving EGFR Endosomal Trafficking and Inhibiting NRF2 Activation. Redox Biol., 41.","DOI":"10.1016\/j.redox.2021.101942"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wang, H.-H., Fan, S.-Q., Zhan, Y.-T., Peng, S.-P., and Wang, W.-Y. (2024). Suppression of the SLC7A11\/Glutathione Axis Causes Ferroptosis and Apoptosis and Alters the Mitogen-Activated Protein Kinase Pathway in Nasopharyngeal Carcinoma. Int. J. Biol. Macromol., 254.","DOI":"10.1016\/j.ijbiomac.2023.127976"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Li, L., Zeng, J., He, S., Yang, Y., and Wang, C. (2024). METTL14 Decreases FTH1 mRNA Stability via m6A Methylation to Promote Sorafenib-Induced Ferroptosis of Cervical Cancer. Cancer Biol. Ther., 25.","DOI":"10.1080\/15384047.2024.2349429"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3349\/ymj.2021.62.9.843","article-title":"Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells","volume":"62","author":"Song","year":"2021","journal-title":"Yonsei Med. J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e2102799","DOI":"10.1002\/adhm.202102799","article-title":"Metabolic Intervention Nanoparticles for Triple-Negative Breast Cancer Therapy via Overcoming FSP1-Mediated Ferroptosis Resistance","volume":"11","author":"Yang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"eabl8920","DOI":"10.1126\/sciadv.abl8920","article-title":"Dexamethasone Sensitizes to Ferroptosis by Glucocorticoid Receptor-Induced Dipeptidase-1 Expression and Glutathione Depletion","volume":"8","author":"Maremonti","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","article-title":"Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke","volume":"177","author":"Alim","year":"2019","journal-title":"Cell"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/18\/3131\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:54:08Z","timestamp":1760111648000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/18\/3131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,11]]},"references-count":94,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["cancers16183131"],"URL":"https:\/\/doi.org\/10.3390\/cancers16183131","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,11]]}}}