{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:10:14Z","timestamp":1789560614067,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,22]],"date-time":"2024-09-22T00:00:00Z","timestamp":1726963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AOK Baden-Wuerttemberg"},{"name":"open-access publication fund of Heidelberg University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background\/Objectives: Breast cancer may negatively affect later pregnancy and childbirth. We aimed to analyze the impact of previous breast cancer on obstetric outcomes in postdiagnosis pregnancies. Methods: Insurance claims data in Southern Germany were used to identify breast cancer (BC) survivors with at least one subsequent delivery after cancer diagnosis between 2010 and 2020. In total, 74 BC survivors were compared to 222 age-matched controls with frequency matching on their age at their postdiagnosis delivery. Results: Endocrine therapy was associated with a significantly lower probability of birth compared to BC survivors without endocrine therapy (HR 0.36; 95% CI 0.18\u20130.53; p &lt; 0.0001). The risks of preterm birth, low birth weight (LBW), gestational diabetes, hypertensive disorders, and cesarean section were not significantly increased among BC survivors compared to healthy controls. BC survivors were at an increased risk for a small-for-gestational-age (SGA) fetus (OR 3.24; 95% CI 1.17\u20138.97, p = 0.03). Delivery in less than 2 years after diagnosis increased the risk for SGA (OR 5.73; 95% CI 1.37\u201324.02, p = 0.03) and LBW (OR 4.57; 95% CI 1.32\u201315.87, p = 0.02). Conclusions: Our findings are encouraging regarding the risks of preterm delivery, gestational diabetes, hypertensive disorders, and cesarean section to women who consider pregnancy after BC. Delivery in less than 2 years after diagnosis was associated with an increased risk for SGA and LBW.<\/jats:p>","DOI":"10.3390\/cancers16183230","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T09:15:07Z","timestamp":1727082907000},"page":"3230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Adverse Obstetric Outcomes after Breast Cancer Diagnosis: An Observational Database Study in Germany"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-3872","authenticated-orcid":false,"given":"Anna Sophie","family":"Scholz","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7649-4914","authenticated-orcid":false,"given":"Alexandra","family":"von Au","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Gutsfeld","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-701X","authenticated-orcid":false,"given":"Tjeerd Maarten Hein","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7653-8283","authenticated-orcid":false,"given":"Dominik","family":"Dannehl","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Hassdenteufel","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Hawighorst-Knapstein","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, AOK Baden-Wuerttemberg, 70188 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Chaudhuri","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, AOK Baden-Wuerttemberg, 70188 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Department of Gynecology, University Hospital Halle (Saale), 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-1094","authenticated-orcid":false,"given":"Sara Yvonne","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1227-1118","authenticated-orcid":false,"given":"Andreas Daniel","family":"Hartkopf","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University Hospital Tuebingen, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Fetal Medicine, University Hospital Halle (Saale), 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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