{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:28:57Z","timestamp":1760146137542,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Government (National Research Agency, ANR; CNRS; INSERM) through the \u2018Invest-ments for the Future\u2019 LABEX SIGNALIFE","award":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"],"award-info":[{"award-number":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"]}]},{"name":"Campus France","award":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"],"award-info":[{"award-number":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"]}]},{"name":"Iraqi Ministry of Higher Education and Scientific Research","award":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"],"award-info":[{"award-number":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"]}]},{"name":"Fondation de l\u2019Avenir","award":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"],"award-info":[{"award-number":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"]}]},{"name":"Association pour la Recherche contre le Cancer","award":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"],"award-info":[{"award-number":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"]}]},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie","award":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"],"award-info":[{"award-number":["ANR-11-LABEX-0028-01","ARC, SFI201212055859","UMR7284"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Xeroderma pigmentosum (XP) is a very rare recessive disease caused by the incapacity to resolve ultraviolet-induced DNA lesions through Nucleotide Excision Repair (NER). Most XP patients suffer from aggressive skin carcinoma and melanoma at a very early age (&lt;8). Our previous results showed that primary XP fibroblasts isolated from healthy (non-photo-exposed) skin negatively impact the extracellular matrix and fail to activate the innate immune system. Here, we show for the first time that XP-C fibroblasts also play a major role in cancer cell invasion ex vivo and in vivo through the overexpression of Hepatocyte Growth Factor\/Scatter Factor (HGF\/SF) in the absence of genotoxic attacks. The use of inhibitors of the activation of the HGF\/SF pathway counteracted the effects of XP fibroblasts on the growth of cancer cells, suggesting new perspectives in the care of XP patients.<\/jats:p>","DOI":"10.3390\/cancers16193277","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T06:55:52Z","timestamp":1727333752000},"page":"3277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Xeroderma Pigmentosum Type C Primary Skin Fibroblasts Overexpress HGF and Promote Squamous Cell Carcinoma Invasion in the Absence of Genotoxic Stress"],"prefix":"10.3390","volume":"16","author":[{"given":"Sahar","family":"Al-qaraghuli","sequence":"first","affiliation":[{"name":"INSERM U1081\u2013CNRS UMR7284-UNS, CEDEX 02, F-06107 Nice, France"},{"name":"Facult\u00e9 de M\u00e9dicine, 2\u00e8me \u00e9tage, CNRS UMR 6267\u2014INSERM U998\u2014UNSA, F-06107 Nice Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Gache","sequence":"additional","affiliation":[{"name":"INSERM U1081\u2013CNRS UMR7284-UNS, CEDEX 02, F-06107 Nice, France"},{"name":"Facult\u00e9 de M\u00e9dicine, 2\u00e8me \u00e9tage, CNRS UMR 6267\u2014INSERM U998\u2014UNSA, F-06107 Nice Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Goncalves-Maia","sequence":"additional","affiliation":[{"name":"INSERM U1081\u2013CNRS UMR7284-UNS, CEDEX 02, F-06107 Nice, France"},{"name":"Facult\u00e9 de M\u00e9dicine, 2\u00e8me \u00e9tage, CNRS UMR 6267\u2014INSERM U998\u2014UNSA, F-06107 Nice Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Alcor","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9dicine, 2\u00e8me \u00e9tage, CNRS UMR 6267\u2014INSERM U998\u2014UNSA, F-06107 Nice Cedex 2, France"},{"name":"INSERM U1065, C3M, Microscopy Facility, F-06200 Nice, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Muzotte","sequence":"additional","affiliation":[{"name":"BRIC, UMR 1312, Inserm, Universit\u00e9 de Bordeaux, F-33076 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid","family":"Mahfouf","sequence":"additional","affiliation":[{"name":"BRIC, UMR 1312, Inserm, Universit\u00e9 de Bordeaux, F-33076 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid-Reza","family":"Rezvani","sequence":"additional","affiliation":[{"name":"BRIC, UMR 1312, Inserm, Universit\u00e9 de Bordeaux, F-33076 Bordeaux, France"},{"name":"Centre de R\u00e9f\u00e9rence pour les Maladies Rares de la Peau, CHU de Bordeaux, F-33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-8599","authenticated-orcid":false,"given":"Thierry","family":"Magnaldo","sequence":"additional","affiliation":[{"name":"INSERM U1081\u2013CNRS UMR7284-UNS, CEDEX 02, F-06107 Nice, France"},{"name":"Facult\u00e9 de M\u00e9dicine, 2\u00e8me \u00e9tage, CNRS UMR 6267\u2014INSERM U998\u2014UNSA, F-06107 Nice Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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