{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:05:43Z","timestamp":1791432343486,"version":"4.3.3"},"reference-count":74,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Atypical spindle cell\/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell\/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and\/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks MDM2 gene amplification but can show RB1 gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity.<\/jats:p>","DOI":"10.3390\/cancers16183146","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T05:31:44Z","timestamp":1726205504000},"page":"3146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atypical Spindle Cell\/Pleomorphic Lipomatous Tumor: A Review and Update"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-8000","authenticated-orcid":false,"given":"Jun","family":"Nishio","sequence":"first","affiliation":[{"name":"Section of Orthopaedic Surgery, Department of Medicine, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-3496","authenticated-orcid":false,"given":"Shizuhide","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-0783","authenticated-orcid":false,"given":"Yoshiro","family":"Chijiiwa","sequence":"additional","affiliation":[{"name":"Section of Orthopaedic Surgery, Department of Medicine, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiro","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9902-1383","authenticated-orcid":false,"given":"Mikiko","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Creytens, D., and Marino-Enriquez, A. (2020). Atypical spindle cell\/pleomorphic lipomatous tumor. World Health Organization (WHO) Classification of Soft Tissue and Bone Tumours, International Agency for Research on Cancer (IARC). [5th ed.].","DOI":"10.1111\/cup.13731"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00000478-199409000-00006","article-title":"Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Analysis of six cases","volume":"18","author":"Mentzel","year":"1994","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/modpathol.2010.66","article-title":"Well-differentiated spindle cell liposarcoma (\u2018atypical spindle cell lipomatous tumor\u2019) does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: Clinicopathologic, immunohistochemical, and molecular analysis of six cases","volume":"23","author":"Mentzel","year":"2010","journal-title":"Mod. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/PAS.0b013e31829562ed","article-title":"Fibrosarcoma-loke lipomatous neoplasm: A reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous tumor unrelated to other liposarcomas","volume":"37","author":"Deyrup","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_5","first-page":"97","article-title":"Atypical spindle cell lipoma: A clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma","volume":"465","author":"Creytens","year":"2014","journal-title":"Virchows Arch."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PAS.0000000000000770","article-title":"Atypical spindle cell lipomatous tumor: Clinico-pathologic characterization of 232 cases demonstrating a morphologic spectrum","volume":"41","author":"Nascimento","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_7","first-page":"1282","article-title":"\u2018Atypical\u2019 pleomorphic lipomatous tumor: A clinicopathologic, immunohistochemical and molecular study of 21 cases, emphasizing its relationship to atypical spindle cell lipomatous tumor and suggesting a morphologic spectrum (atypical spindle cell\/pleomorphic lipomatous tumor)","volume":"45","author":"Creytens","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_8","first-page":"1443","article-title":"Atypical pleomorphic lipomatous tumor: Expanding our current understanding in a clinicopathologic analysis of 64 cases","volume":"41","author":"Anderson","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/pin.12719","article-title":"Atypical spindle cell\/pleomorphic lipomatous tumor: A clinicopathologic, immunohistochemical, and molecular study of 20 cases","volume":"68","author":"Koca","year":"2018","journal-title":"Pathol. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00795-022-00327-8","article-title":"Atypical spindle cell\/pleomorphic lipomatous tumor with a sarcomatous component showing high mitotic activity and Ki-67 labeling index: Report of a unique case mimicking dedifferentiated liposarcoma","volume":"55","author":"Sugita","year":"2022","journal-title":"Med. Mol. Morphol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"100454","DOI":"10.1016\/j.modpat.2024.100454","article-title":"Atypical spindle cell\/pleomorphic lipomatous tumor with sarcomatous transformation: Clinicopathologic and molecular analysis of 4 cases","volume":"37","author":"Perret","year":"2024","journal-title":"Mod. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.12998\/wjcc.v10.i8.2584","article-title":"Large retroperitoneal atypical spindle cell lipomatous tumor, an extremely rare neoplasm: A case report","volume":"10","author":"Bae","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e6868","DOI":"10.1002\/ccr3.6868","article-title":"Lumbar paraspinal atypical spindle cell\/pleomorphic lipomatous tumor: A report of a rare case","volume":"11","author":"Cheng","year":"2023","journal-title":"Clin. Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"rjad040","DOI":"10.1093\/jscr\/rjad040","article-title":"An extremely rare neoplasm `atypical spindle cell pleomorphic lipomatous tumor\u2019: A case report","volume":"2023","author":"Lugwaja","year":"2023","journal-title":"J. Surg. Case Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1177\/0003134820933601","article-title":"Atypical spindle cell lipomatous lesion resected form patient with history of CLL","volume":"86","author":"Wehrle","year":"2020","journal-title":"Am. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ichikawa, J., Kawasaki, T., Imada, H., Kanno, S., Taniguchi, N., Ashizawa, T., and Haro, H. (2022). Case report: Atypical spindle cell\/pleomorphic lipomatous tumor masquerading as a myxoid liposarcoma or intramuscular myxoma. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.1033114"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"rjae219","DOI":"10.1093\/jscr\/rjae219","article-title":"Pediatric case of atypical spindle cell\/pleomorphic lipomatous tumor within the vastus lateralis muscle","volume":"2024","author":"Iseed","year":"2024","journal-title":"J. Surg. Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cancergencyto.2008.04.004","article-title":"Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas","volume":"184","author":"Italiano","year":"2008","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/cup.14230","article-title":"Histopathologic and genetic findings in atypical spindle cell\/pleomorphic lipomatous tumors and atypical pleomorphic fibromas","volume":"49","author":"Kouhsari","year":"2022","journal-title":"J. Cutan. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/jcp-2024-209480","article-title":"RB1: Governor of the cell cycle in health and disease\u2014A primer for the practicing pathologist","volume":"77","author":"Cordier","year":"2024","journal-title":"J. Clin. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Libbrecht, S., Van Dorpe, J., and Creytens, D. (2021). The rapidly expanding group of RB1-deleted soft tissue tumors: An updated review. Diagnostics, 11.","DOI":"10.3390\/diagnostics11030430"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1038\/s41379-021-00862-2","article-title":"Myxoid pleomorphic liposarcoma-A clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma","volume":"34","author":"Creytens","year":"2021","journal-title":"Mod. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1097\/CM9.0000000000001692","article-title":"Atypical spindle cell lipomatous tumor\/atypical pleomorphic lipomatous tumor and atypical mammary-type myofibroblastoma: Clinicopathological, immunohistochemical, and multiplex fluorescence in situ hybridization analysis","volume":"134","author":"Zhang","year":"2021","journal-title":"Chin. Med. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1530\/JME-18-0178","article-title":"Molecular mechanisms of FOXO1 in adipocyte differentiation","volume":"62","author":"Chen","year":"2019","journal-title":"J. Mol. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/his.14593","article-title":"Well-differentiated lipomatous neoplasms with p53 alterations: A clinicopathological and molecular study of eight cases with features of atypical pleomorphic lipomatous tumour","volume":"80","author":"Hammer","year":"2022","journal-title":"Histopathology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/1066896918809189","article-title":"Atypical spindle cell lipomatous tumor with benign heterologous (metaplastic) cartilaginous differentiation","volume":"27","author":"Creytens","year":"2019","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/1066896919846561","article-title":"\u201cFat-rich\u201d (spindle cell-poor) variant of atypical spindle cell\/pleomorphic lipomatous tumor: Striking mimic of \u201cclassical\u201d atypical lipomatous tumor\/well-differentiated liposarcoma","volume":"27","author":"Creytens","year":"2019","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/10668969221098086","article-title":"Atypical spindle cell\/pleomorphic lipomatous tumor with pleomorphic hyalinizing angiectatic tumor-like growth pattern: A search for diagnostic clues","volume":"31","author":"Cordier","year":"2023","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_29","first-page":"769","article-title":"Atypical spindle cell\/pleomorphic lipomatous tumor","volume":"35","author":"Lecoutere","year":"2020","journal-title":"Histol. Histopathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.path.2023.07.004","article-title":"Atypical spindle cell\/pleomorphic lipomatous tumor","volume":"17","author":"Qorbani","year":"2024","journal-title":"Surg. Pathol. Clin."},{"key":"ref_31","unstructured":"Billings, S.D., and Ud Din, N. (2020). Spindle cell lipoma and pleomorphic lipoma. World Health Organization (WHO) Classification of Soft Tissue and Bone Tumours, International Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"282","DOI":"10.21873\/cdp.10213","article-title":"Spindle cell lipoma and pleomorphic lipoma: An update and review","volume":"3","author":"Ohshima","year":"2023","journal-title":"Cancer Diag. Progn."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2214\/ajr.181.5.1811251","article-title":"Imaging characteristics of spindle cell lipoma","volume":"181","author":"Bancroft","year":"2003","journal-title":"Am. J. Roentgenol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00256-014-1834-5","article-title":"Imaging characteristics of spindle cell lipoma and its variants","volume":"43","author":"Khashper","year":"2014","journal-title":"Skelet. Radiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00428-004-1085-2","article-title":"Desmin expression in spindle cell lipoma: A potential diagnostic pitfall","volume":"445","author":"Aramburu","year":"2004","journal-title":"Virchows Arch."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00428-016-1996-8","article-title":"S-100 protein expressing spindle cells in spindle cell lipoma: A diagnostic pitfall","volume":"469","author":"Mentzel","year":"2016","journal-title":"Virchows Arch."},{"key":"ref_37","first-page":"193","article-title":"Cytogenetics of spindle cell\/pleomorphic lipomas: Karyotyping and FISH analysis of 31 tumors","volume":"15","author":"Panagopoulos","year":"2018","journal-title":"Cancer Genom. Proteom."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01194267","article-title":"A new cytogenetic subgroup in lipomas: Loss of chromosome 16 material in spindle cell and pleomorphic lipomas","volume":"120","author":"Mandahl","year":"1994","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_39","unstructured":"Sbaraglia, M., Dei Tos, A.P., and Pedeutour, F. (2020). Atypical lipomatous tumour\/well-differentiated liposarcoma. World Health Organization (WHO) Classification of Soft Tissue and Bone Tumours, International Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.21873\/anticanres.16624","article-title":"Biology and management of deep-seated atypical lipomatous tumor of the extremities","volume":"43","author":"Nishio","year":"2023","journal-title":"Anticancer Res."},{"key":"ref_41","first-page":"74","article-title":"18F-FDG PET\/CT imaging features of lipomatous tumors","volume":"10","author":"Baffour","year":"2020","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"107301","DOI":"10.1016\/j.ejso.2023.107301","article-title":"Low local recurrence rates following marginal surgical resection of non-coelomic atypical lipomatous tumours\/well-differentiated liposarcomas","volume":"50","author":"Sivarajah","year":"2024","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/jjco\/hyab185","article-title":"Marginal resection for patients with atypical lipomatous tumours of the extremities and trunk wall: A systematic review and meta-analysis","volume":"52","author":"Kido","year":"2022","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ejso.2014.11.044","article-title":"Clinical outcome of deep-seated atypical lipomatous tumor of the extremities with median-term follow-up study","volume":"41","author":"Kito","year":"2015","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_45","unstructured":"Dei Tos, A.P., Marino-Enriquez, A., and Pedeutour, F. (2020). Dedifferentiated liposarcoma. World Health Organization (WHO) Classification of Soft Tissue and Bone Tumours, International Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Nishio, J., Nakayama, S., Nabeshima, K., and Yamamoto, T. (2021). Biology and management of dedifferentiated liposarcoma: State of the art and perspectives. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153230"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.clinimag.2009.12.025","article-title":"Dedifferentiated liposarcoma of retroperitoneum: Spectrum of imaging findings in 15 patients","volume":"34","author":"Hong","year":"2010","journal-title":"Clin. Imaging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1097\/CORR.0000000000001338","article-title":"What are the results of resection of localized dedifferentiated liposarcomas in the extremities?","volume":"478","author":"Nakata","year":"2020","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/PAS.0b013e3182417330","article-title":"Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas form other adipocytic tumors","volume":"36","author":"Thway","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/gcc.20835","article-title":"Evaluation of well-differentiated\/de-differentiated liposarcomas by high-resolution oligonucleotide array-based comparative genomic hybridization","volume":"50","author":"Tap","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_51","unstructured":"Pedeutour, F., and Montgomery, E.A. (2020). Pleomorphic liposarcoma. World Health Organization (WHO) Classification of Soft Tissue and Bone Tumours, International Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1097\/01.pas.0000135524.73447.4a","article-title":"Pleomorphic liposarcoma: Clinicopathologic analysis of 57 cases","volume":"28","author":"Hornick","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00000478-200205000-00006","article-title":"Pleomorphic liposarcoma: Clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: A study from the French Federation of Cancer Centers Sarcoma Group","volume":"26","author":"Gebhard","year":"2002","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/jso.24949","article-title":"Imaging of liposarcomas for clinicians: Characteristic features and differential considerations","volume":"117","author":"Teniola","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1148\/rg.255055106","article-title":"From the archives of the AFIP: Imaging of musculoskeletal liposarcoma with radiologic-pathologic correlation","volume":"25","author":"Murphey","year":"2005","journal-title":"Radiographics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1148\/rg.2016150133","article-title":"Spectrum of fat-containing soft-tissue masses at MR imaging: The common, the uncommon, the characteristic, and the sometimes confusing","volume":"36","author":"Gupta","year":"2016","journal-title":"Radiographics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1002\/cncr.26195","article-title":"Pleomorphic liposarcoma: Clinical observations and molecular variables","volume":"117","author":"Ghadimi","year":"2011","journal-title":"Cancer"},{"key":"ref_58","first-page":"722","article-title":"Epithelioid variant of pleomorphic liposarcoma: A study of 12 cases of a distinctive variant of high-grade liposarcoma","volume":"12","author":"Miettinen","year":"1999","journal-title":"Mod. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/(SICI)1098-2264(199805)22:1<16::AID-GCC3>3.0.CO;2-A","article-title":"Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: A report of the CHAMP Study Group. Chromosomes and MorPhology","volume":"22","author":"Mertens","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/labinvest.3700202","article-title":"Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalances","volume":"85","author":"Idbaih","year":"2005","journal-title":"Lab. Investig."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ng.619","article-title":"subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy","volume":"42","author":"Barretina","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_62","first-page":"29932998","article-title":"Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma","volume":"62","author":"Fritz","year":"2002","journal-title":"Cancer Res."},{"key":"ref_63","unstructured":"Alaggio, R., and Creytens, F. (2020). Myxoid pleomorphic liposarcoma. World Health Organization (WHO) Classification of Soft Tissue and Bone Tumours, International Agency for Research on Cancer (IARC). [5th ed.]."},{"key":"ref_64","first-page":"1101","article-title":"Myxoid pleomorphic liposarcoma","volume":"39","author":"Fadaei","year":"2024","journal-title":"Histol. Histopathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41379-022-01107-6","article-title":"Myxoid pleomorphic liposarcoma is distinguished from other liposarcomas by widespread loss of heterozygosity and significantly worse overall survival: A genomic and clinicopathologic study","volume":"35","author":"Dermawan","year":"2022","journal-title":"Mod. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00383-017-4063-x","article-title":"Pleomorphic myxoid liposarcoma in an adolescent with Li-Fraumeni syndrome","volume":"33","author":"Sinclair","year":"2017","journal-title":"Pediatr. Surg. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijporl.2019.05.016","article-title":"head and neck pleomorphic myxoid liposarcoma in a child with Li-Fraumeni syndrome","volume":"123","author":"Francom","year":"2019","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.path.2023.06.005","article-title":"Myxoid pleomorphic liposarcoma","volume":"17","author":"Dermawan","year":"2024","journal-title":"Surg. Pathol. Clin."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.pathol.2023.06.005","article-title":"Myxoid pleomorphic liposarcoma of the orbit: Intratumoural genetic similarities and heterogeneity","volume":"56","author":"Tan","year":"2024","journal-title":"Pathology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e31360","DOI":"10.1097\/MD.0000000000031360","article-title":"Myxoid pleomorphic liposarcoma in the teres minor muscle: A case report","volume":"101","author":"Choi","year":"2022","journal-title":"Medicine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/jclinpath-2014-202420","article-title":"Array-based comparative genomic hybridization analysis of a pleomorphic myxoid liposarcoma","volume":"67","author":"Creytens","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/his.12913","article-title":"Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near-haploidization and loss of the RB1 gene","volume":"69","author":"Hofvander","year":"2016","journal-title":"Histopathology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/PAS.0b013e3181963c9c","article-title":"Liposarcomas in young patients: A study of 82 cases occurring in patients younger than 22 years of age","volume":"33","author":"Alaggio","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/PAS.0b013e3182562bc1","article-title":"Liposarcomas of the mediastinum and thorax: A clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features","volume":"36","author":"Boland","year":"2012","journal-title":"Am. J. Surg. Pathol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/18\/3146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:55:29Z","timestamp":1760111729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/16\/18\/3146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":74,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["cancers16183146"],"URL":"https:\/\/doi.org\/10.3390\/cancers16183146","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]}}}